2-methylellipticinium

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2-methylellipticinium: RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	125771
CHEMBL ID	16756
MeSH ID	M0088662

Synonyms (17)

Synonym
NCI60_003145
NCI60_003152
NEURO_000184
NEURO_000187
2-methylellipticine
CHEMBL16756
2,5,11-trimethyl-6h-pyrido[4,3-b]carbazol-2-ium
69467-91-0
6h-pyrido(4,3-b)carbazolium, 2,5,11-trimethyl-
nsc 226137
2-methylellipticinium
DTXSID10219686
6h-pyrido[4,3-b]carbazolium, 2,5,11-trimethyl-
2,5,11-trimethyl-6h-pyrido[4,3-b]carbazole
2,5,11-trimethyl-6h-pyrido[4,3-b]carbazolium
W9SB84PL4Y
2-n-methylellipticinium

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (12)

Assay ID	Title	Year	Journal	Article
AID117798	The effect on NADH oxidation in the presence of MPO-H2O2.	1981	Journal of medicinal chemistry, Mar, Volume: 24, Issue:3	Bioactivation of the antitumor drugs 9-hydroxyellipticine and derivatives by a peroxidase-hydrogen peroxide system.
AID96665	Growth inhibitory activity against L1210 lymphocytic leukemia cells.	1983	Journal of medicinal chemistry, Oct, Volume: 26, Issue:10	Autoxidation of the antitumor drug 9-hydroxyellipticine and its derivatives.
AID81867	Inhibitory effect against HCT8 Human colon adenocarcinoma; inactive	1986	Journal of medicinal chemistry, Jul, Volume: 29, Issue:7	Basically substituted ellipticine analogues as potential antitumor agents.
AID97904	Compound was tested for its cytotoxic activity against murine leukemia L1210 cells in mice after intraperitoneal treatment, expressed as LD0 (highest nonlethal dose).	1981	Journal of medicinal chemistry, Mar, Volume: 24, Issue:3	Bioactivation of the antitumor drugs 9-hydroxyellipticine and derivatives by a peroxidase-hydrogen peroxide system.
AID54618	Apparent binding constant (Kapp) for calf thymus DNA was measured by competition with ethidium bromide	1984	Journal of medicinal chemistry, Sep, Volume: 27, Issue:9	Potential antitumor agents: synthesis and biological properties of aliphatic amino acid 9-hydroxyellipticinium derivatives.
AID96644	Compound was tested for its antitumor activity against murine leukemia L1210 cells in vitro, expressed as ID50	1981	Journal of medicinal chemistry, Mar, Volume: 24, Issue:3	Bioactivation of the antitumor drugs 9-hydroxyellipticine and derivatives by a peroxidase-hydrogen peroxide system.
AID96662	Dose that reduces the L1210 leukemia cell growth in vitro by 50% after 48 hr as compared to controls	1984	Journal of medicinal chemistry, Sep, Volume: 27, Issue:9	Potential antitumor agents: synthesis and biological properties of aliphatic amino acid 9-hydroxyellipticinium derivatives.
AID132189	Percent Increase in life span (ILS) over controls (10e5 L1210 leukemia cells) at LD0/2 by ip administration of the drug into mouse (single injection 2 hr after cell grafting)	1984	Journal of medicinal chemistry, Sep, Volume: 27, Issue:9	Potential antitumor agents: synthesis and biological properties of aliphatic amino acid 9-hydroxyellipticinium derivatives.
AID100465	Inhibitory effect against L1210 leukemia in tissue culture	1986	Journal of medicinal chemistry, Jul, Volume: 29, Issue:7	Basically substituted ellipticine analogues as potential antitumor agents.
AID117503	he effect on oxygen consumed in the presence of MPO-H2O2.	1981	Journal of medicinal chemistry, Mar, Volume: 24, Issue:3	Bioactivation of the antitumor drugs 9-hydroxyellipticine and derivatives by a peroxidase-hydrogen peroxide system.
AID116287	Increase in life span over controls (10e5 cells) in mice after intraperitoneal treatment of the compound.	1981	Journal of medicinal chemistry, Mar, Volume: 24, Issue:3	Bioactivation of the antitumor drugs 9-hydroxyellipticine and derivatives by a peroxidase-hydrogen peroxide system.
AID134221	Compound tested in vivo for highest nontoxic lethal dose administered intraperitoneally that reduces the L1210 leukemia cell growth	1984	Journal of medicinal chemistry, Sep, Volume: 27, Issue:9	Potential antitumor agents: synthesis and biological properties of aliphatic amino acid 9-hydroxyellipticinium derivatives.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	11 (91.67)	18.7374
1990's	1 (8.33)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.71

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	11.71 (24.57)
Research Supply Index	2.56 (2.92)
Research Growth Index	4.27 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (11.71)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	12 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
ellipticine ellipticine : A organic heterotetracyclic compound that is pyrido[4,3-b]carbazole carrying two methyl substituents at positions 5 and 11.	7.88	4	indole alkaloid; organic heterotetracyclic compound; organonitrogen heterocyclic compound; polycyclic heteroarene	antineoplastic agent; plant metabolite
ethidium Ethidium: A trypanocidal agent and possible antiviral agent that is widely used in experimental cell biology and biochemistry. Ethidium has several experimentally useful properties including binding to nucleic acids, noncompetitive inhibition of nicotinic acetylcholine receptors, and fluorescence among others. It is most commonly used as the bromide.. ethidium : The fluorescent compound widely used in experimental cell biology and biochemistry to reveal double-stranded DNA and RNA.	1.97	1	phenanthridines	fluorochrome; intercalator
phenobarbital Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.. phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.	1.95	1	barbiturates	anticonvulsant; drug allergen; excitatory amino acid antagonist; sedative
1,2-dipalmitoylphosphatidylcholine 1,2-Dipalmitoylphosphatidylcholine: Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.	1.97	1
epirubicin Epirubicin: An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA.	1.97	1	aminoglycoside; anthracycline antibiotic; anthracycline; deoxy hexoside; monosaccharide derivative; p-quinones; primary alpha-hydroxy ketone; tertiary alpha-hydroxy ketone	antimicrobial agent; antineoplastic agent; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor
elliptinium elliptinium: synthetic ellipticine deriv; RN given refers to parent cpd; structure given in first source	3.35	7	carbazoles
9-methoxyellipticine 9-methoxyellipticine: RN given refers to parent cpd	1.96	1
9-hydroxyellipticine 9-hydroxyellipticine: RN given refers to parent cpd. 9-hydroxyellipticine : A organic heterotetracyclic compound that is ellipticine in which the hydrogen at position 9 has been replaced by a hydroxy group.	2.65	3	organic heterotetracyclic compound; organonitrogen heterocyclic compound	antineoplastic agent
n(2),n(6)-dimethyl-9-hydroxyellipticinium N(2),N(6)-dimethyl-9-hydroxyellipticinium: RN given refers to parent cpd; structure given in second source	2.36	2
valinomycin Valinomycin: A cyclododecadepsipeptide ionophore antibiotic produced by Streptomyces fulvissimus and related to the enniatins. It is composed of 3 moles each of L-valine, D-alpha-hydroxyisovaleric acid, D-valine, and L-lactic acid linked alternately to form a 36-membered ring. (From Merck Index, 11th ed) Valinomycin is a potassium selective ionophore and is commonly used as a tool in biochemical studies.. valinomycin : A twelve-membered cyclodepsipeptide composed of three repeating D-alpha-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl units joined in sequence. An antibiotic found in several Streptomyces strains.	1.96	1	cyclodepsipeptide; macrocycle	antimicrobial agent; antiviral agent; bacterial metabolite; potassium ionophore
3,3'-dihexyl-2,2'-oxacarbocyanine 3,3'-dihexyl-2,2'-oxacarbocyanine: a fluorescent probe	1.96	1
carbocyanines Carbocyanines: Compounds that contain three methine groups. They are frequently used as cationic dyes used for differential staining of biological materials.	1.96	1	cyanine dye; organic iodide salt	fluorochrome
1,2-dielaidoylphosphatidylethanolamine 1,2-dielaidoylphosphatidylethanolamine: RN given refers to (E,E)-isomer; member of a class of cationic lipid formulations called cytofectins	1.97	1

Condition	Relationship Strength	Studies
Leukemia L 1210 [description not available]	2.88	4
Central Nervous System Neoplasm [description not available]	1.98	1
Central Nervous System Neoplasms Benign and malignant neoplastic processes that arise from or secondarily involve the brain, spinal cord, or meninges.	1.98	1

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