Page last updated: 2024-12-07

(hexadecanoyl)aminofluorescein

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

(Hexadecanoyl)aminofluorescein, often abbreviated as **C16-FAM**, is a fluorescent lipid analog. Let's break down its components and importance in research:

**Components:**

* **Fluorescein:** This is a highly fluorescent dye that emits green light when excited with blue light. It's a common tool in fluorescence microscopy and other imaging techniques.
* **Hexadecanoyl (C16):** This is a long-chain fatty acid with 16 carbon atoms. It's essentially a hydrocarbon tail that makes the molecule hydrophobic (water-repelling).
* **Amine (NH2):** This group acts as a linker, attaching the fluorescein to the fatty acid chain.

**Why is C16-FAM important for research?**

C16-FAM is a powerful tool for studying a variety of biological processes, especially those involving membranes. Here are some key reasons:

* **Membrane labeling:** Due to its hydrophobic tail, C16-FAM integrates into cell membranes. This makes it an excellent tool for visualizing and tracking membrane dynamics, including:
* **Membrane fluidity:** C16-FAM's fluorescence can be used to measure the fluidity of cell membranes, which is crucial for proper cellular function.
* **Lipid rafts:** These are specialized microdomains within cell membranes that are enriched in cholesterol and sphingolipids. C16-FAM can be used to study their formation, structure, and function.
* **Membrane trafficking:** C16-FAM can be used to trace the movement of membranes and organelles within cells.
* **Membrane structure and organization:** C16-FAM can help researchers study the organization of lipids within membranes, including the formation of lipid bilayers and the arrangement of different lipid types.
* **Drug delivery and biocompatibility:** C16-FAM can be used to study the interactions of drugs and other molecules with cell membranes, providing insights into drug delivery mechanisms and potential toxicity.
* **Biophysical studies:** C16-FAM can be used to measure biophysical parameters like membrane tension and curvature, which are important for understanding cell shape and motility.

**Summary:**

C16-FAM, as a fluorescent lipid analog, is a versatile tool for studying a wide range of biological phenomena related to membranes. Its ability to label, track, and probe these structures makes it valuable for research in various fields, including cell biology, biochemistry, pharmacology, and nanotechnology.

Cross-References

ID SourceID
PubMed CID126322
SCHEMBL ID702075
MeSH IDM0163641

Synonyms (19)

Synonym
(hexadecanoyl)aminofluorescein
afc16
5-hexadecanoylaminofluorescein
n-(3',6'-dihydroxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-5-yl)hexadecanamide
2-[butyl(3-methylphenyl)amino]ethyl(3,4-dichlorophenyl)carbamate
73024-80-3
hexadecanamide, n-(3',6'-dihydroxy-3-oxospiro(isobenzofuran-1(3h),9'-(9h)xanthen)-5-yl)-
5-(n-hexadecanoyl)aminofluorescein
5-(n-hexadecanoyl)aminofluoroscein
5-(hexadecanoylamino)fluorescein
FT-0620444
SCHEMBL702075
5-(hexadecanoylamino)fluorescein5-hexadecanoylaminofluorescein
mfcd00134895
n-(3',6'-dihydroxy-3-oxo-3h-spiro[2-benzofuran-1,9'-xanthen]-5-yl)hexadecanimidic acid
DTXSID60993787
n-(3',6'-dihydroxy-3-oxo-3h-spiro[isobenzofuran-1,9'-xanthen]-5-yl)palmitamide
haf [5-hexadecanoylaminofluorescein]
CS-0137546
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (9.09)18.7374
1990's6 (54.55)18.2507
2000's2 (18.18)29.6817
2010's2 (18.18)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.57

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.57 (24.57)
Research Supply Index2.48 (2.92)
Research Growth Index5.06 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.57)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]