Compounds > (hexadecanoyl)aminofluorescein
Page last updated: 2024-12-07

(hexadecanoyl)aminofluorescein

(Hexadecanoyl)aminofluorescein, often abbreviated as **C16-FAM**, is a fluorescent lipid analog. Let's break down its components and importance in research:

**Components:**

* **Fluorescein:** This is a highly fluorescent dye that emits green light when excited with blue light. It's a common tool in fluorescence microscopy and other imaging techniques.
* **Hexadecanoyl (C16):** This is a long-chain fatty acid with 16 carbon atoms. It's essentially a hydrocarbon tail that makes the molecule hydrophobic (water-repelling).
* **Amine (NH2):** This group acts as a linker, attaching the fluorescein to the fatty acid chain.

**Why is C16-FAM important for research?**

C16-FAM is a powerful tool for studying a variety of biological processes, especially those involving membranes. Here are some key reasons:

* **Membrane labeling:** Due to its hydrophobic tail, C16-FAM integrates into cell membranes. This makes it an excellent tool for visualizing and tracking membrane dynamics, including:
* **Membrane fluidity:** C16-FAM's fluorescence can be used to measure the fluidity of cell membranes, which is crucial for proper cellular function.
* **Lipid rafts:** These are specialized microdomains within cell membranes that are enriched in cholesterol and sphingolipids. C16-FAM can be used to study their formation, structure, and function.
* **Membrane trafficking:** C16-FAM can be used to trace the movement of membranes and organelles within cells.
* **Membrane structure and organization:** C16-FAM can help researchers study the organization of lipids within membranes, including the formation of lipid bilayers and the arrangement of different lipid types.
* **Drug delivery and biocompatibility:** C16-FAM can be used to study the interactions of drugs and other molecules with cell membranes, providing insights into drug delivery mechanisms and potential toxicity.
* **Biophysical studies:** C16-FAM can be used to measure biophysical parameters like membrane tension and curvature, which are important for understanding cell shape and motility.

**Summary:**

C16-FAM, as a fluorescent lipid analog, is a versatile tool for studying a wide range of biological phenomena related to membranes. Its ability to label, track, and probe these structures makes it valuable for research in various fields, including cell biology, biochemistry, pharmacology, and nanotechnology.

Cross-References

ID SourceID
PubMed CID126322
SCHEMBL ID702075
MeSH IDM0163641

Synonyms (19)

Synonym
(hexadecanoyl)aminofluorescein
afc16
5-hexadecanoylaminofluorescein
n-(3',6'-dihydroxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-5-yl)hexadecanamide
2-[butyl(3-methylphenyl)amino]ethyl(3,4-dichlorophenyl)carbamate
73024-80-3
hexadecanamide, n-(3',6'-dihydroxy-3-oxospiro(isobenzofuran-1(3h),9'-(9h)xanthen)-5-yl)-
5-(n-hexadecanoyl)aminofluorescein
5-(n-hexadecanoyl)aminofluoroscein
5-(hexadecanoylamino)fluorescein
FT-0620444
SCHEMBL702075
5-(hexadecanoylamino)fluorescein5-hexadecanoylaminofluorescein
mfcd00134895
n-(3',6'-dihydroxy-3-oxo-3h-spiro[2-benzofuran-1,9'-xanthen]-5-yl)hexadecanimidic acid
DTXSID60993787
n-(3',6'-dihydroxy-3-oxo-3h-spiro[isobenzofuran-1,9'-xanthen]-5-yl)palmitamide
haf [5-hexadecanoylaminofluorescein]
CS-0137546
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (9.09)18.7374
1990's6 (54.55)18.2507
2000's2 (18.18)29.6817
2010's2 (18.18)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.57

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.57 (24.57)
Research Supply Index2.48 (2.92)
Research Growth Index5.06 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.57)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
hydrogen carbonate
Bicarbonates: Inorganic salts that contain the -HCO3 radical. They are an important factor in determining the pH of the blood and the concentration of bicarbonate ions is regulated by the kidney. Levels in the blood are an index of the alkali reserve or buffering capacity.. hydrogencarbonate : The carbon oxoanion resulting from the removal of a proton from carbonic acid.		210carbon oxoanioncofactor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
hydrogen
Hydrogen: The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.. dihydrogen : An elemental molecule consisting of two hydrogens joined by a single bond.		210elemental hydrogen;
elemental molecule;
gas molecular entity		antioxidant;
electron donor;
food packaging gas;
fuel;
human metabolite
erythrosine
Fluoresceins: A family of spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one derivatives. These are used as dyes, as indicators for various metals, and as fluorescent labels in immunoassays.		3.79110
etodolac
Etodolac: A non-steroidal anti-inflammatory agent and cyclooxygenase-2 (COX-2) inhibitor with potent analgesic and anti-arthritic properties. It has been shown to be effective in the treatment of OSTEOARTHRITIS; RHEUMATOID ARTHRITIS; ANKYLOSING SPONDYLITIS; and in the alleviation of postoperative pain (PAIN, POSTOPERATIVE).. etodolac : A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl moiety. A preferential inhibitor of cyclo-oxygenase 2 and non-steroidal anti-inflammatory, it is used for the treatment of rheumatoid arthritis and osteoarthritis, and for the alleviation of postoperative pain. Administered as the racemate, only the (S)-enantiomer is active.		2.0410monocarboxylic acid;
organic heterotricyclic compound		antipyretic;
cyclooxygenase 2 inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug
kainic acid
Kainic Acid: (2S-(2 alpha,3 beta,4 beta))-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid. Ascaricide obtained from the red alga Digenea simplex. It is a potent excitatory amino acid agonist at some types of excitatory amino acid receptors and has been used to discriminate among receptor types. Like many excitatory amino acid agonists it can cause neurotoxicity and has been used experimentally for that purpose.		2.110dicarboxylic acid;
L-proline derivative;
non-proteinogenic L-alpha-amino acid;
pyrrolidinecarboxylic acid		antinematodal drug;
excitatory amino acid agonist
fluorescein
Fluorescein: A phthalic indicator dye that appears yellow-green in normal tear film and bright green in a more alkaline medium such as the aqueous humor.. fluorescein (lactone form) : A xanthene dye that is highly fluorescent, detectable even when present in minute quantities. Used forensically to detect traces of blood, in analytical chemistry as an indicator in silver nitrate titrations and in microscopy.		2.7302-benzofurans;
gamma-lactone;
organic heteropentacyclic compound;
oxaspiro compound;
polyphenol;
xanthene dye		fluorescent dye;
radioopaque medium
fluorescein-5-isothiocyanate
Fluorescein-5-isothiocyanate: Fluorescent probe capable of being conjugated to tissue and proteins. It is used as a label in fluorescent antibody staining procedures as well as protein- and amino acid-binding techniques.. fluorescein 5-isothiocyanate : The 5-isomer of fluorescein isothiocyanate. Acts as a fluorescent probe capable of being conjugated to tissue and proteins; used as a label in fluorescent antibody staining procedures as well as protein- and amino acid-binding techniques.		1.9810fluorescein isothiocyanate
mannose
mannopyranose : The pyranose form of mannose.		1.9910D-aldohexose;
D-mannose;
mannopyranose		metabolite
lanthanum
[no description available]		1.9910f-block element atom;
lanthanoid atom;
scandium group element atom
glutamic acid
Glutamic Acid: A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.. glutamic acid : An alpha-amino acid that is glutaric acid bearing a single amino substituent at position 2.		2.4920glutamic acid;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
ferroptosis inducer;
micronutrient;
mouse metabolite;
neurotransmitter;
nutraceutical
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid
[no description available]		2.0410chromanol;
monocarboxylic acid;
phenols		antioxidant;
ferroptosis inhibitor;
neuroprotective agent;
radical scavenger;
Wnt signalling inhibitor
5-(n-dodecanoyl)aminofluorescein
5-dodecanoylaminofluorescein: used for determining micelle concentration via fluorescence anisotropy		2.6830
fusidic acid
Fusidic Acid: An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed). It acts by inhibiting translocation during protein synthesis.. fusidic acid : A steroid antibiotic that is isolated from the fermentation broth of Fusidium coccineum.		1.981011alpha-hydroxy steroid;
3alpha-hydroxy steroid;
alpha,beta-unsaturated monocarboxylic acid;
steroid acid;
steroid antibiotic;
sterol ester		EC 2.7.1.33 (pantothenate kinase) inhibitor;
Escherichia coli metabolite;
protein synthesis inhibitor
tauro-24,25-dihydrofusidate
tauro-24,25-dihydrofusidate: affects nasal absorption of insulin in sheep		1.9810
barium
Barium: An element of the alkaline earth group of metals. It has an atomic symbol Ba, atomic number 56, and atomic weight 138. All of its acid-soluble salts are poisonous.		1.9910alkaline earth metal atom;
elemental barium
diphenylhexatriene
Diphenylhexatriene: A fluorescent compound that emits light only in specific configurations in certain lipid media. It is used as a tool in the study of membrane lipids.		2.0410alkatrienefluorochrome
1-(4'-carboxyethyl)-6-diphenyl-1,3,5-hexatriene
1-(4'-carboxyethyl)-6-diphenyl-1,3,5-hexatriene: fluorescence donor in membrane fusion		2.0410
carbocyanines
Carbocyanines: Compounds that contain three methine groups. They are frequently used as cationic dyes used for differential staining of biological materials.		1.9910cyanine dye;
organic iodide salt		fluorochrome
sodium salicylate
[no description available]		1.9810organic molecular entity
mannans
[no description available]		1.9910
trypan blue
Trypan Blue: A diazo-naphthalene sulfonate that is widely used as a stain.. trypan blue : An organosulfonate salt that is the tetrasodium salt of 3,3'-[(3,3'-dimethylbiphenyl-4,4'-diyl)didiazene-2,1-diyl]bis(5-amino-4-hydroxynaphthalene-2,7-disulfonic acid).		1.9810
ConditionIndicatedRelationship StrengthStudiesTrials
Cancer of Colon
[description not available]		01.9810
Colonic Neoplasms
Tumors or cancer of the COLON.		01.9810
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