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ala-thr-trp-leu-pro-pro-arg

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Description

Ala-Thr-Trp-Leu-Pro-Pro-Arg: targets vascular endothelial growth factor receptor [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID78062667
MeSH IDM000608294
PubMed CID9854089
CHEMBL ID1095672
MeSH IDM000608294

Synonyms (7)

Synonym
ala-thr-trp-leu-pro-pro-arg
CHEMBL1095672 ,
atwlppr
bdbm50317441
CS-0084563
atwlppr peptide
HY-P1663
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (3)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Neuropilin-1Homo sapiens (human)IC50 (µMol)311.62133.00005.25008.0000AID1637868; AID480965
Leukotriene A-4 hydrolaseHomo sapiens (human)IC50 (µMol)19.00000.00051.28547.6500AID480965
Neuropilin-1Rattus norvegicus (Norway rat)IC50 (µMol)5.88285.86005.88285.9000AID1298849; AID1637862
Neuropilin-1Rattus norvegicus (Norway rat)Ki5.20005.20005.20005.2000AID1181040
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (85)

Processvia Protein(s)Taxonomy
substrate-dependent cell migration, cell extensionNeuropilin-1Homo sapiens (human)
angiogenesisNeuropilin-1Homo sapiens (human)
branching involved in blood vessel morphogenesisNeuropilin-1Homo sapiens (human)
neuron migrationNeuropilin-1Homo sapiens (human)
positive regulation of endothelial cell proliferationNeuropilin-1Homo sapiens (human)
sprouting angiogenesisNeuropilin-1Homo sapiens (human)
cell migration involved in sprouting angiogenesisNeuropilin-1Homo sapiens (human)
outflow tract septum morphogenesisNeuropilin-1Homo sapiens (human)
signal transductionNeuropilin-1Homo sapiens (human)
integrin-mediated signaling pathwayNeuropilin-1Homo sapiens (human)
cell-cell signalingNeuropilin-1Homo sapiens (human)
axon guidanceNeuropilin-1Homo sapiens (human)
axonal fasciculationNeuropilin-1Homo sapiens (human)
motor neuron axon guidanceNeuropilin-1Homo sapiens (human)
animal organ morphogenesisNeuropilin-1Homo sapiens (human)
positive regulation of endothelial cell migrationNeuropilin-1Homo sapiens (human)
positive regulation of smooth muscle cell migrationNeuropilin-1Homo sapiens (human)
facial nerve structural organizationNeuropilin-1Homo sapiens (human)
trigeminal nerve structural organizationNeuropilin-1Homo sapiens (human)
vestibulocochlear nerve structural organizationNeuropilin-1Homo sapiens (human)
branchiomotor neuron axon guidanceNeuropilin-1Homo sapiens (human)
gonadotrophin-releasing hormone neuronal migration to the hypothalamusNeuropilin-1Homo sapiens (human)
retinal ganglion cell axon guidanceNeuropilin-1Homo sapiens (human)
regulation of Cdc42 protein signal transductionNeuropilin-1Homo sapiens (human)
cellular response to hepatocyte growth factor stimulusNeuropilin-1Homo sapiens (human)
endothelial cell chemotaxisNeuropilin-1Homo sapiens (human)
cellular response to vascular endothelial growth factor stimulusNeuropilin-1Homo sapiens (human)
ventral trunk neural crest cell migrationNeuropilin-1Homo sapiens (human)
neuropilin signaling pathwayNeuropilin-1Homo sapiens (human)
VEGF-activated neuropilin signaling pathwayNeuropilin-1Homo sapiens (human)
negative regulation of neuron apoptotic processNeuropilin-1Homo sapiens (human)
positive regulation of angiogenesisNeuropilin-1Homo sapiens (human)
symbiont entry into host cellNeuropilin-1Homo sapiens (human)
platelet-derived growth factor receptor signaling pathwayNeuropilin-1Homo sapiens (human)
vascular endothelial growth factor receptor signaling pathwayNeuropilin-1Homo sapiens (human)
hepatocyte growth factor receptor signaling pathwayNeuropilin-1Homo sapiens (human)
positive regulation of axon extension involved in axon guidanceNeuropilin-1Homo sapiens (human)
negative regulation of axon extension involved in axon guidanceNeuropilin-1Homo sapiens (human)
artery morphogenesisNeuropilin-1Homo sapiens (human)
axon extension involved in axon guidanceNeuropilin-1Homo sapiens (human)
positive regulation of peptidyl-tyrosine phosphorylationNeuropilin-1Homo sapiens (human)
positive chemotaxisNeuropilin-1Homo sapiens (human)
positive regulation of filopodium assemblyNeuropilin-1Homo sapiens (human)
positive regulation of stress fiber assemblyNeuropilin-1Homo sapiens (human)
positive regulation of focal adhesion assemblyNeuropilin-1Homo sapiens (human)
axonogenesis involved in innervationNeuropilin-1Homo sapiens (human)
regulation of vesicle-mediated transportNeuropilin-1Homo sapiens (human)
dichotomous subdivision of terminal units involved in salivary gland branchingNeuropilin-1Homo sapiens (human)
angiogenesis involved in coronary vascular morphogenesisNeuropilin-1Homo sapiens (human)
coronary artery morphogenesisNeuropilin-1Homo sapiens (human)
retina vasculature morphogenesis in camera-type eyeNeuropilin-1Homo sapiens (human)
renal artery morphogenesisNeuropilin-1Homo sapiens (human)
sympathetic ganglion developmentNeuropilin-1Homo sapiens (human)
trigeminal ganglion developmentNeuropilin-1Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascadeNeuropilin-1Homo sapiens (human)
semaphorin-plexin signaling pathwayNeuropilin-1Homo sapiens (human)
commissural neuron axon guidanceNeuropilin-1Homo sapiens (human)
positive regulation of cell migration involved in sprouting angiogenesisNeuropilin-1Homo sapiens (human)
endothelial tip cell fate specificationNeuropilin-1Homo sapiens (human)
sensory neuron axon guidanceNeuropilin-1Homo sapiens (human)
motor neuron migrationNeuropilin-1Homo sapiens (human)
sympathetic neuron projection extensionNeuropilin-1Homo sapiens (human)
sympathetic neuron projection guidanceNeuropilin-1Homo sapiens (human)
postsynapse organizationNeuropilin-1Homo sapiens (human)
basal dendrite developmentNeuropilin-1Homo sapiens (human)
basal dendrite arborizationNeuropilin-1Homo sapiens (human)
positive regulation of substrate adhesion-dependent cell spreadingNeuropilin-1Homo sapiens (human)
neural crest cell migration involved in autonomic nervous system developmentNeuropilin-1Homo sapiens (human)
protein localization to early endosomeNeuropilin-1Homo sapiens (human)
facioacoustic ganglion developmentNeuropilin-1Homo sapiens (human)
dorsal root ganglion morphogenesisNeuropilin-1Homo sapiens (human)
otic placode developmentNeuropilin-1Homo sapiens (human)
negative regulation of extrinsic apoptotic signaling pathwayNeuropilin-1Homo sapiens (human)
neural crest cell migrationNeuropilin-1Homo sapiens (human)
regulation of vascular endothelial growth factor receptor signaling pathwayNeuropilin-1Homo sapiens (human)
vasculogenesisNeuropilin-1Homo sapiens (human)
response to woundingNeuropilin-1Homo sapiens (human)
proteolysisLeukotriene A-4 hydrolaseHomo sapiens (human)
lipid metabolic processLeukotriene A-4 hydrolaseHomo sapiens (human)
response to zinc ionLeukotriene A-4 hydrolaseHomo sapiens (human)
leukotriene biosynthetic processLeukotriene A-4 hydrolaseHomo sapiens (human)
protein metabolic processLeukotriene A-4 hydrolaseHomo sapiens (human)
peptide catabolic processLeukotriene A-4 hydrolaseHomo sapiens (human)
response to peptide hormoneLeukotriene A-4 hydrolaseHomo sapiens (human)
type I pneumocyte differentiationLeukotriene A-4 hydrolaseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (19)

Processvia Protein(s)Taxonomy
vascular endothelial growth factor receptor activityNeuropilin-1Homo sapiens (human)
GTPase activator activityNeuropilin-1Homo sapiens (human)
protein bindingNeuropilin-1Homo sapiens (human)
heparin bindingNeuropilin-1Homo sapiens (human)
coreceptor activityNeuropilin-1Homo sapiens (human)
semaphorin receptor activityNeuropilin-1Homo sapiens (human)
growth factor bindingNeuropilin-1Homo sapiens (human)
protein kinase bindingNeuropilin-1Homo sapiens (human)
cytokine bindingNeuropilin-1Homo sapiens (human)
vascular endothelial growth factor bindingNeuropilin-1Homo sapiens (human)
metal ion bindingNeuropilin-1Homo sapiens (human)
RNA bindingLeukotriene A-4 hydrolaseHomo sapiens (human)
aminopeptidase activityLeukotriene A-4 hydrolaseHomo sapiens (human)
epoxide hydrolase activityLeukotriene A-4 hydrolaseHomo sapiens (human)
leukotriene-A4 hydrolase activityLeukotriene A-4 hydrolaseHomo sapiens (human)
protein bindingLeukotriene A-4 hydrolaseHomo sapiens (human)
peptidase activityLeukotriene A-4 hydrolaseHomo sapiens (human)
zinc ion bindingLeukotriene A-4 hydrolaseHomo sapiens (human)
tripeptide aminopeptidase activityLeukotriene A-4 hydrolaseHomo sapiens (human)
metalloaminopeptidase activityLeukotriene A-4 hydrolaseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (21)

Processvia Protein(s)Taxonomy
extracellular spaceNeuropilin-1Homo sapiens (human)
early endosomeNeuropilin-1Homo sapiens (human)
cytosolNeuropilin-1Homo sapiens (human)
neurofilamentNeuropilin-1Homo sapiens (human)
plasma membraneNeuropilin-1Homo sapiens (human)
focal adhesionNeuropilin-1Homo sapiens (human)
axonNeuropilin-1Homo sapiens (human)
cytoplasmic vesicleNeuropilin-1Homo sapiens (human)
mitochondrial membraneNeuropilin-1Homo sapiens (human)
neuron projectionNeuropilin-1Homo sapiens (human)
postsynaptic membraneNeuropilin-1Homo sapiens (human)
sorting endosomeNeuropilin-1Homo sapiens (human)
glutamatergic synapseNeuropilin-1Homo sapiens (human)
semaphorin receptor complexNeuropilin-1Homo sapiens (human)
receptor complexNeuropilin-1Homo sapiens (human)
focal adhesionNeuropilin-1Homo sapiens (human)
plasma membraneNeuropilin-1Homo sapiens (human)
axonNeuropilin-1Homo sapiens (human)
extracellular regionLeukotriene A-4 hydrolaseHomo sapiens (human)
nucleoplasmLeukotriene A-4 hydrolaseHomo sapiens (human)
cytosolLeukotriene A-4 hydrolaseHomo sapiens (human)
extracellular exosomeLeukotriene A-4 hydrolaseHomo sapiens (human)
tertiary granule lumenLeukotriene A-4 hydrolaseHomo sapiens (human)
ficolin-1-rich granule lumenLeukotriene A-4 hydrolaseHomo sapiens (human)
cytosolLeukotriene A-4 hydrolaseHomo sapiens (human)
nucleusLeukotriene A-4 hydrolaseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (25)

Assay IDTitleYearJournalArticle
AID1637868Inhibition of human biotinylated VEGF-A165 binding to recombinant human NRP1 receptor after 2 hrs by chemiluminescence analysis
AID1298847Inhibition of (bt)-VEGF165 binding to purified recombinant rat NRP1/Fc chimera at 0.1 uM measured after overnight incubation by ELISA method2016Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12
Design, synthesis and in vitro biological evaluation of a small cyclic peptide as inhibitor of vascular endothelial growth factor binding to neuropilin-1.
AID1181040Inhibition of biotinylated VEGF-A165 from rat recombinant NRP-1 Fc domain2014Bioorganic & medicinal chemistry, Aug-01, Volume: 22, Issue:15
Discovery of novel inhibitors of vascular endothelial growth factor-A-Neuropilin-1 interaction by structure-based virtual screening.
AID1298848Inhibition of (bt)-VEGF165 binding to purified recombinant rat NRP1/Fc chimera at 0.01 uM measured after overnight incubation by ELISA method2016Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12
Design, synthesis and in vitro biological evaluation of a small cyclic peptide as inhibitor of vascular endothelial growth factor binding to neuropilin-1.
AID1637872Inhibition of human biotinylated VEGF-A165 binding to recombinant human NRP1 receptor at 10 uM after 2 hrs by chemiluminescence analysis relative to control
AID1298846Inhibition of (bt)-VEGF165 binding to purified recombinant rat NRP1/Fc chimera at 0.3 uM measured after overnight incubation by ELISA method2016Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12
Design, synthesis and in vitro biological evaluation of a small cyclic peptide as inhibitor of vascular endothelial growth factor binding to neuropilin-1.
AID1421451Inhibition of biotinylated VEGF-A165 binding to rat NRP1/FC chimera at 1 uM after 40 mins by ELISA relative to control
AID1637870Inhibition of human biotinylated VEGF-A165 binding to recombinant human NRP1 receptor at 50 uM after 2 hrs by chemiluminescence analysis relative to control
AID1298844Inhibition of (bt)-VEGF165 binding to purified recombinant rat NRP1/Fc chimera at 3 uM measured after overnight incubation by ELISA method2016Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12
Design, synthesis and in vitro biological evaluation of a small cyclic peptide as inhibitor of vascular endothelial growth factor binding to neuropilin-1.
AID1637863Inhibition of human biotinylated VEGF-A165 binding to Fc-tagged recombinant rat NRP1 receptor at 10 uM after 2 hrs by colorimetric analysis relative to control
AID1637871Inhibition of human biotinylated VEGF-A165 binding to recombinant human NRP1 receptor at 25 uM after 2 hrs by chemiluminescence analysis relative to control
AID480965Inhibition of VEGF binding to NRP1 expressed in CHO cells2010Bioorganic & medicinal chemistry, May-01, Volume: 18, Issue:9
Sugar-based peptidomimetics as potential inhibitors of the vascular endothelium growth factor binding to neuropilin-1.
AID1298849Inhibition of (bt)-VEGF165 binding to purified recombinant rat NRP1/Fc chimera measured after overnight incubation by ELISA method2016Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12
Design, synthesis and in vitro biological evaluation of a small cyclic peptide as inhibitor of vascular endothelial growth factor binding to neuropilin-1.
AID1637862Inhibition of human biotinylated VEGF-A165 binding to Fc-tagged recombinant rat NRP1 receptor after 2 hrs by colorimetric analysis
AID1637869Inhibition of human biotinylated VEGF-A165 binding to recombinant human NRP1 receptor at 100 uM after 2 hrs by chemiluminescence analysis relative to control
AID480967Inhibition of biotinylated VEGF165 binding to recombinant NRP1 at 100 uM after 2 hrs by competitive binding assay2010Bioorganic & medicinal chemistry, May-01, Volume: 18, Issue:9
Sugar-based peptidomimetics as potential inhibitors of the vascular endothelium growth factor binding to neuropilin-1.
AID1637864Inhibition of human biotinylated VEGF-A165 binding to Fc-tagged recombinant rat NRP1 receptor at 3 uM after 2 hrs by colorimetric analysis relative to control
AID1298843Inhibition of (bt)-VEGF165 binding to purified recombinant rat NRP1/Fc chimera at 10 uM measured after overnight incubation by ELISA method2016Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12
Design, synthesis and in vitro biological evaluation of a small cyclic peptide as inhibitor of vascular endothelial growth factor binding to neuropilin-1.
AID1421452Inhibition of biotinylated VEGF-A165 binding to rat NRP1/FC chimera at 0.3 uM after 40 mins by ELISA relative to control
AID1181039Inhibition of biotinylated VEGF-A165 from rat recombinant NRP-1 Fc domain at 100 uM2014Bioorganic & medicinal chemistry, Aug-01, Volume: 22, Issue:15
Discovery of novel inhibitors of vascular endothelial growth factor-A-Neuropilin-1 interaction by structure-based virtual screening.
AID1637867Inhibition of human biotinylated VEGF-A165 binding to Fc-tagged recombinant rat NRP1 receptor at 0.1 uM after 2 hrs by colorimetric analysis relative to control
AID1298845Inhibition of (bt)-VEGF165 binding to purified recombinant rat NRP1/Fc chimera at 1 uM measured after overnight incubation by ELISA method2016Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12
Design, synthesis and in vitro biological evaluation of a small cyclic peptide as inhibitor of vascular endothelial growth factor binding to neuropilin-1.
AID1637865Inhibition of human biotinylated VEGF-A165 binding to Fc-tagged recombinant rat NRP1 receptor at 1 uM after 2 hrs by colorimetric analysis relative to control
AID1637866Inhibition of human biotinylated VEGF-A165 binding to Fc-tagged recombinant rat NRP1 receptor at 0.3 uM after 2 hrs by colorimetric analysis relative to control
AID1298842Inhibition of (bt)-VEGF165 binding to purified recombinant rat NRP1/Fc chimera at 100 uM measured after overnight incubation by ELISA method2016Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12
Design, synthesis and in vitro biological evaluation of a small cyclic peptide as inhibitor of vascular endothelial growth factor binding to neuropilin-1.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (13)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's12 (92.31)24.3611
2020's1 (7.69)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.94

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.94 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.73 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.94)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]