| Assay ID | Title | Year | Journal | Article |
|---|
| AID1436637 | Inhibition of Escherichia coli LpxC using UDP-3-O-(R-3-hydroxymyristoyl)GlcNAc as substrate after 60 mins by OPA reagent based fluorescence assay | 2017 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 27, Issue:4
| Sulfonamide-based non-alkyne LpxC inhibitors as Gram-negative antibacterial agents. |
| AID649186 | Antibacterial activity against Escherichia coli after 16 to 20 hrs by broth microdilution method | 2012 | Journal of medicinal chemistry, Jan-26, Volume: 55, Issue:2
| Potent inhibitors of LpxC for the treatment of Gram-negative infections. |
| AID535078 | Antimicrobial activity against genomovar type V Burkholderia vietnamiensis FC441 at 40 ug/disk by disk diffusion growth inhibition assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID532948 | Antimicrobial activity against genomovar type I Burkholderia cepacia CEP509 at 40 ug/disk by disk diffusion growth inhibition assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID1700261 | Antibacterial activity against Pseudomonas aeruginosa PAO1 assessed as bacterial growth inhibition by CLSI based broth microdilution method | 2020 | Bioorganic & medicinal chemistry, 12-15, Volume: 28, Issue:24
| N-Hydroxyformamide LpxC inhibitors, their in vivo efficacy in a mouse Escherichia coli infection model, and their safety in a rat hemodynamic assay. |
| AID535087 | Antimicrobial activity against genomovar type II Burkholderia multivorans ATCC 17616 | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID535114 | Antimicrobial activity against genomovar type III Burkholderia cenocepacia PC184 at 40 ug/disk by disk diffusion growth inhibition assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID766714 | Antimicrobial activity against Vibrio cholerae P4 after 22 hrs by MTT assay | 2013 | Journal of medicinal chemistry, Sep-12, Volume: 56, Issue:17
| Synthesis, structure, and antibiotic activity of aryl-substituted LpxC inhibitors. |
| AID1324790 | Antibacterial activity against Pseudomonas aeruginosa PAO1 measured after 16 to 20 hrs by microbroth dilution assay | 2016 | Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
| Drug discovery strategies to outer membrane targets in Gram-negative pathogens. |
| AID1313581 | Antibacterial activity against wild-type Escherichia coli TG1 after 16 to 20 hrs by agar dilution method | 2016 | ACS medicinal chemistry letters, Jun-09, Volume: 7, Issue:6
| LpxC Inhibitors: Design, Synthesis, and Biological Evaluation of Oxazolidinones as Gram-negative Antibacterial Agents. |
| AID535092 | Antimicrobial activity against genomovar type IX Burkholderia pyrrocinia C1469 at 40 ug/disk by disk diffusion growth inhibition assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID766719 | Ratio of MIC for wild type Escherichia coli W3110 to MIC for Escherichia coli CMR300 | 2013 | Journal of medicinal chemistry, Sep-12, Volume: 56, Issue:17
| Synthesis, structure, and antibiotic activity of aryl-substituted LpxC inhibitors. |
| AID766720 | Antimicrobial activity against Pseudomonas aeruginosa PAO1 after 22 hrs by MTT assay | 2013 | Journal of medicinal chemistry, Sep-12, Volume: 56, Issue:17
| Synthesis, structure, and antibiotic activity of aryl-substituted LpxC inhibitors. |
| AID1436639 | Antibacterial activity against Klebsiella pneumoniae ATCC 13883 by agar dilution method | 2017 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 27, Issue:4
| Sulfonamide-based non-alkyne LpxC inhibitors as Gram-negative antibacterial agents. |
| AID766715 | Antimicrobial activity against Klebsiella pneumoniae 43816 after 22 hrs by MTT assay | 2013 | Journal of medicinal chemistry, Sep-12, Volume: 56, Issue:17
| Synthesis, structure, and antibiotic activity of aryl-substituted LpxC inhibitors. |
| AID532946 | Antimicrobial activity against genomovar type I Burkholderia cepacia ATCC 25416 at 40 ug/disk by disk diffusion growth inhibition assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID1894124 | Antibacterial activity against Escherichia coli assessed as bacterial growth inhibition | 2021 | Journal of medicinal chemistry, 02-25, Volume: 64, Issue:4
| Chemical Highlights Supporting the Role of Lipid A in Efficient Biological Adaptation of Gram-Negative Bacteria to External Stresses. |
| AID535096 | Antimicrobial activity against genomovar type II Burkholderia multivorans C5393 | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID1700260 | Antibacterial activity against Escherichia coli ATCC 25922 assessed as bacterial growth inhibition by CLSI based broth microdilution method | 2020 | Bioorganic & medicinal chemistry, 12-15, Volume: 28, Issue:24
| N-Hydroxyformamide LpxC inhibitors, their in vivo efficacy in a mouse Escherichia coli infection model, and their safety in a rat hemodynamic assay. |
| AID1171333 | Antimicrobial activity against Escherichia coli ARC523 W3110 harboring mutant by CLSI dilution method | 2014 | ACS medicinal chemistry letters, Nov-13, Volume: 5, Issue:11
| Synthesis, Structure, and SAR of Tetrahydropyran-Based LpxC Inhibitors. |
| AID535109 | Antimicrobial activity against genomovar type III Burkholderia cenocepacia ATCC 17765 at 40 ug/disk by disk diffusion growth inhibition assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID330343 | Inhibition of Escherichia coli LpxC at 4 nM | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Nov-20, Volume: 104, Issue:47
| Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding. |
| AID535115 | Antimicrobial activity against genomovar type III Burkholderia cenocepacia CEP511 at 40 ug/disk by disk diffusion growth inhibition assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID551680 | Antibacterial activity against Escherichia coli W3110 by NCCLS assay | 2011 | Bioorganic & medicinal chemistry, Jan-15, Volume: 19, Issue:2
| Syntheses, structures and antibiotic activities of LpxC inhibitors based on the diacetylene scaffold. |
| AID330338 | Inhibition of Escherichia coli LpxC Q202W/G210S mutant | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Nov-20, Volume: 104, Issue:47
| Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding. |
| AID1700262 | Antibacterial activity against Klebsiella pneumoniae ATCC 700603 assessed as bacterial growth inhibition by CLSI based broth microdilution method | 2020 | Bioorganic & medicinal chemistry, 12-15, Volume: 28, Issue:24
| N-Hydroxyformamide LpxC inhibitors, their in vivo efficacy in a mouse Escherichia coli infection model, and their safety in a rat hemodynamic assay. |
| AID535085 | Antimicrobial activity against genomovar type II Burkholderia multivorans JTC | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID330346 | Activity of Escherichia coli LpxC Q202W/G210S mutant | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Nov-20, Volume: 104, Issue:47
| Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding. |
| AID535108 | Antimicrobial activity against genomovar type V Burkholderia vietnamiensis LMG 16232 at 40 ug/disk by disk diffusion growth inhibition assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID535113 | Antimicrobial activity against genomovar type III Burkholderia cenocepacia C6433 at 40 ug/disk by disk diffusion growth inhibition assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID535107 | Antimicrobial activity against genomovar type V Burkholderia vietnamiensis PC259 at 40 ug/disk by disk diffusion growth inhibition assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID330349 | Ratio of Kcat to Km of Rhizobium leguminosarum LpxC | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Nov-20, Volume: 104, Issue:47
| Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding. |
| AID535081 | Antimicrobial activity against genomovar type III Burkholderia cenocepacia C5424 at 40 ug/disk by disk diffusion growth inhibition assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID330336 | Inhibition of Aquifex aeolicus LpxC | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Nov-20, Volume: 104, Issue:47
| Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding. |
| AID330352 | Activity of Rhizobium leguminosarum LpxC W206Q/S214G mutant | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Nov-20, Volume: 104, Issue:47
| Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding. |
| AID649189 | Antibacterial activity against Acinetobacter baumannii after 16 to 20 hrs by broth microdilution method | 2012 | Journal of medicinal chemistry, Jan-26, Volume: 55, Issue:2
| Potent inhibitors of LpxC for the treatment of Gram-negative infections. |
| AID652927 | Inhibition of Escherichia coli LpxC | 2012 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 22, Issue:7
| Structure based design of an in vivo active hydroxamic acid inhibitor of P. aeruginosa LpxC. |
| AID1584702 | Antimicrobial activity against Escherichia coli ATCC 25922 after 20 hrs by CLSI protocol-based microdilution assay | 2018 | Journal of medicinal chemistry, 10-25, Volume: 61, Issue:20
| Application of Virtual Screening to the Identification of New LpxC Inhibitor Chemotypes, Oxazolidinone and Isoxazoline. |
| AID1584700 | Binding affinity to Pseudomonas aeruginosa PAO1 NB52019 LpxC after 60 to 420 secs by SPR method | 2018 | Journal of medicinal chemistry, 10-25, Volume: 61, Issue:20
| Application of Virtual Screening to the Identification of New LpxC Inhibitor Chemotypes, Oxazolidinone and Isoxazoline. |
| AID568324 | Inhibition of Escherichia coli LpxC | 2011 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 21, Issue:4
| Design and synthesis of potent Gram-negative specific LpxC inhibitors. |
| AID1275729 | Inhibition of Escherichia coli LpxC C63A mutant using UDP-3-O-[(R)-3-hydroxymyristoyl]-N-acetylglucosamine substrate after 30 mins by fluorescence-bsed microplate assay | 2016 | Bioorganic & medicinal chemistry, Mar-01, Volume: 24, Issue:5
| Synthesis and biological evaluation of enantiomerically pure glyceric acid derivatives as LpxC inhibitors. |
| AID535100 | Antimicrobial activity against genomovar type VII Burkholderia ambifaria CEP0996 at 40 ug/disk by disk diffusion growth inhibition assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID1875126 | Antibacterial activity against Escherichia coli ATCC 25922 | 2022 | Journal of medicinal chemistry, 09-08, Volume: 65, Issue:17
| Structure-Kinetic Relationship Studies for the Development of Long Residence Time LpxC Inhibitors. |
| AID1171331 | Antimicrobial activity against Pseudomonas aeruginosa PAO1 ARC545 by CLSI dilution method | 2014 | ACS medicinal chemistry letters, Nov-13, Volume: 5, Issue:11
| Synthesis, Structure, and SAR of Tetrahydropyran-Based LpxC Inhibitors. |
| AID1700259 | Displacement of fluorescent ligand from Escherichia coli LpxC measured after 30 mins by fluorescence anisotrophy assay | 2020 | Bioorganic & medicinal chemistry, 12-15, Volume: 28, Issue:24
| N-Hydroxyformamide LpxC inhibitors, their in vivo efficacy in a mouse Escherichia coli infection model, and their safety in a rat hemodynamic assay. |
| AID535084 | Antimicrobial activity against genomovar type II Burkholderia multivorans CF-A1-1 | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID535117 | Antimicrobial activity against genomovar type III Burkholderia cenocepacia J2315 at 40 ug/disk by disk diffusion growth inhibition assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID1313582 | Antibacterial activity against Escherichia coli KAM3 harboring acrB deletion mutant after 16 to 20 hrs by agar dilution method | 2016 | ACS medicinal chemistry letters, Jun-09, Volume: 7, Issue:6
| LpxC Inhibitors: Design, Synthesis, and Biological Evaluation of Oxazolidinones as Gram-negative Antibacterial Agents. |
| AID330348 | Activity of Rhizobium leguminosarum LpxC | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Nov-20, Volume: 104, Issue:47
| Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding. |
| AID1436641 | Antibacterial activity against Staphylococcus aureus ATCC 29213 by agar dilution method | 2017 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 27, Issue:4
| Sulfonamide-based non-alkyne LpxC inhibitors as Gram-negative antibacterial agents. |
| AID1368994 | Inhibition of LpxC in Escherichia coli AB1157 assessed as reduction in microbial growth incubated for 22 hrs by MTT assay | 2018 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 28, Issue:2
| Design, synthesis and structure-activity relationship evaluation of novel LpxC inhibitors as Gram-negative antibacterial agents. |
| AID1720235 | Inhibition of LpxC C63A mutant in Escherichia coli assessed as reduction in bacterial growth preincubated for 30 mins followed by incubation for 10 mins by spectrophotometric analysis | 2020 | Bioorganic & medicinal chemistry, 07-01, Volume: 28, Issue:13
| Synthesis and biological evaluation of triazolyl-substituted benzyloxyacetohydroxamic acids as LpxC inhibitors. |
| AID649187 | Antibacterial activity against Enterobacter aerogenes after 16 to 20 hrs by broth microdilution method | 2012 | Journal of medicinal chemistry, Jan-26, Volume: 55, Issue:2
| Potent inhibitors of LpxC for the treatment of Gram-negative infections. |
| AID1780308 | Antibacterial activity against wild type Pseudomonas aeruginosa LESB58 LpxA Gly120Ala mutant assessed as resistance development by measuring fold increase in MIC | | | |
| AID649185 | Antibacterial activity against Klebsiella pneumoniae after 16 to 20 hrs by broth microdilution method | 2012 | Journal of medicinal chemistry, Jan-26, Volume: 55, Issue:2
| Potent inhibitors of LpxC for the treatment of Gram-negative infections. |
| AID535098 | Antimicrobial activity against genomovar type VII Burkholderia ambifaria AMMD at 40 ug/disk by disk diffusion growth inhibition assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID535091 | Antimicrobial activity against genomovar type IX Burkholderia pyrrocinia BC011 at 40 ug/disk by disk diffusion growth inhibition assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID535116 | Antimicrobial activity against genomovar type II Burkholderia multivorans 2492-2 at 40 ug/disk by disk diffusion growth inhibition assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID330351 | Ratio of Kcat to Km of Rhizobium leguminosarum LpxC S214G mutant | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Nov-20, Volume: 104, Issue:47
| Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding. |
| AID532949 | Antimicrobial activity against genomovar type II Burkholderia multivorans C5393 at 40 ug/disk by disk diffusion growth inhibition assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID1171329 | Inhibition of Pseudomonas aeruginosa LpxC using UDP-3-O-(R-3-hydroxydecanoyl)-N-acetylglucosamine as substrate preincubated for 20 mins before substrate addition by LC/MS/MS analysis | 2014 | ACS medicinal chemistry letters, Nov-13, Volume: 5, Issue:11
| Synthesis, Structure, and SAR of Tetrahydropyran-Based LpxC Inhibitors. |
| AID330337 | Inhibition of Escherichia coli LpxC | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Nov-20, Volume: 104, Issue:47
| Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding. |
| AID532943 | Antimicrobial activity against genomovar type II Burkholderia multivorans CFA11 at 40 ug/disk by disk diffusion growth inhibition assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID535089 | Antimicrobial activity against genomovar type IX Burkholderia pyrrocinia ATCC 15958 at 40 ug/disk by disk diffusion growth inhibition assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID1780306 | Antibacterial activity against wild type Pseudomonas aeruginosa LESB58 RS21000 and RS21005 mutant assessed as reduction in bacterial growth by broth microdilution assay | | | |
| AID535101 | Antimicrobial activity against genomovar type VIII Burkholderia anthina W92 at 40 ug/disk by disk diffusion growth inhibition assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID1171334 | Inhibition of MMP2 (unknown origin) at 30 uM | 2014 | ACS medicinal chemistry letters, Nov-13, Volume: 5, Issue:11
| Synthesis, Structure, and SAR of Tetrahydropyran-Based LpxC Inhibitors. |
| AID1720231 | Antibacterial activity against Escherichia coli D22 incubated assessed as prevention of visible growth for 20 hrs by two-fold serial microbroth dilution method | 2020 | Bioorganic & medicinal chemistry, 07-01, Volume: 28, Issue:13
| Synthesis and biological evaluation of triazolyl-substituted benzyloxyacetohydroxamic acids as LpxC inhibitors. |
| AID535077 | Antimicrobial activity against genomovar type VI Burkholderia dolosa STM1441 at 40 ug/disk by disk diffusion growth inhibition assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID1275726 | Antibacterial activity against Escherichia coli D22 incubated overnight by agar disk diffusion clearance assay | 2016 | Bioorganic & medicinal chemistry, Mar-01, Volume: 24, Issue:5
| Synthesis and biological evaluation of enantiomerically pure glyceric acid derivatives as LpxC inhibitors. |
| AID535111 | Antimicrobial activity against genomovar type IV Burkholderia stabilis LMG 14294 at 40 ug/disk by disk diffusion growth inhibition assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID649180 | Antibacterial activity against Pseudomonas aeruginosa PAO1 after 16 to 20 hrs by broth microdilution method | 2012 | Journal of medicinal chemistry, Jan-26, Volume: 55, Issue:2
| Potent inhibitors of LpxC for the treatment of Gram-negative infections. |
| AID535080 | Antimicrobial activity against genomovar type III Burkholderia cenocepacia J415 at 40 ug/disk by disk diffusion growth inhibition assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID532944 | Antimicrobial activity against genomovar type II Burkholderia multivorans JTC at 40 ug/disk by disk diffusion growth inhibition assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID535093 | Antimicrobial activity against Escherichia coli 25922 | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID766725 | Inhibition of Escherichia coli LpxC enzyme | 2013 | Journal of medicinal chemistry, Sep-12, Volume: 56, Issue:17
| Synthesis, structure, and antibiotic activity of aryl-substituted LpxC inhibitors. |
| AID1780303 | Antibacterial activity against wild type Pseudomonas aeruginosa LESB58 assessed as reduction in bacterial growth by broth microdilution assay | | | |
| AID532945 | Antimicrobial activity against genomovar type II Burkholderia multivorans C1962 at 40 ug/disk by disk diffusion growth inhibition assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID1313585 | Ratio of MIC for wild-type Escherichia coli TG1 to MIC for Escherichia coli KAM3 acrB deletion mutant | 2016 | ACS medicinal chemistry letters, Jun-09, Volume: 7, Issue:6
| LpxC Inhibitors: Design, Synthesis, and Biological Evaluation of Oxazolidinones as Gram-negative Antibacterial Agents. |
| AID535112 | Antimicrobial activity against genomovar type IV Burkholderia stabilis C7322 at 40 ug/disk by disk diffusion growth inhibition assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID1436638 | Antibacterial activity against Escherichia coli TG1 by agar dilution method | 2017 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 27, Issue:4
| Sulfonamide-based non-alkyne LpxC inhibitors as Gram-negative antibacterial agents. |
| AID1275725 | Antibacterial activity against Escherichia coli BL21(DE3) incubated overnight by agar disk diffusion clearance assay | 2016 | Bioorganic & medicinal chemistry, Mar-01, Volume: 24, Issue:5
| Synthesis and biological evaluation of enantiomerically pure glyceric acid derivatives as LpxC inhibitors. |
| AID649184 | Antibacterial activity against Pseudomonas aeruginosa after 16 to 20 hrs by broth microdilution method | 2012 | Journal of medicinal chemistry, Jan-26, Volume: 55, Issue:2
| Potent inhibitors of LpxC for the treatment of Gram-negative infections. |
| AID330344 | Activity of Escherichia coli LpxC | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Nov-20, Volume: 104, Issue:47
| Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding. |
| AID1584703 | Antimicrobial activity against Klebsiella pneumoniae ATCC 43816 after 20 hrs by CLSI protocol-based microdilution assay | 2018 | Journal of medicinal chemistry, 10-25, Volume: 61, Issue:20
| Application of Virtual Screening to the Identification of New LpxC Inhibitor Chemotypes, Oxazolidinone and Isoxazoline. |
| AID1720233 | Antibacterial activity against Escherichia coli D22 assessed as zone of growth inhibition at 10 mmol incubated for overnight by disc diffusion method | 2020 | Bioorganic & medicinal chemistry, 07-01, Volume: 28, Issue:13
| Synthesis and biological evaluation of triazolyl-substituted benzyloxyacetohydroxamic acids as LpxC inhibitors. |
| AID330353 | Ratio of Kcat to Km of Rhizobium leguminosarum LpxC W206Q/S214G mutant | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Nov-20, Volume: 104, Issue:47
| Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding. |
| AID1780307 | Antibacterial activity against wild type Pseudomonas aeruginosa LESB58 LpxA Ser150Ala mutant assessed as resistance development by measuring fold increase in MIC | | | |
| AID766722 | Antimicrobial activity against wild type Escherichia coli W3110 after 22 hrs by MTT assay | 2013 | Journal of medicinal chemistry, Sep-12, Volume: 56, Issue:17
| Synthesis, structure, and antibiotic activity of aryl-substituted LpxC inhibitors. |
| AID1313580 | Inhibition of Escherichia coli LpxC using UDP-3-O-(R-3-hydroxymyristoyl)GlcNAc as substrate measured after 60 mins by fluorescence analysis | 2016 | ACS medicinal chemistry letters, Jun-09, Volume: 7, Issue:6
| LpxC Inhibitors: Design, Synthesis, and Biological Evaluation of Oxazolidinones as Gram-negative Antibacterial Agents. |
| AID649181 | Antibacterial activity against Staphylococcus aureus ATCC 29213 after 16 to 20 hrs by broth microdilution method | 2012 | Journal of medicinal chemistry, Jan-26, Volume: 55, Issue:2
| Potent inhibitors of LpxC for the treatment of Gram-negative infections. |
| AID532940 | Antimicrobial activity against genomovar type III Burkholderia cenocepacia BC7 at 40 ug/disk by disk diffusion growth inhibition assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID551681 | Antibacterial activity against Escherichia coli W3110RL replaced with Rhizobium leguminosarum lpxC gene by NCCLS assay | 2011 | Bioorganic & medicinal chemistry, Jan-15, Volume: 19, Issue:2
| Syntheses, structures and antibiotic activities of LpxC inhibitors based on the diacetylene scaffold. |
| AID1324796 | Inhibition of wild-type Pseudomonas aeruginosa PAO1 LpxC assessed as deacetylation preincubated for 30 mins followed by addition of UDP-3-O-(R-hydroxydecanoyl)-N-acetylglucosamine as substrate measured after 60 mins by mass spectrometry | 2016 | Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
| Drug discovery strategies to outer membrane targets in Gram-negative pathogens. |
| AID535099 | Antimicrobial activity against genomovar type VII Burkholderia ambifaria ATCC 53266 at 40 ug/disk by disk diffusion growth inhibition assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID766713 | Antimicrobial activity against Francisella novicida U 112 after 22 hrs by MTT assay | 2013 | Journal of medicinal chemistry, Sep-12, Volume: 56, Issue:17
| Synthesis, structure, and antibiotic activity of aryl-substituted LpxC inhibitors. |
| AID551683 | Antibacterial activity against Pseudomonas aeruginosa PAO1 by NCCLS assay | 2011 | Bioorganic & medicinal chemistry, Jan-15, Volume: 19, Issue:2
| Syntheses, structures and antibiotic activities of LpxC inhibitors based on the diacetylene scaffold. |
| AID1064753 | Antimicrobial activity against Escherichia coli D22 at 10 mM after overnight incubation by agar disc diffusion method | 2014 | Bioorganic & medicinal chemistry, Feb-01, Volume: 22, Issue:3
| Synthesis, biological evaluation and molecular docking studies of benzyloxyacetohydroxamic acids as LpxC inhibitors. |
| AID535086 | Antimicrobial activity against genomovar type II Burkholderia multivorans C1962 | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID1894126 | Binding affinity to Escherichia coli LpxC assessed as inhibition constant | 2021 | Journal of medicinal chemistry, 02-25, Volume: 64, Issue:4
| Chemical Highlights Supporting the Role of Lipid A in Efficient Biological Adaptation of Gram-Negative Bacteria to External Stresses. |
| AID330339 | Inhibition of Rhizobium leguminosarum LpxC | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Nov-20, Volume: 104, Issue:47
| Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding. |
| AID551682 | Antibacterial activity against Escherichia coli W3110PA replaced with Pseudomonas aeruginosa lpxC gene by NCCLS assay | 2011 | Bioorganic & medicinal chemistry, Jan-15, Volume: 19, Issue:2
| Syntheses, structures and antibiotic activities of LpxC inhibitors based on the diacetylene scaffold. |
| AID330341 | Inhibition of Rhizobium leguminosarum LpxC W206Q/S214G mutant | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Nov-20, Volume: 104, Issue:47
| Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding. |
| AID1584701 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 after 20 hrs by CLSI protocol-based microdilution assay | 2018 | Journal of medicinal chemistry, 10-25, Volume: 61, Issue:20
| Application of Virtual Screening to the Identification of New LpxC Inhibitor Chemotypes, Oxazolidinone and Isoxazoline. |
| AID1313583 | Antibacterial activity against wild-type Klebsiella pneumoniae ATCC 13883 by agar dilution method | 2016 | ACS medicinal chemistry letters, Jun-09, Volume: 7, Issue:6
| LpxC Inhibitors: Design, Synthesis, and Biological Evaluation of Oxazolidinones as Gram-negative Antibacterial Agents. |
| AID1064754 | Antimicrobial activity against Escherichia coli BL21(DE3) at 10 mM after overnight incubation by agar disc diffusion method | 2014 | Bioorganic & medicinal chemistry, Feb-01, Volume: 22, Issue:3
| Synthesis, biological evaluation and molecular docking studies of benzyloxyacetohydroxamic acids as LpxC inhibitors. |
| AID535102 | Antimicrobial activity against genomovar type V Burkholderia vietnamiensis LMG 10929 at 40 ug/disk by disk diffusion growth inhibition assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID535075 | Antimicrobial activity against genomovar type VIII Burkholderia anthina J2552 at 40 ug/disk by disk diffusion growth inhibition assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID535106 | Antimicrobial activity against genomovar type IV Burkholderia stabilis LMG 18888 at 40 ug/disk by disk diffusion growth inhibition assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID1720232 | Antibacterial activity against Escherichia coli BL21 (DE3) assessed as prevention of visible growth incubated for 20 hrs by two-fold serial microbroth dilution method | 2020 | Bioorganic & medicinal chemistry, 07-01, Volume: 28, Issue:13
| Synthesis and biological evaluation of triazolyl-substituted benzyloxyacetohydroxamic acids as LpxC inhibitors. |
| AID1720234 | Antibacterial activity against Escherichia coli BL21 (DE3) assessed as zone of growth inhibition at 10 mmol incubated for overnight by disc diffusion method | 2020 | Bioorganic & medicinal chemistry, 07-01, Volume: 28, Issue:13
| Synthesis and biological evaluation of triazolyl-substituted benzyloxyacetohydroxamic acids as LpxC inhibitors. |
| AID330350 | Activity of Rhizobium leguminosarum LpxC S214G mutant | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Nov-20, Volume: 104, Issue:47
| Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding. |
| AID1368992 | Inhibition of LpxC in Pseudomonas aeruginosa PA14 assessed as reduction in microbial growth incubated for 22 hrs by MTT assay | 2018 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 28, Issue:2
| Design, synthesis and structure-activity relationship evaluation of novel LpxC inhibitors as Gram-negative antibacterial agents. |
| AID649179 | Inhibition of Pseudomonas aeruginosa LpxC using UDP-3-O-(R-hydroxydecanoyl)-N-acetylglucosamine incubated for 30 mins prior to substrate addition measured after 60 mins by mass spectrophotometry | 2012 | Journal of medicinal chemistry, Jan-26, Volume: 55, Issue:2
| Potent inhibitors of LpxC for the treatment of Gram-negative infections. |
| AID532941 | Antimicrobial activity against genomovar type III Burkholderia cenocepacia K562 at 40 ug/disk by disk diffusion growth inhibition assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID766718 | Antimicrobial activity against Escherichia coli W3110PA after 22 hrs by MTT assay | 2013 | Journal of medicinal chemistry, Sep-12, Volume: 56, Issue:17
| Synthesis, structure, and antibiotic activity of aryl-substituted LpxC inhibitors. |
| AID535083 | Antimicrobial activity against genomovar type II Burkholderia multivorans LMG 13010 at 40 ug/disk by disk diffusion growth inhibition assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID1780309 | Antibacterial activity against wild type Pseudomonas aeruginosa LESB58 RS21000 and RS21005 mutant assessed as resistance development by measuring fold increase in MIC | | | |
| AID1171337 | Inhibition of MMP13 (unknown origin) at 30 uM | 2014 | ACS medicinal chemistry letters, Nov-13, Volume: 5, Issue:11
| Synthesis, Structure, and SAR of Tetrahydropyran-Based LpxC Inhibitors. |
| AID1894132 | Inhibition of Pseudomonas aeruginosa LpxC | 2021 | Journal of medicinal chemistry, 02-25, Volume: 64, Issue:4
| Chemical Highlights Supporting the Role of Lipid A in Efficient Biological Adaptation of Gram-Negative Bacteria to External Stresses. |
| AID1894133 | Binding affinity to Pseudomonas aeruginosa LpxC assessed as inhibition constant | 2021 | Journal of medicinal chemistry, 02-25, Volume: 64, Issue:4
| Chemical Highlights Supporting the Role of Lipid A in Efficient Biological Adaptation of Gram-Negative Bacteria to External Stresses. |
| AID1647091 | Lipophilicity, logP of compound | 2020 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 30, Issue:2
| Propargylglycine-based antimicrobial compounds are targets of TolC-dependent efflux systems in Escherichia coli. |
| AID649188 | Antibacterial activity against Citrobacter freundii after 16 to 20 hrs by broth microdilution method | 2012 | Journal of medicinal chemistry, Jan-26, Volume: 55, Issue:2
| Potent inhibitors of LpxC for the treatment of Gram-negative infections. |
| AID1171332 | Antimicrobial activity against TolC-deficient Escherichia coli ARC524 W3110 harboring mutant by CLSI dilution method | 2014 | ACS medicinal chemistry letters, Nov-13, Volume: 5, Issue:11
| Synthesis, Structure, and SAR of Tetrahydropyran-Based LpxC Inhibitors. |
| AID766717 | Antimicrobial activity against Salmonella enterica typhimurium LT2 after 22 hrs by MTT assay | 2013 | Journal of medicinal chemistry, Sep-12, Volume: 56, Issue:17
| Synthesis, structure, and antibiotic activity of aryl-substituted LpxC inhibitors. |
| AID1275727 | Antibacterial activity against Escherichia coli BL21(DE3) incubated for 20 hrs by microdilution assay | 2016 | Bioorganic & medicinal chemistry, Mar-01, Volume: 24, Issue:5
| Synthesis and biological evaluation of enantiomerically pure glyceric acid derivatives as LpxC inhibitors. |
| AID1368991 | Inhibition of LpxC in Pseudomonas aeruginosa PAO1 assessed as reduction in microbial growth incubated for 22 hrs by MTT assay | 2018 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 28, Issue:2
| Design, synthesis and structure-activity relationship evaluation of novel LpxC inhibitors as Gram-negative antibacterial agents. |
| AID535073 | Antimicrobial activity against genomovar type II Burkholderia multivorans C1576 | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID1780305 | Antibacterial activity against wild type Pseudomonas aeruginosa LESB58 LpxA Gly120Ala mutant assessed as reduction in bacterial growth by broth microdilution assay | | | |
| AID535076 | Antimicrobial activity against genomovar type VIII Burkholderia anthina C1765 at 40 ug/disk by disk diffusion growth inhibition assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID1368993 | Inhibition of LpxC in Escherichia coli DH5[alpha] assessed as reduction in microbial growth incubated for 22 hrs by MTT assay | 2018 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 28, Issue:2
| Design, synthesis and structure-activity relationship evaluation of novel LpxC inhibitors as Gram-negative antibacterial agents. |
| AID1171330 | Antimicrobial activity against MexABCDXY-deficient Pseudomonas aeruginosa PAO1 ARC546 by CLSI dilution method | 2014 | ACS medicinal chemistry letters, Nov-13, Volume: 5, Issue:11
| Synthesis, Structure, and SAR of Tetrahydropyran-Based LpxC Inhibitors. |
| AID535097 | Antimicrobial activity against genomovar type II Burkholderia multivorans LMG 13010 | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID535110 | Antimicrobial activity against genomovar type III Burkholderia cenocepacia SAL1 at 40 ug/disk by disk diffusion growth inhibition assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID1064752 | Inhibition of Escherichia coli LpxC using UDP-3-O-[(R)-3-hydroxymyristoyl]-N-acetylglucosamine as substrate incubated for 30 mins prior to enzyme addition by fluorescence assay | 2014 | Bioorganic & medicinal chemistry, Feb-01, Volume: 22, Issue:3
| Synthesis, biological evaluation and molecular docking studies of benzyloxyacetohydroxamic acids as LpxC inhibitors. |
| AID766721 | Antimicrobial activity against Escherichia coli CMR300 after 22 hrs by MTT assay | 2013 | Journal of medicinal chemistry, Sep-12, Volume: 56, Issue:17
| Synthesis, structure, and antibiotic activity of aryl-substituted LpxC inhibitors. |
| AID330342 | Inhibition of Rhizobium leguminosarum LpxC at 0.5 uM | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Nov-20, Volume: 104, Issue:47
| Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding. |
| AID535095 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 10145 | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID535090 | Antimicrobial activity against genomovar type IX Burkholderia pyrrocinia ATCC 39277 at 40 ug/disk by disk diffusion growth inhibition assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID532947 | Antimicrobial activity against genomovar type I Burkholderia cepacia ATCC 17759 at 40 ug/disk by disk diffusion growth inhibition assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID535074 | Antimicrobial activity against genomovar type VIII Burkholderia anthina AU1293 at 40 ug/disk by disk diffusion growth inhibition assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID535079 | Antimicrobial activity against genomovar type IV Burkholderia stabilis LMG 14086 at 40 ug/disk by disk diffusion growth inhibition assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID1275728 | Antibacterial activity against Escherichia coli D22 incubated for 20 hrs by microdilution assay | 2016 | Bioorganic & medicinal chemistry, Mar-01, Volume: 24, Issue:5
| Synthesis and biological evaluation of enantiomerically pure glyceric acid derivatives as LpxC inhibitors. |
| AID330345 | Ratio of Kcat to Km for Escherichia coli LpxC | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Nov-20, Volume: 104, Issue:47
| Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding. |
| AID535104 | Antimicrobial activity against genomovar type VI Burkholderia dolosa CEP021 at 40 ug/disk by disk diffusion growth inhibition assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID535082 | Antimicrobial activity against genomovar type II Burkholderia multivorans ATCC 17616 at 40 ug/disk by disk diffusion growth inhibition assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID330340 | Inhibition of Rhizobium leguminosarum LpxC S214G mutant | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Nov-20, Volume: 104, Issue:47
| Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding. |
| AID535105 | Antimicrobial activity against genomovar type VI Burkholderia dolosa E12 at 40 ug/disk by disk diffusion growth inhibition assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID1700258 | Displacement of fluorescent ligand from Pseudomonas aeruginosa LpxC measured after 30 mins by fluorescence anisotrophy assay | 2020 | Bioorganic & medicinal chemistry, 12-15, Volume: 28, Issue:24
| N-Hydroxyformamide LpxC inhibitors, their in vivo efficacy in a mouse Escherichia coli infection model, and their safety in a rat hemodynamic assay. |
| AID535094 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID532942 | Antimicrobial activity against genomovar type II Burkholderia multivorans C1576 at 40 ug/disk by disk diffusion growth inhibition assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID535103 | Antimicrobial activity against genomovar type VI Burkholderia dolosa AU0645 at 40 ug/disk by disk diffusion growth inhibition assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID1436640 | Antibacterial activity against Pseudomonas aeruginosa PAO 4009 by agar dilution method | 2017 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 27, Issue:4
| Sulfonamide-based non-alkyne LpxC inhibitors as Gram-negative antibacterial agents. |
| AID1780304 | Antibacterial activity against wild type Pseudomonas aeruginosa LESB58 LpxA Ser150Ala mutant assessed as reduction in bacterial growth by broth microdilution assay | | | |
| AID1894131 | Antibacterial activity against Pseudomonas aeruginosa PA01 assessed as bacterial growth inhibition | 2021 | Journal of medicinal chemistry, 02-25, Volume: 64, Issue:4
| Chemical Highlights Supporting the Role of Lipid A in Efficient Biological Adaptation of Gram-Negative Bacteria to External Stresses. |
| AID330347 | Ratio of Kcat to Km of Escherichia coli LpxC Q202W/G210S mutant | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Nov-20, Volume: 104, Issue:47
| Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding. |
| AID535088 | Antimicrobial activity against genomovar type II Burkholderia multivorans 249-2 | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |