cefepime and Shock--Cardiogenic

Dosing of cefepime during high blood flow (Qb; 300 ml/min), high dialysate flow (Qd; 3 liter/h) continuous venovenous hemodialysis (CVVHD) is undefined. Six patients on CVVHD had serum and effluent cefepime concentrations measured at 0.5, 1, 2, 6, and 12 h after dosing. Three patients had cefepime concentrations less than the MIC for Pseudomonas aeruginosa. A dose of 2,000 mg every 12 h or 1,000 mg every 8 h may increase time at a therapeutic concentration.

Topics: Adult; Anti-Bacterial Agents; Cefepime; Cephalosporins; Chromatography, High Pressure Liquid; Female; Half-Life; Hemofiltration; Humans; Kidney Failure, Chronic; Kidney Tubular Necrosis, Acute; Male; Microbial Sensitivity Tests; Middle Aged; Pseudomonas aeruginosa; Shock, Cardiogenic; Spectrophotometry, Ultraviolet; Young Adult