cefepime and Severe-Combined-Immunodeficiency

Catheter related infections are reported as one of the most common source of nosocomial infections. Rhizobium radibacter infections are generally manifested by fever and leukocytosis. Here, a 14 months-old girl diagnosed as T (-) B (-) NK (+) severe combined immunodeficiency (SCID) is presented. She had received repeated (x3) unconditioned haploidentical hematopoetic stem cell transplantations. During the follow-up, she has been arised an asymptomatic infection with R. Radiobacter, which was isolated from central venous catheter and peripheral blood while she was clinically stable, free of symptoms, fever or leukocytosis. She was treated successfully with cefepime and amikacin and did not require catheter removal. So, it is once more clear that the blood cultures should be obtained on regular basis from all patients with an intravascular device, even they were asymptomatic.

Topics: Agrobacterium tumefaciens; Amikacin; Anti-Bacterial Agents; Blood; Catheter-Related Infections; Catheterization, Central Venous; Catheters; Cefepime; Cephalosporins; Cross Infection; Female; Gram-Negative Bacterial Infections; Humans; Immunocompromised Host; Infant; Severe Combined Immunodeficiency; Stem Cell Transplantation