Deficiency, Factor 5

A deficiency of blood coagulation factor V (known as proaccelerin or accelerator globulin or labile factor) leading to a rare hemorrhagic tendency known as Owren's disease or parahemophilia. It varies greatly in severity. Factor V deficiency is an autosomal recessive trait. (Dorland, 27th ed)

Synonym
Factor V Deficiency
Factor Five Deficiency
Owren's Disease
Parahemophilia
Owren Parahemophilia
Factor 5 Deficiency
Deficiency, Factor V
Deficiency, Factor 5
Owren Disease
Deficiency, Factor Five
Labile Factor Deficiency

Excerpt	Reference
"Factor V deficiency is rare."	( Bennett, K; Daley, ML; Pike, C, 1997)
"Congenital factor V deficiency is an uncommon bleeding disorder that necessitates hemostatic correction before surgery."	( Iguro, Y; Kinjo, T; Masuda, H; Sakata, R; Toyokawa, K; Yotsumoto, G, 2005)
"Factor V deficiency is a rare coagulation disorder."	( Esquivel, P; Stalnaker, M, 2015)
"Factor V deficiency is a rare cause of menorrhagia."	( Esquivel, P; Stalnaker, M, 2015)
"Acquired factor V deficiency is a rare coagulation disorder, and it can sometimes be life threatening."	( Fujiwara, N; Hamada, O; Kitamura, K; Miyakawa, Y; Takemoto, K, 2019)

Excerpt	Reference
"Factor V deficiency has been identified in 8 of 8 patients 7--20 yr of age, with Philadelphia-positive (Ph1+) chronic myelogenous leukemia (CML)."	( Bennett, AJ; Coccia, PF; Edson, JR; Hasegawa, DK; Krivit, W; Nesbit, ME; Ramsay, NK, 1980)

Excerpt	Reference
"In our patient, factor V deficiency due to inhibitors developed each time that the patient received repeated cephradine treatment."	( Pei, SN; Wu, MT, 2010)
"We describe a case of 2 siblings with Factor V deficiency and menorrhagia who achieved control of bleeding with differing treatments."	( Esquivel, P; Stalnaker, M, 2015)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	95 (51.35)	23.3326
1990's	27 (14.59)	12.5806
2000's	29 (15.68)	18.1394
2010's	29 (15.68)	28.8240
2020's	5 (2.70)	9.53

Drug	Relationship Strength	Studies
ammonium hydroxide	low	1
choline	low	1
coumarin	low	2
salicylic acid	low	1
aminocaproic acid	low	1
dalteparin	low	1
urea	low	1
aminopropionitrile	low	1
phenytoin	low	1
aspirin	low	4
azathioprine	low	1
chlorpromazine	low	1
ciprofloxacin	low	1
flumazenil	low	1
guaifenesin	low	1
hydroxyurea	low	1
lidocaine	low	1
metoclopramide	low	1
nicardipine	low	1
omeprazole	low	1
phenobarbital	low	1
primidone	low	1
thalidomide	low	1
tranexamic acid	low	4
prednisolone	low	4
prednisone	low	7
alanine	low	1
serine	low	1
chloramphenicol	low	1
glutamine	low	1
adenosine diphosphate	low	4
edetic acid	low	2
leucine	low	1
ampicillin	low	1
cytarabine	low	1
histidine	low	1
valine	low	1
arginine	low	4
methylprednisolone	low	3
azacitidine	low	1
levonorgestrel	low	1
thorium dioxide	low	1
mannose	low	1
streptomycin	low	2
manganese	low	1
trolamine salicylate	low	1
cephradine	low	1
cefotetan	low	1
adenosine	low	1
cephalosporin c	low	1
fibrinogen	low	20
homocysteine	low	1
firefly luciferin	low	1
h-d-phe-pip-arg-pna	low	1
garenoxacin	low	1
levofloxacin	low	1
fibrin	low	7
pentostatin	low	1
meropenem	low	1
micafungin	low	1
arginine vasopressin	low	2
mercaptopurine	low	2
enclomiphene	low	1
thioguanine anhydrous	low	1
dermatan sulfate	low	2
naphthoquinones	low	1
bilirubin	low	1
vitamin k semiquinone radical	low	11
s 1108	low	1
vitamin k 1	low	1
deamino arginine vasopressin	low	11
enalapril	low	1
phosphorus	low	1
cefepime	low	1
ticagrelor	low	1
rivaroxaban	low	1
apixaban	low	1
acid phosphatase	low	2
fibrinopeptide b	low	1
ristocetin	low	3
menotropins	low	1
bucladesine	low	1
ro13-9904	low	2
sodium ethylxanthate	low	1
fibrinopeptide a	low	2
heparitin sulfate	low	2
dicumarol	low	1
acenocoumarol	low	1
warfarin	low	10
kaolinite	low	2
cyclosporine	low	1
thromboplastin	low	36
muramidase	low	1
chondroitin sulfates	low	2
folic acid	low	1
phosphorus radioisotopes	low	1

Protein Targets (1,050)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	19	0	0	19
Luciferase	5	0	0	5
RAR-related orphan receptor gamma	20	0	0	20
retinoid X nuclear receptor alpha	19	0	0	19
G	16	0	0	16
peroxisome proliferator activated receptor gamma	11	0	0	11
euchromatic histone-lysine N-methyltransferase 2	30	0	0	30
thyroid stimulating hormone receptor	8	0	0	8
chromobox protein homolog 1	16	0	0	16
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	5	0	0	5
geminin	27	0	0	27
muscleblind-like protein 1 isoform 1	5	0	0	5
Interferon beta	19	0	0	19
HLA class I histocompatibility antigen, B alpha chain	16	0	0	16
Guanine nucleotide-binding protein G	1	0	0	1
Inositol hexakisphosphate kinase 1	16	0	0	16
cytochrome P450 2C9, partial	16	0	0	16
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain B, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
Chain A, Uncharacterized protein MJ0883	0	0	1	1
AR protein	28	0	0	28
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
regulator of G-protein signaling 4	8	0	0	8
glucocorticoid receptor [Homo sapiens]	21	0	0	21
estrogen nuclear receptor alpha	27	0	0	27
NPYLR7B	0	0	1	1
arylsulfatase A	10	0	0	10
IDH1	10	0	0	10
Histone H2A.x	12	0	0	12
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
mitogen-activated protein kinase 1	3	0	0	3
flap endonuclease 1	11	0	0	11
nuclear receptor ROR-gamma isoform 1	6	0	0	6
peripheral myelin protein 22	11	0	0	11
survival motor neuron protein isoform d	9	0	0	9
high affinity choline transporter 1 isoform a	0	1	0	1
Sodium/nucleoside cotransporter 1	0	2	0	2
Calcium dependent protein kinase	0	1	0	1
Mitogen-activated protein kinase kinase kinase 7	0	0	2	2
Sodium/nucleoside cotransporter 2	0	2	0	2
Voltage-dependent calcium channel gamma-2 subunit	11	0	0	11
Rap guanine nucleotide exchange factor 3	7	0	0	7
Purine nucleoside phosphorylase	0	1	0	1
Epidermal growth factor receptor	0	4	0	4
Phosphoglycerate kinase 1	0	1	0	1
Adenosine deaminase	0	1	0	2
Avidin	0	0	1	1
Adenosine deaminase	0	0	0	1
Glyceraldehyde-3-phosphate dehydrogenase	0	3	0	3
Receptor tyrosine-protein kinase erbB-2	0	3	0	3
Insulin receptor	0	0	0	1
Phosphoglycerate kinase 2	0	1	0	1
Heat shock protein HSP 90-alpha	0	2	2	5
Platelet-derived growth factor receptor beta	0	0	0	1
Adenosine receptor A3	0	8	2	11
Heat shock 70 kDa protein 1A	0	2	1	3
Heat shock cognate 71 kDa protein	0	0	2	2
Fibroblast growth factor receptor 1	0	0	0	1
Inosine-5'-monophosphate dehydrogenase 2	0	1	0	1
Endoplasmin	0	1	1	3
Glutamate receptor 2	11	0	0	11
Inosine-5'-monophosphate dehydrogenase 1	0	1	0	1
Fibroblast growth factor receptor 2	0	0	0	1
Fibroblast growth factor receptor 4	0	0	0	1
Fibroblast growth factor receptor 3	0	0	0	1
Streptavidin	0	0	1	1
Adenosylhomocysteinase	0	0	0	1
Adenosine receptor A1	0	2	1	5
Adenosine receptor A3	0	2	0	2
Adenosine receptor A2a	0	2	2	5
Adenosine receptor A2b	0	0	1	2
Adenosine receptor A2b	0	1	1	2
Adenylate kinase 2, mitochondrial	0	1	0	1
Adenosine receptor A1	0	3	2	6
Adenosine receptor A2a	0	3	1	6
Adenylate kinase isoenzyme 1	0	1	0	1
Phosphatidylinositol 4-kinase alpha	0	4	0	5
Adenosine receptor A1	0	0	1	1
Adenosine kinase	0	0	0	1
Adenosine deaminase	0	1	0	2
Equilibrative nucleoside transporter 2	0	2	0	2
Phosphatidylinositol 4-kinase type 2-beta	0	4	0	5
Histone-lysine N-methyltransferase, H3 lysine-79 specific	0	1	0	1
Equilibrative nucleoside transporter 1	0	2	0	2
Phosphatidylinositol 4-kinase type 2-alpha	0	4	0	5
Solute carrier family 28 member 3	0	2	0	2
Adenosine kinase	0	1	0	2
Phosphatidylinositol 4-kinase beta	0	4	0	5
5-methylthioadenosine/S-adenosylhomocysteine deaminase	0	0	0	1
Adenosine transporter 1	0	0	0	1
Chain A, Heat Shock Protein 90	0	0	1	1
Chain A, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain B, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, Myosin Ie Heavy Chain	0	0	1	1
Chain A, Preprotein translocase secA	0	0	1	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Phosphoribosylformylglycinamidine synthase	0	1	0	1
Chain A, nucleoside diphosphate kinase A	0	0	1	1
Chain B, nucleoside diphosphate kinase A	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A, Kinesin-like protein KIF11	0	1	0	1
HPr kinase/phosphorylase	0	0	1	1
ATP-dependent molecular chaperone HSP82	0	0	0	1
Heat shock protein HSP 90-beta	0	1	1	3
2-dehydropantoate 2-reductase	0	1	1	2
Endoplasmic reticulum chaperone BiP	0	0	1	1
Pyruvate kinase PKM	0	0	0	1
Pyruvate kinase PKLR	0	0	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
5'-nucleotidase	0	1	0	1
Mu-type opioid receptor	0	2	1	3
Delta-type opioid receptor	0	2	1	3
Kappa-type opioid receptor	0	2	1	3
Endoplasmin	0	1	1	2
P2Y purinoceptor 2	0	0	1	1
P2X purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2X purinoceptor 1	0	0	1	1
P2X purinoceptor 4	0	0	1	1
P2X purinoceptor 5	0	0	1	1
P2X purinoceptor 6	0	0	1	1
P2X purinoceptor 3	0	0	1	1
Inositol monophosphatase 1	5	0	0	5
Heat shock protein 75 kDa, mitochondrial	0	1	0	1
P2Y purinoceptor 6	0	0	1	1
P2Y purinoceptor 11	0	0	1	1
P2Y purinoceptor 12	0	0	1	1
Sensor protein kinase WalK	0	1	0	1
P2X purinoceptor 2	0	0	1	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	14	0	0	14
Carbonic anhydrase 1	0	6	0	12
Carbonic anhydrase 2	0	7	0	14
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	2
Glutamate receptor ionotropic, NMDA 1	0	2	0	4
Proton-coupled amino acid transporter 1	0	4	0	5
Adenosine deaminase	0	0	0	1
Carbonic anhydrase 4	0	0	0	2
Chain A, PLASMINOGEN	0	0	2	2
Chain A, PLASMINOGEN	0	0	2	2
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
Chain A, Ferritin light chain	4	0	0	4
Chain A, Apolipoprotein	0	0	1	1
15-lipoxygenase, partial	2	0	0	2
ATAD5 protein, partial	9	0	0	9
aldehyde dehydrogenase 1 family, member A1	21	0	0	21
cytochrome P450 family 3 subfamily A polypeptide 4	14	0	0	14
EWS/FLI fusion protein	17	0	0	17
nonstructural protein 1	2	0	0	2
D(1A) dopamine receptor	4	0	0	4
thyroid hormone receptor beta isoform a	6	0	0	6
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
histone acetyltransferase KAT2A isoform 1	11	0	0	11
lamin isoform A-delta10	18	0	0	18
Plasminogen	0	4	2	6
Lysyl oxidase homolog 2	0	1	0	1
Protein-lysine 6-oxidase	0	1	0	1
Protein-lysine 6-oxidase	0	1	0	1
Lysyl oxidase homolog 2	0	1	0	1
Lysyl oxidase homolog 3	0	1	0	1
Lysyl oxidase homolog 4	0	1	0	1
Lysyl oxidase homolog 2	0	1	0	1
Chain A, Mutant Al2 6e7p9g	0	0	1	1
Chain A, Beta-lactamase	10	0	0	10
Chain A, 2-oxoglutarate Oxygenase	11	0	0	11
Chain A, Cruzipain	3	0	0	3
Beta-lactamase	0	0	0	3
acid sphingomyelinase	2	0	0	2
GLS protein	11	0	0	11
GLI family zinc finger 3	20	0	0	20
apical membrane antigen 1, AMA1	4	0	0	4
retinoic acid nuclear receptor alpha variant 1	21	0	0	21
farnesoid X nuclear receptor	16	0	0	16
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	4
Metallo-beta-lactamase type 2	0	0	1	5
Metallo-beta-lactamase VIM-11	0	0	0	4
Metallo-beta-lactamase VIM-2	0	0	0	4
Beta-lactamase	0	0	0	4
Metallo-beta-lactamase	0	0	0	4
Beta-lactamase	0	0	0	3
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	9	0	0	9
thyroid hormone receptor beta isoform 2	13	0	0	13
DNA polymerase beta	5	0	0	5
DNA polymerase eta isoform 1	4	0	0	4
DNA polymerase iota isoform a (long)	15	0	0	15
DNA polymerase kappa isoform 1	9	0	0	9
60 kDa heat shock protein, mitochondrial	0	1	0	1
Beta-lactamase OXA-7	0	0	0	1
Solute carrier family 15 member 1	0	7	0	7
Solute carrier family 15 member 1	0	3	0	4
Spike glycoprotein	10	1	1	12
10 kDa heat shock protein, mitochondrial	0	1	0	1
Angiopoietin-1 receptor	0	0	1	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Solute carrier family 15 member 2	0	3	0	3
Thiosulfate sulfurtransferase	0	1	0	1
Metallo-beta-lactamase VIM-13	0	1	0	5
Efflux transporter	0	0	0	2
Beta-lactamase	0	0	0	3
Beta-lactamase Toho-1	0	0	0	2
Beta-lactamase	0	0	0	2
Class D beta-lactamase	0	0	0	1
60 kDa chaperonin	0	1	0	1
Metallo-beta-lactamase	0	0	0	4
Solute carrier family 15 member 2	0	4	0	4
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	1	4
10 kDa chaperonin	0	1	0	1
Metallo-b-lactamase	0	0	0	4
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	3
Histamine H3 receptor	0	0	0	3
Beta-lactamase class B VIM-2	0	0	1	5
Beta-lactamase VIM-1	0	1	0	5
ATP-dependent phosphofructokinase	8	0	0	8
Chain A, Coagulation factor X (EC 3.4.21.6) (Stuart factor) (Stuart-Prower factor)	0	1	0	1
Coagulation factor X	0	1	0	1
Prothrombin	0	2	0	2
Coagulation factor X	0	4	0	4
Trypsin-1	0	1	0	1
Trypsin-2	0	1	0	1
Trypsin-3	0	1	0	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
thioredoxin reductase	14	0	0	14
phosphopantetheinyl transferase	11	0	0	11
NFKB1 protein, partial	4	0	0	4
thyroid stimulating hormone receptor	7	0	0	7
alpha-galactosidase	2	0	0	2
cytochrome P450 2C19 precursor	4	0	0	4
muscarinic acetylcholine receptor M1	11	0	0	11
lethal factor (plasmid)	7	0	0	7
Cytochrome P450 3A4	0	5	0	6
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
vitamin D3 receptor isoform VDRA	10	0	0	10
ATP-binding cassette sub-family C member 3	0	21	0	21
Multidrug resistance-associated protein 4	0	21	0	22
Bile salt export pump	0	33	0	33
Translocator protein	0	0	1	1
Vasopressin V2 receptor	0	3	2	6
Oxytocin receptor	0	1	2	3
Vasopressin V1a receptor	0	0	2	2
Vasopressin V1a receptor	0	2	2	4
Vasopressin V1b receptor	0	2	2	4
Vasopressin V2 receptor	0	0	1	1
Vasopressin V1b receptor	0	1	1	3
Translocator protein	0	2	0	3
Oxytocin receptor	0	1	0	1
Vasopressin V2 receptor	0	2	2	4
Canalicular multispecific organic anion transporter 1	0	20	0	20
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, HADH2 protein	7	0	0	7
Chain B, HADH2 protein	7	0	0	7
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	4	0	0	4
hypothetical protein, conserved	2	0	0	2
estrogen-related nuclear receptor alpha	21	0	0	21
cytochrome P450 2D6	8	0	0	8
glucocerebrosidase	3	0	0	3
peroxisome proliferator-activated receptor delta	11	0	0	11
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
Bloom syndrome protein isoform 1	8	0	0	8
Prostaglandin-H2 D-isomerase	0	1	0	1
Solute carrier family 22 member 6	0	3	0	3
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Fatty acid-binding protein, liver	0	2	0	2
Integrin beta-3	5	1	0	6
Myeloperoxidase	0	2	0	2
Prostaglandin G/H synthase 1	0	2	0	2
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	5	1	0	6
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	6	0	6
Substance-P receptor	0	1	0	2
Prostaglandin G/H synthase 2	0	4	0	4
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	4	0	0	4
Ras-related protein Rab-2A	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	7	5	0	13
Prostaglandin G/H synthase 2	0	2	0	2
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	2	0	2
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 6	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	4	1	5
Sigma non-opioid intracellular receptor 1	0	0	1	1
glp-1 receptor, partial	5	0	0	5
pregnane X receptor	4	0	0	4
Fumarate hydratase	6	0	0	6
PPM1D protein	3	0	0	3
TDP1 protein	21	0	0	21
Thrombopoietin	2	0	0	2
Smad3	4	0	0	4
estrogen receptor 2 (ER beta)	9	0	0	9
nuclear receptor subfamily 1, group I, member 3	20	0	0	20
progesterone receptor	13	0	0	13
pregnane X nuclear receptor	18	0	0	18
polyprotein	6	0	0	6
67.9K protein	4	0	0	4
Parkin	2	0	0	2
vitamin D (1,25- dihydroxyvitamin D3) receptor	15	0	0	15
aryl hydrocarbon receptor	9	0	0	9
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	11	0	0	11
activating transcription factor 6	6	0	0	6
peripheral myelin protein 22 isoform 1	5	0	0	5
hemoglobin subunit beta	4	0	0	4
cellular tumor antigen p53 isoform a	6	0	0	6
huntingtin isoform 2	2	0	0	2
ras-related protein Rab-9A	3	0	0	3
serine/threonine-protein kinase mTOR isoform 1	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 1	18	0	0	18
urokinase-type plasminogen activator precursor	5	0	0	5
plasminogen precursor	5	0	0	5
urokinase plasminogen activator surface receptor precursor	5	0	0	5
Cellular tumor antigen p53	18	0	0	18
DNA (cytosine-5)-methyltransferase 1	0	1	0	1
D(1A) dopamine receptor	4	0	0	4
Multidrug and toxin extrusion protein 1	0	4	0	4
Histone-lysine N-methyltransferase EHMT2	0	1	0	1
ATPase family AAA domain-containing protein 5	7	0	0	7
Ataxin-2	9	0	0	9
acetylcholinesterase	9	0	0	9
SMAD family member 2	4	0	0	4
SMAD family member 3	4	0	0	4
Microtubule-associated protein tau	7	0	0	7
thioredoxin glutathione reductase	5	0	0	5
P53	1	0	0	1
v-jun sarcoma virus 17 oncogene homolog (avian)	11	0	0	11
heat shock protein beta-1	8	0	0	8
cytochrome P450 3A4 isoform 1	7	0	0	7
M-phase phosphoprotein 8	3	0	0	3
Gamma-aminobutyric acid receptor subunit pi	7	4	0	12
Bile salt export pump	0	6	0	6
Gamma-aminobutyric acid receptor subunit beta-1	7	4	0	12
Gamma-aminobutyric acid receptor subunit delta	7	4	0	12
Gamma-aminobutyric acid receptor subunit gamma-2	7	4	0	12
Gamma-aminobutyric acid receptor subunit alpha-5	7	4	0	12
Gamma-aminobutyric acid receptor subunit alpha-3	7	4	0	12
Gamma-aminobutyric acid receptor subunit gamma-1	7	4	0	12
Gamma-aminobutyric acid receptor subunit alpha-2	7	4	0	12
Gamma-aminobutyric acid receptor subunit alpha-4	7	4	0	12
Gamma-aminobutyric acid receptor subunit gamma-3	7	4	0	12
Gamma-aminobutyric acid receptor subunit alpha-6	7	4	0	12
Gamma-aminobutyric acid receptor subunit beta-3	7	4	0	12
Gamma-aminobutyric acid receptor subunit beta-2	7	4	0	12
GABA theta subunit	7	4	0	12
Gamma-aminobutyric acid receptor subunit epsilon	7	4	0	12
Protein-arginine deiminase type-4	0	3	0	3
Chain A, Putative fructose-1,6-bisphosphate aldolase	8	0	0	8
USP1 protein, partial	12	0	0	12
caspase-1 isoform alpha precursor	1	0	0	1
Caspase-7	1	0	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	3
Solute carrier organic anion transporter family member 1B1	0	2	0	3
vasopressin V1b receptor	1	0	0	1
cAMP-dependent protein kinase type I-alpha regulatory subunit	0	0	1	1
cAMP-dependent protein kinase type II-beta regulatory subunit	0	0	1	1
cAMP-dependent protein kinase catalytic subunit beta isoform 1	0	0	1	1
relaxin receptor 1 isoform 1	1	0	0	1
relaxin receptor 2 isoform 1	1	0	0	1
neuropeptide S receptor isoform A	1	0	0	1
cAMP-dependent protein kinase catalytic subunit beta isoform 3	0	0	1	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase VIM-19	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 5	0	1	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	3
Beta-lactamase SHV-1	0	0	0	3
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	3
Kappa-type opioid receptor	0	0	0	2
Beta-lactamase TEM	0	0	0	3
Beta-lactamase	0	0	0	1
B2 metallo-beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase VIM-2	0	0	0	3
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
BlaVIM-1	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
Chain A, JmjC domain-containing histone demethylation protein 3A	7	0	0	7
bromodomain adjacent to zinc finger domain 2B	5	0	0	5
potassium voltage-gated channel subfamily H member 2 isoform d	4	0	0	4
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3A isoform a	0	1	0	1
TAR DNA-binding protein 43	3	0	0	3
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
endonuclease IV	5	0	0	5
WRN	1	0	0	1
Beta-lactamase	0	0	0	1
DNA (cytosine-5)-methyltransferase 1 isoform b	0	1	0	1
importin subunit beta-1 isoform 1	1	0	0	1
serine/threonine-protein kinase PLK1	2	0	0	2
snurportin-1	1	0	0	1
carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1	0	1	0	1
Solute carrier family 22 member 8	0	1	0	2
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase OXA-1	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 6	0	3	0	3
Solute carrier family 22 member 7	0	1	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	2	0	2
Solute carrier family 22 member 11	0	1	0	1
Solute carrier family 22 member 8	0	1	0	1
Solute carrier family 22 member 7	0	1	0	1
phosphoglycerate kinase	1	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	3	0	0	3
streptokinase A precursor	0	0	3	3
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Methionine--tRNA ligase, mitochondrial	0	0	1	1
Proteasome subunit beta type-11	0	0	0	1
caspase 7, apoptosis-related cysteine protease	2	0	0	2
NADPH oxidase 1	0	1	0	1
Snq2p	0	0	0	1
caspase-3	2	0	0	2
Adenylate cyclase type 1	0	2	0	2
Caspase-7	2	0	0	2
Spike glycoprotein	0	1	1	2
Replicase polyprotein 1ab	0	2	1	3
cytochrome P450 2D6 isoform 1	3	0	0	3
caspase-3	2	0	0	2
histone deacetylase 9 isoform 3	1	0	0	1
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
Proteasome subunit alpha type-7	0	0	0	1
Solute carrier family 22 member 1	0	2	0	3
Polyunsaturated fatty acid lipoxygenase ALOX15B	3	0	0	3
Transmembrane protease serine 2	0	1	1	2
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
5-hydroxytryptamine receptor 4	0	6	0	6
Potassium channel subfamily K member 2	0	2	0	2
Albumin	0	1	2	3
Albumin	0	0	3	3
Major prion protein	0	0	1	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Major prion protein	0	0	1	1
Cytochrome P450 1A2	0	1	1	2
Tyrosine-protein kinase Fyn	0	2	0	2
Procathepsin L	0	1	1	2
Aldo-keto reductase family 1 member B1	0	4	0	4
Muscarinic acetylcholine receptor M2	0	4	0	4
Muscarinic acetylcholine receptor M4	0	4	0	4
ATP-dependent translocase ABCB1	0	3	0	5
Muscarinic acetylcholine receptor M1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
5-hydroxytryptamine receptor 2C	0	2	0	2
Muscarinic acetylcholine receptor M5	0	1	0	1
Muscarinic acetylcholine receptor M5	0	4	0	4
Alpha-2A adrenergic receptor	0	6	0	6
Replicase polyprotein 1a	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Cys-loop ligand-gated ion channel	0	1	0	1
Calmodulin-1	0	2	1	3
Replicase polyprotein 1ab	0	2	1	3
Cytochrome P450 2D6	0	5	1	6
Muscarinic acetylcholine receptor M2	0	1	0	1
Muscarinic acetylcholine receptor M1	0	4	0	4
Cytochrome P450 2C9	0	11	0	11
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
Angiotensin-converting enzyme	0	3	0	3
D(2) dopamine receptor	0	4	0	5
5-hydroxytryptamine receptor 2A	0	2	0	2
Alpha-1B adrenergic receptor	0	7	0	7
Sphingomyelin phosphodiesterase	0	1	0	1
Alpha-2B adrenergic receptor	0	4	0	4
Alpha-2C adrenergic receptor	0	4	0	4
D	0	3	0	3
D(3) dopamine receptor	0	3	0	3
5-hydroxytryptamine receptor 1A	0	6	0	6
Alpha-2B adrenergic receptor	0	3	0	3
D(2) dopamine receptor	0	2	0	2
Muscarinic acetylcholine receptor M3	0	4	0	4
Proteasome subunit beta type-1	0	0	0	1
Substance-K receptor	0	4	0	4
D(1A) dopamine receptor	0	2	0	3
D(4) dopamine receptor	0	2	0	3
D(1B) dopamine receptor	0	1	0	2
Adenylate cyclase type 3	0	2	0	2
Alpha-2C adrenergic receptor	0	3	0	3
UDP-glucuronosyltransferase 1A4	0	2	0	3
Alpha-2A adrenergic receptor	0	3	0	3
Alpha-1D adrenergic receptor	0	3	0	3
Sodium-dependent noradrenaline transporter	0	4	0	4
Sodium-dependent dopamine transporter	0	2	0	2
Histamine H2 receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	2	0	2
D(1B) dopamine receptor	0	3	0	3
Proteasome subunit alpha type-1	0	0	0	1
Proteasome subunit alpha type-2	0	0	0	1
Proteasome subunit alpha type-3	0	0	0	1
Proteasome subunit alpha type-4	0	0	0	1
Adenylate cyclase type 2	0	2	0	2
Adenylate cyclase type 4	0	2	0	2
Proteasome subunit beta type-8	0	0	0	1
Proteasome subunit beta type-9	0	0	0	1
Proteasome subunit alpha type-5	0	0	0	1
Proteasome subunit beta type-4	0	0	0	1
Proteasome subunit beta type-6	0	0	0	1
Proteasome subunit beta type-5	0	0	0	1
5-hydroxytryptamine receptor 2A	0	6	0	6
5-hydroxytryptamine receptor 2C	0	6	0	6
5-hydroxytryptamine receptor 1B	0	3	0	3
Trypanothione reductase	0	2	0	2
D(4) dopamine receptor	0	3	0	3
5-hydroxytryptamine receptor 2B	0	2	0	2
Histamine H1 receptor	0	1	1	2
Sodium-dependent serotonin transporter	0	4	0	4
Melanocortin receptor 4	0	2	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
Melanocortin receptor 5	0	2	0	2
Pleiotropic ABC efflux transporter of multiple drugs	0	1	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
Histamine H1 receptor	0	2	0	2
D(3) dopamine receptor	0	6	0	7
Sodium channel protein type 1 subunit alpha	0	3	0	3
Sodium channel protein type 4 subunit alpha	0	3	0	4
Adenylate cyclase type 8	0	2	0	2
Proteasome subunit beta type-10	0	0	0	1
5-hydroxytryptamine receptor 2B	0	6	0	6
Melanocortin receptor 3	0	2	0	2
Alpha-1A adrenergic receptor	0	7	0	7
Histamine H2 receptor	6	0	0	6
Proteasome subunit beta type-3	0	0	0	1
Proteasome subunit beta type-2	0	0	0	1
5-hydroxytryptamine receptor 6	0	4	0	4
5-hydroxytryptamine receptor 7	0	2	0	2
Cytochrome P450 2J2	0	4	0	4
Gastrin/cholecystokinin type B receptor	0	1	0	1
Proteasome subunit alpha type-6	0	0	1	2
D(2) dopamine receptor	0	4	0	5
Calmodulin	0	1	1	2
Aldehyde oxidase 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	3
Glutamate receptor ionotropic, NMDA 2B	0	1	0	3
Glutamate receptor ionotropic, NMDA 2C	0	1	0	3
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Sodium-dependent dopamine transporter	0	4	0	4
Adenylate cyclase type 6	0	2	0	2
Adenylate cyclase type 5	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Aldehyde oxidase	0	2	0	2
Potassium voltage-gated channel subfamily H member 2	0	9	0	10
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Sodium channel protein type 5 subunit alpha	0	3	0	3
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	3	0	3
Glutamate receptor ionotropic, NMDA 2D	0	1	0	3
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Adenylyl cyclase 7	0	2	0	2
Proteasome subunit alpha-type 8	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	3
D	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	3	0	3
Proteasome subunit beta type-7	0	0	0	1
Angiotensin-converting enzyme 2	0	2	1	3
Sodium channel protein type 3 subunit alpha	0	4	0	4
Glutamate receptor ionotropic, NMDA 3A	0	1	0	3
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Histamine H3 receptor	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
Solute carrier family 22 member 1	0	1	0	2
Solute carrier family 22 member 2	0	0	0	1
Solute carrier family 22 member 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	2	0	2
Neuronal acetylcholine receptor subunit beta-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-5	0	1	0	1
Acetylcholinesterase	0	4	0	4
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Choline O-acetyltransferase	0	0	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-9	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Solute carrier family 22 member 1	0	1	0	2
High affinity choline transporter 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-10	0	1	0	1
Solute carrier family 22 member 2	0	1	0	2
cytochrome P450 2C9 precursor	3	0	0	3
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	2
DNA gyrase subunit A	0	1	0	3
DNA gyrase subunit B	0	1	0	3
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	2
DNA topoisomerase 4 subunit A	0	1	0	2
DNA topoisomerase 2-alpha	0	1	0	4
DNA gyrase subunit A	0	1	0	2
Cytochrome P450 2C19	0	2	0	3
Multidrug resistance protein MdtK	0	0	1	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	2	0	2
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	0	0	2
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
Integrase	0	2	0	2
GALC protein	1	0	0	1
nuclear receptor subfamily 1, group I, member 2	3	0	0	3
glycogen synthase kinase-3 alpha	0	0	0	1
Exportin-1	0	1	0	1
Carbonic anhydrase 12	0	2	0	5
NAD-dependent histone deacetylase SIR2	0	1	0	3
Carbonic anhydrase 3	0	2	0	4
Cytochrome P450 2A6	0	0	0	1
Aldo-keto reductase family 1 member B1	0	3	0	3
UDP-glucuronosyltransferase 2B7	0	2	0	2
UDP-glucuronosyltransferase 1-6	0	2	0	2
Amine oxidase [flavin-containing] B	0	1	0	1
Cytochrome P450 2A5	0	0	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Acetylcholinesterase	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	2	0	2
Glyceraldehyde-3-phosphate dehydrogenase, glycosomal	0	1	0	1
Carbonic anhydrase 4	0	3	0	5
Carbonic anhydrase 6	0	2	0	4
Carbonic anhydrase 5A, mitochondrial	0	3	0	5
UDP-glucuronosyltransferase 2B10	0	2	0	2
Carbonic anhydrase 7	0	2	0	4
Quinone oxidoreductase	0	0	0	1
Beta-secretase 1	0	1	0	1
Sorbitol dehydrogenase	0	1	0	1
Induced myeloid leukemia cell differentiation protein Mcl-1	0	2	0	2
Carbonic anhydrase 9	0	3	0	7
Zn finger protein	0	1	0	1
Dihydroorotate dehydrogenase	0	1	0	1
Carbonic anhydrase 13	0	1	0	2
Carbonic anhydrase 15	0	2	0	4
Carbonic anhydrase 13	0	2	0	3
Carbonic anhydrase 14	0	2	0	4
Carbonic anhydrase 5B, mitochondrial	0	2	0	4
LMP1 [Human herpesvirus 4]	0	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 2	9	0	0	9
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Thymidine kinase 2, mitochondrial	0	1	0	1
Thymidine kinase, cytosolic	0	1	0	1
Thymidine kinase	0	1	0	1
Thymidylate synthase	0	1	0	2
Thymidine kinase	0	1	0	1
Deoxycytidine kinase	0	0	0	1
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	1	0	2
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	2	0	2
Thymidine kinase	0	1	0	1
Deoxynucleoside kinase	0	1	0	1
hypoxia-inducible factor 1 alpha subunit	9	0	0	9
NAD	0	1	0	1
Cholinesterase	0	1	0	1
Urease	0	1	0	1
NAD	0	1	0	2
Mitogen-activated protein kinase 1	0	1	0	1
ATP phosphoribosyltransferase	0	1	0	1
Proprotein convertase subtilisin/kexin type 7	0	2	0	2
G-protein coupled receptor 35	0	2	2	4
Eyes absent homolog 2	0	1	0	1
Amyloid-beta precursor protein	0	1	0	1
Angiotensin-converting enzyme	0	2	0	2
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Type-2 angiotensin II receptor	0	1	0	1
Succinyl-diaminopimelate desuccinylase	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Angiotensin-converting enzyme	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	2	0	0	2
ubiquitin-conjugating enzyme E2 N	0	1	0	1
protein AF-9 isoform a	0	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
Estrogen receptor	0	4	0	4
Beta-3 adrenergic receptor	0	2	0	2
C-8 sterol isomerase	0	1	0	1
Alpha-synuclein	2	1	0	3
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	3	0	3
Gamma-aminobutyric acid receptor subunit delta	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	3	1	4
Gamma-aminobutyric acid receptor subunit beta-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	3	1	4
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	3	1	4
Gamma-aminobutyric acid receptor subunit alpha-5	0	3	1	4
Gamma-aminobutyric acid receptor subunit alpha-3	0	3	1	4
Gamma-aminobutyric acid receptor subunit alpha-2	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-2	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	3	0	3
Gamma-aminobutyric acid receptor subunit epsilon	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-6	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-3	0	3	0	3
Gamma-aminobutyric acid receptor subunit theta	0	3	0	3
Chain A, Dihydrofolate reductase	0	0	1	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
Thymidylate synthase	0	2	0	2
Dihydrofolate reductase	0	0	1	1
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Multidrug resistance associated protein	0	0	0	1
Chain A, Glutamine Binding Protein	0	0	1	1
Neutral amino acid transporter A	0	2	0	2
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	2	0	2
Carbonic anhydrase-like protein, putative	0	0	0	3
Amino acid transporter	0	2	0	2
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Plasma kallikrein	0	0	0	2
Histidine-binding periplasmic protein	0	0	1	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Large neutral amino acids transporter small subunit 1	0	5	0	5
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	2	0	2
Stromelysin-1	0	0	2	2
Urease subunit alpha	0	2	0	2
Ribonucleoside-diphosphate reductase large subunit	0	1	0	1
Urease subunit beta	0	2	0	2
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Phospholipase A-2-activating protein	0	1	0	1
CAAX prenyl protease 2 isoform 2	0	0	0	1
Tubulin beta-4A chain	0	1	0	1
Tubulin beta chain	0	1	0	1
Tubulin alpha-3C chain	0	1	0	1
Tubulin alpha-1B chain	0	1	0	1
Tubulin alpha-4A chain	0	1	0	1
Tubulin beta-4B chain	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
DNA primase	0	1	0	1
Tubulin beta-3 chain	0	1	0	1
Tubulin beta-2A chain	0	1	0	1
Tubulin beta-8 chain	0	1	0	1
Tubulin alpha-3E chain	0	1	0	1
Tubulin alpha-1A chain	0	1	0	1
Tubulin alpha-1C chain	0	1	0	1
Tubulin beta-6 chain	0	1	0	1
Tubulin beta-2B chain	0	1	0	1
Tubulin beta-1 chain	0	1	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
transcriptional regulator ERG isoform 3	5	0	0	5
Progesterone receptor	0	2	1	4
Potassium channel subfamily K member 3	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Alpha-mannosidase 2C1	0	1	0	1
Fucose-binding lectin PA-IIL	0	1	0	1
CD209 antigen	0	1	0	1
UDP-glucose 6-dehydrogenase	0	1	0	1
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	2
UDP-glucose 6-dehydrogenase	0	1	0	1
Purine nucleoside phosphorylase	0	0	1	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase IMP-1	0	0	0	1
Beta-lactamase	0	0	0	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	3	0	3
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	2	0	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Glucocorticoid receptor	0	6	2	13
Glycine receptor subunit alpha-1	0	6	0	6
Androgen receptor	0	3	0	3
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
5-hydroxytryptamine receptor 3E	0	0	1	1
5-hydroxytryptamine receptor 3B	0	0	1	1
5-hydroxytryptamine receptor 3A	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 1F	0	1	0	1
5-hydroxytryptamine receptor 3A	0	2	0	2
5-hydroxytryptamine receptor 3A	0	0	1	1
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Lactoperoxidase	0	1	0	1
5-hydroxytryptamine receptor 4	0	1	0	2
5-hydroxytryptamine receptor 3D	0	0	1	1
5-hydroxytryptamine receptor 3C	0	0	1	1
5-hydroxytryptamine receptor 3B	0	1	0	1
5-hydroxytryptamine receptor 3B	0	2	0	2
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	3	0	3
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Equilibrative nucleoside transporter 1	0	1	0	1
B2 bradykinin receptor	0	1	0	1
Chymotrypsinogen A	0	1	0	1
Beta-lactamase	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Quinolone resistance protein NorA	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
ClpP	1	0	0	1
Mcl-1	0	1	0	1
pyruvate kinase PKM isoform a	1	0	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-2	0	1	0	1
Bifunctional cytochrome P450/NADPH--P450 reductase	0	0	1	1
Potassium-transporting ATPase subunit beta	0	1	0	1
Potassium-transporting ATPase alpha chain 1	0	1	0	1
Potassium-transporting ATPase alpha chain 1	0	1	0	1
Bombesin receptor subtype-3	0	0	1	1
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Potassium-transporting ATPase subunit beta	0	1	0	1
Potassium-transporting ATPase alpha chain 2	0	0	0	1
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit gamma	0	1	0	1
WD repeat-containing protein 5	0	1	0	1
Glutathione S-transferase omega-1	0	1	0	1
Histone-lysine N-methyltransferase 2A	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Cytosolic endo-beta-N-acetylglucosaminidase	0	1	0	1
Muscarinic acetylcholine receptor	0	1	0	1
Adenosine deaminase	0	1	0	1
Gamma-aminobutyric acid	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
luciferase	0	0	0	1
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
dopamine D1 receptor	1	0	0	1
Chain A, Activated Factor Xa Heavy Chain	0	1	0	1
Coagulation factor XII	0	1	0	1
Suppressor of tumorigenicity 14 protein	0	1	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Polyphenol oxidase 2	0	1	0	3
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Acetylcholinesterase	0	1	0	1
Pyruvate kinase PKM	0	0	1	1
Cholinesterase	0	1	0	1
Cereblon isoform 4	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Protein cereblon	0	2	1	4
PAX8	0	0	0	1
Apoptosis regulator Bcl-2	0	1	0	1
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	0	0	1	1
Mitogen-activated protein kinase 3	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Bcl-2-like protein 1	0	1	0	1
P2Y purinoceptor 13	0	1	0	1
P2Y purinoceptor 12	0	2	0	2
Urokinase-type plasminogen activator	0	1	0	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
SLC16A10 protein	0	0	0	1
Tubulin--tyrosine ligase	0	1	0	1
Monocarboxylate transporter 10	0	0	0	1
Taste receptor type 2 member 14	0	0	0	1
Olfactory receptor 51E2	0	0	1	1
Chain A, Arginase 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Protease	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(11)

Research Excerpts

Overview

Context

Treatment

Research

Studies (185)

Protein Targets (1,050)

Deficiency, Factor 5

Synonyms(11)

Research Excerpts

Overview

Context

Treatment

Research

Studies (185)

Drugs Studied (115)

Protein Targets (1,050)