An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the action of UDP-3-O-acyl-N-acetylglucosamine deacetylase (EC 3.5.1.108).
ChEBI ID: 134109
| Member | Definition | Class |
|---|---|---|
| chir 090 | An L-threonine derivative obtained by formal condensation of the carboxy group of 4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)benzoic acid with the amino group of N-hydroxy-L-threoninamide. | CHIR-090 |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (8.57) | 29.6817 |
| 2010's | 24 (68.57) | 24.3611 |
| 2020's | 8 (22.86) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 3 (8.57%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 32 (91.43%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 26.8370 | 1 | 1 |
| G | Vesicular stomatitis virus | Potency | 26.8370 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 26.8370 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 26.8370 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 26.8370 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| UDP-3-O-acyl-N-acetylglucosamine deacetylase | Escherichia coli K-12 | IC50 | 0.0305 | 4 | 4 |
| UDP-3-O-acyl-N-acetylglucosamine deacetylase | Pseudomonas aeruginosa PAO1 | IC50 | 0.0788 | 4 | 4 |
| UDP-3-O-acyl-N-acetylglucosamine deacetylase | Escherichia coli K-12 | Ki | 0.0037 | 7 | 7 |
| UDP-3-O-acyl-N-acetylglucosamine deacetylase | Rhizobium leguminosarum bv. trifolii WSM1325 | Ki | 0.0032 | 2 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| UDP-3-O-acyl-N-acetylglucosamine deacetylase | Pseudomonas aeruginosa PAO1 | Kd | 0.0005 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| UDP-3-O-acyl-N-acetylglucosamine deacetylase | Escherichia coli K-12 | Km | 7.5000 | 2 | 2 |
| UDP-3-O-acyl-N-acetylglucosamine deacetylase | Rhizobium leguminosarum bv. trifolii WSM1325 | Km | 6.9500 | 2 | 2 |