Compounds > bal 30072
Page last updated: 2024-11-13

bal 30072

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

BAL 30072: a siderophore with antibacterial activity; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID52942440
CHEMBL ID1256967
SCHEMBL ID13318507
MeSH IDM0549796

Synonyms (12)

Synonym
(s)-3-(2-(2-aminothiazol-4-yl)-2-((1,5-dihydroxy-4-oxo-1,4-dihydropyridin-2-yl)methoxyimino)acetamido)-2,2-dimethyl-4-oxoazetidin-1-yl hydrogen sulfate
bdbm50327179
CHEMBL1256967 ,
bal30072
unii-ly97zjm4qx
ly97zjm4qx ,
bal 30072
4-thiazoleacetamide, 2-amino-alpha-(((1,4-dihydro-1,5-dihydroxy-4-oxo-2-pyridinyl)methoxy)imino)-n-((3s)-2,2-dimethyl-4-oxo-1-(sulfooxy)-3-azetidinyl)-, (alphaz)-
941285-15-0
4-thiazoleacetamide, 2-amino-.alpha.-(((1,4-dihydro-1,5-dihydroxy-4-oxo-2-pyridinyl)methoxy)imino)-n-((3s)-2,2-dimethyl-4-oxo-1-(sulfooxy)-3-azetidinyl)-, (.alpha.z)-
SCHEMBL13318507
AKOS040741286

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" In conclusion, BAL30072 is toxic for liver mitochondria and inhibits glycolysis at clinically relevant concentrations."( Mechanisms of hepatotoxicity associated with the monocyclic β-lactam antibiotic BAL30072.
Church, RJ; Engelhardt, M; Howell, BA; Krähenbühl, S; Maurer, M; Messner, S; Paech, F; Schmitt-Hoffmann, AH; Spickermann, J; Wind, M; Witschi, AT; Woodhead, J, 2017)		0.46

Compound-Compound Interactions

ExcerptReferenceRelevance
"We investigated the activity of BAL30072, a dihydroxypyridone monosulfactam, against carbapenem-resistant Enterobacteriaceae and non-fermenters (i) alone, (ii) combined with BAL29880 (to inhibit AmpC) and/or clavulanate [to inhibit extended-spectrum β-lactamases (ESBLs)] and (iii) combined 1:1 with meropenem."( Activity of BAL30072 alone or combined with β-lactamase inhibitors or with meropenem against carbapenem-resistant Enterobacteriaceae and non-fermenters.
Adkin, R; Hope, R; Livermore, DM; Mushtaq, S; Woodford, N, 2013)		0.39
" In this study, the in vitro activity of the novel monosulfactam BAL30072 was investigated both alone and in combination with meropenem against a diverse collection of commonly encountered Gram-negative pathogens."( In vitro activity of the novel monosulfactam BAL30072 alone and in combination with meropenem versus a diverse collection of important Gram-negative pathogens.
Hornsey, M; Phee, L; Stubbings, W; Wareham, DW, 2013)		0.39

Dosage Studied

ExcerptRelevanceReference
"This annex study to a phase 1 study aimed to correlate urinary concentrations and bactericidal titers (UBTs) of BAL30072, a novel siderophore monosulfactam, in healthy subjects in order to evaluate which dosage of BAL30072 should be investigated in a clinical study on complicated urinary tract infection (UTI)."( Urinary Concentrations and Antibacterial Activity of BAL30072, a Novel Siderophore Monosulfactam, against Uropathogens after Intravenous Administration in Healthy Subjects.
Blenk, H; Naber, KG; Straubinger, M; Wagenlehner, FM, 2016)		0.43
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (2)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Beta-lactamaseCitrobacter freundiiIC50 (µMol)2.70000.93001.81502.7000AID518502
AmpC Escherichia coliIC50 (µMol)0.50000.06000.28000.5000AID518501
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Other Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (222)

Assay IDTitleYearJournalArticle
AID518246Antimicrobial activity against Pseudomonas aeruginosa BA assessed as appearance of colony at 4 times MIC concentration2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID1373282Antimicrobial activity against Escherichia coli expressing beta-lactamase CTXM-15 by CLSI broth microdilution method2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.
AID517963Antimicrobial activity against Pseudomonas aeruginosa by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID1139546Antibacterial activity against Escherichia coli DH5alpha expressing beta-lactamase OXA-58 by CLSI broth microdilution method2014Journal of medicinal chemistry, May-08, Volume: 57, Issue:9
Siderophore receptor-mediated uptake of lactivicin analogues in gram-negative bacteria.
AID1443399Antibacterial activity against extended spectrum beta-lactamase IMP-4 producing multidrug resistant Pseudomonas aeruginosa clinical isolates after 18 hrs by broth microdilution method2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
Discovery of Novel Pyridone-Conjugated Monosulfactams as Potent and Broad-Spectrum Antibiotics for Multidrug-Resistant Gram-Negative Infections.
AID1373303Antimicrobial activity against Escherichia coli expressing beta-lactamase TEM-121 by CLSI broth microdilution method2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.
AID1443402Drug degradation in human plasma at 10 uM after 4 hrs by LC-MS/MS analysis2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
Discovery of Novel Pyridone-Conjugated Monosulfactams as Potent and Broad-Spectrum Antibiotics for Multidrug-Resistant Gram-Negative Infections.
AID1373295Antimicrobial activity against Escherichia coli expressing beta-lactamase VEB-1 by CLSI broth microdilution method2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.
AID517948Antimicrobial activity against Citrobacter freundii by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518505Inhibition of Escherichia coli Penicillin-binding protein 1A2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID517947Antimicrobial activity against Enterobacter aerogenes by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID517961Antimicrobial activity against Stenotrophomonas maltophilia by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID1373308Antimicrobial activity against Escherichia coli expressing beta-lactamase SPM-1 by CLSI broth microdilution method2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.
AID517949Antimicrobial activity against Providencia stuartii by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID1139536Antibacterial activity against Escherichia coli DH5alpha by CLSI broth microdilution method2014Journal of medicinal chemistry, May-08, Volume: 57, Issue:9
Siderophore receptor-mediated uptake of lactivicin analogues in gram-negative bacteria.
AID1443397In vivo antibacterial activity against multidrug resistant Klebsiella pneumoniae isolate 212232 infected in Kunming mouse systemic infection model assessed as increase in mouse survival administered subcutaneously 0.5 to 4 hrs post infection measured afte2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
Discovery of Novel Pyridone-Conjugated Monosulfactams as Potent and Broad-Spectrum Antibiotics for Multidrug-Resistant Gram-Negative Infections.
AID518484Ratio of Kcat to Km for beta-lactamase KPC-22010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID1139542Antibacterial activity against Escherichia coli DH5alpha expressing beta-lactamase CTX-M-15 by CLSI broth microdilution method2014Journal of medicinal chemistry, May-08, Volume: 57, Issue:9
Siderophore receptor-mediated uptake of lactivicin analogues in gram-negative bacteria.
AID518245Antimicrobial activity against Klebsiella pneumoniae 1338665 assessed as appearance of colony at 4 times MIC concentration2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID1373306Antimicrobial activity against Escherichia coli expressing beta-lactamase NDM-1 by CLSI broth microdilution method2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.
AID1373291Antimicrobial activity against Escherichia coli expressing beta-lactamase PER-2 by CLSI broth microdilution method2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.
AID518237Antimicrobial activity against Pseudomonas aeruginosa 527 assessed as highest concentration at which colonies reappeared2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518460Antimicrobial activity against Acinetobacter junii 15218 assessed as number of passages required for MIC to rise above 4 times original MIC2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518477Binding affinity to Pseudomonas aeruginosa 143724R beta-lactamase class C2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518476Binding affinity to Pseudomonas aeruginosa 18S/H beta-lactamase class C2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518481Binding affinity to Escherichia coli Penicillin-binding protein 32010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID1139543Antibacterial activity against Escherichia coli DH5alpha expressing beta-lactamase VIM-2 by CLSI broth microdilution method2014Journal of medicinal chemistry, May-08, Volume: 57, Issue:9
Siderophore receptor-mediated uptake of lactivicin analogues in gram-negative bacteria.
AID518234Antimicrobial activity against Escherichia coli W3110 assessed as highest concentration at which colonies reappeared2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID678451Antibacterial activity against Klebsiella pneumoniae2012Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18
Novel monobactams utilizing a siderophore uptake mechanism for the treatment of gram-negative infections.
AID518497Inhibition of beta-lactamase SHV-42010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID1373294Antimicrobial activity against Escherichia coli expressing beta-lactamase SME-1 by CLSI broth microdilution method2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.
AID1373286Antimicrobial activity against Escherichia coli expressing beta-lactamase KPC-3 by CLSI broth microdilution method2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.
AID1373313Antimicrobial activity against Escherichia coli expressing beta-lactamase MIR-1 by CLSI broth microdilution method2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.
AID1373315Antimicrobial activity against Escherichia coli expressing beta-lactamase Oxa-10 by CLSI broth microdilution method2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.
AID518215Antimicrobial activity against Stenotrophomonas maltophilia 1AC736 assessed as log reduction in colony count within 6 hrs selected after 1 to 16 times MIC compound exposure2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID1443406Volume of distribution in steady state in Sprague-Dawley rat at 1 mg/kg, iv measured up to 180 mins by LC-MS/MS analysis2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
Discovery of Novel Pyridone-Conjugated Monosulfactams as Potent and Broad-Spectrum Antibiotics for Multidrug-Resistant Gram-Negative Infections.
AID517952Antimicrobial activity against Enterobacter cloacae by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID517957Antimicrobial activity against Proteus mirabilis by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518192Antimicrobial activity against mexAB-oprM protein and mexCD-oprJ deficient Pseudomonas aeruginosa PAO238 by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518226Antimicrobial activity against Pseudomonas aeruginosa BA by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID517955Antimicrobial activity against Klebsiella pneumoniae by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518478Binding affinity to Escherichia coli Penicillin-binding protein 1A2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID1373283Antimicrobial activity against Escherichia coli expressing beta-lactamase GES-1 by CLSI broth microdilution method2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.
AID517958Antimicrobial activity against Serratia marcescens by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID678452Antibacterial activity against Escherichia coli2012Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18
Novel monobactams utilizing a siderophore uptake mechanism for the treatment of gram-negative infections.
AID1373319Antimicrobial activity against Escherichia coli expressing beta-lactamase Oxa-48 by CLSI broth microdilution method2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.
AID1139547Antibacterial activity against Escherichia coli DH5alpha expressing beta-lactamase KPC-3 by CLSI broth microdilution method2014Journal of medicinal chemistry, May-08, Volume: 57, Issue:9
Siderophore receptor-mediated uptake of lactivicin analogues in gram-negative bacteria.
AID518507Inhibition of Escherichia coli Penicillin-binding protein 22010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518490Ratio of Kcat to Km for Pseudomonas aeruginosa 143724R beta-lactamase class C2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID1443410Antibacterial activity against extended spectrum beta-lactamases producing Escherichia coli clinical isolates after 18 hrs by broth microdilution method2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
Discovery of Novel Pyridone-Conjugated Monosulfactams as Potent and Broad-Spectrum Antibiotics for Multidrug-Resistant Gram-Negative Infections.
AID518243Antimicrobial activity against Enterobacter cloacae S9369 assessed as appearance of colony at 4 times MIC concentration2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID517950Antimicrobial activity against Proteus vulgaris by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518500Inhibition of beta-lactamase VIM-12010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID1373290Antimicrobial activity against Escherichia coli expressing beta-lactamase PER-1 by CLSI broth microdilution method2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.
AID1139544Antibacterial activity against Escherichia coli DH5alpha expressing beta-lactamase NDM-1 by CLSI broth microdilution method2014Journal of medicinal chemistry, May-08, Volume: 57, Issue:9
Siderophore receptor-mediated uptake of lactivicin analogues in gram-negative bacteria.
AID1443409In vivo antibacterial activity against Escherichia coli isolate 210737 infected in Kunming mouse systemic infection model assessed as increase in mouse survival administered subcutaneously 0.5 to 4 hrs post infection measured after 48 hrs by Bliss method2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
Discovery of Novel Pyridone-Conjugated Monosulfactams as Potent and Broad-Spectrum Antibiotics for Multidrug-Resistant Gram-Negative Infections.
AID518241Antimicrobial activity against Acinetobacter junii 15218 assessed as appearance of colony at 4 times MIC concentration2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518470Binding affinity to beta-lactamase SHV-42010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID517959Antimicrobial activity against Acinetobacter sp. by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID1443396Antibacterial activity against Klebsiella pneumoniae isolate 212232 after 18 hrs by broth microdilution method2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
Discovery of Novel Pyridone-Conjugated Monosulfactams as Potent and Broad-Spectrum Antibiotics for Multidrug-Resistant Gram-Negative Infections.
AID518459Antimicrobial activity against Acinetobacter baumannii HPA74510 assessed as number of passages required for MIC to rise above 4 times original MIC2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID1443403AUC (0 to t) in Sprague-Dawley rat at 1 mg/kg, iv measured up to 180 mins by LC-MS/MS analysis2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
Discovery of Novel Pyridone-Conjugated Monosulfactams as Potent and Broad-Spectrum Antibiotics for Multidrug-Resistant Gram-Negative Infections.
AID517954Antimicrobial activity against Klebsiella oxytoca by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518247Antimicrobial activity against Pseudomonas aeruginosa 527 assessed as appearance of colony at 4 times MIC concentration2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518210Antimicrobial activity against Enterobacter cloacae S9369 assessed as log reduction in colony count after 24 hrs2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID1373310Antimicrobial activity against Escherichia coli expressing beta-lactamase AmpC by CLSI broth microdilution method2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.
AID518236Antimicrobial activity against Pseudomonas aeruginosa BA assessed as highest concentration at which colonies reappeared2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518504Inhibition of Pseudomonas aeruginosa 143724R beta-lactamase class C2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518463Antimicrobial activity against Klebsiella pneumoniae 1338665 assessed as number of passages required for MIC to rise above 4 times original MIC2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID517967Antimicrobial activity against Klebsiella pneumoniae 1357E harboring beta-lactamase TEM-10 by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID517985Antimicrobial activity against Pseudomonas aeruginosa BA harboring beta-lactamase Class C by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518231Antimicrobial activity against Acinetobacter junii 15218 assessed as highest concentration at which colonies reappeared2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518501Inhibition of Escherichia coli ATCC 25922 AmpC2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID517956Antimicrobial activity against Proteus penneri by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID1373280Antimicrobial activity against wild type Escherichia coli by CLSI broth microdilution method2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.
AID518233Antimicrobial activity against Enterobacter cloacae S9369 assessed as highest concentration at which colonies reappeared2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID517960Antimicrobial activity against Burkholderia sp. by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518480Binding affinity to Escherichia coli Penicillin-binding protein 22010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518238Antimicrobial activity against Pseudomonas aeruginosa 621 assessed as highest concentration at which colonies reappeared2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID517972Antimicrobial activity against Pseudomonas aeruginosa 1937E harboring beta-lactamase PSE-4 and class C enzymes by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID1373317Antimicrobial activity against Escherichia coli expressing beta-lactamase Oxa-23 by CLSI broth microdilution method2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.
AID518188Antimicrobial activity against Acinetobacter baumannii HPA I-16 harboring beta-lactamase OXA-27 by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518202Microbicidal activity against Enterobacter cloacae S9369 selected after 8 times MIC compound exposure2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518483Ratio of Kcat to Km for beta-lactamase SHV-42010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518479Binding affinity to Escherichia coli Penicillin-binding protein 1B2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID1373304Antimicrobial activity against Escherichia coli expressing beta-lactamase GIM-1 by CLSI broth microdilution method2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.
AID1139537Antibacterial activity against Escherichia coli DH5alpha harboring pUCP26 empty vector by CLSI broth microdilution method2014Journal of medicinal chemistry, May-08, Volume: 57, Issue:9
Siderophore receptor-mediated uptake of lactivicin analogues in gram-negative bacteria.
AID517976Antimicrobial activity against Klebsiella pneumoniae YC harboring beta-lactamase KPC-2,TEM-1and SHV-2 by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID1373320Antimicrobial activity against Escherichia coli expressing beta-lactamase Oxa-51 by CLSI broth microdilution method2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.
AID518471Binding affinity to beta-lactamase KPC-22010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID517965Antimicrobial activity against Escherichia coli K802N harboring beta-lactamase TEM-3 by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518184Antimicrobial activity against Pseudomonas aeruginosa 18S/H harboring beta-lactamase Class C by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID1139540Antibacterial activity against Escherichia coli DH5alpha expressing beta-lactamase TEM-1 by CLSI broth microdilution method2014Journal of medicinal chemistry, May-08, Volume: 57, Issue:9
Siderophore receptor-mediated uptake of lactivicin analogues in gram-negative bacteria.
AID518461Antimicrobial activity against Enterobacter cloacae S4741B assessed as number of passages required for MIC to rise above 4 times original MIC2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518197Antimicrobial activity against fpvA deficient Pseudomonas aeruginosa (560546)9 M.P. by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518468Binding affinity to beta-lactamase TEM-32010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518248Antimicrobial activity against Pseudomonas aeruginosa 621 assessed as appearance of colony at 4 times MIC concentration2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518496Inhibition of beta-lactamase SHV-22010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518208Microbicidal activity against Stenotrophomonas maltophilia 1AC736 selected after MIC of compound exposure2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518187Antimicrobial activity against Acinetobacter baumannii HPA 4737 harboring beta-lactamase OXA-26 by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID517953Antimicrobial activity against Escherichia coli by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518475Binding affinity to Citrobacter freundii AmpC2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518240Antimicrobial activity against Acinetobacter baumannii HPA74510 assessed as appearance of colony at 4 times MIC concentration2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID517982Antimicrobial activity against Stenotrophomonas maltophilia B715 harboring beta-lactamase L1and L2 by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID1373307Antimicrobial activity against Escherichia coli expressing beta-lactamase NDM-5 by CLSI broth microdilution method2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.
AID517951Antimicrobial activity against Providencia rettgeri by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID1139539Antibacterial activity against Escherichia coli DH5alpha expressing beta-lactamase SHV-12 by CLSI broth microdilution method2014Journal of medicinal chemistry, May-08, Volume: 57, Issue:9
Siderophore receptor-mediated uptake of lactivicin analogues in gram-negative bacteria.
AID518495Inhibition of beta-lactamase TEM-32010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518200Antimicrobial activity against Pseudomonas aeruginosa BA(C1-106) selected after 25 ug/ml of compound exposure by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID517980Antimicrobial activity against Pseudomonas aeruginosa HPA996 harboring beta-lactamase VIM-2 by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518469Binding affinity to beta-lactamase SHV-22010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518191Antimicrobial activity against Pseudomonas aeruginosa PAO1 by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518207Microbicidal activity against Pseudomonas aeruginosa (560546)9 M.P. selected after 4 times MIC compound exposure2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518195Antimicrobial activity against mexAB-oprM, mexCD-oprJ, mexEF-oprN, mexJK, mexXY, opmH and pscC gene deficient Pseudomonas aeruginosa PAO750 by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID678449Antibacterial activity against beta-lactam- and quinolone-resistant Pseudomonas aeruginosa 1042-062012Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18
Novel monobactams utilizing a siderophore uptake mechanism for the treatment of gram-negative infections.
AID1373309Antimicrobial activity against Escherichia coli expressing beta-lactamase VIM-1 by CLSI broth microdilution method2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.
AID518206Microbicidal activity against Pseudomonas aeruginosa 527 selected after 4 times MIC compound exposure2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID517969Antimicrobial activity against Klebsiella pneumoniae 26768WU harboring beta-lactamase SHV-5 by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518239Antimicrobial activity against Pseudomonas aeruginosa 860 assessed as highest concentration at which colonies reappeared2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518498Inhibition of beta-lactamase KPC-22010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID1373312Antimicrobial activity against Escherichia coli expressing beta-lactamase CMY-2 by CLSI broth microdilution method2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.
AID1373298Antimicrobial activity against Escherichia coli expressing beta-lactamase TEM-1 by CLSI broth microdilution method2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.
AID517981Antimicrobial activity against Providencia rettgeri J96 harboring beta-lactamase IMP-1 by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518492Ratio of Kcat to Km for Escherichia coli Penicillin-binding protein 1B2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518190Antimicrobial activity against oprD protein deficient Pseudomonas aeruginosa C2 by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID1373301Antimicrobial activity against Escherichia coli expressing beta-lactamase TEM-24 by CLSI broth microdilution method2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.
AID518235Antimicrobial activity against Klebsiella pneumoniae 1338665 assessed as highest concentration at which colonies reappeared2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID1373311Antimicrobial activity against Escherichia coli expressing beta-lactamase DHA by CLSI broth microdilution method2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.
AID518242Antimicrobial activity against Enterobacter cloacae S4741B assessed as appearance of colony at 4 times MIC concentration2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID1373316Antimicrobial activity against Escherichia coli expressing beta-lactamase Oxa-18 by CLSI broth microdilution method2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.
AID1373305Antimicrobial activity against Escherichia coli expressing beta-lactamase IMP-1 by CLSI broth microdilution method2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.
AID518209Antimicrobial activity against Acinetobacter baumannii HPA74510 assessed as log reduction in colony count after 24 hrs2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518472Binding affinity to Beta-lactamase IMP12010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID1373288Antimicrobial activity against Escherichia coli expressing beta-lactamase KPC-8 by CLSI broth microdilution method2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.
AID518464Antimicrobial activity against Pseudomonas aeruginosa BA assessed as number of passages required for MIC to rise above 4 times original MIC2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518214Antimicrobial activity against Pseudomonas aeruginosa HPA10586 assessed as log reduction in colony count within 6 hrs selected after 1 to 16 times MIC compound exposure2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518244Antimicrobial activity against Escherichia coli W3110 assessed as appearance of colony at 4 times MIC concentration2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518465Antimicrobial activity against Pseudomonas aeruginosa 527 assessed as number of passages required for MIC to rise above 4 times original MIC2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID678448Antibacterial activity against penicillin-resistant, quinolone-sensitive Pseudomonas aeruginosa 1091-052012Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18
Novel monobactams utilizing a siderophore uptake mechanism for the treatment of gram-negative infections.
AID1373323Antimicrobial activity against Escherichia coli expressing beta-lactamase Oxa-181 by CLSI broth microdilution method2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.
AID517974Antimicrobial activity against Escherichia coli nmcA harboring beta-lactamase NMCA by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID1373284Antimicrobial activity against Escherichia coli expressing beta-lactamase IMI-1 by CLSI broth microdilution method2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.
AID1443400Fraction unbound in human plasma at 10 uM after 4 hrs by LC-MS/MS based rapid equilibrium dialysis method2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
Discovery of Novel Pyridone-Conjugated Monosulfactams as Potent and Broad-Spectrum Antibiotics for Multidrug-Resistant Gram-Negative Infections.
AID518205Microbicidal activity against Pseudomonas aeruginosa HPA10586 selected after 8 times MIC compound exposure2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID1139541Antibacterial activity against Escherichia coli DH5alpha expressing beta-lactamase TEM-24 by CLSI broth microdilution method2014Journal of medicinal chemistry, May-08, Volume: 57, Issue:9
Siderophore receptor-mediated uptake of lactivicin analogues in gram-negative bacteria.
AID517975Antimicrobial activity against Klebsiella pneumoniae CRE harboring beta-lactamase KPC-2 by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID517970Antimicrobial activity against Klebsiella oxytoca 1028E harboring beta-lactamase K1 by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518462Antimicrobial activity against Enterobacter cloacae S9369 assessed as number of passages required for MIC to rise above 4 times original MIC2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID1443405Antibacterial activity against Escherichia coli isolate 210737 after 18 hrs by broth microdilution method2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
Discovery of Novel Pyridone-Conjugated Monosulfactams as Potent and Broad-Spectrum Antibiotics for Multidrug-Resistant Gram-Negative Infections.
AID518474Binding affinity to Escherichia coli ATCC 25922 AmpC2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID1443407Antibacterial activity against extended spectrum beta-lactamase KPC-2 producing multidrug resistant Klebsiella pneumoniae clinical isolates after 18 hrs by broth microdilution method2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
Discovery of Novel Pyridone-Conjugated Monosulfactams as Potent and Broad-Spectrum Antibiotics for Multidrug-Resistant Gram-Negative Infections.
AID518502Inhibition of Citrobacter freundii AmpC2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518193Antimicrobial activity against mexAB-oprM protein and mexCD-oprJ deficient Pseudomonas aeruginosa PAO253 overexpressing MexEF-OprN gene by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518503Inhibition of Pseudomonas aeruginosa 18S/H beta-lactamase class C2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518196Antimicrobial activity against fpvA, fpvB, fptA and pirA gene deficient Pseudomonas aeruginosa 860 by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518232Antimicrobial activity against Enterobacter cloacae S4741B assessed as highest concentration at which colonies reappeared2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID1443404Elimination half life in Sprague-Dawley rat at 1 mg/kg, iv by LC-MS/MS analysis2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
Discovery of Novel Pyridone-Conjugated Monosulfactams as Potent and Broad-Spectrum Antibiotics for Multidrug-Resistant Gram-Negative Infections.
AID517973Antimicrobial activity against Serratia marcescens S6 harboring beta-lactamase SME-1.AmpC by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518186Antimicrobial activity against Acinetobacter baumannii HPA 327009 harboring beta-lactamase OXA-25 by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518493Ratio of Kcat to Km for Escherichia coli Penicillin-binding protein 22010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518488Ratio of Kcat to Km for Citrobacter freundii AmpC2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID1373293Antimicrobial activity against Escherichia coli expressing beta-lactamase SHV-12 by CLSI broth microdilution method2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.
AID517983Antimicrobial activity against Enterobacter cloacae 908R harboring beta-lactamase AmpC by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518213Antimicrobial activity against Enterobacter cloacae S9369 assessed as log reduction in colony count within 6 hrs selected after 4 to 8 times MIC compound exposure2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID1373322Antimicrobial activity against Escherichia coli expressing beta-lactamase Oxa-160 by CLSI broth microdilution method2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.
AID517979Antimicrobial activity against Pseudomonas aeruginosa HPA10586 harboring beta-lactamase VIM-1 by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID678450Antibacterial activity against Pseudomonas aeruginosa2012Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18
Novel monobactams utilizing a siderophore uptake mechanism for the treatment of gram-negative infections.
AID517977Antimicrobial activity against Acinetobacter baumannii HPA74510 harboring beta-lactamase IMP-4 by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID1373281Antimicrobial activity against Escherichia coli expressing beta-lactamase CTXM-3 by CLSI broth microdilution method2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.
AID1373287Antimicrobial activity against Escherichia coli expressing beta-lactamase KPC-4 by CLSI broth microdilution method2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.
AID518494Ratio of Kcat to Km for Escherichia coli Penicillin-binding protein 32010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID1373302Antimicrobial activity against Escherichia coli expressing beta-lactamase TEM-47 by CLSI broth microdilution method2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.
AID518249Antimicrobial activity against Pseudomonas aeruginosa 860 assessed as appearance of colony at 4 times MIC concentration2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID678453Antibacterial activity against Acinetobacter baumannii2012Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18
Novel monobactams utilizing a siderophore uptake mechanism for the treatment of gram-negative infections.
AID1373299Antimicrobial activity against Escherichia coli expressing beta-lactamase TEM-10 by CLSI broth microdilution method2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.
AID1373321Antimicrobial activity against Escherichia coli expressing beta-lactamase Oxa-146 by CLSI broth microdilution method2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.
AID1373314Antimicrobial activity against Escherichia coli expressing beta-lactamase P99 by CLSI broth microdilution method2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.
AID518487Ratio of Kcat to Km for Escherichia coli ATCC 25922 AmpC2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518506Inhibition of Escherichia coli Penicillin-binding protein 1B2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID1373289Antimicrobial activity against Escherichia coli expressing beta-lactamase NMC-A by CLSI broth microdilution method2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.
AID1373285Antimicrobial activity against Escherichia coli expressing beta-lactamase KPC-2 by CLSI broth microdilution method2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.
AID518198Antimicrobial activity against pfeA deficient Pseudomonas aeruginosa 134 by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518203Microbicidal activity against Enterobacter cloacae S4741B selected after 4 times MIC compound exposure2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518485Ratio of Kcat to Km for Beta-lactamase IMP12010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518201Microbicidal activity against Acinetobacter baumannii HPA74510 selected after 4 times MIC compound exposure2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518194Antimicrobial activity against mexAB-oprM protein and mexZ deficient Pseudomonas aeruginosa PAO267 by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518508Inhibition of Escherichia coli Penicillin-binding protein 32010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518189Antimicrobial activity against Pseudomonas aeruginosa B4 by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518218Antimicrobial activity against Escherichia coli W3110 assessed as appearance of short filaments at 4 ug/mL after 3 hrs by phase-contrast microscopy2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID1443401Clearance in Sprague-Dawley rat at 1 mg/kg, iv measured up to 180 mins by LC-MS/MS analysis2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
Discovery of Novel Pyridone-Conjugated Monosulfactams as Potent and Broad-Spectrum Antibiotics for Multidrug-Resistant Gram-Negative Infections.
AID518482Ratio of Kcat to Km for beta-lactamase TEM-32010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518230Antimicrobial activity against Acinetobacter baumannii HPA74510 assessed as highest concentration at which colonies reappeared2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID1373324Antimicrobial activity against Escherichia coli expressing beta-lactamase Oxa-225 by CLSI broth microdilution method2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.
AID518466Antimicrobial activity against Pseudomonas aeruginosa 621 assessed as number of passages required for MIC to rise above 4 times original MIC2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID1373297Antimicrobial activity against Escherichia coli expressing beta-lactamase VEB-7 by CLSI broth microdilution method2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.
AID517968Antimicrobial activity against Escherichia coli A harboring beta-lactamase CTX-M 15 by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID1373300Antimicrobial activity against Escherichia coli expressing beta-lactamase TEM-16 by CLSI broth microdilution method2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.
AID517978Antimicrobial activity against Pseudomonas aeruginosa HPA101-1477 harboring beta-lactamase IMP-1 by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518486Ratio of Kcat to Km for beta-lactamase VIM-12010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518211Antimicrobial activity against Enterobacter cloacae S4741B assessed as log reduction in colony count after 24 hrs2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID517971Antimicrobial activity against Pseudomonas aeruginosa 1973E harboring beta-lactamase PSE-1 and class C enzymes by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID1373292Antimicrobial activity against Escherichia coli expressing beta-lactamase PER-4 by CLSI broth microdilution method2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.
AID1139545Antibacterial activity against Escherichia coli DH5alpha expressing beta-lactamase OXA-24/40 by CLSI broth microdilution method2014Journal of medicinal chemistry, May-08, Volume: 57, Issue:9
Siderophore receptor-mediated uptake of lactivicin analogues in gram-negative bacteria.
AID517964Antimicrobial activity against Escherichia coli HB101 harboring beta-lactamase TEM-5 by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518491Ratio of Kcat to Km for Escherichia coli Penicillin-binding protein 1A2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID1443408Antibacterial activity against extended spectrum beta-lactamase OXA-23 producing multidrug resistant Acinetobacter baumannii clinical isolates after 18 hrs by broth microdilution method2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
Discovery of Novel Pyridone-Conjugated Monosulfactams as Potent and Broad-Spectrum Antibiotics for Multidrug-Resistant Gram-Negative Infections.
AID518467Antimicrobial activity against Stenotrophomonas maltophilia 1AC736 assessed as number of passages required for MIC to rise above 4 times original MIC2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518489Ratio of Kcat to Km for Pseudomonas aeruginosa 18S/H beta-lactamase class C2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518473Binding affinity to beta-lactamase VIM-12010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID1443398In vivo antibacterial activity against multidrug resistant Klebsiella pneumoniae isolate 212232 infected in Kunming mouse systemic infection model assessed as increase in mouse survival at 100 mg/kg, sc administered 0.5 to 4 hrs post infection measured af2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
Discovery of Novel Pyridone-Conjugated Monosulfactams as Potent and Broad-Spectrum Antibiotics for Multidrug-Resistant Gram-Negative Infections.
AID1373296Antimicrobial activity against Escherichia coli expressing beta-lactamase VEB-4 by CLSI broth microdilution method2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.
AID518185Antimicrobial activity against Serratia marcescens 1T9 harboring beta-lactamase Class C by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518216Antimicrobial activity against Escherichia coli W3110 assessed as appearance of spheroplast at 4 ug/mL after 3 hrs by phase-contrast microscopy2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518199Antimicrobial activity against Pseudomonas aeruginosa BA(C2-107) selected after 25 ug/ml of compound exposure by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518212Antimicrobial activity against Pseudomonas aeruginosa 1024 assessed as log reduction in colony count within 6 hrs selected after 4 to 8 times MIC compound exposure2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID1139538Antibacterial activity against Escherichia coli DH5alpha expressing beta-lactamase SHV-5 by CLSI broth microdilution method2014Journal of medicinal chemistry, May-08, Volume: 57, Issue:9
Siderophore receptor-mediated uptake of lactivicin analogues in gram-negative bacteria.
AID1373318Antimicrobial activity against Escherichia coli expressing beta-lactamase Oxa-40 by CLSI broth microdilution method2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.
AID517966Antimicrobial activity against Escherichia coli CF102 harboring beta-lactamase TEM-3 by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518499Inhibition of Beta-lactamase IMP12010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID518204Microbicidal activity against Pseudomonas aeruginosa BA selected after 8 times MIC compound exposure2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID517962Antimicrobial activity against Enterobacteriaceae by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
AID517984Antimicrobial activity against Escherichia coli Libyien harboring beta-lactamase CMY-2 by broth dilution method2010Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (20)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's20 (100.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials2 (10.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other18 (90.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
aztreonam
Aztreonam: A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. It is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges, bladder, and kidneys. It may cause a superinfection with gram-positive organisms.. aztreonam : A synthetic monocyclic beta-lactam antibiotic (monobactam), used primarily to treat infections caused by Gram-negative bacteria. It inhibits mucopeptide synthesis in the bacterial cell wall, thereby blocking peptidoglycan crosslinking.		2.5120
ciprofloxacin
Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.. ciprofloxacin : A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.		2.0510aminoquinoline;
cyclopropanes;
fluoroquinolone antibiotic;
N-arylpiperazine;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone;
zwitterion		antibacterial drug;
antiinfective agent;
antimicrobial agent;
DNA synthesis inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
environmental contaminant;
topoisomerase IV inhibitor;
xenobiotic
ampicillin
Ampicillin: Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.. ampicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group.		2.110beta-lactam antibiotic;
penicillin allergen;
penicillin		antibacterial drug
thiazoles
[no description available]		6.241721,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
piperacillin
Piperacillin: Semisynthetic, broad-spectrum, AMPICILLIN derived ureidopenicillin antibiotic proposed for PSEUDOMONAS infections. It is also used in combination with other antibiotics.. piperacillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-[(4-ethyl-2,3-dioxopiperazin-1-yl)carboxamido]-2-phenylacetamido group.		2.1710penicillin allergen;
penicillin		antibacterial drug
cephalosporin c
cephalosporin C: RN given refers to parent cpd; structure in Merck, 9th ed, #1937. cephalosporin C : A cephalosporin antibiotic carrying a 3-acetoxymethyl substituent and a 6-oxo-N(6)-L-lysino group at position 7.		2.1710cephalosporinfungal metabolite
doripenem
Doripenem: A carbapenem derivative antibacterial agent that is more stable to renal dehydropeptidase I than IMIPENEM, but does not need to be given with an enzyme inhibitor such as CILASTATIN. It is used in the treatment of infections such as HOSPITAL-ACQUIRED PNEUMONIA, and complicated intra-abdominal or urinary-tract infections, including PYELONEPHRITIS.		2.5220carbapenems
imipenem, anhydrous
Imipenem: Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor.. imipenem : A broad-spectrum, intravenous beta-lactam antibiotic of the carbapenem subgroup.		2.7830beta-lactam antibiotic allergen;
carbapenems;
zwitterion		antibacterial drug
carbapenems
[no description available]		2.0810
beta-lactams
2-azetidinone: structure in first source. azetidin-2-one : An unsubstituted beta-lactam compound.. beta-lactam : A lactam in which the amide bond is contained within a four-membered ring, which includes the amide nitrogen and the carbonyl carbon.		2.520beta-lactam antibiotic allergen;
beta-lactam
meropenem
Meropenem: A thienamycin derivative antibacterial agent that is more stable to renal dehydropeptidase I than IMIPENEM, but does not need to be given with an enzyme inhibitor such as CILASTATIN. It is used in the treatment of bacterial infections, including infections in immunocompromised patients.. meropenem : A carbapenemcarboxylic acid in which the azetidine and pyrroline rings carry 1-hydroxymethyl and in which the azetidine and pyrroline rings carry 1-hydroxymethyl and 5-(dimethylcarbamoyl)pyrrolidin-3-ylthio substituents respectively.		3.790alpha,beta-unsaturated monocarboxylic acid;
carbapenemcarboxylic acid;
organic sulfide;
pyrrolidinecarboxamide		antibacterial agent;
antibacterial drug;
drug allergen
pyochelin
pyochelin: phenolic iron-binding cpd from Pseudomonas aeruginosa; promotes the growth of bacterium when added to iron-deficient media. pyochelin : A member of the class of thiazolidines that is (4R)-3-methyl-1,3-thiazolidine-4-carboxylic acid which is substituted at position 2 by a (4R)-2-(2-hydroxyphenyl)-4,5-dihydro-1,3-thiazol-4-yl group. A siderophore that is produced by Pseudomonas aeruginosa (via condensation of salicylic acid and two molecules of cysteine) as a mixture of two easily interconvertible diastereoisomers, pyochelin I (major) and pyochelin II (minor). The enantiomeric compounds, enant-pyochelin, are produced by Pseudomonas fluorescens.		2.0810monocarboxylic acid;
phenols;
thiazolidines		metabolite;
siderophore
cefepime
Cefepime: A fourth-generation cephalosporin antibacterial agent that is used in the treatment of infections, including those of the abdomen, urinary tract, respiratory tract, and skin. It is effective against PSEUDOMONAS AERUGINOSA and may also be used in the empiric treatment of FEBRILE NEUTROPENIA.. cefepime : A cephalosporin bearing (1-methylpyrrolidinium-1-yl)methyl and (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido groups at positions 3 and 7, respectively, of the cephem skeleton.		2.7930cephalosporin;
oxime O-ether		antibacterial drug
ceftazidime
[no description available]		2.520cephalosporin;
oxime O-ether		antibacterial drug;
drug allergen;
EC 2.4.1.129 (peptidoglycan glycosyltransferase) inhibitor
aztreonam
[no description available]		3.250beta-lactam antibiotic allergen;
monobactam		antibacterial drug;
drug allergen;
EC 2.4.1.129 (peptidoglycan glycosyltransferase) inhibitor
carumonam
carumonam: structure given in first source; RN given refers to (2S-(2alpha,3alpha(Z))-isomer. carumonam : An N-sulfonated monobactam antibiotic.		2.1710monobactamantibacterial drug
ConditionIndicatedRelationship StrengthStudiesTrials
Bacterial Infections, Gram-Negative
[description not available]		03.250
Gram-Negative Bacterial Infections
Infections caused by bacteria that show up as pink (negative) when treated by the gram-staining method.		03.250
E coli Infections
[description not available]		02.1510
Infections, Klebsiella
[description not available]		02.1510
Escherichia coli Infections
Infections with bacteria of the species ESCHERICHIA COLI.		02.1510
Klebsiella Infections
Infections with bacteria of the genus KLEBSIELLA.		02.1510
Absence Seizure
[description not available]		02.1710
Seizures
Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.		02.1710
Acute Liver Injury, Drug-Induced
[description not available]		03.5311
Chemical and Drug Induced Liver Injury
A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.		03.5311
Cronobacter Infections
[description not available]		02.0810
Enterobacteriaceae Infections
Infections with bacteria of the family ENTEROBACTERIACEAE.		02.0810
Urinary Tract Infections
Inflammatory responses of the epithelium of the URINARY TRACT to microbial invasions. They are often bacterial infections with associated BACTERIURIA and PYURIA.		03.5111
Acinetobacter Infections
Infections with bacteria of the genus ACINETOBACTER.		02.0610
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.0610
Rodent Diseases
Diseases of rodents of the order RODENTIA. This term includes diseases of Sciuridae (squirrels), Geomyidae (gophers), Heteromyidae (pouched mice), Castoridae (beavers), Cricetidae (rats and mice), Muridae (Old World rats and mice), Erethizontidae (porcupines), and Caviidae (guinea pigs).		02.0610
Burkholderia pseudomallei Infection
[description not available]		02.0610