Page last updated: 2024-12-08

10-gingerol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

## 10-Gingerol: The Spicy Compound With Potential

10-gingerol is a **natural compound** found in ginger (Zingiber officinale). It's a **phenolic compound**, specifically a **gingerol**, which gives ginger its characteristic spicy flavor and aroma.

**Here's why 10-gingerol is important for research:**

* **Anti-inflammatory properties:** 10-gingerol has shown promising **anti-inflammatory effects** in various studies. It might help reduce inflammation by inhibiting the production of pro-inflammatory molecules like prostaglandins. This makes it a potential therapeutic agent for inflammatory conditions like arthritis and inflammatory bowel disease.
* **Antioxidant potential:** 10-gingerol possesses **antioxidant activity**, protecting cells from damage caused by free radicals. This could be beneficial in preventing various diseases associated with oxidative stress, like cancer and heart disease.
* **Analgesic effects:** Some research suggests that 10-gingerol might have **pain-relieving properties**, potentially acting on the nervous system to reduce pain signals. This could be beneficial for managing pain associated with conditions like osteoarthritis and headaches.
* **Gastroprotective effects:** Studies have shown that 10-gingerol might help protect the stomach lining from damage caused by ulcers and other factors. It could also improve digestion and reduce nausea.
* **Anti-cancer potential:** Preliminary research indicates that 10-gingerol might have **anti-cancer effects**, potentially inhibiting the growth and spread of cancer cells. However, more studies are needed to confirm its efficacy.

**Ongoing Research:**

Researchers are continuously investigating the potential benefits of 10-gingerol and its role in various diseases. Studies are ongoing to explore its effects on:

* **Cardiovascular health**
* **Neurological conditions**
* **Metabolic disorders**
* **Immune system modulation**

**Important Notes:**

* 10-gingerol research is still in its early stages. While promising, more research is needed to fully understand its potential therapeutic applications.
* Ginger is generally considered safe for consumption, but excessive consumption can lead to gastrointestinal side effects.
* Always consult with a healthcare professional before using ginger or 10-gingerol supplements for medicinal purposes.

**Overall, 10-gingerol is a promising natural compound with a variety of potential health benefits. Ongoing research is crucial to further explore its applications and develop safe and effective therapeutic strategies based on its properties.**

Cross-References

ID SourceID
PubMed CID168115
CHEMBL ID549472
CHEBI ID81134
SCHEMBL ID16488702
MeSH IDM0561987

Synonyms (39)

Synonym
AC-1446
10-gingerol
3-tetradecanone, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-, (s)-
(s)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-tetradecanone
(10)-gingerol
23513-15-7
C17496
(5s)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)tetradecan-3-one
CHEMBL549472 ,
chebi:81134 ,
bdbm50317425
unii-nd6zli4j0v
nd6zli4j0v ,
S9091
[10]-gingerol
(s)- 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-tetradecanone
AKOS015888437
SCHEMBL16488702
Q-100301
(+)-(s)-(10)-gingerol
10-gingerol (constituent of ginger) [dsc]
(5s)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-tetradecanone
3-tetradecanone, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-, (5s)-
(5s)-(10)-gingerol
mfcd01682694
DTXSID80178079 ,
[10]-gingerol, analytical standard
[10]-gingerol, >=95% (hplc)
AS-71715
(s)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)tetradecan-3-one
Q27155092
(+)-(s)-[10]-gingerol
CS-0008981
HY-N0448
CCG-268037
SRCG-00267
PD053774
dtxcid60100570
10-gingerol (constituent of ginger)
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (3)

ClassDescription
beta-hydroxy ketoneA ketone containing a hydroxy group on the beta-carbon relative to the C=O group.
phenolsOrganic aromatic compounds having one or more hydroxy groups attached to a benzene or other arene ring.
monomethoxybenzeneCompounds containing a benzene skeleton substituted with one methoxy group.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (6)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Cytochrome P450 1A2Homo sapiens (human)IC50 (µMol)20.80000.00011.774010.0000AID1443034
Cytochrome P450 3A4Homo sapiens (human)IC50 (µMol)22.50000.00011.753610.0000AID1443032; AID1443033; AID1443034
5-hydroxytryptamine receptor 1AHomo sapiens (human)Ki3.74000.00010.532610.0000AID480937
Cytochrome P450 2C9 Homo sapiens (human)IC50 (µMol)16.30000.00002.800510.0000AID1443030
Aldo-keto reductase family 1 member B1Homo sapiens (human)IC50 (µMol)126.00000.00101.191310.0000AID1646332
Cytochrome P450 2C19Homo sapiens (human)IC50 (µMol)13.60000.00002.398310.0000AID1443031
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (66)

Processvia Protein(s)Taxonomy
steroid catabolic processCytochrome P450 1A2Homo sapiens (human)
porphyrin-containing compound metabolic processCytochrome P450 1A2Homo sapiens (human)
xenobiotic metabolic processCytochrome P450 1A2Homo sapiens (human)
cholesterol metabolic processCytochrome P450 1A2Homo sapiens (human)
estrogen metabolic processCytochrome P450 1A2Homo sapiens (human)
toxin biosynthetic processCytochrome P450 1A2Homo sapiens (human)
post-embryonic developmentCytochrome P450 1A2Homo sapiens (human)
alkaloid metabolic processCytochrome P450 1A2Homo sapiens (human)
regulation of gene expressionCytochrome P450 1A2Homo sapiens (human)
monoterpenoid metabolic processCytochrome P450 1A2Homo sapiens (human)
dibenzo-p-dioxin metabolic processCytochrome P450 1A2Homo sapiens (human)
epoxygenase P450 pathwayCytochrome P450 1A2Homo sapiens (human)
lung developmentCytochrome P450 1A2Homo sapiens (human)
methylationCytochrome P450 1A2Homo sapiens (human)
monocarboxylic acid metabolic processCytochrome P450 1A2Homo sapiens (human)
xenobiotic catabolic processCytochrome P450 1A2Homo sapiens (human)
retinol metabolic processCytochrome P450 1A2Homo sapiens (human)
long-chain fatty acid biosynthetic processCytochrome P450 1A2Homo sapiens (human)
cellular respirationCytochrome P450 1A2Homo sapiens (human)
aflatoxin metabolic processCytochrome P450 1A2Homo sapiens (human)
hydrogen peroxide biosynthetic processCytochrome P450 1A2Homo sapiens (human)
oxidative demethylationCytochrome P450 1A2Homo sapiens (human)
cellular response to cadmium ionCytochrome P450 1A2Homo sapiens (human)
omega-hydroxylase P450 pathwayCytochrome P450 1A2Homo sapiens (human)
lipid hydroxylationCytochrome P450 3A4Homo sapiens (human)
lipid metabolic processCytochrome P450 3A4Homo sapiens (human)
steroid catabolic processCytochrome P450 3A4Homo sapiens (human)
xenobiotic metabolic processCytochrome P450 3A4Homo sapiens (human)
steroid metabolic processCytochrome P450 3A4Homo sapiens (human)
cholesterol metabolic processCytochrome P450 3A4Homo sapiens (human)
androgen metabolic processCytochrome P450 3A4Homo sapiens (human)
estrogen metabolic processCytochrome P450 3A4Homo sapiens (human)
alkaloid catabolic processCytochrome P450 3A4Homo sapiens (human)
monoterpenoid metabolic processCytochrome P450 3A4Homo sapiens (human)
calcitriol biosynthetic process from calciolCytochrome P450 3A4Homo sapiens (human)
xenobiotic catabolic processCytochrome P450 3A4Homo sapiens (human)
vitamin D metabolic processCytochrome P450 3A4Homo sapiens (human)
vitamin D catabolic processCytochrome P450 3A4Homo sapiens (human)
retinol metabolic processCytochrome P450 3A4Homo sapiens (human)
retinoic acid metabolic processCytochrome P450 3A4Homo sapiens (human)
long-chain fatty acid biosynthetic processCytochrome P450 3A4Homo sapiens (human)
aflatoxin metabolic processCytochrome P450 3A4Homo sapiens (human)
oxidative demethylationCytochrome P450 3A4Homo sapiens (human)
behavioral fear response5-hydroxytryptamine receptor 1AHomo sapiens (human)
G protein-coupled receptor signaling pathway5-hydroxytryptamine receptor 1AHomo sapiens (human)
adenylate cyclase-inhibiting serotonin receptor signaling pathway5-hydroxytryptamine receptor 1AHomo sapiens (human)
serotonin receptor signaling pathway5-hydroxytryptamine receptor 1AHomo sapiens (human)
gamma-aminobutyric acid signaling pathway5-hydroxytryptamine receptor 1AHomo sapiens (human)
positive regulation of cell population proliferation5-hydroxytryptamine receptor 1AHomo sapiens (human)
regulation of serotonin secretion5-hydroxytryptamine receptor 1AHomo sapiens (human)
regulation of vasoconstriction5-hydroxytryptamine receptor 1AHomo sapiens (human)
exploration behavior5-hydroxytryptamine receptor 1AHomo sapiens (human)
regulation of dopamine metabolic process5-hydroxytryptamine receptor 1AHomo sapiens (human)
serotonin metabolic process5-hydroxytryptamine receptor 1AHomo sapiens (human)
regulation of hormone secretion5-hydroxytryptamine receptor 1AHomo sapiens (human)
regulation of behavior5-hydroxytryptamine receptor 1AHomo sapiens (human)
chemical synaptic transmission5-hydroxytryptamine receptor 1AHomo sapiens (human)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger5-hydroxytryptamine receptor 1AHomo sapiens (human)
xenobiotic metabolic processCytochrome P450 2C9 Homo sapiens (human)
steroid metabolic processCytochrome P450 2C9 Homo sapiens (human)
cholesterol metabolic processCytochrome P450 2C9 Homo sapiens (human)
estrogen metabolic processCytochrome P450 2C9 Homo sapiens (human)
monoterpenoid metabolic processCytochrome P450 2C9 Homo sapiens (human)
epoxygenase P450 pathwayCytochrome P450 2C9 Homo sapiens (human)
urea metabolic processCytochrome P450 2C9 Homo sapiens (human)
monocarboxylic acid metabolic processCytochrome P450 2C9 Homo sapiens (human)
xenobiotic catabolic processCytochrome P450 2C9 Homo sapiens (human)
long-chain fatty acid biosynthetic processCytochrome P450 2C9 Homo sapiens (human)
amide metabolic processCytochrome P450 2C9 Homo sapiens (human)
icosanoid biosynthetic processCytochrome P450 2C9 Homo sapiens (human)
oxidative demethylationCytochrome P450 2C9 Homo sapiens (human)
omega-hydroxylase P450 pathwayCytochrome P450 2C9 Homo sapiens (human)
retinoid metabolic processAldo-keto reductase family 1 member B1Homo sapiens (human)
epithelial cell maturationAldo-keto reductase family 1 member B1Homo sapiens (human)
renal water homeostasisAldo-keto reductase family 1 member B1Homo sapiens (human)
carbohydrate metabolic processAldo-keto reductase family 1 member B1Homo sapiens (human)
prostaglandin metabolic processAldo-keto reductase family 1 member B1Homo sapiens (human)
C21-steroid hormone biosynthetic processAldo-keto reductase family 1 member B1Homo sapiens (human)
L-ascorbic acid biosynthetic processAldo-keto reductase family 1 member B1Homo sapiens (human)
regulation of urine volumeAldo-keto reductase family 1 member B1Homo sapiens (human)
retinol metabolic processAldo-keto reductase family 1 member B1Homo sapiens (human)
negative regulation of apoptotic processAldo-keto reductase family 1 member B1Homo sapiens (human)
daunorubicin metabolic processAldo-keto reductase family 1 member B1Homo sapiens (human)
doxorubicin metabolic processAldo-keto reductase family 1 member B1Homo sapiens (human)
fructose biosynthetic processAldo-keto reductase family 1 member B1Homo sapiens (human)
cellular hyperosmotic salinity responseAldo-keto reductase family 1 member B1Homo sapiens (human)
metanephric collecting duct developmentAldo-keto reductase family 1 member B1Homo sapiens (human)
long-chain fatty acid metabolic processCytochrome P450 2C19Homo sapiens (human)
xenobiotic metabolic processCytochrome P450 2C19Homo sapiens (human)
steroid metabolic processCytochrome P450 2C19Homo sapiens (human)
monoterpenoid metabolic processCytochrome P450 2C19Homo sapiens (human)
epoxygenase P450 pathwayCytochrome P450 2C19Homo sapiens (human)
xenobiotic catabolic processCytochrome P450 2C19Homo sapiens (human)
omega-hydroxylase P450 pathwayCytochrome P450 2C19Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (46)

Processvia Protein(s)Taxonomy
monooxygenase activityCytochrome P450 1A2Homo sapiens (human)
iron ion bindingCytochrome P450 1A2Homo sapiens (human)
protein bindingCytochrome P450 1A2Homo sapiens (human)
electron transfer activityCytochrome P450 1A2Homo sapiens (human)
oxidoreductase activityCytochrome P450 1A2Homo sapiens (human)
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygenCytochrome P450 1A2Homo sapiens (human)
enzyme bindingCytochrome P450 1A2Homo sapiens (human)
heme bindingCytochrome P450 1A2Homo sapiens (human)
demethylase activityCytochrome P450 1A2Homo sapiens (human)
caffeine oxidase activityCytochrome P450 1A2Homo sapiens (human)
aromatase activityCytochrome P450 1A2Homo sapiens (human)
estrogen 16-alpha-hydroxylase activityCytochrome P450 1A2Homo sapiens (human)
estrogen 2-hydroxylase activityCytochrome P450 1A2Homo sapiens (human)
hydroperoxy icosatetraenoate dehydratase activityCytochrome P450 1A2Homo sapiens (human)
monooxygenase activityCytochrome P450 3A4Homo sapiens (human)
steroid bindingCytochrome P450 3A4Homo sapiens (human)
iron ion bindingCytochrome P450 3A4Homo sapiens (human)
protein bindingCytochrome P450 3A4Homo sapiens (human)
steroid hydroxylase activityCytochrome P450 3A4Homo sapiens (human)
retinoic acid 4-hydroxylase activityCytochrome P450 3A4Homo sapiens (human)
oxidoreductase activityCytochrome P450 3A4Homo sapiens (human)
oxygen bindingCytochrome P450 3A4Homo sapiens (human)
enzyme bindingCytochrome P450 3A4Homo sapiens (human)
heme bindingCytochrome P450 3A4Homo sapiens (human)
vitamin D3 25-hydroxylase activityCytochrome P450 3A4Homo sapiens (human)
caffeine oxidase activityCytochrome P450 3A4Homo sapiens (human)
quinine 3-monooxygenase activityCytochrome P450 3A4Homo sapiens (human)
testosterone 6-beta-hydroxylase activityCytochrome P450 3A4Homo sapiens (human)
1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activityCytochrome P450 3A4Homo sapiens (human)
anandamide 8,9 epoxidase activityCytochrome P450 3A4Homo sapiens (human)
anandamide 11,12 epoxidase activityCytochrome P450 3A4Homo sapiens (human)
anandamide 14,15 epoxidase activityCytochrome P450 3A4Homo sapiens (human)
aromatase activityCytochrome P450 3A4Homo sapiens (human)
vitamin D 24-hydroxylase activityCytochrome P450 3A4Homo sapiens (human)
estrogen 16-alpha-hydroxylase activityCytochrome P450 3A4Homo sapiens (human)
estrogen 2-hydroxylase activityCytochrome P450 3A4Homo sapiens (human)
1,8-cineole 2-exo-monooxygenase activityCytochrome P450 3A4Homo sapiens (human)
G protein-coupled serotonin receptor activity5-hydroxytryptamine receptor 1AHomo sapiens (human)
protein binding5-hydroxytryptamine receptor 1AHomo sapiens (human)
receptor-receptor interaction5-hydroxytryptamine receptor 1AHomo sapiens (human)
neurotransmitter receptor activity5-hydroxytryptamine receptor 1AHomo sapiens (human)
serotonin binding5-hydroxytryptamine receptor 1AHomo sapiens (human)
monooxygenase activityCytochrome P450 2C9 Homo sapiens (human)
iron ion bindingCytochrome P450 2C9 Homo sapiens (human)
arachidonic acid epoxygenase activityCytochrome P450 2C9 Homo sapiens (human)
steroid hydroxylase activityCytochrome P450 2C9 Homo sapiens (human)
arachidonic acid 14,15-epoxygenase activityCytochrome P450 2C9 Homo sapiens (human)
arachidonic acid 11,12-epoxygenase activityCytochrome P450 2C9 Homo sapiens (human)
oxidoreductase activityCytochrome P450 2C9 Homo sapiens (human)
(S)-limonene 6-monooxygenase activityCytochrome P450 2C9 Homo sapiens (human)
(S)-limonene 7-monooxygenase activityCytochrome P450 2C9 Homo sapiens (human)
caffeine oxidase activityCytochrome P450 2C9 Homo sapiens (human)
(R)-limonene 6-monooxygenase activityCytochrome P450 2C9 Homo sapiens (human)
aromatase activityCytochrome P450 2C9 Homo sapiens (human)
heme bindingCytochrome P450 2C9 Homo sapiens (human)
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygenCytochrome P450 2C9 Homo sapiens (human)
retinal dehydrogenase activityAldo-keto reductase family 1 member B1Homo sapiens (human)
aldose reductase (NADPH) activityAldo-keto reductase family 1 member B1Homo sapiens (human)
protein bindingAldo-keto reductase family 1 member B1Homo sapiens (human)
electron transfer activityAldo-keto reductase family 1 member B1Homo sapiens (human)
prostaglandin H2 endoperoxidase reductase activityAldo-keto reductase family 1 member B1Homo sapiens (human)
glyceraldehyde oxidoreductase activityAldo-keto reductase family 1 member B1Homo sapiens (human)
allyl-alcohol dehydrogenase activityAldo-keto reductase family 1 member B1Homo sapiens (human)
L-glucuronate reductase activityAldo-keto reductase family 1 member B1Homo sapiens (human)
glycerol dehydrogenase [NADP+] activityAldo-keto reductase family 1 member B1Homo sapiens (human)
all-trans-retinol dehydrogenase (NADP+) activityAldo-keto reductase family 1 member B1Homo sapiens (human)
monooxygenase activityCytochrome P450 2C19Homo sapiens (human)
iron ion bindingCytochrome P450 2C19Homo sapiens (human)
steroid hydroxylase activityCytochrome P450 2C19Homo sapiens (human)
oxidoreductase activityCytochrome P450 2C19Homo sapiens (human)
(S)-limonene 6-monooxygenase activityCytochrome P450 2C19Homo sapiens (human)
(S)-limonene 7-monooxygenase activityCytochrome P450 2C19Homo sapiens (human)
oxygen bindingCytochrome P450 2C19Homo sapiens (human)
enzyme bindingCytochrome P450 2C19Homo sapiens (human)
heme bindingCytochrome P450 2C19Homo sapiens (human)
(R)-limonene 6-monooxygenase activityCytochrome P450 2C19Homo sapiens (human)
aromatase activityCytochrome P450 2C19Homo sapiens (human)
long-chain fatty acid omega-1 hydroxylase activityCytochrome P450 2C19Homo sapiens (human)
arachidonic acid epoxygenase activityCytochrome P450 2C19Homo sapiens (human)
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygenCytochrome P450 2C19Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (10)

Processvia Protein(s)Taxonomy
endoplasmic reticulum membraneCytochrome P450 1A2Homo sapiens (human)
intracellular membrane-bounded organelleCytochrome P450 1A2Homo sapiens (human)
intracellular membrane-bounded organelleCytochrome P450 1A2Homo sapiens (human)
cytoplasmCytochrome P450 3A4Homo sapiens (human)
endoplasmic reticulum membraneCytochrome P450 3A4Homo sapiens (human)
intracellular membrane-bounded organelleCytochrome P450 3A4Homo sapiens (human)
plasma membrane5-hydroxytryptamine receptor 1AHomo sapiens (human)
synapse5-hydroxytryptamine receptor 1AHomo sapiens (human)
plasma membrane5-hydroxytryptamine receptor 1AHomo sapiens (human)
dendrite5-hydroxytryptamine receptor 1AHomo sapiens (human)
endoplasmic reticulum membraneCytochrome P450 2C9 Homo sapiens (human)
plasma membraneCytochrome P450 2C9 Homo sapiens (human)
intracellular membrane-bounded organelleCytochrome P450 2C9 Homo sapiens (human)
cytoplasmCytochrome P450 2C9 Homo sapiens (human)
intracellular membrane-bounded organelleCytochrome P450 2C9 Homo sapiens (human)
extracellular spaceAldo-keto reductase family 1 member B1Homo sapiens (human)
nucleoplasmAldo-keto reductase family 1 member B1Homo sapiens (human)
cytosolAldo-keto reductase family 1 member B1Homo sapiens (human)
extracellular exosomeAldo-keto reductase family 1 member B1Homo sapiens (human)
cytosolAldo-keto reductase family 1 member B1Homo sapiens (human)
endoplasmic reticulum membraneCytochrome P450 2C19Homo sapiens (human)
plasma membraneCytochrome P450 2C19Homo sapiens (human)
intracellular membrane-bounded organelleCytochrome P450 2C19Homo sapiens (human)
intracellular membrane-bounded organelleCytochrome P450 2C19Homo sapiens (human)
cytoplasmCytochrome P450 2C19Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (36)

Assay IDTitleYearJournalArticle
AID1443027Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate preincubated for 10 mins followed by NADPH addition measured after 15 mins2017Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism.
AID1646334Aggregation-based inhibition of human recombinant AKR1B1 assessed as D,L-glyceraldehyde reduction at 300 uM incubated in sodium phosphate buffer at pH 6.2 in presence of NADPH and 0.05% Triton X-100 by detergent-addition assay2020Bioorganic & medicinal chemistry letters, 01-15, Volume: 30, Issue:2
Early identification of promiscuous attributes of aldose reductase inhibitors using a DMSO-perturbation assay.
AID480936Cytotoxicity against human Caco-2 cells at 50 ug/ml2010Bioorganic & medicinal chemistry, May-01, Volume: 18, Issue:9
Identification of serotonin 5-HT1A receptor partial agonists in ginger.
AID480941Antagonist activity at 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 8-OH-DPAT-induced [S35]GTPgammaS binding by scintillation counting2010Bioorganic & medicinal chemistry, May-01, Volume: 18, Issue:9
Identification of serotonin 5-HT1A receptor partial agonists in ginger.
AID421740Antiallergic activity in mIgE-DNP and DNP-BSA-stimulated rat RBL2H3 cells assessed as inhibition of beta-hexosaminidase release at 1 uM pretreated before mIgE-DNP challenge measured after 12 hrs relative to control2009Journal of natural products, May-22, Volume: 72, Issue:5
Antiallergic potential on RBL-2H3 cells of some phenolic constituents of Zingiber officinale (ginger).
AID421742Antiallergic activity in mIgE-DNP and DNP-BSA-stimulated rat RBL2H3 cells assessed as inhibition of beta-hexosaminidase release at 200 uM pretreated before mIgE-DNP challenge measured after 12 hrs2009Journal of natural products, May-22, Volume: 72, Issue:5
Antiallergic potential on RBL-2H3 cells of some phenolic constituents of Zingiber officinale (ginger).
AID421739Cytotoxicity against rat RBL2H3 cells at 120 uM after 12 hrs by MTT assay2009Journal of natural products, May-22, Volume: 72, Issue:5
Antiallergic potential on RBL-2H3 cells of some phenolic constituents of Zingiber officinale (ginger).
AID1443024Inhibition of CYP2C19 in human liver microsomes using (S)-mephenytoin as substrate preincubated for 10 mins followed by NADPH addition measured after 40 mins2017Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism.
AID421747Antiallergic activity in mIgE-DNP and DNP-BSA-stimulated rat RBL2H3 cells assessed as inhibition of beta-hexosaminidase release at 100 uM pretreated before mIgE-DNP challenge measured after 24 hrs relative to control2009Journal of natural products, May-22, Volume: 72, Issue:5
Antiallergic potential on RBL-2H3 cells of some phenolic constituents of Zingiber officinale (ginger).
AID1646331Inhibition of human recombinant AKR1B1 assessed as D,L-glyceraldehyde reduction at 100 uM incubated in sodium phosphate buffer at pH 6.2 in presence of NADPH relative to control2020Bioorganic & medicinal chemistry letters, 01-15, Volume: 30, Issue:2
Early identification of promiscuous attributes of aldose reductase inhibitors using a DMSO-perturbation assay.
AID1439509Antihelmintic activity against Hymenolepis nana2017European journal of medicinal chemistry, Mar-31, Volume: 129Medicinal plants used as anthelmintics: Ethnomedical, pharmacological, and phytochemical studies.
AID1443033Inhibition of recombinant human CYP3A4 expressed in baculosomes using Vivid BOMR substrate red measured every 30 sec for 30 mins by fluorescence assay2017Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism.
AID1443034Inhibition of recombinant human CYP3A4 expressed in baculosomes using Vivid BOMCC substrate blue measured every 30 sec for 30 mins by fluorescence assay2017Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism.
AID1443026Inhibition of CYP2A6 in human liver microsomes using Coumarin as substrate preincubated for 10 mins followed by NADPH addition measured after 15 mins2017Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism.
AID1219968Antioxidant activity assessed as DPPH radical scavenging activity2012Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 40, Issue:4
Metabolism of [6]-shogaol in mice and in cancer cells.
AID1443030Inhibition of recombinant human CYP2C9 expressed in baculosomes using Vivid OOMR substrate red measured every 30 sec for 30 mins by fluorescence assay2017Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism.
AID421737Cytotoxicity against rat RBL2H3 cells after 12 hrs by MTT assay2009Journal of natural products, May-22, Volume: 72, Issue:5
Antiallergic potential on RBL-2H3 cells of some phenolic constituents of Zingiber officinale (ginger).
AID421749Antiallergic activity in mIgE-DNP and DNP-BSA-stimulated rat RBL2H3 cells assessed as inhibition of beta-hexosaminidase release at 200 uM pretreated before mIgE-DNP challenge measured after 24 hrs relative to control2009Journal of natural products, May-22, Volume: 72, Issue:5
Antiallergic potential on RBL-2H3 cells of some phenolic constituents of Zingiber officinale (ginger).
AID1443021Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 10 mins followed by NADPH addition measured after 20 mins2017Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism.
AID1443022Inhibition of CYP2C8 in human liver microsomes using amodiaquin as substrate preincubated for 10 mins followed by NADPH addition measured after 10 mins2017Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism.
AID480938Displacement of [3H]8-OH-DPAT from 5HT1A receptor expressed in HEK293 cells at 25 ug/ml after 2 hrs by liquid scintillation counting2010Bioorganic & medicinal chemistry, May-01, Volume: 18, Issue:9
Identification of serotonin 5-HT1A receptor partial agonists in ginger.
AID1646332Inhibition of human recombinant AKR1B1 assessed as D,L-glyceraldehyde reduction incubated in sodium phosphate buffer at pH 6.2 in presence of NADPH2020Bioorganic & medicinal chemistry letters, 01-15, Volume: 30, Issue:2
Early identification of promiscuous attributes of aldose reductase inhibitors using a DMSO-perturbation assay.
AID421748Antiallergic activity in mIgE-DNP and DNP-BSA-stimulated rat RBL2H3 cells assessed as inhibition of beta-hexosaminidase release at 100 uM pretreated before mIgE-DNP challenge measured after 48 hrs relative to control2009Journal of natural products, May-22, Volume: 72, Issue:5
Antiallergic potential on RBL-2H3 cells of some phenolic constituents of Zingiber officinale (ginger).
AID1443025Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate preincubated for 10 mins followed by NADPH addition measured after 10 mins2017Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism.
AID480937Displacement of [3H]8-OH-DPAT from 5HT1A receptor expressed in HEK293 cells after 2 hrs by liquid scintillation counting2010Bioorganic & medicinal chemistry, May-01, Volume: 18, Issue:9
Identification of serotonin 5-HT1A receptor partial agonists in ginger.
AID421745Antiallergic activity in mIgE-DNP and DNP-BSA-stimulated rat RBL2H3 cells assessed as inhibition of beta-hexosaminidase release at 1 uM pretreated before mIgE-DNP challenge measured after 24 hrs relative to control2009Journal of natural products, May-22, Volume: 72, Issue:5
Antiallergic potential on RBL-2H3 cells of some phenolic constituents of Zingiber officinale (ginger).
AID421746Antiallergic activity in mIgE-DNP and DNP-BSA-stimulated rat RBL2H3 cells assessed as inhibition of beta-hexosaminidase release at 1 uM pretreated before mIgE-DNP challenge measured after 48 hrs relative to control2009Journal of natural products, May-22, Volume: 72, Issue:5
Antiallergic potential on RBL-2H3 cells of some phenolic constituents of Zingiber officinale (ginger).
AID480939Agonist activity at 5HT1A receptor expressed in HEK293 cells by [S35]GTPgammaS binding assay relative to 8-OH-DPAT2010Bioorganic & medicinal chemistry, May-01, Volume: 18, Issue:9
Identification of serotonin 5-HT1A receptor partial agonists in ginger.
AID421741Antiallergic activity in mIgE-DNP and DNP-BSA-stimulated rat RBL2H3 cells assessed as inhibition of beta-hexosaminidase release at 100 uM pretreated before mIgE-DNP challenge measured after 12 hrs2009Journal of natural products, May-22, Volume: 72, Issue:5
Antiallergic potential on RBL-2H3 cells of some phenolic constituents of Zingiber officinale (ginger).
AID480943Permeability in human Caco-2 cells assessed as passive diffusion after 3 hrs by HPLC2010Bioorganic & medicinal chemistry, May-01, Volume: 18, Issue:9
Identification of serotonin 5-HT1A receptor partial agonists in ginger.
AID480944Inhibition of human MDR1 expressed in MDCK cells assessed as fluorescence activity at 30 uM after 1.5 hrs by rhodamine 123 efflux test2010Bioorganic & medicinal chemistry, May-01, Volume: 18, Issue:9
Identification of serotonin 5-HT1A receptor partial agonists in ginger.
AID1443032Inhibition of recombinant human CYP3A4 expressed in baculosomes using Vivid DBOMF substrate green measured every 30 sec for 30 mins by fluorescence assay2017Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism.
AID421750Antiallergic activity in mIgE-DNP and DNP-BSA-stimulated rat RBL2H3 cells assessed as inhibition of beta-hexosaminidase release at 200 uM pretreated before mIgE-DNP challenge measured after 48 hrs relative to control2009Journal of natural products, May-22, Volume: 72, Issue:5
Antiallergic potential on RBL-2H3 cells of some phenolic constituents of Zingiber officinale (ginger).
AID480942Antagonist activity at 5HT1A receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced [S35]GTPgammaS binding by scintillation counting2010Bioorganic & medicinal chemistry, May-01, Volume: 18, Issue:9
Identification of serotonin 5-HT1A receptor partial agonists in ginger.
AID1443031Inhibition of recombinant human CYP2C19 expressed in baculosomes using Vivid EOMCC substrate blue measured every 30 sec for 30 mins by fluorescence assay2017Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism.
AID1443023Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 10 mins followed by NADPH addition measured after 7 mins2017Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's4 (66.67)24.3611
2020's1 (16.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 22.57

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index22.57 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.73 (4.65)
Search Engine Demand Index29.35 (26.88)
Search Engine Supply Index3.00 (0.95)

This Compound (22.57)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (16.67%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (83.33%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]