sulforaphane has been researched along with Pancreatic Neoplasms in 29 studies
sulforaphane: from Cardaria draba L.
sulforaphane : An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.
Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Excerpt | Relevance | Reference |
---|---|---|
"Pancreatic cancer is one of the most aggressive human cancers and is expected to surpass breast cancer to become the third chief cause of cancer-related deaths in the United States." | 2.55 | Plant Derived Inhibitor Sulforaphane in Combinatorial Therapy Against Therapeutically Challenging Pancreatic Cancer. ( Abdullah, E; Altaf, M; Ganai, SA; Rashid, R, 2017) |
"The therapy resistance of pancreatic cancer is associated with the loss of gap junction intercellular communication and connexin 43 expression." | 1.56 | Inhibition of miR30a-3p by sulforaphane enhances gap junction intercellular communication in pancreatic cancer. ( Georgikou, C; Gladkich, J; Gretz, N; Gross, W; Herr, I; Karakhanova, S; Schäfer, M; Sticht, C; Torre, C; Xiao, X; Yin, L, 2020) |
"However, its anti-tumor effect on pancreatic cancer is still poorly understood." | 1.48 | Activation of Nrf2 by Sulforaphane Inhibits High Glucose-Induced Progression of Pancreatic Cancer via AMPK Dependent Signaling. ( Chen, K; Chen, X; Duan, W; Jiang, Z; Li, X; Ma, J; Ma, Q; Wang, Z; Wu, Z; Zhou, C, 2018) |
"In four established pancreatic cancer cell lines we investigated clonogenic survival, analyzed cell cycle distribution and compared DNA damage via flow cytometry and western blot after treatment with SFN and RT." | 1.46 | Sulforaphane enhances irradiation effects in terms of perturbed cell cycle progression and increased DNA damage in pancreatic cancer cells. ( Combs, SE; Debus, J; Fortunato, F; Liermann, J; Naumann, P; Schmid, TE; Weber, KJ, 2017) |
"Pancreatic cancer is a deadly disease killing 37,000 Americans each year." | 1.39 | A novel combinatorial nanotechnology-based oral chemopreventive regimen demonstrates significant suppression of pancreatic cancer neoplastic lesions. ( Grandhi, BK; Prabhu, S; Thakkar, A; Wang, J, 2013) |
"Sulforaphane inhibited pancreatic cancer cell growth in vitro with IC(50)s of around 10-15 μM and induced apoptosis." | 1.38 | Sulforaphane inhibits pancreatic cancer through disrupting Hsp90-p50(Cdc37) complex and direct interactions with amino acids residues of Hsp90. ( Boelens, R; Carroll, K; Duarte, AM; Jiang, Y; Karagöz, GE; Li, Y; Rüdiger, SG; Schwartz, SJ; Seo, YH; Sun, D; Yu, Y; Zhang, T, 2012) |
"Pancreatic cancer is the fourth largest cause of cancer deaths in the Unites States and the prognosis is grim with <5% survival chances upon diagnosis." | 1.38 | Chemoprevention of pancreatic cancer using solid-lipid nanoparticulate delivery of a novel aspirin, curcumin and sulforaphane drug combination regimen. ( Grandhi, BK; Prabhu, S; Sutaria, D; Thakkar, A; Wang, J, 2012) |
"Given the requirement for Hedgehog in pancreatic cancer, we investigated whether hedgehog blockade by SFN could target the stem cell population in pancreatic cancer." | 1.38 | Sonic hedgehog signaling inhibition provides opportunities for targeted therapy by sulforaphane in regulating pancreatic cancer stem cell self-renewal. ( Fu, J; Rodova, M; Shankar, S; Srivastava, RK; Watkins, DN, 2012) |
"Sorafenib (SO) is a promising new multikinase inhibitor for treatment of advanced kidney and liver cancers." | 1.36 | Synergistic activity of sorafenib and sulforaphane abolishes pancreatic cancer stem cell characteristics. ( Baumann, B; Büchler, MW; Gladkich, J; Herr, I; Kallifatidis, G; Liu, L; Mattern, J; Rausch, V; Salnikov, AV; Schemmer, P; Wirth, T; Zöller, M, 2010) |
"Using in vitro and in vivo models of pancreatic cancer stem cells we found quercetin-mediated reduction of self-renewal as measured by spheroid and colony formation." | 1.36 | Dietary polyphenol quercetin targets pancreatic cancer stem cells. ( Baumann, B; Büchler, MW; Giese, N; Gladkich, J; Herr, I; Kallifatidis, G; Mattern, J; Moldenhauer, G; Rausch, V; Salnikov, AV; Wirth, T; Zhou, W, 2010) |
"Sulforaphane-treated cells accumulated in metaphase as determined by flow cytometry [4C DNA content, cyclin A(-), cyclin B1(+), and phospho-histone H3 (Ser(10))(+)]." | 1.32 | The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice. ( Cao, P; Gronda, M; Hedley, DW; Jacobberger, JW; Pham, NA; Schimmer, AD, 2004) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 5 (17.24) | 29.6817 |
2010's | 21 (72.41) | 24.3611 |
2020's | 3 (10.34) | 2.80 |
Authors | Studies |
---|---|
Georgikou, C | 3 |
Yin, L | 3 |
Gladkich, J | 7 |
Xiao, X | 3 |
Sticht, C | 3 |
Torre, C | 1 |
Gretz, N | 2 |
Gross, W | 7 |
Schäfer, M | 1 |
Karakhanova, S | 2 |
Herr, I | 12 |
Buglioni, L | 1 |
Bremerich, M | 1 |
Roubicek, N | 1 |
Bolm, C | 1 |
Naumann, P | 2 |
Liermann, J | 1 |
Fortunato, F | 2 |
Schmid, TE | 1 |
Weber, KJ | 1 |
Debus, J | 1 |
Combs, SE | 1 |
Chen, X | 1 |
Jiang, Z | 1 |
Zhou, C | 1 |
Chen, K | 1 |
Li, X | 1 |
Wang, Z | 1 |
Wu, Z | 1 |
Ma, J | 1 |
Ma, Q | 1 |
Duan, W | 1 |
Desai, P | 1 |
Thakkar, A | 5 |
Ann, D | 1 |
Wang, J | 5 |
Prabhu, S | 5 |
Yin, Y | 2 |
Liu, L | 4 |
Luo, Y | 1 |
Fellenberg, J | 1 |
Lozanovski, VJ | 1 |
Polychronidis, G | 1 |
Gharabaghi, N | 1 |
Mehrabi, A | 1 |
Hackert, T | 1 |
Schemmer, P | 5 |
Sutaria, D | 2 |
Grandhi, BK | 3 |
Forster, T | 1 |
Rausch, V | 5 |
Zhang, Y | 2 |
Isayev, O | 1 |
Heilmann, K | 1 |
Schoensiegel, F | 1 |
Nessling, M | 1 |
Richter, K | 1 |
Labsch, S | 2 |
Nwaeburu, CC | 1 |
Mattern, J | 6 |
Giese, N | 2 |
Werner, J | 3 |
Gebhard, MM | 1 |
Gerhauser, C | 1 |
Schaefer, M | 1 |
Appari, M | 1 |
Babu, KR | 1 |
Kaczorowski, A | 1 |
Chenreddy, S | 1 |
Fan, P | 1 |
Zhao, Z | 1 |
Bauer, N | 1 |
Gao, C | 1 |
Ganai, SA | 1 |
Rashid, R | 1 |
Abdullah, E | 1 |
Altaf, M | 1 |
Kallifatidis, G | 4 |
Baumann, B | 3 |
Apel, A | 1 |
Beckermann, BM | 1 |
Groth, A | 1 |
Li, Z | 1 |
Kolb, A | 1 |
Moldenhauer, G | 3 |
Altevogt, P | 1 |
Wirth, T | 3 |
Büchler, MW | 5 |
Salnikov, AV | 4 |
Shabbeer, S | 1 |
Sobolewski, M | 1 |
Anchoori, RK | 1 |
Kachhap, S | 1 |
Hidalgo, M | 1 |
Jimeno, A | 1 |
Davidson, N | 1 |
Carducci, MA | 1 |
Khan, SR | 1 |
Lampe, JW | 1 |
Zöller, M | 1 |
Zhou, W | 1 |
Srivastava, RK | 3 |
Tang, SN | 1 |
Zhu, W | 1 |
Meeker, D | 1 |
Shankar, S | 3 |
Zentgraf, H | 1 |
Li, Y | 2 |
Zhang, T | 2 |
Schwartz, SJ | 2 |
Sun, D | 2 |
Karagöz, GE | 1 |
Seo, YH | 1 |
Jiang, Y | 1 |
Yu, Y | 1 |
Duarte, AM | 1 |
Boelens, R | 1 |
Carroll, K | 1 |
Rüdiger, SG | 1 |
Rodova, M | 1 |
Fu, J | 2 |
Watkins, DN | 2 |
Li, SH | 1 |
Pham, NA | 1 |
Jacobberger, JW | 1 |
Schimmer, AD | 1 |
Cao, P | 1 |
Gronda, M | 1 |
Hedley, DW | 1 |
Kuroiwa, Y | 1 |
Nishikawa, A | 1 |
Kitamura, Y | 1 |
Kanki, K | 1 |
Ishii, Y | 1 |
Umemura, T | 1 |
Hirose, M | 1 |
1 review available for sulforaphane and Pancreatic Neoplasms
Article | Year |
---|---|
Plant Derived Inhibitor Sulforaphane in Combinatorial Therapy Against Therapeutically Challenging Pancreatic Cancer.
Topics: Antineoplastic Agents, Phytogenic; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumo | 2017 |
1 trial available for sulforaphane and Pancreatic Neoplasms
Article | Year |
---|---|
Broccoli sprout supplementation in patients with advanced pancreatic cancer is difficult despite positive effects-results from the POUDER pilot study.
Topics: Aged; Biological Products; Brassica; Carcinoma, Pancreatic Ductal; Dietary Supplements; Female; Gluc | 2020 |
Broccoli sprout supplementation in patients with advanced pancreatic cancer is difficult despite positive effects-results from the POUDER pilot study.
Topics: Aged; Biological Products; Brassica; Carcinoma, Pancreatic Ductal; Dietary Supplements; Female; Gluc | 2020 |
Broccoli sprout supplementation in patients with advanced pancreatic cancer is difficult despite positive effects-results from the POUDER pilot study.
Topics: Aged; Biological Products; Brassica; Carcinoma, Pancreatic Ductal; Dietary Supplements; Female; Gluc | 2020 |
Broccoli sprout supplementation in patients with advanced pancreatic cancer is difficult despite positive effects-results from the POUDER pilot study.
Topics: Aged; Biological Products; Brassica; Carcinoma, Pancreatic Ductal; Dietary Supplements; Female; Gluc | 2020 |
27 other studies available for sulforaphane and Pancreatic Neoplasms
Article | Year |
---|---|
Inhibition of miR30a-3p by sulforaphane enhances gap junction intercellular communication in pancreatic cancer.
Topics: Adult; Aged; Animals; Cell Communication; Cell Line, Tumor; Connexin 43; Deoxycytidine; Female; Gap | 2020 |
Novel Broccoli Sulforaphane-Based Analogues Inhibit the Progression of Pancreatic Cancer without Side Effects.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Brassica; Caenorhabditis elegans; Chick Embryo; Hep G2 | 2020 |
Sulforaphane enhances irradiation effects in terms of perturbed cell cycle progression and increased DNA damage in pancreatic cancer cells.
Topics: Apoptosis; Blotting, Western; Cell Cycle; Cell Division; Cell Line, Tumor; Cell Proliferation; DNA D | 2017 |
Activation of Nrf2 by Sulforaphane Inhibits High Glucose-Induced Progression of Pancreatic Cancer via AMPK Dependent Signaling.
Topics: AMP-Activated Protein Kinases; Animals; Anticarcinogenic Agents; Apoptosis; Cell Line, Tumor; Cell M | 2018 |
Loratadine self-microemulsifying drug delivery systems (SMEDDS) in combination with sulforaphane for the synergistic chemoprevention of pancreatic cancer.
Topics: Anticarcinogenic Agents; Cell Line, Tumor; Cell Survival; Chemoprevention; Drug Delivery Systems; Dr | 2019 |
MicroRNA-365a-3p inhibits c-Rel-mediated NF-κB signaling and the progression of pancreatic cancer.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Mo | 2019 |
The molecular mechanism of action of aspirin, curcumin and sulforaphane combinations in the chemoprevention of pancreatic cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Aspirin; Cell Line, Tumor; Cell Survival; Curcumin; | 2013 |
A novel combinatorial nanotechnology-based oral chemopreventive regimen demonstrates significant suppression of pancreatic cancer neoplastic lesions.
Topics: Adenocarcinoma; Administration, Oral; Animals; Antineoplastic Agents; Antineoplastic Combined Chemot | 2013 |
Sulforaphane counteracts aggressiveness of pancreatic cancer driven by dysregulated Cx43-mediated gap junctional intercellular communication.
Topics: Adenocarcinoma; Anticarcinogenic Agents; Apoptosis; Blotting, Western; Carcinoma, Pancreatic Ductal; | 2014 |
Sulforaphane, quercetin and catechins complement each other in elimination of advanced pancreatic cancer by miR-let-7 induction and K-ras inhibition.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Pancreatic Ductal; | 2014 |
Evaluation of ibuprofen loaded solid lipid nanoparticles and its combination regimens for pancreatic cancer chemoprevention.
Topics: Anticarcinogenic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Surv | 2015 |
Continuous exposure of pancreatic cancer cells to dietary bioactive agents does not induce drug resistance unlike chemotherapy.
Topics: Antineoplastic Agents; Biomarkers, Tumor; Carcinogenesis; Cell Line, Tumor; Cell Survival; Clone Cel | 2016 |
Sulforaphane targets pancreatic tumour-initiating cells by NF-kappaB-induced antiapoptotic signalling.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Cells, Cultured; Down-Regulation; Gene Expression Regul | 2009 |
Fenugreek: a naturally occurring edible spice as an anticancer agent.
Topics: Anticarcinogenic Agents; Breast Neoplasms; Cell Death; Cell Line, Tumor; Diosgenin; Dose-Response Re | 2009 |
Sulforaphane: from chemoprevention to pancreatic cancer treatment?
Topics: Anticarcinogenic Agents; Apoptosis; Gene Expression Regulation, Neoplastic; Humans; Isothiocyanates; | 2009 |
Synergistic activity of sorafenib and sulforaphane abolishes pancreatic cancer stem cell characteristics.
Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase 1 Family; Animals; Antineoplastic Combined Chemothera | 2010 |
Dietary polyphenol quercetin targets pancreatic cancer stem cells.
Topics: Animals; Apoptosis; Cell Growth Processes; Cell Line, Tumor; Drug Synergism; Fluorescent Antibody Te | 2010 |
Sulforaphane increases drug-mediated cytotoxicity toward cancer stem-like cells of pancreas and prostate.
Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase 1 Family; Animals; Antineoplastic Combined Chemothera | 2011 |
Sulforaphane synergizes with quercetin to inhibit self-renewal capacity of pancreatic cancer stem cells.
Topics: Analysis of Variance; Apoptosis; Blotting, Western; Cell Line, Tumor; Drug Synergism; Genetic Vector | 2011 |
Autophagy and cell death signaling following dietary sulforaphane act independently of each other and require oxidative stress in pancreatic cancer.
Topics: Anticarcinogenic Agents; Autophagy; Cell Line, Tumor; Humans; Isothiocyanates; Oxidative Stress; Pan | 2011 |
Sulforaphane potentiates the efficacy of 17-allylamino 17-demethoxygeldanamycin against pancreatic cancer through enhanced abrogation of Hsp90 chaperone function.
Topics: Animals; Antineoplastic Agents; Benzoquinones; Blotting, Western; Brassica; Caspase 3; Cell Line, Tu | 2011 |
Sulforaphane inhibits pancreatic cancer through disrupting Hsp90-p50(Cdc37) complex and direct interactions with amino acids residues of Hsp90.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents, Phytogenic; Binding Sites; Cell Cycle Protei | 2012 |
Chemoprevention of pancreatic cancer using solid-lipid nanoparticulate delivery of a novel aspirin, curcumin and sulforaphane drug combination regimen.
Topics: Apoptosis; Aspirin; Cell Line, Tumor; Cell Survival; Chemoprevention; Curcumin; Drug Combinations; D | 2012 |
Sonic hedgehog signaling inhibition provides opportunities for targeted therapy by sulforaphane in regulating pancreatic cancer stem cell self-renewal.
Topics: Anticarcinogenic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation | 2012 |
Sulforaphane regulates self-renewal of pancreatic cancer stem cells through the modulation of Sonic hedgehog-GLI pathway.
Topics: Animals; Antineoplastic Agents; Apoptosis Regulatory Proteins; Cell Line, Tumor; Cell Proliferation; | 2013 |
The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice.
Topics: Animals; Anticarcinogenic Agents; Antigens; Apoptosis; Blotting, Western; Caspase 3; Caspase 8; Casp | 2004 |
Protective effects of benzyl isothiocyanate and sulforaphane but not resveratrol against initiation of pancreatic carcinogenesis in hamsters.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents, Phytogenic; Carcinogenicity Tests; Carcinogens; Cell | 2006 |