Page last updated: 2024-11-04

sulforaphane and Pancreatic Neoplasms

sulforaphane has been researched along with Pancreatic Neoplasms in 29 studies

sulforaphane: from Cardaria draba L.
sulforaphane : An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.

Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).

Research Excerpts

ExcerptRelevanceReference
"Pancreatic cancer is one of the most aggressive human cancers and is expected to surpass breast cancer to become the third chief cause of cancer-related deaths in the United States."2.55Plant Derived Inhibitor Sulforaphane in Combinatorial Therapy Against Therapeutically Challenging Pancreatic Cancer. ( Abdullah, E; Altaf, M; Ganai, SA; Rashid, R, 2017)
"The therapy resistance of pancreatic cancer is associated with the loss of gap junction intercellular communication and connexin 43 expression."1.56Inhibition of miR30a-3p by sulforaphane enhances gap junction intercellular communication in pancreatic cancer. ( Georgikou, C; Gladkich, J; Gretz, N; Gross, W; Herr, I; Karakhanova, S; Schäfer, M; Sticht, C; Torre, C; Xiao, X; Yin, L, 2020)
"However, its anti-tumor effect on pancreatic cancer is still poorly understood."1.48Activation of Nrf2 by Sulforaphane Inhibits High Glucose-Induced Progression of Pancreatic Cancer via AMPK Dependent Signaling. ( Chen, K; Chen, X; Duan, W; Jiang, Z; Li, X; Ma, J; Ma, Q; Wang, Z; Wu, Z; Zhou, C, 2018)
"In four established pancreatic cancer cell lines we investigated clonogenic survival, analyzed cell cycle distribution and compared DNA damage via flow cytometry and western blot after treatment with SFN and RT."1.46Sulforaphane enhances irradiation effects in terms of perturbed cell cycle progression and increased DNA damage in pancreatic cancer cells. ( Combs, SE; Debus, J; Fortunato, F; Liermann, J; Naumann, P; Schmid, TE; Weber, KJ, 2017)
"Pancreatic cancer is a deadly disease killing 37,000 Americans each year."1.39A novel combinatorial nanotechnology-based oral chemopreventive regimen demonstrates significant suppression of pancreatic cancer neoplastic lesions. ( Grandhi, BK; Prabhu, S; Thakkar, A; Wang, J, 2013)
"Sulforaphane inhibited pancreatic cancer cell growth in vitro with IC(50)s of around 10-15 μM and induced apoptosis."1.38Sulforaphane inhibits pancreatic cancer through disrupting Hsp90-p50(Cdc37) complex and direct interactions with amino acids residues of Hsp90. ( Boelens, R; Carroll, K; Duarte, AM; Jiang, Y; Karagöz, GE; Li, Y; Rüdiger, SG; Schwartz, SJ; Seo, YH; Sun, D; Yu, Y; Zhang, T, 2012)
"Pancreatic cancer is the fourth largest cause of cancer deaths in the Unites States and the prognosis is grim with <5% survival chances upon diagnosis."1.38Chemoprevention of pancreatic cancer using solid-lipid nanoparticulate delivery of a novel aspirin, curcumin and sulforaphane drug combination regimen. ( Grandhi, BK; Prabhu, S; Sutaria, D; Thakkar, A; Wang, J, 2012)
"Given the requirement for Hedgehog in pancreatic cancer, we investigated whether hedgehog blockade by SFN could target the stem cell population in pancreatic cancer."1.38Sonic hedgehog signaling inhibition provides opportunities for targeted therapy by sulforaphane in regulating pancreatic cancer stem cell self-renewal. ( Fu, J; Rodova, M; Shankar, S; Srivastava, RK; Watkins, DN, 2012)
"Sorafenib (SO) is a promising new multikinase inhibitor for treatment of advanced kidney and liver cancers."1.36Synergistic activity of sorafenib and sulforaphane abolishes pancreatic cancer stem cell characteristics. ( Baumann, B; Büchler, MW; Gladkich, J; Herr, I; Kallifatidis, G; Liu, L; Mattern, J; Rausch, V; Salnikov, AV; Schemmer, P; Wirth, T; Zöller, M, 2010)
"Using in vitro and in vivo models of pancreatic cancer stem cells we found quercetin-mediated reduction of self-renewal as measured by spheroid and colony formation."1.36Dietary polyphenol quercetin targets pancreatic cancer stem cells. ( Baumann, B; Büchler, MW; Giese, N; Gladkich, J; Herr, I; Kallifatidis, G; Mattern, J; Moldenhauer, G; Rausch, V; Salnikov, AV; Wirth, T; Zhou, W, 2010)
"Sulforaphane-treated cells accumulated in metaphase as determined by flow cytometry [4C DNA content, cyclin A(-), cyclin B1(+), and phospho-histone H3 (Ser(10))(+)]."1.32The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice. ( Cao, P; Gronda, M; Hedley, DW; Jacobberger, JW; Pham, NA; Schimmer, AD, 2004)

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (17.24)29.6817
2010's21 (72.41)24.3611
2020's3 (10.34)2.80

Authors

AuthorsStudies
Georgikou, C3
Yin, L3
Gladkich, J7
Xiao, X3
Sticht, C3
Torre, C1
Gretz, N2
Gross, W7
Schäfer, M1
Karakhanova, S2
Herr, I12
Buglioni, L1
Bremerich, M1
Roubicek, N1
Bolm, C1
Naumann, P2
Liermann, J1
Fortunato, F2
Schmid, TE1
Weber, KJ1
Debus, J1
Combs, SE1
Chen, X1
Jiang, Z1
Zhou, C1
Chen, K1
Li, X1
Wang, Z1
Wu, Z1
Ma, J1
Ma, Q1
Duan, W1
Desai, P1
Thakkar, A5
Ann, D1
Wang, J5
Prabhu, S5
Yin, Y2
Liu, L4
Luo, Y1
Fellenberg, J1
Lozanovski, VJ1
Polychronidis, G1
Gharabaghi, N1
Mehrabi, A1
Hackert, T1
Schemmer, P5
Sutaria, D2
Grandhi, BK3
Forster, T1
Rausch, V5
Zhang, Y2
Isayev, O1
Heilmann, K1
Schoensiegel, F1
Nessling, M1
Richter, K1
Labsch, S2
Nwaeburu, CC1
Mattern, J6
Giese, N2
Werner, J3
Gebhard, MM1
Gerhauser, C1
Schaefer, M1
Appari, M1
Babu, KR1
Kaczorowski, A1
Chenreddy, S1
Fan, P1
Zhao, Z1
Bauer, N1
Gao, C1
Ganai, SA1
Rashid, R1
Abdullah, E1
Altaf, M1
Kallifatidis, G4
Baumann, B3
Apel, A1
Beckermann, BM1
Groth, A1
Li, Z1
Kolb, A1
Moldenhauer, G3
Altevogt, P1
Wirth, T3
Büchler, MW5
Salnikov, AV4
Shabbeer, S1
Sobolewski, M1
Anchoori, RK1
Kachhap, S1
Hidalgo, M1
Jimeno, A1
Davidson, N1
Carducci, MA1
Khan, SR1
Lampe, JW1
Zöller, M1
Zhou, W1
Srivastava, RK3
Tang, SN1
Zhu, W1
Meeker, D1
Shankar, S3
Zentgraf, H1
Li, Y2
Zhang, T2
Schwartz, SJ2
Sun, D2
Karagöz, GE1
Seo, YH1
Jiang, Y1
Yu, Y1
Duarte, AM1
Boelens, R1
Carroll, K1
Rüdiger, SG1
Rodova, M1
Fu, J2
Watkins, DN2
Li, SH1
Pham, NA1
Jacobberger, JW1
Schimmer, AD1
Cao, P1
Gronda, M1
Hedley, DW1
Kuroiwa, Y1
Nishikawa, A1
Kitamura, Y1
Kanki, K1
Ishii, Y1
Umemura, T1
Hirose, M1

Reviews

1 review available for sulforaphane and Pancreatic Neoplasms

ArticleYear
Plant Derived Inhibitor Sulforaphane in Combinatorial Therapy Against Therapeutically Challenging Pancreatic Cancer.
    Anti-cancer agents in medicinal chemistry, 2017, Volume: 17, Issue:3

    Topics: Antineoplastic Agents, Phytogenic; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumo

2017

Trials

1 trial available for sulforaphane and Pancreatic Neoplasms

ArticleYear
Broccoli sprout supplementation in patients with advanced pancreatic cancer is difficult despite positive effects-results from the POUDER pilot study.
    Investigational new drugs, 2020, Volume: 38, Issue:3

    Topics: Aged; Biological Products; Brassica; Carcinoma, Pancreatic Ductal; Dietary Supplements; Female; Gluc

2020
Broccoli sprout supplementation in patients with advanced pancreatic cancer is difficult despite positive effects-results from the POUDER pilot study.
    Investigational new drugs, 2020, Volume: 38, Issue:3

    Topics: Aged; Biological Products; Brassica; Carcinoma, Pancreatic Ductal; Dietary Supplements; Female; Gluc

2020
Broccoli sprout supplementation in patients with advanced pancreatic cancer is difficult despite positive effects-results from the POUDER pilot study.
    Investigational new drugs, 2020, Volume: 38, Issue:3

    Topics: Aged; Biological Products; Brassica; Carcinoma, Pancreatic Ductal; Dietary Supplements; Female; Gluc

2020
Broccoli sprout supplementation in patients with advanced pancreatic cancer is difficult despite positive effects-results from the POUDER pilot study.
    Investigational new drugs, 2020, Volume: 38, Issue:3

    Topics: Aged; Biological Products; Brassica; Carcinoma, Pancreatic Ductal; Dietary Supplements; Female; Gluc

2020

Other Studies

27 other studies available for sulforaphane and Pancreatic Neoplasms

ArticleYear
Inhibition of miR30a-3p by sulforaphane enhances gap junction intercellular communication in pancreatic cancer.
    Cancer letters, 2020, 01-28, Volume: 469

    Topics: Adult; Aged; Animals; Cell Communication; Cell Line, Tumor; Connexin 43; Deoxycytidine; Female; Gap

2020
Novel Broccoli Sulforaphane-Based Analogues Inhibit the Progression of Pancreatic Cancer without Side Effects.
    Biomolecules, 2020, 05-15, Volume: 10, Issue:5

    Topics: Animals; Anticarcinogenic Agents; Apoptosis; Brassica; Caenorhabditis elegans; Chick Embryo; Hep G2

2020
Sulforaphane enhances irradiation effects in terms of perturbed cell cycle progression and increased DNA damage in pancreatic cancer cells.
    PloS one, 2017, Volume: 12, Issue:7

    Topics: Apoptosis; Blotting, Western; Cell Cycle; Cell Division; Cell Line, Tumor; Cell Proliferation; DNA D

2017
Activation of Nrf2 by Sulforaphane Inhibits High Glucose-Induced Progression of Pancreatic Cancer via AMPK Dependent Signaling.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2018, Volume: 50, Issue:3

    Topics: AMP-Activated Protein Kinases; Animals; Anticarcinogenic Agents; Apoptosis; Cell Line, Tumor; Cell M

2018
Loratadine self-microemulsifying drug delivery systems (SMEDDS) in combination with sulforaphane for the synergistic chemoprevention of pancreatic cancer.
    Drug delivery and translational research, 2019, Volume: 9, Issue:3

    Topics: Anticarcinogenic Agents; Cell Line, Tumor; Cell Survival; Chemoprevention; Drug Delivery Systems; Dr

2019
MicroRNA-365a-3p inhibits c-Rel-mediated NF-κB signaling and the progression of pancreatic cancer.
    Cancer letters, 2019, 06-28, Volume: 452

    Topics: Animals; Anticarcinogenic Agents; Apoptosis; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Mo

2019
The molecular mechanism of action of aspirin, curcumin and sulforaphane combinations in the chemoprevention of pancreatic cancer.
    Oncology reports, 2013, Volume: 29, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Aspirin; Cell Line, Tumor; Cell Survival; Curcumin;

2013
A novel combinatorial nanotechnology-based oral chemopreventive regimen demonstrates significant suppression of pancreatic cancer neoplastic lesions.
    Cancer prevention research (Philadelphia, Pa.), 2013, Volume: 6, Issue:10

    Topics: Adenocarcinoma; Administration, Oral; Animals; Antineoplastic Agents; Antineoplastic Combined Chemot

2013
Sulforaphane counteracts aggressiveness of pancreatic cancer driven by dysregulated Cx43-mediated gap junctional intercellular communication.
    Oncotarget, 2014, Mar-30, Volume: 5, Issue:6

    Topics: Adenocarcinoma; Anticarcinogenic Agents; Apoptosis; Blotting, Western; Carcinoma, Pancreatic Ductal;

2014
Sulforaphane, quercetin and catechins complement each other in elimination of advanced pancreatic cancer by miR-let-7 induction and K-ras inhibition.
    International journal of oncology, 2014, Volume: 45, Issue:4

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Pancreatic Ductal;

2014
Evaluation of ibuprofen loaded solid lipid nanoparticles and its combination regimens for pancreatic cancer chemoprevention.
    International journal of oncology, 2015, Volume: 46, Issue:4

    Topics: Anticarcinogenic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Surv

2015
Continuous exposure of pancreatic cancer cells to dietary bioactive agents does not induce drug resistance unlike chemotherapy.
    Cell death & disease, 2016, 06-02, Volume: 7, Issue:6

    Topics: Antineoplastic Agents; Biomarkers, Tumor; Carcinogenesis; Cell Line, Tumor; Cell Survival; Clone Cel

2016
Sulforaphane targets pancreatic tumour-initiating cells by NF-kappaB-induced antiapoptotic signalling.
    Gut, 2009, Volume: 58, Issue:7

    Topics: Animals; Anticarcinogenic Agents; Apoptosis; Cells, Cultured; Down-Regulation; Gene Expression Regul

2009
Fenugreek: a naturally occurring edible spice as an anticancer agent.
    Cancer biology & therapy, 2009, Volume: 8, Issue:3

    Topics: Anticarcinogenic Agents; Breast Neoplasms; Cell Death; Cell Line, Tumor; Diosgenin; Dose-Response Re

2009
Sulforaphane: from chemoprevention to pancreatic cancer treatment?
    Gut, 2009, Volume: 58, Issue:7

    Topics: Anticarcinogenic Agents; Apoptosis; Gene Expression Regulation, Neoplastic; Humans; Isothiocyanates;

2009
Synergistic activity of sorafenib and sulforaphane abolishes pancreatic cancer stem cell characteristics.
    Cancer research, 2010, Jun-15, Volume: 70, Issue:12

    Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase 1 Family; Animals; Antineoplastic Combined Chemothera

2010
Dietary polyphenol quercetin targets pancreatic cancer stem cells.
    International journal of oncology, 2010, Volume: 37, Issue:3

    Topics: Animals; Apoptosis; Cell Growth Processes; Cell Line, Tumor; Drug Synergism; Fluorescent Antibody Te

2010
Sulforaphane increases drug-mediated cytotoxicity toward cancer stem-like cells of pancreas and prostate.
    Molecular therapy : the journal of the American Society of Gene Therapy, 2011, Volume: 19, Issue:1

    Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase 1 Family; Animals; Antineoplastic Combined Chemothera

2011
Sulforaphane synergizes with quercetin to inhibit self-renewal capacity of pancreatic cancer stem cells.
    Frontiers in bioscience (Elite edition), 2011, 01-01, Volume: 3, Issue:2

    Topics: Analysis of Variance; Apoptosis; Blotting, Western; Cell Line, Tumor; Drug Synergism; Genetic Vector

2011
Autophagy and cell death signaling following dietary sulforaphane act independently of each other and require oxidative stress in pancreatic cancer.
    International journal of oncology, 2011, Volume: 39, Issue:1

    Topics: Anticarcinogenic Agents; Autophagy; Cell Line, Tumor; Humans; Isothiocyanates; Oxidative Stress; Pan

2011
Sulforaphane potentiates the efficacy of 17-allylamino 17-demethoxygeldanamycin against pancreatic cancer through enhanced abrogation of Hsp90 chaperone function.
    Nutrition and cancer, 2011, Volume: 63, Issue:7

    Topics: Animals; Antineoplastic Agents; Benzoquinones; Blotting, Western; Brassica; Caspase 3; Cell Line, Tu

2011
Sulforaphane inhibits pancreatic cancer through disrupting Hsp90-p50(Cdc37) complex and direct interactions with amino acids residues of Hsp90.
    The Journal of nutritional biochemistry, 2012, Volume: 23, Issue:12

    Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents, Phytogenic; Binding Sites; Cell Cycle Protei

2012
Chemoprevention of pancreatic cancer using solid-lipid nanoparticulate delivery of a novel aspirin, curcumin and sulforaphane drug combination regimen.
    International journal of oncology, 2012, Volume: 41, Issue:6

    Topics: Apoptosis; Aspirin; Cell Line, Tumor; Cell Survival; Chemoprevention; Curcumin; Drug Combinations; D

2012
Sonic hedgehog signaling inhibition provides opportunities for targeted therapy by sulforaphane in regulating pancreatic cancer stem cell self-renewal.
    PloS one, 2012, Volume: 7, Issue:9

    Topics: Anticarcinogenic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation

2012
Sulforaphane regulates self-renewal of pancreatic cancer stem cells through the modulation of Sonic hedgehog-GLI pathway.
    Molecular and cellular biochemistry, 2013, Volume: 373, Issue:1-2

    Topics: Animals; Antineoplastic Agents; Apoptosis Regulatory Proteins; Cell Line, Tumor; Cell Proliferation;

2013
The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice.
    Molecular cancer therapeutics, 2004, Volume: 3, Issue:10

    Topics: Animals; Anticarcinogenic Agents; Antigens; Apoptosis; Blotting, Western; Caspase 3; Caspase 8; Casp

2004
Protective effects of benzyl isothiocyanate and sulforaphane but not resveratrol against initiation of pancreatic carcinogenesis in hamsters.
    Cancer letters, 2006, Sep-28, Volume: 241, Issue:2

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents, Phytogenic; Carcinogenicity Tests; Carcinogens; Cell

2006