Compounds > butyl isothiocyanate
Page last updated: 2024-12-05

butyl isothiocyanate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Butyl isothiocyanate (BITC) is a naturally occurring compound found in cruciferous vegetables like broccoli, cabbage, and cauliflower. It is known for its pungent, mustard-like aroma. BITC is synthesized through a chemical reaction involving the condensation of an amine with carbon disulfide and subsequent treatment with an alkyl halide. It has been extensively studied for its diverse biological activities, including anticancer, anti-inflammatory, and antimicrobial properties. The compound is believed to exert its effects through various mechanisms, including modulation of cellular signaling pathways, induction of apoptosis, and inhibition of enzymatic activities. BITC has shown promising results in preclinical studies against various cancer cell lines, and its potential as a therapeutic agent is being explored in ongoing research. The study of BITC is crucial for understanding its potential health benefits and exploring its application in medicine and food science.'

butyl isothiocyanate : An isothiocyanate having a butyl group attached to the nitrogen. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID11613
CHEMBL ID1814588
CHEBI ID50534
SCHEMBL ID152568
MeSH IDM0117399

Synonyms (47)

Synonym
unii-4y31800s6c
4y31800s6c ,
1-isothiocyanato-butane
butane, 1-isothiocyanato-
isothiocyanic acid, butyl ester
nsc194808
nsc-194808
n-butyl isothiocyanate
butyl isothiocyanate
592-82-5
1-isothiocyanatobutane
ai3-18424
nsc 194808
einecs 209-770-4
butyl isothiocyanate, 99%
AKOS000118861
isothiocyanic acid butyl ester
I0249
A832240
chebi:50534 ,
CHEMBL1814588
isothiocyanic acid n-butyl ester
buncs
butylsenfoel
FT-0607991
butyl isothiocyanate [usp-rs]
butyl isothiocyanate [fhfi]
fema no. 4082
n-butylisothiocyanate
butylisothiocyanate
n-butyl-isothiocyanate
SCHEMBL152568
DTXSID7060467
1-butyl isothiocyanate
J-670003
1-isothiocyanatobutane #
n-butyl isothio cyanate
mfcd00004824
J-801002
butyl isothiocyanate, united states pharmacopeia (usp) reference standard
butyl isothiocyanate, analytical standard
butyl isothiocyanate, 8ci
F1915-0013
Q27122105
D91107
EN300-19446
Z104473876
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
haptenAny substance capable of eliciting an immune response only when attached to a large carrier such as a protein. Examples include dinitrophenols; oligosaccharides; peptides; and heavy metals.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
isothiocyanateAn organosulfur compound with the general formula R-N=C=S.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (39)

Assay IDTitleYearJournalArticle
AID1105244Antifungal activity against Sclerotinia sclerotiorum assessed as inhibition of mycelial growth in volatile phase at 84 umol/l measured at 20 degC after 5 days2011Pest management science, Jul, Volume: 67, Issue:7
In vitro and in vivo antifungal activity of synthetic pure isothiocyanates against Sclerotinia sclerotiorum.
AID1105127Fungistatic activity in Sclerotinia sclerotiorum assessed as inhibition of mycelial growth in contact phase measured at 20 degC after 5 days2011Pest management science, Jul, Volume: 67, Issue:7
In vitro and in vivo antifungal activity of synthetic pure isothiocyanates against Sclerotinia sclerotiorum.
AID1105093In vivo antifungal Sclerotinia sclerotiorum in Pepper (Capsicum annuum L. cv. Sera Demre) assessed as inhibition of mycelial growth in volatile phase at 168 umol/L measured after 10 to 14 weeks2011Pest management science, Jul, Volume: 67, Issue:7
In vitro and in vivo antifungal activity of synthetic pure isothiocyanates against Sclerotinia sclerotiorum.
AID1105242Antifungal activity against Sclerotinia sclerotiorum assessed as inhibition of mycelial growth in volatile phase at 588 umol/l measured at 20 degC after 5 days2011Pest management science, Jul, Volume: 67, Issue:7
In vitro and in vivo antifungal activity of synthetic pure isothiocyanates against Sclerotinia sclerotiorum.
AID611162Antiproliferative activity against doxorubicin-resistant human LoVo cells after 72 hrs by SRB assay2011Bioorganic & medicinal chemistry letters, Aug-01, Volume: 21, Issue:15
Synthesis and antiproliferative activity of novel α- and β-dialkoxyphosphoryl isothiocyanates.
AID1105173Antifungal activity against Sclerotinia sclerotiorum assessed as inhibition of germination in volatile phase at 844 umol/l measured at 20 degC after 5 days2011Pest management science, Jul, Volume: 67, Issue:7
In vitro and in vivo antifungal activity of synthetic pure isothiocyanates against Sclerotinia sclerotiorum.
AID1105114Fungistatic activity in Sclerotinia sclerotiorum assessed as inhibition of carpogenic germination in volatile phase at 422 umol/l measured at 20 degC after 5 days relative to control2011Pest management science, Jul, Volume: 67, Issue:7
In vitro and in vivo antifungal activity of synthetic pure isothiocyanates against Sclerotinia sclerotiorum.
AID1105245Antifungal activity against Sclerotinia sclerotiorum assessed as inhibition of mycelial growth in volatile phase at 42 umol/l measured at 20 degC after 5 days2011Pest management science, Jul, Volume: 67, Issue:7
In vitro and in vivo antifungal activity of synthetic pure isothiocyanates against Sclerotinia sclerotiorum.
AID1474541Cytotoxicity against human LoVo cells after 72 hrs by sulforhodamine B assay2017European journal of medicinal chemistry, May-26, Volume: 132Novel phosphonate analogs of sulforaphane: Synthesis, in vitro and in vivo anticancer activity.
AID1105177Antifungal activity against Sclerotinia sclerotiorum assessed as inhibition of germination in volatile phase at 42 umol/l measured at 20 degC after 5 days2011Pest management science, Jul, Volume: 67, Issue:7
In vitro and in vivo antifungal activity of synthetic pure isothiocyanates against Sclerotinia sclerotiorum.
AID611159Antiproliferative activity against human T47D cells after 72 hrs by SRB assay2011Bioorganic & medicinal chemistry letters, Aug-01, Volume: 21, Issue:15
Synthesis and antiproliferative activity of novel α- and β-dialkoxyphosphoryl isothiocyanates.
AID1474542Cytotoxicity against human LoVo/DX cells after 72 hrs by sulforhodamine B assay2017European journal of medicinal chemistry, May-26, Volume: 132Novel phosphonate analogs of sulforaphane: Synthesis, in vitro and in vivo anticancer activity.
AID1105137Fungitoxic activity in Sclerotinia sclerotiorum assessed as inhibition of mycelial growth in contact phase at 2531 umol/l measured at 20 degC after 5 days relative to control2011Pest management science, Jul, Volume: 67, Issue:7
In vitro and in vivo antifungal activity of synthetic pure isothiocyanates against Sclerotinia sclerotiorum.
AID611158Antiproliferative activity against human A549 cells after 72 hrs by SRB assay2011Bioorganic & medicinal chemistry letters, Aug-01, Volume: 21, Issue:15
Synthesis and antiproliferative activity of novel α- and β-dialkoxyphosphoryl isothiocyanates.
AID1105212Antifungal activity against Sclerotinia sclerotiorum assessed as inhibition of mycelial growth in contact phase at 591 umol/l measured at 20 degC after 5 days2011Pest management science, Jul, Volume: 67, Issue:7
In vitro and in vivo antifungal activity of synthetic pure isothiocyanates against Sclerotinia sclerotiorum.
AID1105209Antifungal activity against Sclerotinia sclerotiorum assessed as inhibition of mycelial growth in contact phase at 1688 umol/l measured at 20 degC after 5 days2011Pest management science, Jul, Volume: 67, Issue:7
In vitro and in vivo antifungal activity of synthetic pure isothiocyanates against Sclerotinia sclerotiorum.
AID1105115Fungistatic activity in Sclerotinia sclerotiorum assessed as inhibition of carpogenic germination in volatile phase at 84 umol/l measured at 20 degC after 5 days relative to control2011Pest management science, Jul, Volume: 67, Issue:7
In vitro and in vivo antifungal activity of synthetic pure isothiocyanates against Sclerotinia sclerotiorum.
AID1105241Antifungal activity against Sclerotinia sclerotiorum assessed as inhibition of mycelial growth in volatile phase at 840 umol/l measured at 20 degC after 5 days2011Pest management science, Jul, Volume: 67, Issue:7
In vitro and in vivo antifungal activity of synthetic pure isothiocyanates against Sclerotinia sclerotiorum.
AID1105126Fungistatic activity in Sclerotinia sclerotiorum assessed as inhibition of mycelial growth in volatile phase measured at 20 degC after 5 days2011Pest management science, Jul, Volume: 67, Issue:7
In vitro and in vivo antifungal activity of synthetic pure isothiocyanates against Sclerotinia sclerotiorum.
AID1105174Antifungal activity against Sclerotinia sclerotiorum assessed as inhibition of germination in volatile phase at 422 umol/l measured at 20 degC after 5 days2011Pest management science, Jul, Volume: 67, Issue:7
In vitro and in vivo antifungal activity of synthetic pure isothiocyanates against Sclerotinia sclerotiorum.
AID1105176Antifungal activity against Sclerotinia sclerotiorum assessed as inhibition of germination in volatile phase at 84 umol/l measured at 20 degC after 5 days2011Pest management science, Jul, Volume: 67, Issue:7
In vitro and in vivo antifungal activity of synthetic pure isothiocyanates against Sclerotinia sclerotiorum.
AID1105116Fungistatic activity in Sclerotinia sclerotiorum assessed as inhibition of carpogenic germination in volatile phase at 42 umol/l measured at 20 degC after 5 days relative to control2011Pest management science, Jul, Volume: 67, Issue:7
In vitro and in vivo antifungal activity of synthetic pure isothiocyanates against Sclerotinia sclerotiorum.
AID1396798Antiproliferative activity against human LoVo cells after 72 hrs by SRB assay2018Bioorganic & medicinal chemistry letters, 08-15, Volume: 28, Issue:15
Phosphorus-containing isothiocyanate-derived mercapturic acids as a useful alternative for parental isothiocyanates in experimental oncology.
AID611161Antiproliferative activity against human LoVo cells after 72 hrs by SRB assay2011Bioorganic & medicinal chemistry letters, Aug-01, Volume: 21, Issue:15
Synthesis and antiproliferative activity of novel α- and β-dialkoxyphosphoryl isothiocyanates.
AID611160Antiproliferative activity against human MCF7 cells after 72 hrs by SRB assay2011Bioorganic & medicinal chemistry letters, Aug-01, Volume: 21, Issue:15
Synthesis and antiproliferative activity of novel α- and β-dialkoxyphosphoryl isothiocyanates.
AID1105210Antifungal activity against Sclerotinia sclerotiorum assessed as inhibition of mycelial growth in contact phase at 844 umol/l measured at 20 degC after 5 days2011Pest management science, Jul, Volume: 67, Issue:7
In vitro and in vivo antifungal activity of synthetic pure isothiocyanates against Sclerotinia sclerotiorum.
AID1271567Antiproliferative activity against human LoVo/DX cells assessed as reduction in cell viability after 72 hrs by SRB assay2016Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2
Synthesis and biological activity of diisothiocyanate-derived mercapturic acids.
AID1105208Antifungal activity against Sclerotinia sclerotiorum assessed as inhibition of mycelial growth in contact phase at 2531 umol/l measured at 20 degC after 5 days2011Pest management science, Jul, Volume: 67, Issue:7
In vitro and in vivo antifungal activity of synthetic pure isothiocyanates against Sclerotinia sclerotiorum.
AID1396799Antiproliferative activity against human LoVo/DX cells after 72 hrs by SRB assay2018Bioorganic & medicinal chemistry letters, 08-15, Volume: 28, Issue:15
Phosphorus-containing isothiocyanate-derived mercapturic acids as a useful alternative for parental isothiocyanates in experimental oncology.
AID1105175Antifungal activity against Sclerotinia sclerotiorum assessed as inhibition of germination in volatile phase at 253 umol/l measured at 20 degC after 5 days2011Pest management science, Jul, Volume: 67, Issue:7
In vitro and in vivo antifungal activity of synthetic pure isothiocyanates against Sclerotinia sclerotiorum.
AID1271566Antiproliferative activity against human LoVo cells assessed as reduction in cell viability after 72 hrs by SRB assay2016Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2
Synthesis and biological activity of diisothiocyanate-derived mercapturic acids.
AID1105152Fungistatic activity in Sclerotinia sclerotiorum assessed as inhibition of mycelial growth in volatile phase at 588 umol/l measured at 20 degC after 5 days relative to control2011Pest management science, Jul, Volume: 67, Issue:7
In vitro and in vivo antifungal activity of synthetic pure isothiocyanates against Sclerotinia sclerotiorum.
AID1105243Antifungal activity against Sclerotinia sclerotiorum assessed as inhibition of mycelial growth in volatile phase at 422 umol/l measured at 20 degC after 5 days2011Pest management science, Jul, Volume: 67, Issue:7
In vitro and in vivo antifungal activity of synthetic pure isothiocyanates against Sclerotinia sclerotiorum.
AID1105142Fungistatic activity in Sclerotinia sclerotiorum assessed as inhibition of mycelial growth in contact phase at 1688 umol/l measured at 20 degC after 5 days relative to control2011Pest management science, Jul, Volume: 67, Issue:7
In vitro and in vivo antifungal activity of synthetic pure isothiocyanates against Sclerotinia sclerotiorum.
AID1105113Fungistatic activity in Sclerotinia sclerotiorum assessed as inhibition of carpogenic germination in volatile phase at 840 umol/l measured at 20 degC after 5 days relative to control2011Pest management science, Jul, Volume: 67, Issue:7
In vitro and in vivo antifungal activity of synthetic pure isothiocyanates against Sclerotinia sclerotiorum.
AID1105211Antifungal activity against Sclerotinia sclerotiorum assessed as inhibition of mycelial growth in contact phase at 759 umol/l measured at 20 degC after 5 days2011Pest management science, Jul, Volume: 67, Issue:7
In vitro and in vivo antifungal activity of synthetic pure isothiocyanates against Sclerotinia sclerotiorum.
AID1105133Fungistatic activity in Sclerotinia sclerotiorum assessed as viability in volatile phase at 844 umol/l measured at 20 degC after 5 days relative to control2011Pest management science, Jul, Volume: 67, Issue:7
In vitro and in vivo antifungal activity of synthetic pure isothiocyanates against Sclerotinia sclerotiorum.
AID1105125Fungistatic activity in Sclerotinia sclerotiorum assessed as sclerotial viability measured at 20 degC after 5 days2011Pest management science, Jul, Volume: 67, Issue:7
In vitro and in vivo antifungal activity of synthetic pure isothiocyanates against Sclerotinia sclerotiorum.
AID1105094In vivo antifungal Sclerotinia sclerotiorum in Pepper (Capsicum annuum L. cv. Sera Demre) assessed as inhibition of mycelial growth in volatile phase at 84 umol/L measured after 10 to 14 weeks2011Pest management science, Jul, Volume: 67, Issue:7
In vitro and in vivo antifungal activity of synthetic pure isothiocyanates against Sclerotinia sclerotiorum.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (13)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (7.69)18.7374
1990's0 (0.00)18.2507
2000's1 (7.69)29.6817
2010's8 (61.54)24.3611
2020's3 (23.08)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 28.00

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index28.00 (24.57)
Research Supply Index2.64 (2.92)
Research Growth Index5.03 (4.65)
Search Engine Demand Index24.28 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (28.00)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies1 (7.69%)4.05%
Observational0 (0.00%)0.25%
Other12 (92.31%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
carbon monoxide
Carbon Monoxide: Carbon monoxide (CO). A poisonous colorless, odorless, tasteless gas. It combines with hemoglobin to form carboxyhemoglobin, which has no oxygen carrying capacity. The resultant oxygen deprivation causes headache, dizziness, decreased pulse and respiratory rates, unconsciousness, and death. (From Merck Index, 11th ed). carbon monoxide : A one-carbon compound in which the carbon is joined only to a single oxygen. It is a colourless, odourless, tasteless, toxic gas.		210carbon oxide;
gas molecular entity;
one-carbon compound		biomarker;
EC 1.9.3.1 (cytochrome c oxidase) inhibitor;
human metabolite;
ligand;
metabolite;
mitochondrial respiratory-chain inhibitor;
mouse metabolite;
neurotoxin;
neurotransmitter;
P450 inhibitor;
probe;
signalling molecule;
vasodilator agent
dithionite
Dithionite: Dithionite. The dithionous acid ion and its salts.		210sulfur oxide;
sulfur oxoanion
3-nitropropionic acid
3-nitropropionic acid: succinate dehydrogenase inactivator; biosynthesized by FABACEAE plants from ASPARAGINE. 3-nitropropanoic acid : A C-nitro compound that is propanoic acid in which one of the methyl hydrogens has been replaced by a nitro group.		7.610C-nitro compoundantimycobacterial drug;
EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor;
mycotoxin;
neurotoxin
benzyl isothiocyanate
benzyl isothiocyanate: inhibits carcinogen-induced neoplasia; structure in Negwer, 5th ed, #715; also promotes urinary bladder carcinoma		3.250benzenes;
isothiocyanate		antibacterial drug
fomepizole
Fomepizole: A pyrazole and competitive inhibitor of ALCOHOL DEHYDROGENASE that is used for the treatment of poisoning by ETHYLENE GLYCOL or METHANOL.. fomepizole : A member of the class of pyrazoles that is 1H-pyrazole substituted by a methyl group at position 4.		210pyrazolesantidote;
EC 1.1.1.1 (alcohol dehydrogenase) inhibitor;
protective agent
mitoxantrone
Mitoxantrone: An anthracenedione-derived antineoplastic agent.. mitoxantrone : A dihydroxyanthraquinone that is 1,4-dihydroxy-9,10-anthraquinone which is substituted by 6-hydroxy-1,4-diazahexyl groups at positions 5 and 8.		2.5720dihydroxyanthraquinoneanalgesic;
antineoplastic agent
sulforaphane
sulforaphane: from Cardaria draba L.. sulforaphane : An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.		2.8130isothiocyanate;
sulfoxide		antineoplastic agent;
antioxidant;
EC 3.5.1.98 (histone deacetylase) inhibitor;
plant metabolite
allyl isothiocyanate
allyl isothiocyanate: used in the manufacture of flavors, war gases; medical use as a counterirritant; structure. allyl isothiocyanate : An isothiocyanate with the formula CH2=CHCH2N=C=S. A colorless oil with boiling point 152degreeC, it is responsible for the pungent taste of mustard, horseradish, and wasabi.		3.1450alkenyl isothiocyanate;
isothiocyanate		antimicrobial agent;
antineoplastic agent;
apoptosis inducer;
lachrymator;
metabolite
phenylisothiocyanate
phenylisothiocyanate: structure. phenyl isothiocyanate : An isothiocyanate having a phenyl group attached to the nitrogen; used for amino acid sequencing in the Edman degradation.		2.0610isothiocyanateallergen;
reagent
ethyl isothiocyanate
ethyl isothiocyanate : An isothiocyanate having an ethyl group attached to the nitrogen.		2.9540isothiocyanateallergen
methyl isothiocyanate
methyl isothiocyanate: structure. methyl isothiocyanate : An isothiocyanate having a methyl group attached to the nitrogen. It is also the active nematicide of the pronematicide metam-sodium.		2.420isothiocyanatefumigant;
lachrymator;
nematicide
acetylcysteine
N-acetyl-L-cysteine : An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.		2.420acetylcysteine;
L-cysteine derivative;
N-acetyl-L-amino acid		antidote to paracetamol poisoning;
antiinfective agent;
antioxidant;
antiviral drug;
ferroptosis inhibitor;
geroprotector;
human metabolite;
mucolytic;
radical scavenger;
vulnerary
deoxycytidine
[no description available]		2.4110pyrimidine 2'-deoxyribonucleosideEscherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
phenethyl isothiocyanate
phenethyl isothiocyanate: a dietary liver aldehyde dehydrogenase inhibitor; promotes urinary bladder carcinoma. phenethyl isothiocyanate : An isothiocyanate having a phenethyl group attached to the nitrogen. It is a naturally occurring compound found in some cruciferous vegetables (e.g. watercress) and is known to possess anticancer properties.		3.250isothiocyanateantineoplastic agent;
EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor;
metabolite
bitoscanate
bitoscanate: anthelmintic; minor descriptor (75-83); on-line & Index Medicus search THIOCYANATES (75-83); structure		2.1310benzenes
gemcitabine
gemcitabine : A 2'-deoxycytidine having geminal fluoro substituents in the 2'-position. An inhibitor of ribonucleotide reductase, gemcitabine is used in the treatment of various carcinomas, particularly non-small cell lung cancer, pancreatic cancer, bladder cancer and breast cancer.		2.4110organofluorine compound;
pyrimidine 2'-deoxyribonucleoside		antimetabolite;
antineoplastic agent;
antiviral drug;
DNA synthesis inhibitor;
EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor;
environmental contaminant;
immunosuppressive agent;
photosensitizing agent;
prodrug;
radiosensitizing agent;
xenobiotic
isothiocyanic acid
[no description available]		2.4110hydracid;
one-carbon compound
iodosobenzene
iodosobenzene: oxygen donor		210
nadp
[no description available]		210
2,3,4-tri-o-acetylarabinopyranosyl isothiocyanate
2,3,4-tri-O-acetylarabinopyranosyl isothiocyanate: RN given refers to (alpha-D)-isomer		2.4110
sirolimus
Sirolimus: A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.. sirolimus : A macrolide lactam isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent.		2.4110antibiotic antifungal drug;
cyclic acetal;
cyclic ketone;
ether;
macrolide lactam;
organic heterotricyclic compound;
secondary alcohol		antibacterial drug;
anticoronaviral agent;
antineoplastic agent;
bacterial metabolite;
geroprotector;
immunosuppressive agent;
mTOR inhibitor
heme
Heme: The color-furnishing portion of hemoglobin. It is found free in tissues and as the prosthetic group in many hemeproteins.. ferroheme : Any iron(II)--porphyrin coordination complex.. ferroheme b : Heme b in which the iron has oxidation state +2.. heme : A heme is any tetrapyrrolic chelate of iron.		210
ConditionIndicatedRelationship StrengthStudiesTrials
Cancer of Colon
[description not available]		02.520
Colonic Neoplasms
Tumors or cancer of the COLON.		02.520
Experimental Neoplasms
[description not available]		02.1710
Bladder Cancer
[description not available]		02.4110
Urinary Bladder Neoplasms
Tumors or cancer of the URINARY BLADDER.		02.4110
Carcinoma, Transitional Cell
A malignant neoplasm derived from TRANSITIONAL EPITHELIAL CELLS, occurring chiefly in the URINARY BLADDER; URETERS; or RENAL PELVIS.		02.4110
Neuroblastoma
A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)		02.610
Allergic Contact Dermatitis
[description not available]		07.2510
Dermatitis, Allergic Contact
A contact dermatitis due to allergic sensitization to various substances. These substances subsequently produce inflammatory reactions in the skin of those who have acquired hypersensitivity to them as a result of prior exposure.		02.2510
Cancer of Liver
[description not available]		02.0710
Cancer of Prostate
[description not available]		02.0710
Liver Neoplasms
Tumors or cancer of the LIVER.		02.0710
Prostatic Neoplasms
Tumors or cancer of the PROSTATE.		02.0710