Compounds > pmx 464
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pmx 464

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Description

PMX 464: induces Nrf2; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID482697
CHEMBL ID151831
SCHEMBL ID3677914
MeSH IDM0552906

Synonyms (22)

Synonym
4-(1,3-benzothiazol-2-yl)-4-hydroxy-cyclohexa-2,5-dien-1-one
4-benzothiazol-2-yl-4-hydroxy-cyclohexa-2,5-dienone
CHEMBL151831
4-(1,3-benzothiazol-2-yl)-4-hydroxycyclohexa-2,5-dien-1-one
4-(benzothiazol-2-yl)-4-hydroxy-2,5-cyclohexadien-1-one
4-benzothiazol-hcho
2,5-cyclohexadien-1-one, 4-(2-benzothiazolyl)-4-hydroxy-
pmx-464
aw-464
unii-yjx11v636q
yjx11v636q ,
485842-97-5
SCHEMBL3677914
pmx 464
4-(2-benzothiazolyl)-4-hydroxy-2,5-cyclohexadien-1-one
AKOS024458458
GS-1300
4-(benzothiazol-2-yl)-4-hydroxycyclohexa-2,5-dienone
pmx464
Q27294550
HY-108534
CS-0029102
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (85)

Assay IDTitleYearJournalArticle
AID214605Concentration of compound that cause 50% cytotoxicity of UACC-257 melanoma cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID78801Concentration of compound that cause 50% cytotoxicity of HCT-15 colon cancer cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID271194Antitumor activity against human NCI60 cells2006Bioorganic & medicinal chemistry letters, Oct-01, Volume: 16, Issue:19
Antitumour properties of fluorinated benzothiazole-substituted hydroxycyclohexa-2,5-dienones ('quinols').
AID143203Concentration of compound that cause 50% cytotoxicity of NCI-H460 non small cell lung cancer cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID202651Concentration of compound that cause 50% cytotoxicity of SK-OV-3 ovarian cancer cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID84627Concentration of compound that cause 50% cytotoxicity of HT-29 colon cancer cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID271197Inhibition of human thioredoxin signalling assessed as inhibition of insulin reduction at 50 uM2006Bioorganic & medicinal chemistry letters, Oct-01, Volume: 16, Issue:19
Antitumour properties of fluorinated benzothiazole-substituted hydroxycyclohexa-2,5-dienones ('quinols').
AID7248In vitro mean growth lethal concentration in renal subpanel against 60-cell panel2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID202322Concentration of compound that cause 50% cytotoxicity of SK-MEL-5 melanoma cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID78470Concentration of compound that cause 50% cytotoxicity of HCT116 colon cancer cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID7246In vitro mean growth lethal concentration against 60-cell panel2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID103354Inhibitory activity against MCF-7 mammary carcinoma cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID8227Concentration of compound that cause 50% cytotoxicity of 786-0 renal cancer cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID8277Concentration of compound that cause 50% cytotoxicity of A498 renal cancer cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID280946Growth inhibition of NCI60 cells2007Journal of medicinal chemistry, Apr-05, Volume: 50, Issue:7
Quinols as novel therapeutic agents. 7.1 Synthesis of antitumor 4-[1-(arylsulfonyl-1H-indol-2-yl)]-4-hydroxycyclohexa-2,5-dien-1-ones by Sonogashira reactions.
AID280954Growth inhibition of human A549 cells after 72 hrs by MTT assay2007Journal of medicinal chemistry, Apr-05, Volume: 50, Issue:7
Quinols as novel therapeutic agents. 7.1 Synthesis of antitumor 4-[1-(arylsulfonyl-1H-indol-2-yl)]-4-hydroxycyclohexa-2,5-dien-1-ones by Sonogashira reactions.
AID249100Mean in vitro LC50 value against human RXF 393 cell line was determined2005Journal of medicinal chemistry, Jan-27, Volume: 48, Issue:2
Quinols as novel therapeutic agents. 2.(1) 4-(1-Arylsulfonylindol-2-yl)-4-hydroxycyclohexa-2,5-dien-1-ones and related agents as potent and selective antitumor agents.
AID249103Mean in vitro LC50 value against 60 human cancer cell line was determined2005Journal of medicinal chemistry, Jan-27, Volume: 48, Issue:2
Quinols as novel therapeutic agents. 2.(1) 4-(1-Arylsulfonylindol-2-yl)-4-hydroxycyclohexa-2,5-dien-1-ones and related agents as potent and selective antitumor agents.
AID271191Antitumor activity against human MDA-MB-468 cells by MTT assay2006Bioorganic & medicinal chemistry letters, Oct-01, Volume: 16, Issue:19
Antitumour properties of fluorinated benzothiazole-substituted hydroxycyclohexa-2,5-dienones ('quinols').
AID50590In vitro lethal concentration against least sensitive colon SW-620 cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID271192Antitumor activity against human HCT116 cells by MTT assay2006Bioorganic & medicinal chemistry letters, Oct-01, Volume: 16, Issue:19
Antitumour properties of fluorinated benzothiazole-substituted hydroxycyclohexa-2,5-dienones ('quinols').
AID280947Growth inhibition of human HCT116 cells after 72 hrs by MTT assay2007Journal of medicinal chemistry, Apr-05, Volume: 50, Issue:7
Quinols as novel therapeutic agents. 7.1 Synthesis of antitumor 4-[1-(arylsulfonyl-1H-indol-2-yl)]-4-hydroxycyclohexa-2,5-dien-1-ones by Sonogashira reactions.
AID94864Concentration of compound that cause 50% cytotoxicity of KM12 colon cancer cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID145751Concentration of compound that cause 50% cytotoxicity of OVCAR-5 ovarian cancer cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID145730Concentration of compound that cause 50% cytotoxicity of OVCAR-4 ovarian cancer cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID102540Concentration of compound that cause 50% cytotoxicity of MALME -3M melanoma cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID81716Inhibitory activity against HCT116 colon cancer cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID200793Concentration of compound that cause 50% cytotoxicity of SF-268 CNS cancer cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID67453Concentration of compound that cause 50% cytotoxicity of EKVX non small cell lung cancer cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID84626Inhibitory activity against HT-29 colon cancer cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID100711Concentration of compound that cause 50% cytotoxicity of LOX IMVI melanoma cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID214775Concentration of compound that cause 50% cytotoxicity of UACC-62 melanoma cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID143492Concentration of compound that cause 50% cytotoxicity of NCI/ADR-RES breast cancer cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID271193Antitumor activity against human HT29 cells by MTT assay2006Bioorganic & medicinal chemistry letters, Oct-01, Volume: 16, Issue:19
Antitumour properties of fluorinated benzothiazole-substituted hydroxycyclohexa-2,5-dienones ('quinols').
AID144951Concentration of compound that cause 50% cytotoxicity of NCI-H226 non small cell lung cancer cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID79801Concentration of compound that cause 50% cytotoxicity of HCC2998 colon cancer cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID201995Concentration of compound that cause 50% cytotoxicity of SK-MEL-28 melanoma cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID644196Antitrypanosomal activity against blood stream form of Trypanosoma brucei after 69 hrs by resazurin-based fluorescence assay2012Bioorganic & medicinal chemistry, Feb-15, Volume: 20, Issue:4
Quinol derivatives as potential trypanocidal agents.
AID167580Concentration of compound that cause 50% cytotoxicity of RXF393 renal cancer cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID93639Concentration of compound that cause 50% cytotoxicity of IGROV1 ovarian cancer cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID101539Concentration of compound that cause 50% cytotoxicity of M14 melanoma cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID215138Concentration of compound that cause 50% cytotoxicity of UO-31 renal cancer cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID271195Inhibition of human thioredoxin signalling assessed as inhibition of insulin reduction at 10 uM2006Bioorganic & medicinal chemistry letters, Oct-01, Volume: 16, Issue:19
Antitumour properties of fluorinated benzothiazole-substituted hydroxycyclohexa-2,5-dienones ('quinols').
AID7245In vitro mean growth inhibitory activity against 60-cell panel2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID271196Inhibition of human thioredoxin signalling assessed as inhibition of insulin reduction at 25 uM2006Bioorganic & medicinal chemistry letters, Oct-01, Volume: 16, Issue:19
Antitumour properties of fluorinated benzothiazole-substituted hydroxycyclohexa-2,5-dienones ('quinols').
AID10048Concentration of compound that cause 50% cytotoxicity of ACHN renal cancer cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID247303Mean in vitro GI50 value against 60 human cancer cell line was determined2005Journal of medicinal chemistry, Jan-27, Volume: 48, Issue:2
Quinols as novel therapeutic agents. 2.(1) 4-(1-Arylsulfonylindol-2-yl)-4-hydroxycyclohexa-2,5-dien-1-ones and related agents as potent and selective antitumor agents.
AID644197Cytotoxicity against human MRC5 cells after 3 days by resazurin-based fluorescence assay2012Bioorganic & medicinal chemistry, Feb-15, Volume: 20, Issue:4
Quinol derivatives as potential trypanocidal agents.
AID7247In vitro mean growth lethal concentration in colon subpanel against 60-cell panel2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID280948Growth inhibition of human RXF393 cells after 72 hrs by MTT assay2007Journal of medicinal chemistry, Apr-05, Volume: 50, Issue:7
Quinols as novel therapeutic agents. 7.1 Synthesis of antitumor 4-[1-(arylsulfonyl-1H-indol-2-yl)]-4-hydroxycyclohexa-2,5-dien-1-ones by Sonogashira reactions.
AID42749Concentration of compound that cause 50% cytotoxicity of CAKI-1 renal cancer cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID44343Concentration of compound that cause 50% cytotoxicity of CCRF-CEM leukemia cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID200654Concentration of compound that cause 50% cytotoxicity of SNB-75 CNS cancer cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID58059Concentration of compound that cause 50% cytotoxicity of DU-145 prostate cancer cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID10027In vitro lethal concentration against most sensitive ACHN cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID201158Concentration of compound that cause 50% cytotoxicity of SR leukemia cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID249099Mean in vitro LC50 value against human HCT116 cell line was determined2005Journal of medicinal chemistry, Jan-27, Volume: 48, Issue:2
Quinols as novel therapeutic agents. 2.(1) 4-(1-Arylsulfonylindol-2-yl)-4-hydroxycyclohexa-2,5-dien-1-ones and related agents as potent and selective antitumor agents.
AID105647Concentration of compound that cause 50% cytotoxicity of MOLT-4 leukemia cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID145588Concentration of compound that cause 50% cytotoxicity of OVCAR-3 ovarian cancer cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID93969Concentration of compound that cause 50% cytotoxicity of K-562 leukemia cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID103415Concentration of compound that cause 50% cytotoxicity of MCF-7 breast cancer cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID46310Concentration of compound that cause 50% cytotoxicity of COLO 205 colon cancer cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID214220Concentration of compound that cause 50% cytotoxicity of U251 CNS cancer cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID81527Concentration of compound that cause 50% cytotoxicity of HOP-62 non small cell lung cancer cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID42285Concentration of compound that cause 50% cytotoxicity of BT-549 breast cancer cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID82671Concentration of compound that cause 50% cytotoxicity of HL-60(TB) leukemia cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID145083Concentration of compound that cause 50% cytotoxicity of NCI-H23 non small cell lung cancer cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID644200Selectivity ratio of EC50 for human MRC5 cells to EC50 for blood stream form of Trypanosoma brucei2012Bioorganic & medicinal chemistry, Feb-15, Volume: 20, Issue:4
Quinol derivatives as potential trypanocidal agents.
AID201871Concentration of compound that cause 50% cytotoxicity of SW-620 colon cancer cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID8296Inhibitory activity against A549 lung adenocarcinoma cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID271198Inhibition of human thioredoxin signalling assessed as inhibition of insulin reduction at 100 uM2006Bioorganic & medicinal chemistry letters, Oct-01, Volume: 16, Issue:19
Antitumour properties of fluorinated benzothiazole-substituted hydroxycyclohexa-2,5-dienones ('quinols').
AID200976Concentration of compound that cause 50% cytotoxicity of SF-295 CNS cancer cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID9285Concentration of compound that cause 50% cytotoxicity of A549/ATCC non small cell lung cancer cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID201829Concentration of compound that cause 50% cytotoxicity of SK-MEL-2 melanoma cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID145198Concentration of compound that cause 50% cytotoxicity of NCI-H322M non small cell lung cancer cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID145902Concentration of compound that cause 50% cytotoxicity of OVCAR-8 ovarian cancer cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID84357Concentration of compound that cause 50% cytotoxicity of HOP-92 non small cell lung cancer cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID105437Inhibitory activity against MDA-468 mammary carcinoma cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID200472Concentration of compound that cause 50% cytotoxicity of SN12C renal cancer cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID102140Concentration of compound that cause 50% cytotoxicity of MDA-MB-435 breast cancer cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID50587In vitro lethal concentration against most sensitive colon HCT116 cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID271190Antitumor activity against human MCF7 cells by MTT assay2006Bioorganic & medicinal chemistry letters, Oct-01, Volume: 16, Issue:19
Antitumour properties of fluorinated benzothiazole-substituted hydroxycyclohexa-2,5-dienones ('quinols').
AID101958Concentration of compound that cause 50% cytotoxicity of MDA-MB-231/ATCC breast cancer cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID85222Concentration of compound that cause 50% cytotoxicity of Hs 578.T breast cancer cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
AID105224Concentration of compound that cause 50% cytotoxicity of MDA-N breast cancer cell line2003Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (13)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's8 (61.54)29.6817
2010's5 (38.46)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other13 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
spermidine
[no description available]		2.0610polyazaalkane;
triamine		autophagy inducer;
fundamental metabolite;
geroprotector
diminazene
Diminazene: An effective trypanocidal agent.. diminazene : A triazene derivative that is triazene in which each of the terminal nitrogens is substituted by a 4-carbamimidoylphenyl group.		2.0710carboxamidine;
triazene derivative		antiparasitic agent;
trypanocidal drug
pentamidine
Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.. pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.		2.0710aromatic ether;
carboxamidine;
diether		anti-inflammatory agent;
antifungal agent;
calmodulin antagonist;
chemokine receptor 5 antagonist;
EC 2.3.1.48 (histone acetyltransferase) inhibitor;
NMDA receptor antagonist;
S100 calcium-binding protein B inhibitor;
trypanocidal drug;
xenobiotic
sulforaphane
sulforaphane: from Cardaria draba L.. sulforaphane : An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.		2.0510isothiocyanate;
sulfoxide		antineoplastic agent;
antioxidant;
EC 3.5.1.98 (histone deacetylase) inhibitor;
plant metabolite
thiazoles
[no description available]		2.94401,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
melarsoprol
Melarsoprol: Arsenical used in trypanosomiases. It may cause fatal encephalopathy and other undesirable side effects.		2.0710triazines
tiletamine hydrochloride
Cyclohexanones: Cyclohexane ring substituted by one or more ketones in any position.. cyclohexanones : Any alicyclic ketone based on a cyclohexane skeleton and its substituted derivatives thereof.		3.1250
trypanothione
trypanothione disulfide : An organic disulfide resulting from the formal oxidative coupling of the thiol groups of N(1),N(8)-bis(glutathionyl)-spermidine from the insect-parasitic trypanosomatid Crithidia fasciculata.		2.0610organic disulfide
1-methylpropyl-2-imidazolyl disulfide
1-methylpropyl-2-imidazolyl disulfide: a thioredoxin inhibitor with antineoplastic activity		2.1310imidazoles
cysteine
Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.		2.0610cysteiniumfundamental metabolite
ristocetin
Ristocetin: An antibiotic mixture of two components, A and B, obtained from Nocardia lurida (or the same substance produced by any other means). It is no longer used clinically because of its toxicity. It causes platelet agglutination and blood coagulation and is used to assay those functions in vitro.. ristocetin : A heterodetic cyclic peptide that is produced by species of Amycolatopsis and Nocardia.		2.1310glycopeptide;
heterodetic cyclic peptide;
macrocycle;
tetrasaccharide derivative		antibacterial drug;
antimicrobial agent;
bacterial metabolite;
platelet-activating factor receptor agonist
ConditionIndicatedRelationship StrengthStudiesTrials
Cancer of Colon
[description not available]		02.9440
Cancer of Kidney
[description not available]		02.4320
Colonic Neoplasms
Tumors or cancer of the COLON.		02.9440
Kidney Neoplasms
Tumors or cancers of the KIDNEY.		02.4320
Anoxemia
[description not available]		02.0210
Breast Cancer
[description not available]		02.4320
Angiogenesis, Pathologic
[description not available]		02.0210
Hypoxia
Sub-optimal OXYGEN levels in the ambient air of living organisms.		02.0210
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.4320
Blood Clot
[description not available]		02.1310
Thrombosis
Formation and development of a thrombus or blood clot in the blood vessel.		02.1310
Trypanosomiasis
Infection with protozoa of the genus TRYPANOSOMA.		02.0610