Compounds > nitrobenzanthrone
Page last updated: 2024-12-10

nitrobenzanthrone

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Description

3-nitrobenzanthrone: mutagenic environmental contaminant; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID2825690
CHEBI ID181932
SCHEMBL ID7168071
MeSH IDM0300997

Synonyms (20)

Synonym
CHEBI:181932
3-nitrobenzo[b]phenalen-7-one
7h-benz(de)anthracen-7-one, 3-nitro-
3-nitrobenzanthrone
ccris 9003
3-nitro-7h-benz(de)anthracen-7-one
nitrobenzanthrone
17117-34-9
SCHEMBL7168071
o4ojw7bc7w ,
unii-o4ojw7bc7w
QAJOWHGESRCVLY-UHFFFAOYSA-N
C20824
3-nitro-7h-benzo[d,e]anthracen-7-one
7h-benz[de]anthracen-7-one,3-nitro-
FT-0710181
3-nitro-7h-benzo[de]anthracen-7-one
DTXSID60881271
Q3598796
3-nitrobenzanthrone [iarc]

Research Excerpts

Overview

3-Nitrobenzanthrone (3-NBA) is a byproduct of diesel exhaust and is highly present in industrial and populated areas. It is a mutagen and suspected human carcinogen detected in diesel exhaust, airborne particulates, and urban soil.

ExcerptReferenceRelevance
"3-Nitrobenzanthrone (3-NBA) is a suspected human carcinogen present in diesel exhaust. "( Induction of the Antioxidant Response by the Transcription Factor NRF2 Increases Bioactivation of the Mutagenic Air Pollutant 3-Nitrobenzanthrone in Human Lung Cells.
de la Vega, L; Duan, L; Hayes, JD; Murray, JR; Penning, TM, 2019)		1.44
"3-Nitrobenzanthrone (3-NBA) is a byproduct of diesel exhaust and is highly present in industrial and populated areas. "( Kinetic Investigation of Translesion Synthesis across a 3-Nitrobenzanthrone-Derived DNA Lesion Catalyzed by Human DNA Polymerase Kappa.
Phi, KK; Smith, MC; Suo, Z; Tokarsky, EJ, 2019)		1.48
"3-Nitrobenzanthrone (3-NBA) is a highly mutagenic compound and possible human carcinogen found in diesel exhaust. "( TP53 and lacZ mutagenesis induced by 3-nitrobenzanthrone in Xpa-deficient human TP53 knock-in mouse embryo fibroblasts.
Arlt, VM; Kucab, JE; Luijten, M; Phillips, DH; Schmeiser, HH; van Steeg, H; Zwart, EP, 2016)		1.42
"3-Nitrobenzanthrone (3-NBA) is a potent environmental mutagen and a potential human carcinogen present in diesel exhaust and airborne particulates. "( Mutagenic specificity of N-acetoxy-3-aminobenzanthrone, a major metabolically activated form of 3-nitrobenzanthrone, in shuttle vector plasmids propagated in human cells.
Kawanishi, M; Nishida, H; Takamura-Enya, T; Yagi, T, 2008)		1.28
"3-Nitrobenzanthrone (3-NBA) is a mutagen and suspected human carcinogen detected in diesel exhaust, airborne particulate matter, and urban soil. "( Tissue-specific metabolic activation and mutagenicity of 3-nitrobenzanthrone in MutaMouse.
Chen, G; Douglas, GR; Gingerich, J; Soper, L; White, PA, 2008)		1.31
"3-Nitrobenzanthrone (3-NBA) is a potent mutagen and suspected human carcinogen identified in diesel exhaust and urban air pollution."( Genotoxicity of 3-nitrobenzanthrone and 3-aminobenzanthrone in MutaMouse and lung epithelial cells derived from MutaMouse.
Arlt, VM; Douglas, GR; Gingerich, J; Phillips, DH; Schmeiser, HH; White, PA, 2008)		1.24
"3-Nitrobenzanthrone (3-NBA) is a potent mutagen and a suspected human carcinogen present in particulate matter of diesel exhaust and ambient air pollution. "( The carcinogenic air pollutant 3-nitrobenzanthrone induces GC to TA transversion mutations in human p53 sequences.
Hollstein, MC; Krais, A; Schmeiser, HH; vom Brocke, J; Whibley, C, 2009)		1.36
"3-Nitrobenzanthrone (3-NBA) is a mutagenic and carcinogenic environmental pollutant found in diesel exhaust and urban air pollution. "( 3-Nitrobenzanthrone and 3-aminobenzanthrone induce DNA damage and cell signalling in Hepa1c1c7 cells.
Arlt, VM; Holme, JA; Lagadic-Gossmann, D; Landvik, NE; Nagy, E; Phillips, DH; Refsnes, M; Schmeiser, HH; Solhaug, A; Tekpli, X, 2010)		1.8
"3-Nitrobenzanthrone (3-NBA) is a potent mutagen and suspected human carcinogen identified in diesel exhaust. "( Theoretical investigations on the formation of nitrobenzanthrone-DNA adducts.
Arlt, VM; Phillips, DH; Reynisson, J, 2011)		1.35
"3-Nitrobenzanthrone (3-NBA) is an extremely potent mutagen and suspect human carcinogen found in diesel exhaust. "( Carcinogenic 3-nitrobenzanthrone but not 2-nitrobenzanthrone is metabolised to an unusual mercapturic acid in rats.
Frantík, E; Hanzlíková, I; Himl, M; Linhart, I; Mráz, J; Silhánková, A, 2012)		1.45
"3-Nitrobenzanthrone (3-NBA) is an extremely strong mutagen and carcinogen in rats inducing squamous cell carcinoma and adenocarcinoma. "( Development of a two-dimensional high-performance liquid chromatography system coupled with on-line reduction as a new efficient analytical method of 3-nitrobenzanthrone, a potential human carcinogen.
Hasei, T; Nakanishi, H; Toda, Y; Watanabe, T, 2012)		1.3
"3-nitrobenzanthrone (3-NBA) is a potent mutagen and suspected human carcinogen identified in diesel exhaust and ambient air pollution. "( Activation of 3-nitrobenzanthrone and its metabolites by human acetyltransferases, sulfotransferases and cytochrome P450 expressed in Chinese hamster V79 cells.
Arlt, VM; Frank, H; Glatt, H; Muckel, E; Pabel, U; Phillips, DH; Schmeiser, HH; Seidel, A; Sorg, BL, 2003)		1.39
"3-nitrobenzanthrone (3-NBA) is an extremely potent mutagen in the Salmonella reversion assay and a suspected human carcinogen identified in diesel exhaust and in ambient airborne particulate matter. "( DNA adducts and mutagenic specificity of the ubiquitous environmental pollutant 3-nitrobenzanthrone in Muta Mouse.
Arlt, VM; Hayashi, M; Honma, M; Phillips, DH; Schmeiser, HH; Suzuki, T; Zhan, L, 2004)		1.27
"3-Nitrobenzanthrone (3-NBA) is a suspected human carcinogen found in diesel exhaust and ambient air pollution. "( 3-aminobenzanthrone, a human metabolite of the environmental pollutant 3-nitrobenzanthrone, forms DNA adducts after metabolic activation by human and rat liver microsomes: evidence for activation by cytochrome P450 1A1 and P450 1A2.
Arlt, VM; Hewer, A; Phillips, DH; Schmeiser, HH; Sorg, BL; Stiborova, M, 2004)		1.28
"3-Nitrobenzanthrone (3-NBA) is an environmental pollutant and suspected human carcinogen found in emissions from diesel and gasoline engines and on the surface of ambient air particulate matter; human exposure to 3-NBA is likely to occur primarily via the respiratory tract. "( DNA adduct formation by the environmental contaminant 3-nitrobenzanthrone after intratracheal instillation in rats.
Arlt, VM; Bieler, CA; Cornelius, MG; Klein, R; Phillips, DH; Schmeiser, HH; Wiessler, M, 2005)		1.3
"3-Nitrobenzanthrone (3-NBA) is a suspected human carcinogen found in diesel exhaust and ambient air pollution. "( Bioactivation of 3-aminobenzanthrone, a human metabolite of the environmental pollutant 3-nitrobenzanthrone: evidence for DNA adduct formation mediated by cytochrome P450 enzymes and peroxidases.
Arlt, VM; Henderson, CJ; Phillips, DH; Schmeiser, HH; Stiborova, M; Wolf, CR, 2006)		1.28
"3-Nitrobenzanthrone (3-NBA) is a potent mutagen and potential human carcinogen identified in diesel exhaust and ambient air particulate matter. "( Synthesis, characterization, and 32p-postlabeling analysis of DNA adducts derived from the environmental contaminant 3-nitrobenzanthrone.
Arlt, VM; Bieler, CA; Hull, WE; Kliem, C; Mirza, A; Osborne, MR; Phillips, DH; Schmeiser, HH, 2005)		1.26
"3-Nitrobenzanthrone (3-NBA) is a potent mutagen and possible human carcinogen present in diesel exhaust and airborne particulate matter. "( Assessment of 3-nitrobenzanthrone reductase activity in mammalian tissues by normal-phase HPLC with fluorescence detection.
Chen, G; Douglas, GR; Lambert, IB; White, PA, 2005)		1.4
"3-Nitrobenzanthrone (3-NBA) is a potent mutagen and potential human carcinogen identified in diesel exhaust and ambient air particulate matter. "( Identification of three major DNA adducts formed by the carcinogenic air pollutant 3-nitrobenzanthrone in rat lung at the C8 and N2 position of guanine and at the N6 position of adenine.
Arlt, VM; Kanno, T; Kawanishi, M; Osborne, MR; Phillips, DH; Schmeiser, HH; Takamura-Enya, T; Yagi, T, 2006)		1.28
"3-Nitrobenzanthrone (3-NBA) is an extremely potent mutagen in diesel exhaust. "( Carcinogenic 3-nitrobenzanthrone induces oxidative damage to isolated and cellular DNA.
Hisamatsu, Y; Kawanishi, S; Murata, M; Ohnishi, S; Takamura-Enya, T; Tezuka, T, 2006)		1.41
"3-Nitrobenzanthrone (3-NBA) is a suspected human carcinogen identified in diesel exhaust and air pollution. "( Molecular mechanism of genotoxicity of the environmental pollutant 3-nitrobenzanthrone.
Arlt, VM; Frei, E; Henderson, CJ; Phillips, DH; Schmeiser, HH; Stiborová, M; Wolf, CR, 2005)		1.28
"3-Nitrobenzanthrone (3-NBA) is an urban air pollutant and rat lung carcinogen that is among the most potent mutagens yet tested in the Salmonella reversion assay. "( DNA damage and acute toxicity caused by the urban air pollutant 3-nitrobenzanthrone in rats: characterization of DNA adducts in eight different tissues and organs with synthesized standards.
Adachi, S; Möller, L; Nagy, E; Takamura-Enya, T; Zeisig, M, 2006)		1.29
"3-Nitrobenzanthrone is a powerful bacterial mutagen and carcinogen to mammals. "( Structural identification of DNA adducts derived from 3-nitrobenzanthrone, a potent carcinogen present in the atmosphere.
Hisamatsu, Y; Kawanishi, M; Takamura-Enya, T; Yagi, T, 2007)		1.31
"3-Nitrobenzanthrone (3-NBA) is a carcinogen occurring in diesel exhaust and air pollution. "( The environmental pollutant and carcinogen 3-nitrobenzanthrone induces cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase in rat lung and kidney, thereby enhancing its own genotoxicity.
Arlt, VM; Dracínská, H; Frei, E; Hodek, P; Hudecek, J; Mizerovská, J; Phillips, DH; Schmeiser, HH; Stiborová, M, 2008)		1.33
"3-Nitrobenzanthrone (NBA) is a powerful bacterial mutagen and a suspected human carcinogen present in diesel exhaust and airborne particulates [Enya, T., et al. "( Mutagenic specificity of a derivative of 3-nitrobenzanthrone in the supF shuttle vector plasmids.
Enya, T; Kawanishi, M; Matsui, S; Suzuki, H; Takebe, H; Yagi, T, 1998)		1.28

Effects

2-Nitrobenzanthrone (2-NBA) has recently been detected in ambient air particulate matter. 3- nitrobenzenthrone has been isolated from diesel exhaust and airborne particles and identified as a potent direct-acting mutagen in vitro and genotoxic agent in vivo.

ExcerptReferenceRelevance
"2-Nitrobenzanthrone (2-NBA) has recently been detected in ambient air particulate matter. "( Mechanisms of the different DNA adduct forming potentials of the urban air pollutants 2-nitrobenzanthrone and carcinogenic 3-nitrobenzanthrone.
Arlt, VM; Dvorák, Z; Frei, E; Martínek, V; Phillips, DH; Schmeiser, HH; Simánek, V; Sístková, J; Stiborová, M; Svobodová, M; Ulrichová, J, 2010)		1.3
"2-Nitrobenzanthrone (2-NBA) has recently been detected in ambient air particulate matter. "( Activation and detoxification metabolism of urban air pollutants 2-nitrobenzanthrone and carcinogenic 3-nitrobenzanthrone by rat and mouse hepatic microsomes.
Arlt, VM; Borek-Dohalska, L; Cechova, T; Frei, E; Moserova, M; Paca, J; Schmeiser, HH; Stiborova, M, 2012)		1.34
"3-Nitrobenzanthrone (3-NBA) has been isolated from diesel exhaust and airborne particles and identified as a potent direct-acting mutagen in vitro and genotoxic agent in vivo. "( DNA adduct and tumor formations in rats after intratracheal administration of the urban air pollutant 3-nitrobenzanthrone.
Adachi, S; Hisamatsu, Y; Kawamura, K; Möller, L; Nagy, E; Sugeta, A; Zeisig, M, 2005)		1.26
"2-Nitrobenzanthrone (2-NBA) has recently been detected in ambient air particulate matter. "( Mutagenicity and DNA adduct formation by the urban air pollutant 2-nitrobenzanthrone.
Arlt, VM; Gamboa da Costa, G; Glatt, H; Phillips, DH; Reynisson, J; Takamura-Enya, T, 2007)		1.3

Toxicity

ExcerptReferenceRelevance
" The numerous toxic manifestations are discussed."( Nitroaromatic compounds: Environmental toxicity, carcinogenicity, mutagenicity, therapy and mechanism.
Kovacic, P; Somanathan, R, 2014)		0.4

Dosage Studied

ExcerptRelevanceReference
" In this study, acid hydrolysate of globin from rats dosed intraperitoneally with 3-NBA was analysed by HPLC/MS to identify a novel type of cysteine adduct, 3-aminobenzanthron-2-ylcysteine (3-ABA-Cys), confirmed using a synthesised standard."( S-(3-Aminobenzanthron-2-yl)cysteine in the globin of rats as a novel type of adduct and possible biomarker of exposure to 3-nitrobenzanthrone, a potent environmental carcinogen.
Dušková, Š; Hanzlíková, I; Linhart, I; Mráz, J, 2017)		0.66
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
phenanthrenesAny benzenoid aromatic compound that consists of a phenanthrene skeleton and its substituted derivatives thereof.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (86)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's3 (3.49)18.2507
2000's45 (52.33)29.6817
2010's34 (39.53)24.3611
2020's4 (4.65)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 21.63

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index21.63 (24.57)
Research Supply Index4.47 (2.92)
Research Growth Index5.36 (4.65)
Search Engine Demand Index18.60 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (21.63)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews5 (5.81%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other81 (94.19%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
adenine
[no description available]		7.44206-aminopurines;
purine nucleobase		Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
cytosine
[no description available]		2.0510aminopyrimidine;
pyrimidine nucleobase;
pyrimidone		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
hydroxylamine
amino alcohol : An alcohol containing an amino functional group in addition to the alcohol-defining hydroxy group.		2.0510hydroxylaminesalgal metabolite;
bacterial xenobiotic metabolite;
EC 1.1.3.13 (alcohol oxidase) inhibitor;
EC 4.2.1.22 (cystathionine beta-synthase) inhibitor;
EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor;
nitric oxide donor;
nucleophilic reagent
thymine
[no description available]		2.0510pyrimidine nucleobase;
pyrimidone		Escherichia coli metabolite;
human metabolite;
mouse metabolite
aristolochic acid i
aristolochic acid I: phospholipase A inhibitor. aristolochic acid A : An aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.		9.3930aristolochic acids;
aromatic ether;
C-nitro compound;
cyclic acetal;
monocarboxylic acid;
organic heterotetracyclic compound		carcinogenic agent;
metabolite;
mutagen;
nephrotoxin;
toxin
benzo(a)pyrene
Benzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.. benzo[a]pyrene : An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.		3.3660ortho- and peri-fused polycyclic arenecarcinogenic agent;
mouse metabolite
sulforaphane
sulforaphane: from Cardaria draba L.. sulforaphane : An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.		2.2110isothiocyanate;
sulfoxide		antineoplastic agent;
antioxidant;
EC 3.5.1.98 (histone deacetylase) inhibitor;
plant metabolite
4-nitroquinoline-1-oxide
4-nitroquinoline N-oxide : A quinoline N-oxide carrying a nitro substituent at position 4.		2.1710C-nitro compound;
quinoline N-oxide		carcinogenic agent
9,10-dimethyl-1,2-benzanthracene
9,10-Dimethyl-1,2-benzanthracene: Polycyclic aromatic hydrocarbon found in tobacco smoke that is a potent carcinogen.. 7,12-dimethyltetraphene : A tetraphene having methyl substituents at the 7- and 12-positions. It is a potent carcinogen and is present in tobacco smoke.		2.0510ortho-fused polycyclic arene;
tetraphenes		carcinogenic agent
phencyclidine
Phencyclidine: A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to KETAMINE in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE). As a drug of abuse, it is known as PCP and Angel Dust.. phencyclidine : A member of the class of piperidines that is piperidine in which the nitrogen is substituted with a 1-phenylcyclohexyl group. Formerly used as an anaesthetic agent, it exhibits both hallucinogenic and neurotoxic effects.		2.0710benzenes;
piperidines		anaesthetic;
neurotoxin;
NMDA receptor antagonist;
psychotropic drug
3-bromobenzanthrone
[no description available]		2.610
benzanthrone
benzanthrone: RN given refers to parent cpd		7.610phenanthrenes
4-nitrobiphenyl
4-nitrobiphenyl: structure given in first source		3.1910biphenyls
oleanolic acid
[no description available]		2.2110hydroxy monocarboxylic acid;
pentacyclic triterpenoid		plant metabolite
acetylcysteine
N-acetyl-L-cysteine : An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.		2.0710acetylcysteine;
L-cysteine derivative;
N-acetyl-L-amino acid		antidote to paracetamol poisoning;
antiinfective agent;
antioxidant;
antiviral drug;
ferroptosis inhibitor;
geroprotector;
human metabolite;
mucolytic;
radical scavenger;
vulnerary
1-nitropyrene
[no description available]		2.5420nitroarenecarcinogenic agent
1,6-dinitropyrene
[no description available]		2.0110pyrenes
1,8-dinitropyrene
[no description available]		2.0110pyrenes
1,3-dinitropyrene
[no description available]		2.0110pyrenes
bathocuproine
bathocuproine: reagent for copper; RN given refers to parent cpd		2.0310
1,7-phenanthroline
[no description available]		2.0310phenanthroline
arachidonic acid
icosa-5,8,11,14-tetraenoic acid : Any icosatetraenoic acid with the double bonds at positions 5, 8, 11 and 14.. arachidonate : A long-chain fatty acid anion resulting from the removal of a proton from the carboxy group of arachidonic acid.		2.2110icosa-5,8,11,14-tetraenoic acid;
long-chain fatty acid;
omega-6 fatty acid		Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
human metabolite;
mouse metabolite
dactinomycin
Dactinomycin: A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)		2.1710actinomycinmutagen
melphalan
Melphalan: An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen.. melphalan : A phenylalanine derivative comprising L-phenylalanine having [bis(2-chloroethyl)amino group at the 4-position on the phenyl ring.		210L-phenylalanine derivative;
nitrogen mustard;
non-proteinogenic L-alpha-amino acid;
organochlorine compound		alkylating agent;
antineoplastic agent;
carcinogenic agent;
drug allergen;
immunosuppressive agent
dinoprostone
prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.		2.2110prostaglandins Ehuman metabolite;
mouse metabolite;
oxytocic
dinoprost
Dinoprost: A naturally occurring prostaglandin that has oxytocic, luteolytic, and abortifacient activities. Due to its vasocontractile properties, the compound has a variety of other biological actions.. prostaglandin F2alpha : A prostaglandins Falpha that is prosta-5,13-dien-1-oic acid substituted by hydroxy groups at positions 9, 11 and 15. It is a naturally occurring prostaglandin used to induce labor.		2.2110monocarboxylic acid;
prostaglandins Falpha		human metabolite;
mouse metabolite
8-epi-prostaglandin f2alpha
8-epi-prostaglandin F2alpha: a potent preglomerular vasoconstrictor acting principally through thromboxane A2 receptor activation. 8-epi-prostaglandin F2alpha : An isoprostane that is prostaglandin F2alpha having inverted stereochemistry at the 8-position.		2.2110F2-isoprostanebiomarker;
bronchoconstrictor agent;
vasoconstrictor agent
cysteine
Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.		7.1510cysteiniumfundamental metabolite
3-aminobenzanthrone
3-aminobenzanthrone: structure in first source		3.99130
nad
NAD(1-) : An anionic form of nicotinamide adenine dinucleotide arising from deprotonation of the two OH groups of the diphosphate moiety.		2.0310organophosphate oxoanioncofactor;
human metabolite;
hydrogen acceptor;
Saccharomyces cerevisiae metabolite
deoxyguanosine
[no description available]		8.1650purine 2'-deoxyribonucleoside;
purines 2'-deoxy-D-ribonucleoside		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
guanine
[no description available]		7.75302-aminopurines;
oxopurine;
purine nucleobase		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
allopurinol
Allopurinol: A XANTHINE OXIDASE inhibitor that decreases URIC ACID production. It also acts as an antimetabolite on some simpler organisms.. allopurinol : A bicyclic structure comprising a pyrazole ring fused to a hydroxy-substituted pyrimidine ring.		2.4120nucleobase analogue;
organic heterobicyclic compound		antimetabolite;
EC 1.17.3.2 (xanthine oxidase) inhibitor;
gout suppressant;
radical scavenger
8-hydroxy-2'-deoxyguanosine
8-Hydroxy-2'-Deoxyguanosine: Common oxidized form of deoxyguanosine in which C-8 position of guanine base has a carbonyl group.. 8-hydroxy-2'-deoxyguanosine : Guanosine substituted at the purine 8-position by a hydroxy group. It is used as a biomarker of oxidative DNA damage.		2.4320guanosinesbiomarker
phosphorus radioisotopes
Phosphorus Radioisotopes: Unstable isotopes of phosphorus that decay or disintegrate emitting radiation. P atoms with atomic weights 28-34 except 31 are radioactive phosphorus isotopes.		3.2860
ConditionIndicatedRelationship StrengthStudiesTrials
Carcinogenesis
The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between cell proliferation and cell death. Carcinogenesis generally requires a constellation of steps, which may occur quickly or over a period of many years.		02.6620
Cell Transformation, Neoplastic
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.		02.5220
Cancer of Lung
[description not available]		03.6930
Lung Neoplasms
Tumors or cancer of the LUNG.		03.6930
Bladder Cancer
[description not available]		07.5420
Urinary Bladder Neoplasms
Tumors or cancer of the URINARY BLADDER.		02.5420
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		03.0110
Cancer of Skin
[description not available]		03.3720
Skin Neoplasms
Tumors or cancer of the SKIN.		03.3720
Experimental Hepatoma
[description not available]		02.0510
Carcinoma, Anaplastic
[description not available]		02.9710
Benign Neoplasms
[description not available]		02.9710
Cancer, Radiation-Induced
[description not available]		02.9710
Carcinoma
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.		02.9710
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.9710
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.0110
Hepatocellular Carcinoma
[description not available]		02.7130
Cancer of Liver
[description not available]		02.7130
Chromosome-Defective Micronuclei
[description not available]		02.4220
Carcinoma, Hepatocellular
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.		02.7130
Liver Neoplasms
Tumors or cancer of the LIVER.		02.7130