sulforaphane has been researched along with Cancer of Lung in 38 studies
sulforaphane: from Cardaria draba L.
sulforaphane : An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sulforaphane induces Xuanwei lung adenocarcinoma cell apoptosis." | 7.85 | Sulforaphane-induced apoptosis in Xuanwei lung adenocarcinoma cell line XWLC-05. ( Fan, L; Huang, YC; Jiang, H; Li, Y; Wang, CQ; Yao, Q; Zhou, L, 2017) |
| "We have shown previously that naturally occurring isothiocyanates derived from cruciferous vegetables and their N-acetylcysteine conjugates inhibit lung adenoma formation induced by tobacco carcinogens in A/J mice at the post-initiation stage." | 7.73 | Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice. ( Chung, FL; Conaway, CC; Hecht, SS; McIntee, EJ; Pittman, B; Schwartz, JE; Tian, D; Wang, CX; Yang, YM, 2005) |
| "Sulforaphane (SFN) is an isothiocyanate compound derived from glucoraphanin, which is found in cruciferous vegetables, and has been heralded as a chemopreventive and/or chemotherapeutic agent." | 5.46 | Pro-oxidant activity of sulforaphane and cisplatin potentiates apoptosis and simultaneously promotes autophagy in malignant mesothelioma cells. ( Lee, SH; Lee, YJ, 2017) |
| "Worldwide non-small cell lung cancer (NSCLC) causes substantial morbidity and mortality among human populations." | 5.43 | Sulforaphene-Carboplatin Combination Synergistically Enhances Apoptosis by Disruption of Mitochondrial Membrane Potential and Cell Cycle Arrest in Human Non-Small Cell Lung Carcinoma. ( Ahn, JC; Chatterjee, S; Rhee, YH, 2016) |
| "Sulforaphane induces Xuanwei lung adenocarcinoma cell apoptosis." | 3.85 | Sulforaphane-induced apoptosis in Xuanwei lung adenocarcinoma cell line XWLC-05. ( Fan, L; Huang, YC; Jiang, H; Li, Y; Wang, CQ; Yao, Q; Zhou, L, 2017) |
| "We have shown previously that naturally occurring isothiocyanates derived from cruciferous vegetables and their N-acetylcysteine conjugates inhibit lung adenoma formation induced by tobacco carcinogens in A/J mice at the post-initiation stage." | 3.73 | Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice. ( Chung, FL; Conaway, CC; Hecht, SS; McIntee, EJ; Pittman, B; Schwartz, JE; Tian, D; Wang, CX; Yang, YM, 2005) |
| "Sulforaphane (SFN) has been shown to induce the production of reactive oxygen species (ROS) and inhibit epidermal growth factor receptor (EGFR)-mediated signaling in non-small-cell lung cancer (NSCLC)." | 1.51 | High levels of EGFR prevent sulforaphane-induced reactive oxygen species-mediated apoptosis in non-small-cell lung cancer cells. ( Chen, CC; Chen, CY; Huang, KY; Shih, YM; Wang, TH, 2019) |
| "Sulforaphane (SFN) was first isolated from broccoli sprout and it is present at high concentrations in plants belonging to the Cruciferae family." | 1.51 | Expression of cyclin B1, D1 and K in non‑small cell lung cancer H1299 cells following treatment with sulforaphane. ( Grzanka, A; Grzanka, D; Klimaszewska-Wiśniewska, A; Krajewski, A; Żuryń, A, 2019) |
| "Long treatment with paclitaxel (PTX) might increase resistance and side-effects causing a failure in cancer chemotherapy." | 1.48 | Sulforaphane metabolites reduce resistance to paclitaxel via microtubule disruption. ( Li, J; Wang, Y; Wu, W; Yan, Y; Zheng, Z; Zhou, Y, 2018) |
| "Sulforaphane (SFN) is an isothiocyanate compound derived from glucoraphanin, which is found in cruciferous vegetables, and has been heralded as a chemopreventive and/or chemotherapeutic agent." | 1.46 | Pro-oxidant activity of sulforaphane and cisplatin potentiates apoptosis and simultaneously promotes autophagy in malignant mesothelioma cells. ( Lee, SH; Lee, YJ, 2017) |
| "Worldwide non-small cell lung cancer (NSCLC) causes substantial morbidity and mortality among human populations." | 1.43 | Sulforaphene-Carboplatin Combination Synergistically Enhances Apoptosis by Disruption of Mitochondrial Membrane Potential and Cell Cycle Arrest in Human Non-Small Cell Lung Carcinoma. ( Ahn, JC; Chatterjee, S; Rhee, YH, 2016) |
| "Sulforaphane (SFN) is a natural, biologically active compound extracted from cruciferous vegetables such as broccoli and cabbage with anti-inflammatory and anti-cancer properties." | 1.37 | Chemopreventive role of sulforaphane by upholding the GSH redox cycle in pre- and post-initiation phases of experimental lung carcinogenesis. ( Gayathri, R; Gunassekaran, G; Murugan, S; Priya, DK; Sakthisekaran, D, 2011) |
| "Phenethyl isothiocyanate (PEITC) is a more potent inducer of apoptosis than sulforaphane (SFN) in A549 cells, but SFN induces more ROS generation and oxidative damages than PEITC, suggesting that oxidative stress again is probably not a trigger for apoptosis in these cells." | 1.35 | Binding to protein by isothiocyanates: a potential mechanism for apoptosis induction in human non small lung cancer cells. ( Chung, FL; Mi, L, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 11 (28.95) | 29.6817 |
| 2010's | 26 (68.42) | 24.3611 |
| 2020's | 1 (2.63) | 2.80 |
| Authors | Studies |
|---|---|
| Liang, H | 1 |
| Lai, B | 1 |
| Yuan, Q | 1 |
| Wang, X | 3 |
| Yu, C | 1 |
| Wang, C | 1 |
| Ma, Y | 1 |
| Wang, T | 1 |
| Li, Y | 3 |
| Huang, Z | 1 |
| Zhou, M | 1 |
| Sun, P | 1 |
| Zheng, J | 1 |
| Yang, S | 1 |
| Fan, Y | 1 |
| Xiang, R | 1 |
| Meng, W | 1 |
| Meng, J | 1 |
| Zhang, F | 1 |
| Jiang, H | 2 |
| Feng, X | 1 |
| Zhao, F | 1 |
| Wang, K | 1 |
| Wang, TH | 1 |
| Chen, CC | 1 |
| Huang, KY | 1 |
| Shih, YM | 1 |
| Chen, CY | 1 |
| Chen, Y | 2 |
| Chen, JQ | 1 |
| Ge, MM | 1 |
| Zhang, Q | 1 |
| Wang, XQ | 1 |
| Zhu, JY | 1 |
| Xie, CF | 1 |
| Li, XT | 1 |
| Zhong, CY | 1 |
| Han, HY | 1 |
| Zhu, J | 1 |
| Wang, S | 1 |
| Li, X | 1 |
| Jiang, Y | 1 |
| Yang, X | 2 |
| Meng, Y | 1 |
| Zhu, M | 1 |
| Ma, X | 1 |
| Huang, C | 1 |
| Wu, R | 2 |
| Xie, C | 1 |
| Geng, S | 1 |
| Wu, J | 1 |
| Zhong, C | 1 |
| Han, H | 1 |
| Lee, YJ | 1 |
| Lee, SH | 1 |
| Gao, L | 1 |
| Cheng, D | 1 |
| Yang, J | 1 |
| Li, W | 1 |
| Kong, AN | 1 |
| Hu, Y | 2 |
| Zhou, Y | 3 |
| Yang, G | 1 |
| Wang, Y | 3 |
| Zheng, Z | 3 |
| Li, J | 2 |
| Yan, Y | 2 |
| Wu, W | 3 |
| Tsai, JY | 1 |
| Tsai, SH | 1 |
| Wu, CC | 1 |
| Żuryń, A | 2 |
| Krajewski, A | 2 |
| Klimaszewska-Wiśniewska, A | 2 |
| Grzanka, A | 1 |
| Grzanka, D | 2 |
| Lin, K | 1 |
| Ding, X | 1 |
| Zhang, YK | 1 |
| Wang, H | 1 |
| Guo, YW | 1 |
| Yue, Y | 1 |
| Shorey, LE | 1 |
| Madeen, EP | 1 |
| Atwell, LL | 1 |
| Ho, E | 1 |
| Löhr, CV | 1 |
| Pereira, CB | 1 |
| Dashwood, RH | 1 |
| Williams, DE | 1 |
| Su, S | 1 |
| Omiecinski, CJ | 1 |
| Wang, N | 1 |
| Wang, W | 1 |
| Liu, C | 1 |
| Jin, J | 1 |
| Shao, B | 1 |
| Shen, L | 1 |
| Jiang, LL | 1 |
| Zhou, SJ | 1 |
| Zhang, XM | 1 |
| Chen, HQ | 1 |
| Liu, W | 2 |
| Litwiniec, A | 1 |
| Safiejko-Mroczka, B | 1 |
| Gagat, M | 1 |
| Gackowska, L | 1 |
| Chatterjee, S | 1 |
| Rhee, YH | 1 |
| Ahn, JC | 1 |
| Zhou, L | 1 |
| Yao, Q | 1 |
| Huang, YC | 1 |
| Wang, CQ | 1 |
| Fan, L | 1 |
| Wang, DX | 1 |
| Zou, YJ | 1 |
| Zhuang, XB | 1 |
| Chen, SX | 1 |
| Lin, Y | 1 |
| Li, WL | 1 |
| Lin, JJ | 1 |
| Lin, ZQ | 1 |
| Li, QQ | 1 |
| Xie, YK | 1 |
| Wu, Y | 1 |
| Li, LL | 1 |
| Liu, Y | 1 |
| Miao, XB | 1 |
| Liu, QZ | 1 |
| Yao, KT | 1 |
| Xiao, GH | 1 |
| Mi, L | 2 |
| Chung, FL | 3 |
| Singh, SV | 1 |
| Warin, R | 1 |
| Xiao, D | 1 |
| Powolny, AA | 1 |
| Stan, SD | 1 |
| Arlotti, JA | 1 |
| Zeng, Y | 1 |
| Hahm, ER | 1 |
| Marynowski, SW | 1 |
| Bommareddy, A | 1 |
| Desai, D | 1 |
| Amin, S | 1 |
| Parise, RA | 1 |
| Beumer, JH | 1 |
| Chambers, WH | 1 |
| Chu, WF | 1 |
| Wu, DM | 1 |
| Wu, LJ | 1 |
| Li, DZ | 1 |
| Xu, DY | 1 |
| Wang, XF | 1 |
| Tan, XL | 1 |
| Shi, M | 1 |
| Tang, H | 1 |
| Han, W | 1 |
| Spivack, SD | 1 |
| Kalpana Deepa Priya, D | 2 |
| Gayathri, R | 3 |
| Sakthisekaran, D | 3 |
| Priya, DK | 1 |
| Gunassekaran, G | 1 |
| Murugan, S | 2 |
| Devi, JR | 1 |
| Thangam, EB | 1 |
| Gunassekaran, GR | 1 |
| Hecht, SS | 2 |
| Kenney, PM | 1 |
| Wang, M | 1 |
| Upadhyaya, P | 1 |
| Conaway, CC | 1 |
| Wang, CX | 1 |
| Pittman, B | 1 |
| Yang, YM | 1 |
| Schwartz, JE | 1 |
| Tian, D | 1 |
| McIntee, EJ | 1 |
| Kim, SJ | 1 |
| Kim, BS | 1 |
| Kyung, TW | 1 |
| Lee, SC | 1 |
| Rho, CW | 1 |
| Choi, KR | 1 |
| Hwang, HJ | 1 |
| Choi, HS | 1 |
| Thejass, P | 1 |
| Kuttan, G | 1 |
| Jin, CY | 1 |
| Moon, DO | 1 |
| Lee, JD | 1 |
| Heo, MS | 1 |
| Choi, YH | 1 |
| Lee, CM | 1 |
| Park, YM | 1 |
| Kim, GY | 1 |
| Govind, S | 1 |
| Hood, BL | 1 |
| Veenstra, TD | 1 |
| Conrads, TP | 1 |
| Saha, DT | 1 |
| Goldman, R | 1 |
| Harris, KE | 1 |
| Jeffery, EH | 1 |
38 other studies available for sulforaphane and Cancer of Lung
| Article | Year |
|---|---|
Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Anticarcinogenic Agents; Apoptosis; Brassica; Cell | 2008 |
Novel cyclin-dependent kinase 9 (CDK9) inhibitor with suppression of cancer stemness activity against non-small-cell lung cancer.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Cyclin-Depende | 2019 |
Sulforaphane overcomes T790M-mediated gefitinib resistance in vitro through epithelial-mesenchymal transition.
Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Drug Re | 2021 |
High levels of EGFR prevent sulforaphane-induced reactive oxygen species-mediated apoptosis in non-small-cell lung cancer cells.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Apoptosis; Carcinogenesis; Carcinoma, Non-Small-Cell | 2019 |
Sulforaphane inhibits epithelial-mesenchymal transition by activating extracellular signal-regulated kinase 5 in lung cancer cells.
Topics: A549 Cells; Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Enzyme Activation; Epithel | 2019 |
miR-19 targeting of GSK3β mediates sulforaphane suppression of lung cancer stem cells.
Topics: A549 Cells; Apoptosis; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; | 2017 |
Pro-oxidant activity of sulforaphane and cisplatin potentiates apoptosis and simultaneously promotes autophagy in malignant mesothelioma cells.
Topics: Acetylcysteine; Antioxidants; Apoptosis; Autophagy; bcl-2-Associated X Protein; Cell Cycle Checkpoin | 2017 |
Sulforaphane epigenetically demethylates the CpG sites of the miR-9-3 promoter and reactivates miR-9-3 expression in human lung cancer A549 cells.
Topics: A549 Cells; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; CpG Islands; Demethylation; DNA | 2018 |
Sulforaphane-N-Acetyl-Cysteine inhibited autophagy leading to apoptosis via Hsp70-mediated microtubule disruption.
Topics: Acetylcysteine; Aged; Anticarcinogenic Agents; Apoptosis; Autophagy; Carcinoma, Non-Small-Cell Lung; | 2018 |
The chemopreventive isothiocyanate sulforaphane reduces anoikis resistance and anchorage-independent growth in non-small cell human lung cancer cells.
Topics: Anoikis; Anticarcinogenic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Humans; Isothioc | 2019 |
Sulforaphane metabolites reduce resistance to paclitaxel via microtubule disruption.
Topics: A549 Cells; Aged; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Proliferati | 2018 |
Expression of cyclin B1, D1 and K in non‑small cell lung cancer H1299 cells following treatment with sulforaphane.
Topics: Anticarcinogenic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Cycle Checkpoints; Cell Div | 2019 |
Sulforaphane metabolites inhibit migration and invasion via microtubule-mediated Claudins dysfunction or inhibition of autolysosome formation in human non-small cell lung cancer cells.
Topics: A549 Cells; Antineoplastic Agents; Autophagosomes; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamo | 2019 |
Novel role of Snail 1 in promoting tumor neoangiogenesis.
Topics: Anticarcinogenic Agents; Antigens, CD34; Cell Transformation, Neoplastic; Endoglin; Endothelial Cell | 2019 |
Differential modulation of dibenzo[def,p]chrysene transplacental carcinogenesis: maternal diets rich in indole-3-carbinol versus sulforaphane.
Topics: Animals; Anticarcinogenic Agents; Benzopyrenes; Carcinogens; Diet; Female; Indoles; Isothiocyanates; | 2013 |
Intronic DNA elements regulate Nrf2 chemical responsiveness of the human microsomal epoxide hydrolase gene (EPHX1) through a far upstream alternative promoter.
Topics: Anticarcinogenic Agents; Antioxidants; Blotting, Western; Bronchi; Cells, Cultured; Chromatin Immuno | 2014 |
Inhibition of growth and induction of apoptosis in A549 cells by compounds from oxheart cabbage extract.
Topics: A549 Cells; Antineoplastic Agents, Phytogenic; Apoptosis; Brassica; Carcinoma; Cell Proliferation; C | 2016 |
Sulforaphane suppresses in vitro and in vivo lung tumorigenesis through downregulation of HDAC activity.
Topics: Acetylation; Animals; Apoptosis; Carcinogenesis; Cell Cycle; Cell Cycle Checkpoints; Cell Line, Tumo | 2016 |
The effect of sulforaphane on the cell cycle, apoptosis and expression of cyclin D1 and p21 in the A549 non-small cell lung cancer cell line.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Line, | 2016 |
Sulforaphene-Carboplatin Combination Synergistically Enhances Apoptosis by Disruption of Mitochondrial Membrane Potential and Cell Cycle Arrest in Human Non-Small Cell Lung Carcinoma.
Topics: A549 Cells; Antineoplastic Agents, Phytogenic; Apoptosis; Biomarkers; Carboplatin; Cell Cycle Checkp | 2016 |
Sulforaphane-induced apoptosis in Xuanwei lung adenocarcinoma cell line XWLC-05.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Anticarcinogenic Agents; Apoptosis; bcl-2-Associated X Prote | 2017 |
Sulforaphane suppresses EMT and metastasis in human lung cancer through miR-616-5p-mediated GSK3β/β-catenin signaling pathways.
Topics: Animals; beta Catenin; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Epithelial-M | 2017 |
Sulforaphane inhibits cancer stem-like cell properties and cisplatin resistance through miR-214-mediated downregulation of c-MYC in non-small cell lung cancer.
Topics: 3' Untranslated Regions; A549 Cells; Animals; Antineoplastic Agents; beta Catenin; Blotting, Western | 2017 |
Binding to protein by isothiocyanates: a potential mechanism for apoptosis induction in human non small lung cancer cells.
Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Cysteine; DNA Damage; Humans; Isothiocyanates; Lung Neopl | 2008 |
Sulforaphane inhibits prostate carcinogenesis and pulmonary metastasis in TRAMP mice in association with increased cytotoxicity of natural killer cells.
Topics: Angiogenesis Inhibitors; Animals; Anticarcinogenic Agents; Apoptosis; bcl-2-Associated X Protein; Ce | 2009 |
Sulforaphane induces G2-M arrest and apoptosis in high metastasis cell line of salivary gland adenoid cystic carcinoma.
Topics: Anticarcinogenic Agents; Apoptosis; Apoptosis Regulatory Proteins; Carcinoma, Adenoid Cystic; Cell C | 2009 |
Candidate dietary phytochemicals modulate expression of phase II enzymes GSTP1 and NQO1 in human lung cells.
Topics: Anticarcinogenic Agents; Brassica; Bronchi; Camellia sinensis; Catechin; Cell Division; Cell Line; C | 2010 |
Role of sulforaphane in the anti-initiating mechanism of lung carcinogenesis in vivo by modulating the metabolic activation and detoxification of benzo(a)pyrene.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Biotransformation; Female; Glutathione Transferase | 2011 |
Chemopreventive role of sulforaphane by upholding the GSH redox cycle in pre- and post-initiation phases of experimental lung carcinogenesis.
Topics: Adenosine Triphosphatases; Animals; Anticarcinogenic Agents; Antioxidants; Benzo(a)pyrene; Body Weig | 2011 |
Mechanisms of anticancer activity of sulforaphane from Brassica oleracea in HEp-2 human epithelial carcinoma cell line.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Blotting, Western; Brassica; Cell Cycle; Cell Prolifera | 2012 |
Apoptotic role of natural isothiocyanate from broccoli (Brassica oleracea italica) in experimental chemical lung carcinogenesis.
Topics: Administration, Oral; Animals; Anticarcinogenic Agents; Apoptosis; Benzo(a)pyrene; Brassica; Caspase | 2013 |
Benzyl isothiocyanate: an effective inhibitor of polycyclic aromatic hydrocarbon tumorigenesis in A/J mouse lung.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Butylated Hydroxyanisole; Carcinogens; Chrysenes; | 2002 |
Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice.
Topics: Acetylcysteine; Adenocarcinoma; Adenoma; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Body Weig | 2005 |
Suppressive effects of young radish cultivated with sulfur on growth and metastasis of B16-F10 melanoma cells.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Survival; Dose-Response Relationship, Drug; Glutath | 2006 |
Antimetastatic activity of Sulforaphane.
Topics: Animals; Antineoplastic Agents; Biomarkers, Tumor; Brassica; Cell Line; Cell Proliferation; Collagen | 2006 |
Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis through downregulation of ERK and Akt in lung adenocarcinoma A549 cells.
Topics: Adenocarcinoma; Anticarcinogenic Agents; Apoptosis; Caspase 3; Cell Line, Tumor; Down-Regulation; Hu | 2007 |
The role of protein binding in induction of apoptosis by phenethyl isothiocyanate and sulforaphane in human non-small lung cancer cells.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cattle; Cell Line, Tumo | 2007 |
Sulforaphane and erucin increase MRP1 and MRP2 in human carcinoma cell lines.
Topics: Anticarcinogenic Agents; Caco-2 Cells; Carcinoma; Cell Line, Tumor; Endoplasmic Reticulum; Humans; I | 2008 |