Page last updated: 2024-11-04

sulforaphane and Atypical Ductal Hyperplasia

sulforaphane has been researched along with Atypical Ductal Hyperplasia in 3 studies

sulforaphane: from Cardaria draba L.
sulforaphane : An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.

Research Excerpts

Excerpt	Relevance	Reference
" Future studies employing larger sample sizes should evaluate alternative dosing and duration regimens to inform dietary SFN strategies in breast cancer chemoprevention."	2.80	Sulforaphane Bioavailability and Chemopreventive Activity in Women Scheduled for Breast Biopsy. ( Atwell, LL; Farris, P; Ho, E; Mori, M; Naik, AM; Oh, KY; Shannon, J; Thuillier, P; Vetto, JT; Zhang, Z, 2015)
"Previously, we found that basal-like ductal carcinoma in situ (DCIS) contains cancer stem-like cells."	1.40	Characterization of a stem-like subpopulation in basal-like ductal carcinoma in situ (DCIS) lesions. ( Eades, G; Li, Q; Yao, Y; Zhang, Y; Zhou, Q, 2014)

Research

Studies (3)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	3 (100.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Li, Q	1
Eades, G	1
Yao, Y	1
Zhang, Y	1
Zhou, Q	1
Zhang, Z	2
Atwell, LL	2
Farris, PE	1
Ho, E	2
Shannon, J	2
Mori, M	1
Farris, P	1
Vetto, JT	1
Naik, AM	1
Oh, KY	1
Thuillier, P	1

Clinical Trials (1)

Trial Overview

Trial			Phase	Enrollment	Study Type	Start Date	Status
Sulforaphane: A Dietary Histone Deacetylase (HDAC) Inhibitor in Ductal Carcinoma in Situ (DCIS)[NCT00843167]			Phase 2	54 participants (Actual)	Interventional	2009-08-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Histone Deacetylase (HDAC) Activity as Assessed in Peripheral Blood Mononuclear Cells (PBMC) at Baseline and After Completion of Study Therapy

PBMC HDAC activity was evaluated using the positive control, sodium butyrate.HDAC activity is expressed relative to PBMC protein content and negative control. (NCT00843167)
Timeframe: Baseline and End of Study (up to 8 weeks)

Intervention	pmol/min/mg protein (Mean)
Sulforaphane Supplement	-80.39
Placebo	27.52

Change in Isothiocyanate in Urine Samples as Assessed at Baseline and After Completion of Study Therapy

Isothiocyante including sulforaphane in micromolar (µM) concentration was measured following standard chemical measurement procedures and divided by the creatinine values in millimolar (mM) concentration. (NCT00843167)
Timeframe: Baseline and end of study (up to 8 weeks)

Intervention	µM/mM creatinine (Mean)
Sulforaphane Supplement	1.00
Placebo	-0.05

Treatment Compliance

For treatment compliance, participants who take >=80% of the prescribed pills will be considered to be treatment-compliant. (NCT00843167)
Timeframe: Baseline and end of study (up to 8 weeks)

Intervention	participants (Number)
Sulforaphane Supplement	19
Treatment	16

Change in Ki-67 as Assessed at Baseline and After Completion of Study Therapy

Ki-67 was measured through immunohistochemistry method. A modified H-score was recorded, which involved semi-quantitative assessment of both staining intensity (graded as 1-3 with 1 representing weak staining, 2 moderate staining, and 3 strong staining) and percentage of positive cells. The range of the H-score was 0-300. The maximum score indicates the strongest expression, the minimum score indicates no expression of positive tumor area. (NCT00843167)
Timeframe: Baseline and end of study (up to 8 weeks)

Intervention	Log 2 (H-score) (Least Squares Mean)
	Sulforaphane Supplement	Placebo
Benign Tissue; Ki-67	-1.39	0.23
DCIS Tissue; Ki-67	0.42	-0.48
Invasive Ductal Carcinoma Tissue; Ki-67	0.98	0.28

Trials

2 trials available for sulforaphane and Atypical Ductal Hyperplasia

Article	Year
Associations between cruciferous vegetable intake and selected biomarkers among women scheduled for breast biopsies. Public health nutrition, 2016, Volume: 19, Issue:7 Topics: Adult; Aged; Biomarkers; Biopsy; Body Mass Index; Breast Neoplasms; Carcinoma, Intraductal, Noninfil	2016
Sulforaphane Bioavailability and Chemopreventive Activity in Women Scheduled for Breast Biopsy. Cancer prevention research (Philadelphia, Pa.), 2015, Volume: 8, Issue:12 Topics: Anticarcinogenic Agents; Biological Availability; Biomarkers, Tumor; Breast Neoplasms; Carcinoma, In	2015

Other Studies

1 other study available for sulforaphane and Atypical Ductal Hyperplasia

Article	Year
Characterization of a stem-like subpopulation in basal-like ductal carcinoma in situ (DCIS) lesions. The Journal of biological chemistry, 2014, Jan-17, Volume: 289, Issue:3 Topics: Aldehyde Dehydrogenase 1 Family; Animals; Anticarcinogenic Agents; Breast Neoplasms; Carcinoma, Intr	2014