sulforaphane has been researched along with Idiopathic Parkinson Disease in 11 studies
sulforaphane: from Cardaria draba L.
sulforaphane : An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We have addressed this question in human dopaminergic neuroblastoma SH-SY5Y cells exposed to the parkinsonian toxin paraquat (PQ)." | 3.76 | Activation of apoptosis signal-regulating kinase 1 is a key factor in paraquat-induced cell death: modulation by the Nrf2/Trx axis. ( Bravo-San Pedro, JM; Cuadrado, A; Fuentes, JM; Gómez-Sánchez, R; González-Polo, RA; Lastres-Becker, I; Morán, JM; Niso-Santano, M; Ortiz-Ortiz, MA; Soler, G, 2010) |
| " Bioavailability studies also suggest the contribution of SFN metabolites, including erucin (ERN), to the neuroprotective effects of SFN." | 1.48 | Comparison of Adaptive Neuroprotective Mechanisms of Sulforaphane and its Interconversion Product Erucin in in Vitro and in Vivo Models of Parkinson's Disease. ( Cantelli-Forti, G; D'Amico, M; Djemil, A; Hrelia, P; Morroni, F; Pruccoli, L; Sita, G; Tarozzi, A, 2018) |
| "Sulforaphane appears to be a promising compound with neuroprotective properties that may play an important role in preventing PD." | 1.43 | Sulforaphane protects against rotenone-induced neurotoxicity in vivo: Involvement of the mTOR, Nrf2, and autophagy pathways. ( Cai, X; Cao, P; Chen, B; Chen, J; Cheng, X; Hu, Z; Lu, W; Shen, J; Sun, X; Wang, X; Wu, L; Yan, H; Yang, J; Yang, Y; Ye, J; Zhou, Q, 2016) |
| "Although the etiology of Parkinson's disease (PD) remains elusive, recent studies suggest that oxidative stress contributes to the cascade leading to dopaminergic (DAergic) neurodegeneration." | 1.40 | Discovery of vinyl sulfones as a novel class of neuroprotective agents toward Parkinson's disease therapy. ( Choi, JW; Han, SH; Hwang, O; Jang, BK; Kang, YG; Kim, DJ; Kim, JH; Kim, JW; Lee, J; Moon, MK; Park, KD; Song, HJ; Woo, SY; Yeon, SK, 2014) |
| "Parkinson's disease is an environmentally influenced, neurodegenerative disease of unknown origin that is characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta of the brain." | 1.35 | Synergistic neurotoxic effects of arsenic and dopamine in human dopaminergic neuroblastoma SH-SY5Y cells. ( Sens, DA; Shavali, S, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 9 (81.82) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Woo, SY | 2 |
| Kim, JH | 1 |
| Moon, MK | 1 |
| Han, SH | 1 |
| Yeon, SK | 1 |
| Choi, JW | 2 |
| Jang, BK | 1 |
| Song, HJ | 1 |
| Kang, YG | 1 |
| Kim, JW | 2 |
| Lee, J | 2 |
| Kim, DJ | 1 |
| Hwang, O | 1 |
| Park, KD | 2 |
| Kim, S | 1 |
| Park, JH | 1 |
| Kim, HJ | 1 |
| Shin, SJ | 1 |
| Lee, C | 1 |
| Han, SM | 1 |
| Pae, AN | 1 |
| Han, G | 1 |
| Morroni, F | 2 |
| Sita, G | 2 |
| Djemil, A | 1 |
| D'Amico, M | 1 |
| Pruccoli, L | 1 |
| Cantelli-Forti, G | 2 |
| Hrelia, P | 2 |
| Tarozzi, A | 2 |
| Bao, B | 1 |
| Zhang, MQ | 1 |
| Chen, ZY | 1 |
| Wu, XB | 1 |
| Xia, ZB | 1 |
| Chai, JY | 1 |
| Yin, XP | 1 |
| Bolondi, C | 1 |
| Zolezzi Moraga, JM | 1 |
| Shah, SP | 1 |
| Duda, JE | 1 |
| Zhou, Q | 1 |
| Chen, B | 1 |
| Wang, X | 1 |
| Wu, L | 1 |
| Yang, Y | 1 |
| Cheng, X | 1 |
| Hu, Z | 1 |
| Cai, X | 1 |
| Yang, J | 1 |
| Sun, X | 1 |
| Lu, W | 1 |
| Yan, H | 1 |
| Chen, J | 1 |
| Ye, J | 1 |
| Shen, J | 1 |
| Cao, P | 1 |
| Niso-Santano, M | 1 |
| González-Polo, RA | 1 |
| Bravo-San Pedro, JM | 1 |
| Gómez-Sánchez, R | 1 |
| Lastres-Becker, I | 1 |
| Ortiz-Ortiz, MA | 1 |
| Soler, G | 1 |
| Morán, JM | 1 |
| Cuadrado, A | 1 |
| Fuentes, JM | 1 |
| Cook, AL | 1 |
| Vitale, AM | 1 |
| Ravishankar, S | 1 |
| Matigian, N | 1 |
| Sutherland, GT | 1 |
| Shan, J | 1 |
| Sutharsan, R | 1 |
| Perry, C | 1 |
| Silburn, PA | 1 |
| Mellick, GD | 1 |
| Whitelaw, ML | 1 |
| Wells, CA | 1 |
| Mackay-Sim, A | 1 |
| Wood, SA | 1 |
| Shavali, S | 1 |
| Sens, DA | 1 |
| Trinh, K | 1 |
| Moore, K | 1 |
| Wes, PD | 1 |
| Muchowski, PJ | 1 |
| Dey, J | 1 |
| Andrews, L | 1 |
| Pallanck, LJ | 1 |
11 other studies available for sulforaphane and Idiopathic Parkinson Disease
| Article | Year |
|---|---|
Discovery of vinyl sulfones as a novel class of neuroprotective agents toward Parkinson's disease therapy.
Topics: Animals; Base Sequence; Cell Line; Disease Models, Animal; DNA Primers; Heme Oxygenase-1; Humans; Ma | 2014 |
Optimization of Vinyl Sulfone Derivatives as Potent Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Activators for Parkinson's Disease Therapy.
Topics: Animals; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Glutamate-Cysteine Ligase; Heme Ox | 2019 |
Comparison of Adaptive Neuroprotective Mechanisms of Sulforaphane and its Interconversion Product Erucin in in Vitro and in Vivo Models of Parkinson's Disease.
Topics: Animals; Brassica; Cell Line, Tumor; Dopaminergic Neurons; Glutathione; Humans; Isothiocyanates; Mal | 2018 |
Sulforaphane prevents PC12 cells from oxidative damage via the Nrf2 pathway.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Antioxidant Response Elements; Antioxidants; Antiparkinson Age | 2019 |
Neuroprotective effect of sulforaphane in 6-hydroxydopamine-lesioned mouse model of Parkinson's disease.
Topics: Actinin; Adrenergic Agents; Analysis of Variance; Animals; Apomorphine; Caspase 3; Disease Models, A | 2013 |
Dietary modifications in Parkinson's disease: A neuroprotective intervention?
Topics: Animals; Antioxidants; Curcumin; Diet; Ergothioneine; Fragaria; Humans; Inflammation; Isothiocyanate | 2015 |
Sulforaphane protects against rotenone-induced neurotoxicity in vivo: Involvement of the mTOR, Nrf2, and autophagy pathways.
Topics: Animals; Autophagy; Cell Line; Disease Models, Animal; Dopaminergic Neurons; Glutathione; Humans; Is | 2016 |
Activation of apoptosis signal-regulating kinase 1 is a key factor in paraquat-induced cell death: modulation by the Nrf2/Trx axis.
Topics: Animals; Apoptosis; Cell Line; Fibroblasts; Humans; Intracellular Signaling Peptides and Proteins; I | 2010 |
NRF2 activation restores disease related metabolic deficiencies in olfactory neurosphere-derived cells from patients with sporadic Parkinson's disease.
Topics: Case-Control Studies; Cell Line; Female; Gene Silencing; Glutathione; Humans; Isothiocyanates; Male; | 2011 |
Synergistic neurotoxic effects of arsenic and dopamine in human dopaminergic neuroblastoma SH-SY5Y cells.
Topics: Acetylcysteine; Anticarcinogenic Agents; Antioxidants; Arsenites; Cell Line, Tumor; Cell Survival; D | 2008 |
Induction of the phase II detoxification pathway suppresses neuron loss in Drosophila models of Parkinson's disease.
Topics: Age Factors; Allyl Compounds; alpha-Synuclein; Animals; Animals, Genetically Modified; Cell Death; D | 2008 |