Compounds > clostridium perfringens delta-toxin
Page last updated: 2024-11-09

clostridium perfringens delta-toxin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

5,6-dihydrocyclopenta-1,2-dithiole-3-thione: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID825735
CHEMBL ID1173197
SCHEMBL ID16568440
MeSH IDM0093640

Synonyms (14)

Synonym
5,6-dihydro-4h-cyclopenta[c]dithiole-3-thione
5,6-dihydro-4h-cyclopenta[1,2]dithiole-3-thione
FT-0695652
CHEMBL1173197
14085-33-7
5,6-dihydrocyclopenta-1,2-dithiole-3-thione
SCHEMBL16568440
5,6-dihydro-4h-cyclopenta-1,2-dithiole-3-thione
DTXSID50356524
5,6-dihydrocyclopenta[c][1,2]dithiole-3(4h)-thione
cpdt, >=96% (hplc)
5,6-dihydro-4h-cyclopenta[1,2]-dithiole-3-thione
cpdt
NCGC00487217-01

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019)		0.51
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (16)

Assay IDTitleYearJournalArticle
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID492661Ex vivo induction of NQO1 in Sprague-Dawley rat lung at 7.5 umol/kg/day, po for 10 days measured on day 11 relative to control2010Journal of medicinal chemistry, Jun-24, Volume: 53, Issue:12
Synthesis, biological evaluation, and structure-activity relationships of dithiolethiones as inducers of cytoprotective phase 2 enzymes.
AID492660Ex vivo induction of NQO1 in Sprague-Dawley rat kidney at 7.5 umol/kg/day, po for 10 days measured on day 11 relative to control2010Journal of medicinal chemistry, Jun-24, Volume: 53, Issue:12
Synthesis, biological evaluation, and structure-activity relationships of dithiolethiones as inducers of cytoprotective phase 2 enzymes.
AID1173778Toxicity against human SH-SY5Y cells at 100 uM incubated for 24 hrs2014Bioorganic & medicinal chemistry letters, Dec-15, Volume: 24, Issue:24
Synthesis and structure-activity relationships study of dithiolethiones as inducers of glutathione in the SH-SY5Y neuroblastoma cell line.
AID492664Ex vivo induction of NQO1 in Sprague-Dawley rat ileum at 7.5 umol/kg/day, po for 10 days measured on day 11 relative to control2010Journal of medicinal chemistry, Jun-24, Volume: 53, Issue:12
Synthesis, biological evaluation, and structure-activity relationships of dithiolethiones as inducers of cytoprotective phase 2 enzymes.
AID492666Ex vivo induction of NQO1 in Sprague-Dawley rat bladder at 7.5 umol/kg/day, po for 10 days measured on day 11 relative to control2010Journal of medicinal chemistry, Jun-24, Volume: 53, Issue:12
Synthesis, biological evaluation, and structure-activity relationships of dithiolethiones as inducers of cytoprotective phase 2 enzymes.
AID492665Ex vivo induction of NQO1 in Sprague-Dawley rat colon at 7.5 umol/kg/day, po for 10 days measured on day 11 relative to control2010Journal of medicinal chemistry, Jun-24, Volume: 53, Issue:12
Synthesis, biological evaluation, and structure-activity relationships of dithiolethiones as inducers of cytoprotective phase 2 enzymes.
AID1173775Induction of glutathione in human SH-SY5Y cells at 100 uM incubated for 24 hrs by GSH/GSSG Glo assay2014Bioorganic & medicinal chemistry letters, Dec-15, Volume: 24, Issue:24
Synthesis and structure-activity relationships study of dithiolethiones as inducers of glutathione in the SH-SY5Y neuroblastoma cell line.
AID492659Ex vivo induction of NQO1 in Sprague-Dawley rat liver at 7.5 umol/kg/day, po for 10 days measured on day 11 relative to control2010Journal of medicinal chemistry, Jun-24, Volume: 53, Issue:12
Synthesis, biological evaluation, and structure-activity relationships of dithiolethiones as inducers of cytoprotective phase 2 enzymes.
AID1173777Neuroprotection against 50 uM 6-hydroxydopamine-induced neurotoxicity in human SH-SY5Y cells assessed as cell viability at 100 uM pre-incubated for 24 hrs before 6-hydroxydopamine challenge2014Bioorganic & medicinal chemistry letters, Dec-15, Volume: 24, Issue:24
Synthesis and structure-activity relationships study of dithiolethiones as inducers of glutathione in the SH-SY5Y neuroblastoma cell line.
AID492668Ex vivo induction of NQO1 in Sprague-Dawley rat stomach at 7.5 umol/kg/day, po for 10 days measured on day 11 relative to control2010Journal of medicinal chemistry, Jun-24, Volume: 53, Issue:12
Synthesis, biological evaluation, and structure-activity relationships of dithiolethiones as inducers of cytoprotective phase 2 enzymes.
AID492663Ex vivo induction of NQO1 in Sprague-Dawley rat jejunum at 7.5 umol/kg/day, po for 10 days measured on day 11 relative to control2010Journal of medicinal chemistry, Jun-24, Volume: 53, Issue:12
Synthesis, biological evaluation, and structure-activity relationships of dithiolethiones as inducers of cytoprotective phase 2 enzymes.
AID492662Ex vivo induction of NQO1 in Sprague-Dawley rat duodenum at 7.5 umol/kg/day, po for 10 days measured on day 11 relative to control2010Journal of medicinal chemistry, Jun-24, Volume: 53, Issue:12
Synthesis, biological evaluation, and structure-activity relationships of dithiolethiones as inducers of cytoprotective phase 2 enzymes.
AID1173776Neuroprotection against 25 uM 6-hydroxydopamine-induced neurotoxicity in human SH-SY5Y cells assessed as cell viability at 100 uM pre-incubated for 24 hrs before 6-hydroxydopamine challenge2014Bioorganic & medicinal chemistry letters, Dec-15, Volume: 24, Issue:24
Synthesis and structure-activity relationships study of dithiolethiones as inducers of glutathione in the SH-SY5Y neuroblastoma cell line.
AID492667Ex vivo induction of GST in Sprague-Dawley rat bladder at 7.5 umol/kg/day, po for 10 days measured on day 11 relative to control2010Journal of medicinal chemistry, Jun-24, Volume: 53, Issue:12
Synthesis, biological evaluation, and structure-activity relationships of dithiolethiones as inducers of cytoprotective phase 2 enzymes.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (40.00)29.6817
2010's6 (60.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.11

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.11 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.11)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
anethole trithione
Anethole Trithione: Choleretic used to allay dry mouth and constipation due to tranquilizers.		2.110methoxybenzenes
beta-naphthoflavone
beta-Naphthoflavone: A polyaromatic hydrocarbon inducer of P4501A1 and P4501A2 cytochromes. (Proc Soc Exp Biol Med 1994 Dec:207(3):302-308). beta-naphthoflavone : An extended flavonoid resulting from the formal fusion of a benzene ring with the f side of flavone.		2.0510extended flavonoid;
naphtho-gamma-pyrone;
organic heterotricyclic compound		aryl hydrocarbon receptor agonist
ethoxyquin
Ethoxyquin: Antioxidant; also a post-harvest dip to prevent scald on apples and pears.. ethoxyquin : A quinoline that is 1,2-dihydroquinoline bearing three methyl substituents at position 2, 2 and 4 as well as an ethoxy substituent at position 6.		2.0510aromatic ether;
quinolines		antifungal agrochemical;
food antioxidant;
genotoxin;
geroprotector;
herbicide;
Hsp90 inhibitor;
neuroprotective agent;
UDP-glucuronosyltransferase activator
phenobarbital
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.. phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.		2.0510barbituratesanticonvulsant;
drug allergen;
excitatory amino acid antagonist;
sedative
sulforaphane
sulforaphane: from Cardaria draba L.. sulforaphane : An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.		2.0710isothiocyanate;
sulfoxide		antineoplastic agent;
antioxidant;
EC 3.5.1.98 (histone deacetylase) inhibitor;
plant metabolite
4-biphenylamine
4-biphenylamine: used in detection of sulfates, & as a carcinogen in cancer research; RN given refers to parent cpd; structure. biphenyl-4-amine : An aminobiphenyl that is biphenyl substituted by an amino group at position 4.		2.0610aminobiphenylcarcinogenic agent
thiophenes
Thiophenes: A monocyclic heteroarene furan in which the oxygen atom is replaced by a sulfur.. thiophenes : Compounds containing at least one thiophene ring.		2.0510mancude organic heteromonocyclic parent;
monocyclic heteroarene;
thiophenes;
volatile organic compound		non-polar solvent
malondialdehyde
Malondialdehyde: The dialdehyde of malonic acid.. malonaldehyde : A dialdehyde that is propane substituted by two oxo groups at the terminal carbon atoms respectively. A biomarker of oxidative damage to lipids caused by smoking, it exists in vivo mainly in the enol form.		2.1510dialdehydebiomarker
allyl sulfide
allyl sulfide: essence of garlic; inhibits CYP2E1		2.0510organic sulfide
2-tert-butylhydroquinone
2-tert-butylhydroquinone: an anticarcinogenic and chemopreventive agent. 2-tert-butylhydroquinone : A member of the class of hydroquinones in which one of the ring hydrogens of hydroquinone is replaced by a tert-butyl group.		2.0410hydroquinonesfood antioxidant
glutamic acid
Glutamic Acid: A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.. glutamic acid : An alpha-amino acid that is glutaric acid bearing a single amino substituent at position 2.		2.0410glutamic acid;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
ferroptosis inducer;
micronutrient;
mouse metabolite;
neurotransmitter;
nutraceutical
1,2-dithiol-3-thione
1,2-dithiol-3-thione: has antioxidant activity; structure given in first source		2.76301,2-dithiole
desmethylanethol trithione
desmethylanethol trithione: metabolite of anethol trithione; structure given in first source		2.4820
ConditionIndicatedRelationship StrengthStudiesTrials
Bladder Cancer
[description not available]		02.7530
Urinary Bladder Neoplasms
Tumors or cancer of the URINARY BLADDER.		02.7530
Neuroblastoma
A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)		02.110
Alloxan Diabetes
[description not available]		02.1510
Diabetic Cardiomyopathies
Diabetes complications in which VENTRICULAR REMODELING in the absence of CORONARY ATHEROSCLEROSIS and hypertension results in cardiac dysfunctions, typically LEFT VENTRICULAR DYSFUNCTION. The changes also result in myocardial hypertrophy, myocardial necrosis and fibrosis, and collagen deposition due to impaired glucose tolerance.		02.1510
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.0410
Nerve Degeneration
Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.		02.0410
Injuries, Spinal Cord
[description not available]		02.0410
Spinal Cord Injuries
Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).		02.0410