Page last updated: 2024-11-04

sulforaphane and Pregnancy

sulforaphane has been researched along with Pregnancy in 20 studies

sulforaphane: from Cardaria draba L.
sulforaphane : An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.

Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Research Excerpts

ExcerptRelevanceReference
" Using a murine model of obesity-induced glucose dysregulated pregnancy, we demonstrate that NRF2 activation by maternal sulforaphane (SFN) supplementation normalizes NRF2-linked NQO1, GCL and CuZnSOD expression in maternal and fetal liver placental and fetal heart tissue by gestational day 17."8.31Sulforaphane induced NRF2 activation in obese pregnancy attenuates developmental redox imbalance and improves early-life cardiovascular function in offspring. ( Bowe, J; Chapple, SJ; Ehler, E; Mann, GE; Morris, JK; Psefteli, PM; Smith, L; Taylor, PD, 2023)
"Sulforaphane is a naturally occurring phytonutrient found most densely within cruciferous vegetables."7.01Preeclampsia to COVID-19: A journey towards improved placental and vascular function using sulforaphane. ( Fields, NJ; Marshall, SA; Nisi, A; Palmer, KR, 2023)
" To inform future clinical trials, we set out to determine the bioavailability of sulforaphane in non-pregnant and preeclamptic women."7.01Sulforaphane Bioavailability and Effects on Blood Pressure in Women with Pregnancy Hypertension. ( Anderson, D; Creek, DJ; Langston-Cox, AG; Marshall, SA; Palmer, KR; Wallace, EM, 2021)
"Atypical nevi were photographed on days 1 and 28, and plasma and nevus samples were taken on days 1, 2, and 28."6.87Evaluation of Biodistribution of Sulforaphane after Administration of Oral Broccoli Sprout Extract in Melanoma Patients with Multiple Atypical Nevi. ( Beumer, JH; Butterfield, LH; Cassidy, PB; Christner, SM; Dietz, CM; Fahey, JW; Ferris, LK; Hahm, ER; Hughes, E; Kirkwood, JM; Leachman, SA; Lin, Y; Rao, UN; Rose, A; Sander, C; Singh, SV; Tahata, S; Tarhini, AA; Tawbi, H; Wilson, M; Zarour, HM, 2018)
"Hypospadias is a common malformation of the penis."5.72An experimental evaluation of the efficacy of perinatal sulforaphane supplementation to decrease the incidence and severity of vinclozolin-induced hypospadias in the mouse model. ( Amato, CM; Bereman, M; Fricke, A; Marella, S; McCoy, KA; Mogus, JP, 2022)
" Using a murine model of obesity-induced glucose dysregulated pregnancy, we demonstrate that NRF2 activation by maternal sulforaphane (SFN) supplementation normalizes NRF2-linked NQO1, GCL and CuZnSOD expression in maternal and fetal liver placental and fetal heart tissue by gestational day 17."4.31Sulforaphane induced NRF2 activation in obese pregnancy attenuates developmental redox imbalance and improves early-life cardiovascular function in offspring. ( Bowe, J; Chapple, SJ; Ehler, E; Mann, GE; Morris, JK; Psefteli, PM; Smith, L; Taylor, PD, 2023)
"Sulforaphane is a naturally occurring phytonutrient found most densely within cruciferous vegetables."3.01Preeclampsia to COVID-19: A journey towards improved placental and vascular function using sulforaphane. ( Fields, NJ; Marshall, SA; Nisi, A; Palmer, KR, 2023)
" To inform future clinical trials, we set out to determine the bioavailability of sulforaphane in non-pregnant and preeclamptic women."3.01Sulforaphane Bioavailability and Effects on Blood Pressure in Women with Pregnancy Hypertension. ( Anderson, D; Creek, DJ; Langston-Cox, AG; Marshall, SA; Palmer, KR; Wallace, EM, 2021)
"Preeclampsia is a leading cause of maternal and perinatal morbidity and mortality."2.90Prolong: a double-blind randomised placebo-controlled trial of broccoli sprout extract in women with early onset preeclampsia. A clinical trial protocol. ( Langston-Cox, AG; Marshall, SA; Palmer, KR; Wallace, EM, 2019)
"Atypical nevi were photographed on days 1 and 28, and plasma and nevus samples were taken on days 1, 2, and 28."2.87Evaluation of Biodistribution of Sulforaphane after Administration of Oral Broccoli Sprout Extract in Melanoma Patients with Multiple Atypical Nevi. ( Beumer, JH; Butterfield, LH; Cassidy, PB; Christner, SM; Dietz, CM; Fahey, JW; Ferris, LK; Hahm, ER; Hughes, E; Kirkwood, JM; Leachman, SA; Lin, Y; Rao, UN; Rose, A; Sander, C; Singh, SV; Tahata, S; Tarhini, AA; Tawbi, H; Wilson, M; Zarour, HM, 2018)
"Hypospadias is a common malformation of the penis."1.72An experimental evaluation of the efficacy of perinatal sulforaphane supplementation to decrease the incidence and severity of vinclozolin-induced hypospadias in the mouse model. ( Amato, CM; Bereman, M; Fricke, A; Marella, S; McCoy, KA; Mogus, JP, 2022)
"Sulforaphane (SFN) is a derivative of a glucosinolate, which is abundant in cruciferous vegetables, and can pass through the placental barrier."1.62Nano-sulforaphane attenuates PhIP-induced early abnormal embryonic neuro-development. ( Bao, Y; Brand-Saberi, B; Cheng, X; Li, T; Liu, C; Liu, X; Qi, S; Sindi, M; Wang, G; Yan, Y; Yang, W; Yang, X; Zhang, P, 2021)
"Sulforaphane (SFN) is an isothiocyanate derived from cruciferous vegetables."1.48Sulforaphane restores acetyl-histone H3 binding to Bcl-2 promoter and prevents apoptosis in ethanol-exposed neural crest cells and mouse embryos. ( Cai, L; Chen, SY; Chen, X; Feng, W; Liu, J; Wu, X; Yuan, F, 2018)
"Sulforaphane (SFN) is a natural compound that displays antioxidant and anti-inflammatory activities."1.42Sulforaphane rescues memory dysfunction and synaptic and mitochondrial alterations induced by brain iron accumulation. ( Aguzzoli, C; Bogo, MR; Dargél, VA; de Freitas, BS; de Lima, MN; Falavigna, L; Florian, PZ; Kist, LW; Köbe, LM; Lavich, IC; Piffero, B; Schröder, N, 2015)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's10 (50.00)24.3611
2020's10 (50.00)2.80

Authors

AuthorsStudies
Wei, Y1
Chang, L1
Liu, G1
Wang, X1
Yang, Y1
Hashimoto, K2
Amato, CM1
Fricke, A1
Marella, S1
Mogus, JP1
Bereman, M1
McCoy, KA1
Fields, NJ2
Palmer, KR4
Nisi, A1
Marshall, SA6
Rolnik, DL1
Yo, J1
Nold, MF1
Giles, ML1
Krishnaswamy, S1
Serpa Neto, A1
Hodges, RJ1
Psefteli, PM1
Morris, JK1
Ehler, E1
Smith, L1
Bowe, J1
Mann, GE1
Taylor, PD1
Chapple, SJ1
Langston-Cox, AG2
Wallace, EM4
Menon, R3
Peltier, MR2
Langston-Cox, A1
Leo, CH1
Tare, M1
Zhang, P1
Li, T1
Liu, C1
Sindi, M1
Cheng, X1
Qi, S1
Liu, X1
Yan, Y1
Bao, Y1
Brand-Saberi, B1
Yang, W1
Wang, G1
Yang, X1
Anderson, D1
Creek, DJ1
Stalberg, C1
Noda, N1
Polettini, J1
Jacobson, B1
Yuan, F1
Chen, X1
Liu, J1
Feng, W1
Cai, L1
Wu, X1
Chen, SY1
Tahata, S1
Singh, SV1
Lin, Y1
Hahm, ER1
Beumer, JH1
Christner, SM1
Rao, UN1
Sander, C1
Tarhini, AA1
Tawbi, H1
Ferris, LK1
Wilson, M1
Rose, A1
Dietz, CM1
Hughes, E1
Fahey, JW1
Leachman, SA1
Cassidy, PB1
Butterfield, LH1
Zarour, HM1
Kirkwood, JM1
Arita, Y1
Jeong Park, H1
Cantillon, A1
Verma, K1
Getahun, D1
Cox, AG1
Gurusinghe, S1
Abd Rahman, R1
Leaw, B1
Chan, ST1
Mockler, JC1
Murthi, P1
Lim, R1
Shorey, LE1
Madeen, EP1
Atwell, LL1
Ho, E1
Löhr, CV1
Pereira, CB1
Dashwood, RH1
Williams, DE1
McGrath-Morrow, SA1
Lauer, T1
Collaco, JM1
Lopez, A1
Malhotra, D1
Alekseyev, YO1
Neptune, E1
Wise, R1
Biswal, S1
Philbrook, NA1
Winn, LM1
Lavich, IC1
de Freitas, BS1
Kist, LW1
Falavigna, L1
Dargél, VA1
Köbe, LM1
Aguzzoli, C1
Piffero, B1
Florian, PZ1
Bogo, MR1
de Lima, MN1
Schröder, N1

Reviews

1 review available for sulforaphane and Pregnancy

ArticleYear
Preeclampsia to COVID-19: A journey towards improved placental and vascular function using sulforaphane.
    Placenta, 2023, 09-26, Volume: 141

    Topics: Antioxidants; COVID-19; Female; Humans; Infant, Newborn; Placenta; Pre-Eclampsia; Pregnancy

2023

Trials

4 trials available for sulforaphane and Pregnancy

ArticleYear
CO-Sprout-A Pilot Double-Blinded Placebo-Controlled Randomised Trial of Broccoli Sprout Powder Supplementation for Pregnant Women with COVID-19 on the Duration of COVID-19-Associated Symptoms: Study Protocol.
    Nutrients, 2023, Sep-14, Volume: 15, Issue:18

    Topics: Brassica; COVID-19; Double-Blind Method; Female; Humans; Powders; Pregnancy; Pregnant Women; Randomi

2023
Prolong: a double-blind randomised placebo-controlled trial of broccoli sprout extract in women with early onset preeclampsia. A clinical trial protocol.
    BMJ open, 2019, 10-17, Volume: 9, Issue:10

    Topics: Australia; Biomarkers; Brassica; Clinical Trials, Phase III as Topic; Double-Blind Method; Female; H

2019
Sulforaphane Bioavailability and Effects on Blood Pressure in Women with Pregnancy Hypertension.
    Reproductive sciences (Thousand Oaks, Calif.), 2021, Volume: 28, Issue:5

    Topics: Adult; Biological Availability; Blood Pressure; Cross-Over Studies; Female; Humans; Hypertension, Pr

2021
Evaluation of Biodistribution of Sulforaphane after Administration of Oral Broccoli Sprout Extract in Melanoma Patients with Multiple Atypical Nevi.
    Cancer prevention research (Philadelphia, Pa.), 2018, Volume: 11, Issue:7

    Topics: Administration, Oral; Adult; Aged; Biomarkers, Tumor; Biopsy; Brassica; Capsules; Feasibility Studie

2018

Other Studies

15 other studies available for sulforaphane and Pregnancy

ArticleYear
Long-lasting beneficial effects of maternal intake of sulforaphane glucosinolate on gut microbiota in adult offspring.
    The Journal of nutritional biochemistry, 2022, Volume: 109

    Topics: Adult Children; Female; Gastrointestinal Microbiome; Glucosinolates; Humans; Interleukin-6; Isothioc

2022
An experimental evaluation of the efficacy of perinatal sulforaphane supplementation to decrease the incidence and severity of vinclozolin-induced hypospadias in the mouse model.
    Toxicology and applied pharmacology, 2022, 09-15, Volume: 451

    Topics: Animals; Dietary Supplements; Disease Models, Animal; Environmental Pollutants; Female; Humans; Hypo

2022
Sulforaphane induced NRF2 activation in obese pregnancy attenuates developmental redox imbalance and improves early-life cardiovascular function in offspring.
    Redox biology, 2023, Volume: 67

    Topics: Animals; Female; Humans; Isothiocyanates; Male; Mice; Myocytes, Cardiac; NF-E2-Related Factor 2; Obe

2023
Risk of neuropsychiatric disorders in offspring of COVID-19-infected pregnant women and nutritional intervention.
    European archives of psychiatry and clinical neuroscience, 2021, Volume: 271, Issue:2

    Topics: Autism Spectrum Disorder; C-Reactive Protein; COVID-19; Dietary Supplements; Female; Gestational Age

2021
Novel Insights into the Regulatory Role of Nuclear Factor (Erythroid-Derived 2)-Like 2 in Oxidative Stress and Inflammation of Human Fetal Membranes.
    International journal of molecular sciences, 2020, Aug-26, Volume: 21, Issue:17

    Topics: Alkaloids; Extraembryonic Membranes; Female; Gene Expression Regulation; Heme Oxygenase-1; Humans; I

2020
Sulforaphane improves vascular reactivity in mouse and human arteries after "preeclamptic-like" injury.
    Placenta, 2020, Volume: 101

    Topics: Animals; Anticarcinogenic Agents; Drug Evaluation, Preclinical; Female; Human Umbilical Vein Endothe

2020
Nano-sulforaphane attenuates PhIP-induced early abnormal embryonic neuro-development.
    Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft, 2021, Volume: 233

    Topics: Animals; Carcinogens; Chick Embryo; Female; Imidazoles; Isothiocyanates; Placenta; Pregnancy; Sulfox

2021
Pigment epithelial-derived factor in human fetal membranes.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2018, Volume: 31, Issue:15

    Topics: Adult; Eye Proteins; Female; Fetal Membranes, Premature Rupture; Humans; In Vitro Techniques; Isothi

2018
Sulforaphane restores acetyl-histone H3 binding to Bcl-2 promoter and prevents apoptosis in ethanol-exposed neural crest cells and mouse embryos.
    Experimental neurology, 2018, Volume: 300

    Topics: Animals; Apoptosis; Cells, Cultured; Embryonic Development; Enzyme Activation; Ethanol; Female; Hist

2018
Pro- and anti-inflammatory effects of sulforaphane on placental cytokine production.
    Journal of reproductive immunology, 2019, Volume: 131

    Topics: Adult; Cytokines; Escherichia coli; Escherichia coli Infections; Female; Humans; Inflammation; Isoth

2019
Sulforaphane improves endothelial function and reduces placental oxidative stress in vitro.
    Pregnancy hypertension, 2019, Volume: 16

    Topics: Antioxidants; Endothelium, Vascular; Female; Human Umbilical Vein Endothelial Cells; Humans; Isothio

2019
Differential modulation of dibenzo[def,p]chrysene transplacental carcinogenesis: maternal diets rich in indole-3-carbinol versus sulforaphane.
    Toxicology and applied pharmacology, 2013, Jul-01, Volume: 270, Issue:1

    Topics: Animals; Anticarcinogenic Agents; Benzopyrenes; Carcinogens; Diet; Female; Indoles; Isothiocyanates;

2013
Transcriptional responses of neonatal mouse lung to hyperoxia by Nrf2 status.
    Cytokine, 2014, Volume: 65, Issue:1

    Topics: Aerobiosis; Animals; Animals, Newborn; Anticarcinogenic Agents; Cell Cycle; Cyclin-Dependent Kinase

2014
Sub-chronic sulforaphane exposure in CD-1 pregnant mice enhances maternal NADPH quinone oxidoreductase 1 (NQO1) activity and mRNA expression of NQO1, glutathione S-transferase, and glutamate-cysteine ligase: potential implications for fetal protection aga
    Reproductive toxicology (Elmsford, N.Y.), 2014, Volume: 43

    Topics: Animals; Anticarcinogenic Agents; Female; Glutamate-Cysteine Ligase; Glutathione Transferase; Heme O

2014
Sulforaphane rescues memory dysfunction and synaptic and mitochondrial alterations induced by brain iron accumulation.
    Neuroscience, 2015, Aug-20, Volume: 301

    Topics: Animals; Animals, Newborn; Anticarcinogenic Agents; Brain; Catalase; Disease Models, Animal; Dynamin

2015