Page last updated: 2024-11-04

sulforaphane and Autism

sulforaphane has been researched along with Autism in 4 studies

sulforaphane: from Cardaria draba L.
sulforaphane : An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.

Research Excerpts

ExcerptRelevanceReference
"Children with autism spectrum disorder (ASD) have urinary metabolites suggesting impairments in several pathways, including oxidative stress, inflammation, mitochondrial dysfunction, and gut microbiome alterations."6.87Identification of urinary metabolites that correlate with clinical improvements in children with autism treated with sulforaphane from broccoli. ( Bent, S; Cornblatt, B; Dang, K; Delucchi, K; Fahey, JW; Hendren, RL; Kinchen, JM; Lawton, B; Warren, T; Widjaja, F, 2018)
"These mechanisms lead to improvement in autism-like symptoms in BTBR mice."5.51Nrf2 activator, sulforaphane ameliorates autism-like symptoms through suppression of Th17 related signaling and rectification of oxidant-antioxidant imbalance in periphery and brain of BTBR T+tf/J mice. ( Ahmad, SF; Al-Harbi, NO; Alqahtani, F; Alqinyah, M; Attia, SM; Bakheet, SA; Ibrahim, KE; Nadeem, A, 2019)
"Children with autism spectrum disorder (ASD) have urinary metabolites suggesting impairments in several pathways, including oxidative stress, inflammation, mitochondrial dysfunction, and gut microbiome alterations."2.87Identification of urinary metabolites that correlate with clinical improvements in children with autism treated with sulforaphane from broccoli. ( Bent, S; Cornblatt, B; Dang, K; Delucchi, K; Fahey, JW; Hendren, RL; Kinchen, JM; Lawton, B; Warren, T; Widjaja, F, 2018)
"Sulforaphane is an isothiocyanate occurring in stored form as glucoraphanin in cruciferous vegetables such as cabbage, cauliflower, and kale, and at high levels in broccoli especially in broccoli sprouts."2.61Isothiocyanate from Broccoli, Sulforaphane, and Its Properties. ( Anzenbacher, P; Anzenbacherova, E; Vanduchova, A, 2019)
"These mechanisms lead to improvement in autism-like symptoms in BTBR mice."1.51Nrf2 activator, sulforaphane ameliorates autism-like symptoms through suppression of Th17 related signaling and rectification of oxidant-antioxidant imbalance in periphery and brain of BTBR T+tf/J mice. ( Ahmad, SF; Al-Harbi, NO; Alqahtani, F; Alqinyah, M; Attia, SM; Bakheet, SA; Ibrahim, KE; Nadeem, A, 2019)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (75.00)24.3611
2020's1 (25.00)2.80

Authors

AuthorsStudies
Magner, M1
Thorová, K1
Župová, V1
Houška, M1
Švandová, I1
Novotná, P1
Tříska, J1
Vrchotová, N1
Soural, I1
Jílek, L1
Bent, S1
Lawton, B1
Warren, T1
Widjaja, F1
Dang, K1
Fahey, JW1
Cornblatt, B1
Kinchen, JM1
Delucchi, K1
Hendren, RL1
Vanduchova, A1
Anzenbacher, P1
Anzenbacherova, E1
Nadeem, A1
Ahmad, SF1
Al-Harbi, NO1
Attia, SM1
Bakheet, SA1
Ibrahim, KE1
Alqahtani, F1
Alqinyah, M1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Decreasing Risk of Psychosis by Sulforaphane: Study Protocol for a Randomized, Double-blind, Placebo-controlled, Clinical Multicenter Trial (DROPS Trial)[NCT03932136]Phase 3300 participants (Anticipated)Interventional2019-07-14Recruiting
An Examination of Changes in Urinary Metabolites With Use of an Antioxidant Supplement, Sulforaphane, in School-aged Children With Autism[NCT02654743]Phase 321 participants (Actual)Interventional2016-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for sulforaphane and Autism

ArticleYear
Isothiocyanate from Broccoli, Sulforaphane, and Its Properties.
    Journal of medicinal food, 2019, Volume: 22, Issue:2

    Topics: Animals; Antineoplastic Agents, Phytogenic; Autistic Disorder; Brassica; Glucosinolates; Humans; Imi

2019

Trials

2 trials available for sulforaphane and Autism

ArticleYear
Sulforaphane Treatment in Children with Autism: A Prospective Randomized Double-Blind Study.
    Nutrients, 2023, Jan-31, Volume: 15, Issue:3

    Topics: Autism Spectrum Disorder; Autistic Disorder; Child; Double-Blind Method; Humans; Isothiocyanates; Pr

2023
Identification of urinary metabolites that correlate with clinical improvements in children with autism treated with sulforaphane from broccoli.
    Molecular autism, 2018, Volume: 9

    Topics: Adolescent; Antioxidants; Autistic Disorder; Biomarkers; Brassica; Child; Female; Humans; Isothiocya

2018
Identification of urinary metabolites that correlate with clinical improvements in children with autism treated with sulforaphane from broccoli.
    Molecular autism, 2018, Volume: 9

    Topics: Adolescent; Antioxidants; Autistic Disorder; Biomarkers; Brassica; Child; Female; Humans; Isothiocya

2018
Identification of urinary metabolites that correlate with clinical improvements in children with autism treated with sulforaphane from broccoli.
    Molecular autism, 2018, Volume: 9

    Topics: Adolescent; Antioxidants; Autistic Disorder; Biomarkers; Brassica; Child; Female; Humans; Isothiocya

2018
Identification of urinary metabolites that correlate with clinical improvements in children with autism treated with sulforaphane from broccoli.
    Molecular autism, 2018, Volume: 9

    Topics: Adolescent; Antioxidants; Autistic Disorder; Biomarkers; Brassica; Child; Female; Humans; Isothiocya

2018

Other Studies

1 other study available for sulforaphane and Autism

ArticleYear
Nrf2 activator, sulforaphane ameliorates autism-like symptoms through suppression of Th17 related signaling and rectification of oxidant-antioxidant imbalance in periphery and brain of BTBR T+tf/J mice.
    Behavioural brain research, 2019, 05-17, Volume: 364

    Topics: Animals; Antioxidants; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Brain; Cytokin

2019