sulforaphane has been researched along with Hepatocellular Carcinoma in 28 studies
sulforaphane: from Cardaria draba L.
sulforaphane : An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sulforaphane (SFN) is a naturally occurring chemopreventive agent, which effectively inhibits proliferation of HepG2 human hepatocellular carcinoma cells via mitochondria‑mediated apoptosis." | 7.85 | Endoplasmic reticulum stress mediates sulforaphane-induced apoptosis of HepG2 human hepatocellular carcinoma cells. ( Fang, Y; Ji, Y; Qu, Z; Shi, X; Zou, X, 2017) |
| "Angiogenesis plays an important role in hepatocellular carcinoma (HCC), the inhibition of which is explored for cancer prevention and treatment." | 5.46 | Sulforaphane exerts anti-angiogenesis effects against hepatocellular carcinoma through inhibition of STAT3/HIF-1α/VEGF signalling. ( Akbareian, SE; Atkinson, SJ; Bao, Y; Liu, P; Munsterberg, A; Robinson, SD; Zhou, Z, 2017) |
| "However, its effect on hepatocellular carcinoma remains largely unknown." | 5.43 | Sulforaphane inhibits TGF-β-induced epithelial-mesenchymal transition of hepatocellular carcinoma cells via the reactive oxygen species-dependent pathway. ( Deng, C; Han, J; Hou, B; Shen, L; Wu, H; Wu, J, 2016) |
| "Sulforaphane (SFN) is a naturally occurring chemopreventive agent, which effectively inhibits proliferation of HepG2 human hepatocellular carcinoma cells via mitochondria‑mediated apoptosis." | 3.85 | Endoplasmic reticulum stress mediates sulforaphane-induced apoptosis of HepG2 human hepatocellular carcinoma cells. ( Fang, Y; Ji, Y; Qu, Z; Shi, X; Zou, X, 2017) |
| "Angiogenesis plays an important role in hepatocellular carcinoma (HCC), the inhibition of which is explored for cancer prevention and treatment." | 1.46 | Sulforaphane exerts anti-angiogenesis effects against hepatocellular carcinoma through inhibition of STAT3/HIF-1α/VEGF signalling. ( Akbareian, SE; Atkinson, SJ; Bao, Y; Liu, P; Munsterberg, A; Robinson, SD; Zhou, Z, 2017) |
| "However, its effect on hepatocellular carcinoma remains largely unknown." | 1.43 | Sulforaphane inhibits TGF-β-induced epithelial-mesenchymal transition of hepatocellular carcinoma cells via the reactive oxygen species-dependent pathway. ( Deng, C; Han, J; Hou, B; Shen, L; Wu, H; Wu, J, 2016) |
| "In human hepatoma HepG2 cells, sulforaphane induced thioredoxin reductase mRNA and protein by 4- and 2-fold, respectively, whereas thioredoxin mRNA was induced 2." | 1.34 | Dual action of sulforaphane in the regulation of thioredoxin reductase and thioredoxin in human HepG2 and Caco-2 cells. ( Bacon, JR; Bao, Y; Beckett, GJ; Howie, AF; Plumb, GW; Wang, W, 2007) |
| "Sulforaphane (SFN) is an isothiocyanate that is found in abundant quantities in many cruciferous vegetables including broccoli and cauliflower." | 1.34 | Induction of apoptosis by isothiocyanate sulforaphane in human cervical carcinoma HeLa and hepatocarcinoma HepG2 cells through activation of caspase-3. ( Bae, SJ; Choi, YH; Kim, GY; Park, SY; Yoo, YH, 2007) |
| "Sulforaphane is a chemopreventive agent present in various cruciferous vegetables, including broccoli." | 1.33 | Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of DR5. ( Choi, KS; Eom, YW; Kim, EH; Kim, H; Kim, WH; Kwon, TK; Lee, SJ, 2006) |
| "Treatment of human hepatoma (HepG2) and murine hepatoma (Hepa1c1c7) cells with tert-butylhydroquinone (tBHQ) or sulforaphane (SUL), two potent phase II enzyme inducers, stimulated the activity of extracellular signal-regulated protein kinase 2 (ERK2) but not c-Jun N-terminal kinase 1." | 1.30 | Role of a mitogen-activated protein kinase pathway in the induction of phase II detoxifying enzymes by chemicals. ( Der, CJ; Kong, AN; Lei, W; Mandlekar, S; Weber, MJ; Wu, J; Yu, R, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (3.57) | 18.2507 |
| 2000's | 16 (57.14) | 29.6817 |
| 2010's | 11 (39.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Misico, RI | 1 |
| Song, LL | 1 |
| Veleiro, AS | 1 |
| Cirigliano, AM | 1 |
| Tettamanzi, MC | 1 |
| Burton, G | 1 |
| Bonetto, GM | 1 |
| Nicotra, VE | 1 |
| Silva, GL | 1 |
| Gil, RR | 1 |
| Oberti, JC | 1 |
| Kinghorn, AD | 5 |
| Pezzuto, JM | 5 |
| Gu, JQ | 1 |
| Park, EJ | 4 |
| Vigo, JS | 2 |
| Graham, JG | 3 |
| Fong, HH | 4 |
| Su, BN | 2 |
| Nikolic, D | 1 |
| Schunke Vigo, J | 1 |
| Cabieses, F | 2 |
| van Breemen, RB | 1 |
| Farnsworth, NR | 1 |
| Jang, DS | 1 |
| Kang, YH | 2 |
| Hawthorne, ME | 1 |
| Mehta, RG | 1 |
| Carcache-Blanco, EJ | 1 |
| Kardono, LB | 1 |
| Riswan, S | 1 |
| Li, W | 2 |
| Zheng, S | 1 |
| Higgins, M | 1 |
| Morra, RP | 1 |
| Mendis, AT | 1 |
| Chien, CW | 1 |
| Ojima, I | 1 |
| Mierke, DF | 1 |
| Dinkova-Kostova, AT | 1 |
| Honda, T | 1 |
| Ren, K | 1 |
| Li, Z | 1 |
| Li, Y | 1 |
| Zhang, W | 1 |
| Han, X | 1 |
| Liu, P | 1 |
| Atkinson, SJ | 1 |
| Akbareian, SE | 1 |
| Zhou, Z | 1 |
| Munsterberg, A | 1 |
| Robinson, SD | 1 |
| Bao, Y | 2 |
| Kntayya, SB | 1 |
| Ibrahim, MD | 1 |
| Mohd Ain, N | 1 |
| Iori, R | 1 |
| Ioannides, C | 1 |
| Abdull Razis, AF | 2 |
| Yamaguchi, M | 2 |
| Noor, NM | 1 |
| Wu, J | 2 |
| Han, J | 2 |
| Hou, B | 1 |
| Deng, C | 1 |
| Wu, H | 1 |
| Shen, L | 1 |
| Moreno, FS | 1 |
| Heidor, R | 1 |
| Pogribny, IP | 1 |
| Zou, X | 1 |
| Qu, Z | 1 |
| Fang, Y | 1 |
| Shi, X | 1 |
| Ji, Y | 1 |
| Anwar-Mohamed, A | 1 |
| El-Kadi, AO | 1 |
| Moon, DO | 1 |
| Kang, SH | 1 |
| Kim, KC | 1 |
| Kim, MO | 1 |
| Choi, YH | 2 |
| Kim, GY | 2 |
| Jeon, YK | 1 |
| Yoo, DR | 1 |
| Jang, YH | 1 |
| Jang, SY | 1 |
| Nam, MJ | 1 |
| Fukaya, Y | 1 |
| Jeong, WS | 1 |
| Keum, YS | 2 |
| Chen, C | 1 |
| Jain, MR | 1 |
| Shen, G | 1 |
| Kim, JH | 2 |
| Kong, AN | 3 |
| Yeh, CT | 1 |
| Yen, GC | 1 |
| Hwang, ES | 1 |
| Jeffery, EH | 1 |
| Moriarty, RM | 1 |
| Naithani, R | 1 |
| Kosmeder, J | 1 |
| Prakash, O | 1 |
| Kim, H | 1 |
| Kim, EH | 1 |
| Eom, YW | 1 |
| Kim, WH | 1 |
| Kwon, TK | 1 |
| Lee, SJ | 1 |
| Choi, KS | 1 |
| Yu, S | 1 |
| Chang, PP | 1 |
| Yuan, X | 1 |
| Xu, C | 1 |
| Agarwal, A | 1 |
| Bacon, JR | 1 |
| Plumb, GW | 1 |
| Howie, AF | 1 |
| Beckett, GJ | 1 |
| Wang, W | 1 |
| Park, SY | 1 |
| Bae, SJ | 1 |
| Yoo, YH | 1 |
| Yates, MS | 1 |
| Kensler, TW | 1 |
| Yu, R | 1 |
| Lei, W | 1 |
| Mandlekar, S | 1 |
| Weber, MJ | 1 |
| Der, CJ | 1 |
3 reviews available for sulforaphane and Hepatocellular Carcinoma
| Article | Year |
|---|---|
The anti-apoptotic effect of regucalcin is mediated through multisignaling pathways.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Calcium-Binding Proteins; Carcinoma, Hepatocellul | 2013 |
Nutritional Epigenetics and the Prevention of Hepatocellular Carcinoma with Bioactive Food Constituents.
Topics: Animals; Butyric Acid; Carcinoma, Hepatocellular; Catechin; Cell Line, Tumor; Curcumin; Disease Mode | 2016 |
Keap1 eye on the target: chemoprevention of liver cancer.
Topics: Aflatoxins; Animals; Anticarcinogenic Agents; Antioxidants; Carcinoma, Hepatocellular; Clinical Tria | 2007 |
25 other studies available for sulforaphane and Hepatocellular Carcinoma
| Article | Year |
|---|---|
Induction of quinone reductase by withanolides.
Topics: Animals; Brassicaceae; Breast; Carcinoma, Hepatocellular; Colon; Enzyme Induction; Inhibitory Concen | 2002 |
Activity-guided isolation of constituents of Renealmia nicolaioides with the potential to induce the phase II enzyme quinone reductase.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Chalcone; Chalcones; Chromato | 2002 |
Isolation and characterization of miscellaneous secondary metabolites of Deprea subtriflora.
Topics: Animals; Carcinoma, Hepatocellular; Drug Screening Assays, Antitumor; Heterocyclic Compounds, 4 or M | 2003 |
Potential cncer chemopreventive flavonoids from the stems of Tephrosia toxicaria.
Topics: Animals; Anticarcinogenic Agents; Carcinoma, Hepatocellular; Chromones; Flavonoids; Heterocyclic Com | 2003 |
Constituents of the stem bark of Pongamia pinnata with the potential to induce quinone reductase.
Topics: Animals; Anticarcinogenic Agents; Carcinoma, Hepatocellular; Enzyme Induction; Flavonoids; Indonesia | 2003 |
New Monocyclic, Bicyclic, and Tricyclic Ethynylcyanodienones as Activators of the Keap1/Nrf2/ARE Pathway and Inhibitors of Inducible Nitric Oxide Synthase.
Topics: Adaptor Proteins, Signal Transducing; Alkynes; Animals; Anti-Inflammatory Agents; Antineoplastic Age | 2015 |
Sulforaphene enhances radiosensitivity of hepatocellular carcinoma through suppression of the NF-κB pathway.
Topics: Animals; Carcinoma, Hepatocellular; Hep G2 Cells; Humans; Isothiocyanates; Liver Neoplasms; Male; Mi | 2017 |
Sulforaphane exerts anti-angiogenesis effects against hepatocellular carcinoma through inhibition of STAT3/HIF-1α/VEGF signalling.
Topics: Animals; Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Cell Survival; Chick Embryo; | 2017 |
Induction of Apoptosis and Cytotoxicity by Isothiocyanate Sulforaphene in Human Hepatocarcinoma HepG2 Cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Caspases; Cell Cycle Checkp | 2018 |
Sulforaphane is superior to glucoraphanin in modulating carcinogen-metabolising enzymes in Hep G2 cells.
Topics: Anticarcinogenic Agents; Carcinoma, Hepatocellular; Glucosinolates; Glutathione Transferase; Glycosi | 2013 |
Sulforaphane inhibits TGF-β-induced epithelial-mesenchymal transition of hepatocellular carcinoma cells via the reactive oxygen species-dependent pathway.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Movement; Cell Shape; Epi | 2016 |
Endoplasmic reticulum stress mediates sulforaphane-induced apoptosis of HepG2 human hepatocellular carcinoma cells.
Topics: Anticarcinogenic Agents; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Carcinoma, Hepatoc | 2017 |
Sulforaphane induces CYP1A1 mRNA, protein, and catalytic activity levels via an AhR-dependent pathway in murine hepatoma Hepa 1c1c7 and human HepG2 cells.
Topics: Animals; Brassica; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Transformation, Neoplastic; Cyt | 2009 |
Sulforaphane decreases viability and telomerase activity in hepatocellular carcinoma Hep3B cells through the reactive oxygen species-dependent pathway.
Topics: Anticarcinogenic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Down | 2010 |
Sulforaphane induces apoptosis in human hepatic cancer cells through inhibition of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase4, mediated by hypoxia inducible factor-1-dependent pathway.
Topics: Anticarcinogenic Agents; Apoptosis; Carcinoma, Hepatocellular; Drug Evaluation, Preclinical; Enzyme | 2011 |
Overexpression of regucalcin suppresses apoptotic cell death in the cloned rat hepatoma H4-II-E cells induced by a naturally occurring isothiocyanate sulforaphane.
Topics: Animals; Apoptosis; Calcium-Binding Proteins; Carboxylic Ester Hydrolases; Carcinoma, Hepatocellular | 2005 |
Differential expression and stability of endogenous nuclear factor E2-related factor 2 (Nrf2) by natural chemopreventive compounds in HepG2 human hepatoma cells.
Topics: Anticarcinogenic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; DNA-Binding Proteins; Heme Oxy | 2005 |
Effect of sulforaphane on metallothionein expression and induction of apoptosis in human hepatoma HepG2 cells.
Topics: Anticarcinogenic Agents; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Blotting, Western; Ca | 2005 |
Induction of quinone reductase by sulforaphane and sulforaphane N-acetylcysteine conjugate in murine hepatoma cells.
Topics: Acetylcysteine; Animals; Anticarcinogenic Agents; Brassica; Carcinoma, Hepatocellular; Dose-Response | 2005 |
Cancer chemopreventive activity of sulforamate derivatives.
Topics: Animals; Anticarcinogenic Agents; Carcinoma, Hepatocellular; Cell Survival; Isothiocyanates; Liver N | 2006 |
Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of DR5.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; b | 2006 |
Mechanism of action of sulforaphane: inhibition of p38 mitogen-activated protein kinase isoforms contributing to the induction of antioxidant response element-mediated heme oxygenase-1 in human hepatoma HepG2 cells.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Carcinoma, Hepatocellular; Cell Line, Tumor; Cells, | 2006 |
Dual action of sulforaphane in the regulation of thioredoxin reductase and thioredoxin in human HepG2 and Caco-2 cells.
Topics: Caco-2 Cells; Carcinoma, Hepatocellular; Cell Line, Tumor; Gene Expression Regulation; Humans; Isoth | 2007 |
Induction of apoptosis by isothiocyanate sulforaphane in human cervical carcinoma HeLa and hepatocarcinoma HepG2 cells through activation of caspase-3.
Topics: Anticarcinogenic Agents; Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Caspase 3; Cell Li | 2007 |
Role of a mitogen-activated protein kinase pathway in the induction of phase II detoxifying enzymes by chemicals.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Enzyme Induction; Enzyme Inhibitors; Flav | 1999 |