sulforaphane has been researched along with Hepatocellular Carcinoma in 28 studies
sulforaphane: from Cardaria draba L.
sulforaphane : An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.
Excerpt | Relevance | Reference |
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"Sulforaphane (SFN) is a naturally occurring chemopreventive agent, which effectively inhibits proliferation of HepG2 human hepatocellular carcinoma cells via mitochondria‑mediated apoptosis." | 7.85 | Endoplasmic reticulum stress mediates sulforaphane-induced apoptosis of HepG2 human hepatocellular carcinoma cells. ( Fang, Y; Ji, Y; Qu, Z; Shi, X; Zou, X, 2017) |
"Angiogenesis plays an important role in hepatocellular carcinoma (HCC), the inhibition of which is explored for cancer prevention and treatment." | 5.46 | Sulforaphane exerts anti-angiogenesis effects against hepatocellular carcinoma through inhibition of STAT3/HIF-1α/VEGF signalling. ( Akbareian, SE; Atkinson, SJ; Bao, Y; Liu, P; Munsterberg, A; Robinson, SD; Zhou, Z, 2017) |
"However, its effect on hepatocellular carcinoma remains largely unknown." | 5.43 | Sulforaphane inhibits TGF-β-induced epithelial-mesenchymal transition of hepatocellular carcinoma cells via the reactive oxygen species-dependent pathway. ( Deng, C; Han, J; Hou, B; Shen, L; Wu, H; Wu, J, 2016) |
"Sulforaphane (SFN) is a naturally occurring chemopreventive agent, which effectively inhibits proliferation of HepG2 human hepatocellular carcinoma cells via mitochondria‑mediated apoptosis." | 3.85 | Endoplasmic reticulum stress mediates sulforaphane-induced apoptosis of HepG2 human hepatocellular carcinoma cells. ( Fang, Y; Ji, Y; Qu, Z; Shi, X; Zou, X, 2017) |
"Angiogenesis plays an important role in hepatocellular carcinoma (HCC), the inhibition of which is explored for cancer prevention and treatment." | 1.46 | Sulforaphane exerts anti-angiogenesis effects against hepatocellular carcinoma through inhibition of STAT3/HIF-1α/VEGF signalling. ( Akbareian, SE; Atkinson, SJ; Bao, Y; Liu, P; Munsterberg, A; Robinson, SD; Zhou, Z, 2017) |
"However, its effect on hepatocellular carcinoma remains largely unknown." | 1.43 | Sulforaphane inhibits TGF-β-induced epithelial-mesenchymal transition of hepatocellular carcinoma cells via the reactive oxygen species-dependent pathway. ( Deng, C; Han, J; Hou, B; Shen, L; Wu, H; Wu, J, 2016) |
"In human hepatoma HepG2 cells, sulforaphane induced thioredoxin reductase mRNA and protein by 4- and 2-fold, respectively, whereas thioredoxin mRNA was induced 2." | 1.34 | Dual action of sulforaphane in the regulation of thioredoxin reductase and thioredoxin in human HepG2 and Caco-2 cells. ( Bacon, JR; Bao, Y; Beckett, GJ; Howie, AF; Plumb, GW; Wang, W, 2007) |
"Sulforaphane (SFN) is an isothiocyanate that is found in abundant quantities in many cruciferous vegetables including broccoli and cauliflower." | 1.34 | Induction of apoptosis by isothiocyanate sulforaphane in human cervical carcinoma HeLa and hepatocarcinoma HepG2 cells through activation of caspase-3. ( Bae, SJ; Choi, YH; Kim, GY; Park, SY; Yoo, YH, 2007) |
"Sulforaphane is a chemopreventive agent present in various cruciferous vegetables, including broccoli." | 1.33 | Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of DR5. ( Choi, KS; Eom, YW; Kim, EH; Kim, H; Kim, WH; Kwon, TK; Lee, SJ, 2006) |
"Treatment of human hepatoma (HepG2) and murine hepatoma (Hepa1c1c7) cells with tert-butylhydroquinone (tBHQ) or sulforaphane (SUL), two potent phase II enzyme inducers, stimulated the activity of extracellular signal-regulated protein kinase 2 (ERK2) but not c-Jun N-terminal kinase 1." | 1.30 | Role of a mitogen-activated protein kinase pathway in the induction of phase II detoxifying enzymes by chemicals. ( Der, CJ; Kong, AN; Lei, W; Mandlekar, S; Weber, MJ; Wu, J; Yu, R, 1999) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 1 (3.57) | 18.2507 |
2000's | 16 (57.14) | 29.6817 |
2010's | 11 (39.29) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Misico, RI | 1 |
Song, LL | 1 |
Veleiro, AS | 1 |
Cirigliano, AM | 1 |
Tettamanzi, MC | 1 |
Burton, G | 1 |
Bonetto, GM | 1 |
Nicotra, VE | 1 |
Silva, GL | 1 |
Gil, RR | 1 |
Oberti, JC | 1 |
Kinghorn, AD | 5 |
Pezzuto, JM | 5 |
Gu, JQ | 1 |
Park, EJ | 4 |
Vigo, JS | 2 |
Graham, JG | 3 |
Fong, HH | 4 |
Su, BN | 2 |
Nikolic, D | 1 |
Schunke Vigo, J | 1 |
Cabieses, F | 2 |
van Breemen, RB | 1 |
Farnsworth, NR | 1 |
Jang, DS | 1 |
Kang, YH | 2 |
Hawthorne, ME | 1 |
Mehta, RG | 1 |
Carcache-Blanco, EJ | 1 |
Kardono, LB | 1 |
Riswan, S | 1 |
Li, W | 2 |
Zheng, S | 1 |
Higgins, M | 1 |
Morra, RP | 1 |
Mendis, AT | 1 |
Chien, CW | 1 |
Ojima, I | 1 |
Mierke, DF | 1 |
Dinkova-Kostova, AT | 1 |
Honda, T | 1 |
Ren, K | 1 |
Li, Z | 1 |
Li, Y | 1 |
Zhang, W | 1 |
Han, X | 1 |
Liu, P | 1 |
Atkinson, SJ | 1 |
Akbareian, SE | 1 |
Zhou, Z | 1 |
Munsterberg, A | 1 |
Robinson, SD | 1 |
Bao, Y | 2 |
Kntayya, SB | 1 |
Ibrahim, MD | 1 |
Mohd Ain, N | 1 |
Iori, R | 1 |
Ioannides, C | 1 |
Abdull Razis, AF | 2 |
Yamaguchi, M | 2 |
Noor, NM | 1 |
Wu, J | 2 |
Han, J | 2 |
Hou, B | 1 |
Deng, C | 1 |
Wu, H | 1 |
Shen, L | 1 |
Moreno, FS | 1 |
Heidor, R | 1 |
Pogribny, IP | 1 |
Zou, X | 1 |
Qu, Z | 1 |
Fang, Y | 1 |
Shi, X | 1 |
Ji, Y | 1 |
Anwar-Mohamed, A | 1 |
El-Kadi, AO | 1 |
Moon, DO | 1 |
Kang, SH | 1 |
Kim, KC | 1 |
Kim, MO | 1 |
Choi, YH | 2 |
Kim, GY | 2 |
Jeon, YK | 1 |
Yoo, DR | 1 |
Jang, YH | 1 |
Jang, SY | 1 |
Nam, MJ | 1 |
Fukaya, Y | 1 |
Jeong, WS | 1 |
Keum, YS | 2 |
Chen, C | 1 |
Jain, MR | 1 |
Shen, G | 1 |
Kim, JH | 2 |
Kong, AN | 3 |
Yeh, CT | 1 |
Yen, GC | 1 |
Hwang, ES | 1 |
Jeffery, EH | 1 |
Moriarty, RM | 1 |
Naithani, R | 1 |
Kosmeder, J | 1 |
Prakash, O | 1 |
Kim, H | 1 |
Kim, EH | 1 |
Eom, YW | 1 |
Kim, WH | 1 |
Kwon, TK | 1 |
Lee, SJ | 1 |
Choi, KS | 1 |
Yu, S | 1 |
Chang, PP | 1 |
Yuan, X | 1 |
Xu, C | 1 |
Agarwal, A | 1 |
Bacon, JR | 1 |
Plumb, GW | 1 |
Howie, AF | 1 |
Beckett, GJ | 1 |
Wang, W | 1 |
Park, SY | 1 |
Bae, SJ | 1 |
Yoo, YH | 1 |
Yates, MS | 1 |
Kensler, TW | 1 |
Yu, R | 1 |
Lei, W | 1 |
Mandlekar, S | 1 |
Weber, MJ | 1 |
Der, CJ | 1 |
3 reviews available for sulforaphane and Hepatocellular Carcinoma
Article | Year |
---|---|
The anti-apoptotic effect of regucalcin is mediated through multisignaling pathways.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Calcium-Binding Proteins; Carcinoma, Hepatocellul | 2013 |
Nutritional Epigenetics and the Prevention of Hepatocellular Carcinoma with Bioactive Food Constituents.
Topics: Animals; Butyric Acid; Carcinoma, Hepatocellular; Catechin; Cell Line, Tumor; Curcumin; Disease Mode | 2016 |
Keap1 eye on the target: chemoprevention of liver cancer.
Topics: Aflatoxins; Animals; Anticarcinogenic Agents; Antioxidants; Carcinoma, Hepatocellular; Clinical Tria | 2007 |
25 other studies available for sulforaphane and Hepatocellular Carcinoma
Article | Year |
---|---|
Induction of quinone reductase by withanolides.
Topics: Animals; Brassicaceae; Breast; Carcinoma, Hepatocellular; Colon; Enzyme Induction; Inhibitory Concen | 2002 |
Activity-guided isolation of constituents of Renealmia nicolaioides with the potential to induce the phase II enzyme quinone reductase.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Chalcone; Chalcones; Chromato | 2002 |
Isolation and characterization of miscellaneous secondary metabolites of Deprea subtriflora.
Topics: Animals; Carcinoma, Hepatocellular; Drug Screening Assays, Antitumor; Heterocyclic Compounds, 4 or M | 2003 |
Potential cncer chemopreventive flavonoids from the stems of Tephrosia toxicaria.
Topics: Animals; Anticarcinogenic Agents; Carcinoma, Hepatocellular; Chromones; Flavonoids; Heterocyclic Com | 2003 |
Constituents of the stem bark of Pongamia pinnata with the potential to induce quinone reductase.
Topics: Animals; Anticarcinogenic Agents; Carcinoma, Hepatocellular; Enzyme Induction; Flavonoids; Indonesia | 2003 |
New Monocyclic, Bicyclic, and Tricyclic Ethynylcyanodienones as Activators of the Keap1/Nrf2/ARE Pathway and Inhibitors of Inducible Nitric Oxide Synthase.
Topics: Adaptor Proteins, Signal Transducing; Alkynes; Animals; Anti-Inflammatory Agents; Antineoplastic Age | 2015 |
Sulforaphene enhances radiosensitivity of hepatocellular carcinoma through suppression of the NF-κB pathway.
Topics: Animals; Carcinoma, Hepatocellular; Hep G2 Cells; Humans; Isothiocyanates; Liver Neoplasms; Male; Mi | 2017 |
Sulforaphane exerts anti-angiogenesis effects against hepatocellular carcinoma through inhibition of STAT3/HIF-1α/VEGF signalling.
Topics: Animals; Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Cell Survival; Chick Embryo; | 2017 |
Induction of Apoptosis and Cytotoxicity by Isothiocyanate Sulforaphene in Human Hepatocarcinoma HepG2 Cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Caspases; Cell Cycle Checkp | 2018 |
Sulforaphane is superior to glucoraphanin in modulating carcinogen-metabolising enzymes in Hep G2 cells.
Topics: Anticarcinogenic Agents; Carcinoma, Hepatocellular; Glucosinolates; Glutathione Transferase; Glycosi | 2013 |
Sulforaphane inhibits TGF-β-induced epithelial-mesenchymal transition of hepatocellular carcinoma cells via the reactive oxygen species-dependent pathway.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Movement; Cell Shape; Epi | 2016 |
Endoplasmic reticulum stress mediates sulforaphane-induced apoptosis of HepG2 human hepatocellular carcinoma cells.
Topics: Anticarcinogenic Agents; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Carcinoma, Hepatoc | 2017 |
Sulforaphane induces CYP1A1 mRNA, protein, and catalytic activity levels via an AhR-dependent pathway in murine hepatoma Hepa 1c1c7 and human HepG2 cells.
Topics: Animals; Brassica; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Transformation, Neoplastic; Cyt | 2009 |
Sulforaphane decreases viability and telomerase activity in hepatocellular carcinoma Hep3B cells through the reactive oxygen species-dependent pathway.
Topics: Anticarcinogenic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Down | 2010 |
Sulforaphane induces apoptosis in human hepatic cancer cells through inhibition of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase4, mediated by hypoxia inducible factor-1-dependent pathway.
Topics: Anticarcinogenic Agents; Apoptosis; Carcinoma, Hepatocellular; Drug Evaluation, Preclinical; Enzyme | 2011 |
Overexpression of regucalcin suppresses apoptotic cell death in the cloned rat hepatoma H4-II-E cells induced by a naturally occurring isothiocyanate sulforaphane.
Topics: Animals; Apoptosis; Calcium-Binding Proteins; Carboxylic Ester Hydrolases; Carcinoma, Hepatocellular | 2005 |
Differential expression and stability of endogenous nuclear factor E2-related factor 2 (Nrf2) by natural chemopreventive compounds in HepG2 human hepatoma cells.
Topics: Anticarcinogenic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; DNA-Binding Proteins; Heme Oxy | 2005 |
Effect of sulforaphane on metallothionein expression and induction of apoptosis in human hepatoma HepG2 cells.
Topics: Anticarcinogenic Agents; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Blotting, Western; Ca | 2005 |
Induction of quinone reductase by sulforaphane and sulforaphane N-acetylcysteine conjugate in murine hepatoma cells.
Topics: Acetylcysteine; Animals; Anticarcinogenic Agents; Brassica; Carcinoma, Hepatocellular; Dose-Response | 2005 |
Cancer chemopreventive activity of sulforamate derivatives.
Topics: Animals; Anticarcinogenic Agents; Carcinoma, Hepatocellular; Cell Survival; Isothiocyanates; Liver N | 2006 |
Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of DR5.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; b | 2006 |
Mechanism of action of sulforaphane: inhibition of p38 mitogen-activated protein kinase isoforms contributing to the induction of antioxidant response element-mediated heme oxygenase-1 in human hepatoma HepG2 cells.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Carcinoma, Hepatocellular; Cell Line, Tumor; Cells, | 2006 |
Dual action of sulforaphane in the regulation of thioredoxin reductase and thioredoxin in human HepG2 and Caco-2 cells.
Topics: Caco-2 Cells; Carcinoma, Hepatocellular; Cell Line, Tumor; Gene Expression Regulation; Humans; Isoth | 2007 |
Induction of apoptosis by isothiocyanate sulforaphane in human cervical carcinoma HeLa and hepatocarcinoma HepG2 cells through activation of caspase-3.
Topics: Anticarcinogenic Agents; Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Caspase 3; Cell Li | 2007 |
Role of a mitogen-activated protein kinase pathway in the induction of phase II detoxifying enzymes by chemicals.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Enzyme Induction; Enzyme Inhibitors; Flav | 1999 |