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sulforaphane and Hepatocellular Carcinoma

sulforaphane has been researched along with Hepatocellular Carcinoma in 28 studies

sulforaphane: from Cardaria draba L.
sulforaphane : An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.

Research Excerpts

ExcerptRelevanceReference
"Sulforaphane (SFN) is a naturally occurring chemopreventive agent, which effectively inhibits proliferation of HepG2 human hepatocellular carcinoma cells via mitochondria‑mediated apoptosis."7.85Endoplasmic reticulum stress mediates sulforaphane-induced apoptosis of HepG2 human hepatocellular carcinoma cells. ( Fang, Y; Ji, Y; Qu, Z; Shi, X; Zou, X, 2017)
"Angiogenesis plays an important role in hepatocellular carcinoma (HCC), the inhibition of which is explored for cancer prevention and treatment."5.46Sulforaphane exerts anti-angiogenesis effects against hepatocellular carcinoma through inhibition of STAT3/HIF-1α/VEGF signalling. ( Akbareian, SE; Atkinson, SJ; Bao, Y; Liu, P; Munsterberg, A; Robinson, SD; Zhou, Z, 2017)
"However, its effect on hepatocellular carcinoma remains largely unknown."5.43Sulforaphane inhibits TGF-β-induced epithelial-mesenchymal transition of hepatocellular carcinoma cells via the reactive oxygen species-dependent pathway. ( Deng, C; Han, J; Hou, B; Shen, L; Wu, H; Wu, J, 2016)
"Sulforaphane (SFN) is a naturally occurring chemopreventive agent, which effectively inhibits proliferation of HepG2 human hepatocellular carcinoma cells via mitochondria‑mediated apoptosis."3.85Endoplasmic reticulum stress mediates sulforaphane-induced apoptosis of HepG2 human hepatocellular carcinoma cells. ( Fang, Y; Ji, Y; Qu, Z; Shi, X; Zou, X, 2017)
"Angiogenesis plays an important role in hepatocellular carcinoma (HCC), the inhibition of which is explored for cancer prevention and treatment."1.46Sulforaphane exerts anti-angiogenesis effects against hepatocellular carcinoma through inhibition of STAT3/HIF-1α/VEGF signalling. ( Akbareian, SE; Atkinson, SJ; Bao, Y; Liu, P; Munsterberg, A; Robinson, SD; Zhou, Z, 2017)
"However, its effect on hepatocellular carcinoma remains largely unknown."1.43Sulforaphane inhibits TGF-β-induced epithelial-mesenchymal transition of hepatocellular carcinoma cells via the reactive oxygen species-dependent pathway. ( Deng, C; Han, J; Hou, B; Shen, L; Wu, H; Wu, J, 2016)
"In human hepatoma HepG2 cells, sulforaphane induced thioredoxin reductase mRNA and protein by 4- and 2-fold, respectively, whereas thioredoxin mRNA was induced 2."1.34Dual action of sulforaphane in the regulation of thioredoxin reductase and thioredoxin in human HepG2 and Caco-2 cells. ( Bacon, JR; Bao, Y; Beckett, GJ; Howie, AF; Plumb, GW; Wang, W, 2007)
"Sulforaphane (SFN) is an isothiocyanate that is found in abundant quantities in many cruciferous vegetables including broccoli and cauliflower."1.34Induction of apoptosis by isothiocyanate sulforaphane in human cervical carcinoma HeLa and hepatocarcinoma HepG2 cells through activation of caspase-3. ( Bae, SJ; Choi, YH; Kim, GY; Park, SY; Yoo, YH, 2007)
"Sulforaphane is a chemopreventive agent present in various cruciferous vegetables, including broccoli."1.33Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of DR5. ( Choi, KS; Eom, YW; Kim, EH; Kim, H; Kim, WH; Kwon, TK; Lee, SJ, 2006)
"Treatment of human hepatoma (HepG2) and murine hepatoma (Hepa1c1c7) cells with tert-butylhydroquinone (tBHQ) or sulforaphane (SUL), two potent phase II enzyme inducers, stimulated the activity of extracellular signal-regulated protein kinase 2 (ERK2) but not c-Jun N-terminal kinase 1."1.30Role of a mitogen-activated protein kinase pathway in the induction of phase II detoxifying enzymes by chemicals. ( Der, CJ; Kong, AN; Lei, W; Mandlekar, S; Weber, MJ; Wu, J; Yu, R, 1999)

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (3.57)18.2507
2000's16 (57.14)29.6817
2010's11 (39.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Misico, RI1
Song, LL1
Veleiro, AS1
Cirigliano, AM1
Tettamanzi, MC1
Burton, G1
Bonetto, GM1
Nicotra, VE1
Silva, GL1
Gil, RR1
Oberti, JC1
Kinghorn, AD5
Pezzuto, JM5
Gu, JQ1
Park, EJ4
Vigo, JS2
Graham, JG3
Fong, HH4
Su, BN2
Nikolic, D1
Schunke Vigo, J1
Cabieses, F2
van Breemen, RB1
Farnsworth, NR1
Jang, DS1
Kang, YH2
Hawthorne, ME1
Mehta, RG1
Carcache-Blanco, EJ1
Kardono, LB1
Riswan, S1
Li, W2
Zheng, S1
Higgins, M1
Morra, RP1
Mendis, AT1
Chien, CW1
Ojima, I1
Mierke, DF1
Dinkova-Kostova, AT1
Honda, T1
Ren, K1
Li, Z1
Li, Y1
Zhang, W1
Han, X1
Liu, P1
Atkinson, SJ1
Akbareian, SE1
Zhou, Z1
Munsterberg, A1
Robinson, SD1
Bao, Y2
Kntayya, SB1
Ibrahim, MD1
Mohd Ain, N1
Iori, R1
Ioannides, C1
Abdull Razis, AF2
Yamaguchi, M2
Noor, NM1
Wu, J2
Han, J2
Hou, B1
Deng, C1
Wu, H1
Shen, L1
Moreno, FS1
Heidor, R1
Pogribny, IP1
Zou, X1
Qu, Z1
Fang, Y1
Shi, X1
Ji, Y1
Anwar-Mohamed, A1
El-Kadi, AO1
Moon, DO1
Kang, SH1
Kim, KC1
Kim, MO1
Choi, YH2
Kim, GY2
Jeon, YK1
Yoo, DR1
Jang, YH1
Jang, SY1
Nam, MJ1
Fukaya, Y1
Jeong, WS1
Keum, YS2
Chen, C1
Jain, MR1
Shen, G1
Kim, JH2
Kong, AN3
Yeh, CT1
Yen, GC1
Hwang, ES1
Jeffery, EH1
Moriarty, RM1
Naithani, R1
Kosmeder, J1
Prakash, O1
Kim, H1
Kim, EH1
Eom, YW1
Kim, WH1
Kwon, TK1
Lee, SJ1
Choi, KS1
Yu, S1
Chang, PP1
Yuan, X1
Xu, C1
Agarwal, A1
Bacon, JR1
Plumb, GW1
Howie, AF1
Beckett, GJ1
Wang, W1
Park, SY1
Bae, SJ1
Yoo, YH1
Yates, MS1
Kensler, TW1
Yu, R1
Lei, W1
Mandlekar, S1
Weber, MJ1
Der, CJ1

Reviews

3 reviews available for sulforaphane and Hepatocellular Carcinoma

ArticleYear
The anti-apoptotic effect of regucalcin is mediated through multisignaling pathways.
    Apoptosis : an international journal on programmed cell death, 2013, Volume: 18, Issue:10

    Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Calcium-Binding Proteins; Carcinoma, Hepatocellul

2013
Nutritional Epigenetics and the Prevention of Hepatocellular Carcinoma with Bioactive Food Constituents.
    Nutrition and cancer, 2016, Volume: 68, Issue:5

    Topics: Animals; Butyric Acid; Carcinoma, Hepatocellular; Catechin; Cell Line, Tumor; Curcumin; Disease Mode

2016
Keap1 eye on the target: chemoprevention of liver cancer.
    Acta pharmacologica Sinica, 2007, Volume: 28, Issue:9

    Topics: Aflatoxins; Animals; Anticarcinogenic Agents; Antioxidants; Carcinoma, Hepatocellular; Clinical Tria

2007

Other Studies

25 other studies available for sulforaphane and Hepatocellular Carcinoma

ArticleYear
Induction of quinone reductase by withanolides.
    Journal of natural products, 2002, Volume: 65, Issue:5

    Topics: Animals; Brassicaceae; Breast; Carcinoma, Hepatocellular; Colon; Enzyme Induction; Inhibitory Concen

2002
Activity-guided isolation of constituents of Renealmia nicolaioides with the potential to induce the phase II enzyme quinone reductase.
    Journal of natural products, 2002, Volume: 65, Issue:11

    Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Chalcone; Chalcones; Chromato

2002
Isolation and characterization of miscellaneous secondary metabolites of Deprea subtriflora.
    Journal of natural products, 2003, Volume: 66, Issue:8

    Topics: Animals; Carcinoma, Hepatocellular; Drug Screening Assays, Antitumor; Heterocyclic Compounds, 4 or M

2003
Potential cncer chemopreventive flavonoids from the stems of Tephrosia toxicaria.
    Journal of natural products, 2003, Volume: 66, Issue:9

    Topics: Animals; Anticarcinogenic Agents; Carcinoma, Hepatocellular; Chromones; Flavonoids; Heterocyclic Com

2003
Constituents of the stem bark of Pongamia pinnata with the potential to induce quinone reductase.
    Journal of natural products, 2003, Volume: 66, Issue:9

    Topics: Animals; Anticarcinogenic Agents; Carcinoma, Hepatocellular; Enzyme Induction; Flavonoids; Indonesia

2003
New Monocyclic, Bicyclic, and Tricyclic Ethynylcyanodienones as Activators of the Keap1/Nrf2/ARE Pathway and Inhibitors of Inducible Nitric Oxide Synthase.
    Journal of medicinal chemistry, 2015, Jun-11, Volume: 58, Issue:11

    Topics: Adaptor Proteins, Signal Transducing; Alkynes; Animals; Anti-Inflammatory Agents; Antineoplastic Age

2015
Sulforaphene enhances radiosensitivity of hepatocellular carcinoma through suppression of the NF-κB pathway.
    Journal of biochemical and molecular toxicology, 2017, Volume: 31, Issue:8

    Topics: Animals; Carcinoma, Hepatocellular; Hep G2 Cells; Humans; Isothiocyanates; Liver Neoplasms; Male; Mi

2017
Sulforaphane exerts anti-angiogenesis effects against hepatocellular carcinoma through inhibition of STAT3/HIF-1α/VEGF signalling.
    Scientific reports, 2017, 10-04, Volume: 7, Issue:1

    Topics: Animals; Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Cell Survival; Chick Embryo;

2017
Induction of Apoptosis and Cytotoxicity by Isothiocyanate Sulforaphene in Human Hepatocarcinoma HepG2 Cells.
    Nutrients, 2018, Jun-04, Volume: 10, Issue:6

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Caspases; Cell Cycle Checkp

2018
Sulforaphane is superior to glucoraphanin in modulating carcinogen-metabolising enzymes in Hep G2 cells.
    Asian Pacific journal of cancer prevention : APJCP, 2013, Volume: 14, Issue:7

    Topics: Anticarcinogenic Agents; Carcinoma, Hepatocellular; Glucosinolates; Glutathione Transferase; Glycosi

2013
Sulforaphane inhibits TGF-β-induced epithelial-mesenchymal transition of hepatocellular carcinoma cells via the reactive oxygen species-dependent pathway.
    Oncology reports, 2016, Volume: 35, Issue:5

    Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Movement; Cell Shape; Epi

2016
Endoplasmic reticulum stress mediates sulforaphane-induced apoptosis of HepG2 human hepatocellular carcinoma cells.
    Molecular medicine reports, 2017, Volume: 15, Issue:1

    Topics: Anticarcinogenic Agents; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Carcinoma, Hepatoc

2017
Sulforaphane induces CYP1A1 mRNA, protein, and catalytic activity levels via an AhR-dependent pathway in murine hepatoma Hepa 1c1c7 and human HepG2 cells.
    Cancer letters, 2009, Mar-08, Volume: 275, Issue:1

    Topics: Animals; Brassica; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Transformation, Neoplastic; Cyt

2009
Sulforaphane decreases viability and telomerase activity in hepatocellular carcinoma Hep3B cells through the reactive oxygen species-dependent pathway.
    Cancer letters, 2010, Sep-28, Volume: 295, Issue:2

    Topics: Anticarcinogenic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Down

2010
Sulforaphane induces apoptosis in human hepatic cancer cells through inhibition of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase4, mediated by hypoxia inducible factor-1-dependent pathway.
    Biochimica et biophysica acta, 2011, Volume: 1814, Issue:10

    Topics: Anticarcinogenic Agents; Apoptosis; Carcinoma, Hepatocellular; Drug Evaluation, Preclinical; Enzyme

2011
Overexpression of regucalcin suppresses apoptotic cell death in the cloned rat hepatoma H4-II-E cells induced by a naturally occurring isothiocyanate sulforaphane.
    International journal of molecular medicine, 2005, Volume: 15, Issue:5

    Topics: Animals; Apoptosis; Calcium-Binding Proteins; Carboxylic Ester Hydrolases; Carcinoma, Hepatocellular

2005
Differential expression and stability of endogenous nuclear factor E2-related factor 2 (Nrf2) by natural chemopreventive compounds in HepG2 human hepatoma cells.
    Journal of biochemistry and molecular biology, 2005, Mar-31, Volume: 38, Issue:2

    Topics: Anticarcinogenic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; DNA-Binding Proteins; Heme Oxy

2005
Effect of sulforaphane on metallothionein expression and induction of apoptosis in human hepatoma HepG2 cells.
    Carcinogenesis, 2005, Volume: 26, Issue:12

    Topics: Anticarcinogenic Agents; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Blotting, Western; Ca

2005
Induction of quinone reductase by sulforaphane and sulforaphane N-acetylcysteine conjugate in murine hepatoma cells.
    Journal of medicinal food, 2005,Summer, Volume: 8, Issue:2

    Topics: Acetylcysteine; Animals; Anticarcinogenic Agents; Brassica; Carcinoma, Hepatocellular; Dose-Response

2005
Cancer chemopreventive activity of sulforamate derivatives.
    European journal of medicinal chemistry, 2006, Volume: 41, Issue:1

    Topics: Animals; Anticarcinogenic Agents; Carcinoma, Hepatocellular; Cell Survival; Isothiocyanates; Liver N

2006
Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of DR5.
    Cancer research, 2006, Feb-01, Volume: 66, Issue:3

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; b

2006
Mechanism of action of sulforaphane: inhibition of p38 mitogen-activated protein kinase isoforms contributing to the induction of antioxidant response element-mediated heme oxygenase-1 in human hepatoma HepG2 cells.
    Cancer research, 2006, Sep-01, Volume: 66, Issue:17

    Topics: Animals; Anticarcinogenic Agents; Antioxidants; Carcinoma, Hepatocellular; Cell Line, Tumor; Cells,

2006
Dual action of sulforaphane in the regulation of thioredoxin reductase and thioredoxin in human HepG2 and Caco-2 cells.
    Journal of agricultural and food chemistry, 2007, Feb-21, Volume: 55, Issue:4

    Topics: Caco-2 Cells; Carcinoma, Hepatocellular; Cell Line, Tumor; Gene Expression Regulation; Humans; Isoth

2007
Induction of apoptosis by isothiocyanate sulforaphane in human cervical carcinoma HeLa and hepatocarcinoma HepG2 cells through activation of caspase-3.
    Oncology reports, 2007, Volume: 18, Issue:1

    Topics: Anticarcinogenic Agents; Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Caspase 3; Cell Li

2007
Role of a mitogen-activated protein kinase pathway in the induction of phase II detoxifying enzymes by chemicals.
    The Journal of biological chemistry, 1999, Sep-24, Volume: 274, Issue:39

    Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Enzyme Induction; Enzyme Inhibitors; Flav

1999