sulforaphane has been researched along with Neuroblastoma in 12 studies
sulforaphane: from Cardaria draba L.
sulforaphane : An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| " The present study provided detailed insight into the susceptibility of human neuroblastoma cells to treatment with synthetic SFN, in combination with an inhibitor of autophagy, 3-methyladenine (3-MA)." | 7.81 | Inhibition of autophagy by 3-methyladenine potentiates sulforaphane-induced cell death of BE(2)-C human neuroblastoma cells. ( Boratyn, E; Durbas, M; Gaik, M; Horwacik, I; Kołoczek, H; Rokita, H; Szczodrak, M; Szychowska, K; Zając, G, 2015) |
| " In this study, we demonstrated that treatment of the dopaminergic-like neuroblastoma SH-SY5Y cell line with sulforaphane (SF), a cruciferous vegetables inducer, resulted in significant increases of total GSH level, NAD(P)H : quinone oxidoreductase-1, GSH-transferase and -reductase, but not GSH-peroxidase, catalase and superoxide dismutase activities." | 7.75 | Sulforaphane as an inducer of glutathione prevents oxidative stress-induced cell death in a dopaminergic-like neuroblastoma cell line. ( Angeloni, C; Cantelli-Forti, G; Hrelia, P; Hrelia, S; Merlicco, A; Morroni, F; Tarozzi, A, 2009) |
| " We have addressed this question in human dopaminergic neuroblastoma SH-SY5Y cells exposed to the parkinsonian toxin paraquat (PQ)." | 3.76 | Activation of apoptosis signal-regulating kinase 1 is a key factor in paraquat-induced cell death: modulation by the Nrf2/Trx axis. ( Bravo-San Pedro, JM; Cuadrado, A; Fuentes, JM; Gómez-Sánchez, R; González-Polo, RA; Lastres-Becker, I; Morán, JM; Niso-Santano, M; Ortiz-Ortiz, MA; Soler, G, 2010) |
| " In this study, we demonstrated that treatment of the dopaminergic-like neuroblastoma SH-SY5Y cell line with sulforaphane (SF), a cruciferous vegetables inducer, resulted in significant increases of total GSH level, NAD(P)H : quinone oxidoreductase-1, GSH-transferase and -reductase, but not GSH-peroxidase, catalase and superoxide dismutase activities." | 3.75 | Sulforaphane as an inducer of glutathione prevents oxidative stress-induced cell death in a dopaminergic-like neuroblastoma cell line. ( Angeloni, C; Cantelli-Forti, G; Hrelia, P; Hrelia, S; Merlicco, A; Morroni, F; Tarozzi, A, 2009) |
| "Sulforaphane (SFN) promotes protective effects in different cell types." | 1.91 | The isothiocyanate sulforaphane prevents mitochondrial impairment and neuroinflammation in the human dopaminergic SH-SY5Y and in the mouse microglial BV2 cells: role for heme oxygenase-1. ( Brasil, FB; Dall'Oglio, EL; de Almeida, FJS; de Oliveira, MR; Luckachaki, MD, 2023) |
| " Bioavailability studies also suggest the contribution of SFN metabolites, including erucin (ERN), to the neuroprotective effects of SFN." | 1.48 | Comparison of Adaptive Neuroprotective Mechanisms of Sulforaphane and its Interconversion Product Erucin in in Vitro and in Vivo Models of Parkinson's Disease. ( Cantelli-Forti, G; D'Amico, M; Djemil, A; Hrelia, P; Morroni, F; Pruccoli, L; Sita, G; Tarozzi, A, 2018) |
| "Parkinson's disease is an environmentally influenced, neurodegenerative disease of unknown origin that is characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta of the brain." | 1.35 | Synergistic neurotoxic effects of arsenic and dopamine in human dopaminergic neuroblastoma SH-SY5Y cells. ( Sens, DA; Shavali, S, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (33.33) | 29.6817 |
| 2010's | 7 (58.33) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Brasil, FB | 2 |
| de Almeida, FJS | 1 |
| Luckachaki, MD | 1 |
| Dall'Oglio, EL | 1 |
| de Oliveira, MR | 2 |
| Morroni, F | 2 |
| Sita, G | 1 |
| Djemil, A | 1 |
| D'Amico, M | 1 |
| Pruccoli, L | 1 |
| Cantelli-Forti, G | 2 |
| Hrelia, P | 2 |
| Tarozzi, A | 2 |
| Fürstenau, CR | 1 |
| Hsu, YC | 1 |
| Chang, SJ | 1 |
| Wang, MY | 1 |
| Chen, YL | 1 |
| Huang, TY | 1 |
| Lee, JH | 1 |
| Jeong, JK | 1 |
| Park, SY | 1 |
| Lucotte, B | 1 |
| Tajhizi, M | 1 |
| Alkhatib, D | 1 |
| Samuelsson, EB | 1 |
| Wiehager, B | 1 |
| Schedin-Weiss, S | 1 |
| Sundström, E | 1 |
| Winblad, B | 1 |
| Tjernberg, LO | 1 |
| Behbahani, H | 1 |
| Horwacik, I | 1 |
| Gaik, M | 1 |
| Durbas, M | 1 |
| Boratyn, E | 1 |
| Zając, G | 1 |
| Szychowska, K | 1 |
| Szczodrak, M | 1 |
| Kołoczek, H | 1 |
| Rokita, H | 1 |
| Park, HM | 1 |
| Kim, JA | 1 |
| Kwak, MK | 2 |
| Merlicco, A | 1 |
| Hrelia, S | 1 |
| Angeloni, C | 1 |
| Niso-Santano, M | 1 |
| González-Polo, RA | 1 |
| Bravo-San Pedro, JM | 1 |
| Gómez-Sánchez, R | 1 |
| Lastres-Becker, I | 1 |
| Ortiz-Ortiz, MA | 1 |
| Soler, G | 1 |
| Morán, JM | 1 |
| Cuadrado, A | 1 |
| Fuentes, JM | 1 |
| Cho, JM | 1 |
| Huang, B | 1 |
| Shin, S | 1 |
| Kensler, TW | 1 |
| Shavali, S | 1 |
| Sens, DA | 1 |
12 other studies available for sulforaphane and Neuroblastoma
| Article | Year |
|---|---|
The isothiocyanate sulforaphane prevents mitochondrial impairment and neuroinflammation in the human dopaminergic SH-SY5Y and in the mouse microglial BV2 cells: role for heme oxygenase-1.
Topics: Animals; Heme Oxygenase-1; Humans; Isothiocyanates; Mammals; Mice; Microglia; Mitochondria; Neurobla | 2023 |
Comparison of Adaptive Neuroprotective Mechanisms of Sulforaphane and its Interconversion Product Erucin in in Vitro and in Vivo Models of Parkinson's Disease.
Topics: Animals; Brassica; Cell Line, Tumor; Dopaminergic Neurons; Glutathione; Humans; Isothiocyanates; Mal | 2018 |
Sulforaphane Attenuated the Pro-Inflammatory State Induced by Hydrogen Peroxide in SH-SY5Y Cells Through the Nrf2/HO-1 Signaling Pathway.
Topics: Anticarcinogenic Agents; Cell Line, Tumor; Cell Membrane; Cell Nucleus; Cell Survival; Cyclooxygenas | 2018 |
Growth inhibition and apoptosis of neuroblastoma cells through ROS-independent MEK/ERK activation by sulforaphane.
Topics: Anticarcinogenic Agents; Apoptosis; Carcinogenesis; Caspase 3; Caspase 9; Cell Line, Tumor; Cell Mov | 2013 |
Sulforaphane-induced autophagy flux prevents prion protein-mediated neurotoxicity through AMPK pathway.
Topics: AMP-Activated Protein Kinases; Apoptosis; Autophagy; Autophagy-Related Protein 5; Cell Line, Tumor; | 2014 |
Stress Conditions Increase Vimentin Cleavage by Omi/HtrA2 Protease in Human Primary Neurons and Differentiated Neuroblastoma Cells.
Topics: Amyloid beta-Protein Precursor; Axons; Cell Line, Tumor; Culture Media, Serum-Free; Cytosol; High-Te | 2015 |
Inhibition of autophagy by 3-methyladenine potentiates sulforaphane-induced cell death of BE(2)-C human neuroblastoma cells.
Topics: Adenine; Apoptosis; Autophagy; Cell Line, Tumor; Cell Survival; Humans; Isothiocyanates; Membrane Po | 2015 |
Protection against amyloid beta cytotoxicity by sulforaphane: role of the proteasome.
Topics: Amyloid beta-Peptides; Animals; Antioxidants; Cell Line, Tumor; Cell Survival; Cysteine Proteinase I | 2009 |
Sulforaphane as an inducer of glutathione prevents oxidative stress-induced cell death in a dopaminergic-like neuroblastoma cell line.
Topics: Adrenergic Agents; Analysis of Variance; Anticarcinogenic Agents; Caspase 3; Caspase 9; Cell Death; | 2009 |
Activation of apoptosis signal-regulating kinase 1 is a key factor in paraquat-induced cell death: modulation by the Nrf2/Trx axis.
Topics: Animals; Apoptosis; Cell Line; Fibroblasts; Humans; Intracellular Signaling Peptides and Proteins; I | 2010 |
Role of increased expression of the proteasome in the protective effects of sulforaphane against hydrogen peroxide-mediated cytotoxicity in murine neuroblastoma cells.
Topics: Animals; Cell Line, Tumor; Cytoprotection; Hydrogen Peroxide; Isothiocyanates; Mice; Neuroblastoma; | 2007 |
Synergistic neurotoxic effects of arsenic and dopamine in human dopaminergic neuroblastoma SH-SY5Y cells.
Topics: Acetylcysteine; Anticarcinogenic Agents; Antioxidants; Arsenites; Cell Line, Tumor; Cell Survival; D | 2008 |