sulforaphane has been researched along with Alloxan Diabetes in 25 studies
sulforaphane: from Cardaria draba L.
sulforaphane : An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The dietary agent sulforaphane (SFN) has been reported to reduce diabetes-induced renal fibrosis, as well as inhibit histone deacetylase (HDAC) activity." | 8.02 | Sulforaphane Ameliorates Diabetes-Induced Renal Fibrosis through Epigenetic Up-Regulation of BMP-7. ( Cheng, H; Cui, Y; Kong, L; Li, C; Liu, L; Wang, H; Zhao, Y, 2021) |
| "Treatment with sulforaphane restored animals' body weight, reduced blood glucose, glycated hemoglobin, and increased insulin levels." | 5.48 | Extracellular Matrix Remodeling and Modulation of Inflammation and Oxidative Stress by Sulforaphane in Experimental Diabetic Peripheral Neuropathy. ( Abdelkader, NF; El Awdan, SA; El-Shabrawy, OA; Moustafa, PE; Zaki, HF, 2018) |
| "The dietary agent sulforaphane (SFN) has been reported to reduce diabetes-induced renal fibrosis, as well as inhibit histone deacetylase (HDAC) activity." | 4.02 | Sulforaphane Ameliorates Diabetes-Induced Renal Fibrosis through Epigenetic Up-Regulation of BMP-7. ( Cheng, H; Cui, Y; Kong, L; Li, C; Liu, L; Wang, H; Zhao, Y, 2021) |
| "Sulforaphane (SFN) is an ITC shown to possess anticancer activities by both in vivo and epidemiological studies." | 2.52 | Sulforaphane Protects against Cardiovascular Disease via Nrf2 Activation. ( Bai, Y; Cui, J; Ma, C; Wang, X; Zhao, S; Zheng, Y, 2015) |
| "Sulforaphane (SFN) is an organic isothiocyanate found in cruciferous plants." | 1.56 | Sulforaphane protects against skeletal muscle dysfunction in spontaneous type 2 diabetic db/db mice. ( Chen, J; Liao, Z; Lu, A; Pu, D; Sun, Y; Wang, M; Xiao, Q; Zhao, Y; Zhu, S, 2020) |
| "Sulforaphane has antioxidant properties via Nrf2 activation." | 1.51 | Contrast media (meglumine diatrizoate) aggravates renal inflammation, oxidative DNA damage and apoptosis in diabetic rats which is restored by sulforaphane through Nrf2/HO-1 reactivation. ( Abd-Allah, AR; Abdel-Hamied, HE; Alzokaky, AA; Ashour, AA; Ewees, MG; Khaleel, SA; Raslan, NA, 2019) |
| "Sulforaphane (SFN) is a pharmacological activator of Nrf2 that provokes Nrf2-mediated intracellular defenses, including antioxidant and anti-inflammatory responses, under oxidative stress (OS) conditions." | 1.48 | Protective Effects of Sulforaphane on Cognitive Impairments and AD-like Lesions in Diabetic Mice are Associated with the Upregulation of Nrf2 Transcription Activity. ( Chen, J; Luo, C; Lv, A; Pu, D; Sun, Y; Xiao, Q; Zhao, K; Zhao, Y; Zhu, S, 2018) |
| "Treatment with sulforaphane restored animals' body weight, reduced blood glucose, glycated hemoglobin, and increased insulin levels." | 1.48 | Extracellular Matrix Remodeling and Modulation of Inflammation and Oxidative Stress by Sulforaphane in Experimental Diabetic Peripheral Neuropathy. ( Abdelkader, NF; El Awdan, SA; El-Shabrawy, OA; Moustafa, PE; Zaki, HF, 2018) |
| "Sulforaphane (SFN) prevents diabetic nephropathy (DN) in type 1 diabetes via up-regulation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2)." | 1.42 | Metallothionein plays a prominent role in the prevention of diabetic nephropathy by sulforaphane via up-regulation of Nrf2. ( Cai, L; Chen, X; Cheng, Y; Kong, L; Luo, M; Miao, L; Tan, Y; Wang, Y; Wu, H; Zhang, Z, 2015) |
| "These results suggest that type 1 diabetes significantly induced testicular apoptosis and damage along with increasing oxidative stress and cell death and suppressing Nrf2 expression and function." | 1.40 | Protection by sulforaphane from type 1 diabetes-induced testicular apoptosis is associated with the up-regulation of Nrf2 expression and function. ( Bai, Y; Cai, L; Jiang, X; Xin, Y; Zhang, Z, 2014) |
| "Sulforaphane (SFN) is an indirect antioxidant that protects animal tissues from chemical or biological insults by stimulating the expression of several NF-E2-related factor-2 (Nrf2)-regulated phase 2 enzymes." | 1.35 | Sulforaphane protects against cytokine- and streptozotocin-induced beta-cell damage by suppressing the NF-kappaB pathway. ( Kim, EK; Kim, HJ; Kwon, KB; Moon, WS; Park, BH; Park, JW; Park, R; So, HS; Song, MY, 2009) |
| "Sulforaphane was administered 24 hours before isolation islets in concentration 24mg/kg b." | 1.32 | Application of sulforaphane--does it lead to improvement of islet graft survival after warm and/or cold ischemia. ( Kasprzycka-Guttman, T; Rowiński, W; Sołowiej, E; Sołowiej, J, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (8.00) | 29.6817 |
| 2010's | 16 (64.00) | 24.3611 |
| 2020's | 7 (28.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mohamadi, N | 1 |
| Baradaran Rahimi, V | 1 |
| Fadaei, MR | 1 |
| Sharifi, F | 1 |
| Askari, VR | 1 |
| Sun, Y | 3 |
| Zhou, S | 2 |
| Guo, H | 1 |
| Zhang, J | 1 |
| Ma, T | 1 |
| Zheng, Y | 5 |
| Zhang, Z | 9 |
| Cai, L | 10 |
| Lin, CF | 1 |
| Chueh, TH | 1 |
| Chung, CH | 1 |
| Chung, SD | 1 |
| Chang, TC | 1 |
| Chien, CT | 1 |
| Tang, L | 1 |
| Ren, X | 2 |
| Han, Y | 1 |
| Chen, L | 1 |
| Meng, X | 1 |
| Zhang, C | 2 |
| Chu, H | 1 |
| Kong, L | 5 |
| Ma, H | 1 |
| Wang, M | 1 |
| Pu, D | 2 |
| Zhao, Y | 3 |
| Chen, J | 4 |
| Zhu, S | 2 |
| Lu, A | 1 |
| Liao, Z | 1 |
| Xiao, Q | 2 |
| Lv, J | 1 |
| Bao, S | 1 |
| Liu, T | 1 |
| Wei, L | 1 |
| Wang, D | 1 |
| Ye, W | 1 |
| Wang, N | 1 |
| Song, S | 1 |
| Li, J | 1 |
| Chudhary, M | 1 |
| Wang, H | 1 |
| Li, C | 1 |
| Cheng, H | 1 |
| Cui, Y | 1 |
| Liu, L | 1 |
| McDonnell, C | 1 |
| Leánez, S | 1 |
| Pol, O | 1 |
| Lv, A | 1 |
| Luo, C | 1 |
| Zhao, K | 1 |
| Moustafa, PE | 1 |
| Abdelkader, NF | 1 |
| El Awdan, SA | 1 |
| El-Shabrawy, OA | 1 |
| Zaki, HF | 1 |
| Khaleel, SA | 1 |
| Raslan, NA | 1 |
| Alzokaky, AA | 1 |
| Ewees, MG | 1 |
| Ashour, AA | 1 |
| Abdel-Hamied, HE | 1 |
| Abd-Allah, AR | 1 |
| Wang, J | 1 |
| Wang, S | 3 |
| Wang, W | 1 |
| Zheng, Q | 1 |
| Liu, Q | 2 |
| Wang, Y | 5 |
| Sun, W | 2 |
| Tan, Y | 6 |
| Liu, Y | 1 |
| Sun, J | 1 |
| Guo, W | 1 |
| Miao, X | 3 |
| Wu, H | 3 |
| Cong, X | 1 |
| Wintergerst, KA | 1 |
| Kong, X | 1 |
| Jiang, X | 1 |
| Bai, Y | 4 |
| Xin, Y | 2 |
| Yan, X | 1 |
| Mellen, N | 1 |
| Kong, M | 1 |
| Gu, J | 2 |
| Shang, G | 1 |
| Tang, X | 1 |
| Gao, P | 1 |
| Guo, F | 1 |
| Liu, H | 1 |
| Zhao, Z | 1 |
| Chen, Q | 3 |
| Jiang, T | 1 |
| Zhang, N | 1 |
| Li, H | 1 |
| Cheng, Y | 2 |
| Luo, M | 1 |
| Chen, X | 1 |
| Miao, L | 2 |
| Wang, X | 1 |
| Zhao, S | 1 |
| Ma, C | 1 |
| Cui, J | 1 |
| Wang, G | 1 |
| Fang, H | 1 |
| Zhen, Y | 1 |
| Xu, G | 1 |
| Tian, J | 1 |
| Zhang, Y | 1 |
| Zhang, D | 1 |
| Zhang, G | 1 |
| Xu, J | 1 |
| Qiu, M | 1 |
| Ma, Y | 1 |
| Zhang, H | 1 |
| Zhang, X | 1 |
| Xu, Z | 2 |
| Keller, BB | 1 |
| Zhou, H | 1 |
| Song, MY | 1 |
| Kim, EK | 1 |
| Moon, WS | 1 |
| Park, JW | 1 |
| Kim, HJ | 1 |
| So, HS | 1 |
| Park, R | 1 |
| Kwon, KB | 1 |
| Park, BH | 1 |
| Cui, W | 2 |
| Luo, P | 1 |
| Rane, MJ | 1 |
| Barati, MT | 1 |
| Cui, T | 1 |
| Sołowiej, E | 1 |
| Sołowiej, J | 1 |
| Kasprzycka-Guttman, T | 1 |
| Rowiński, W | 1 |
2 reviews available for sulforaphane and Alloxan Diabetes
| Article | Year |
|---|---|
A mechanistic overview of sulforaphane and its derivatives application in diabetes and its complications.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Humans; Isothiocy | 2023 |
Sulforaphane Protects against Cardiovascular Disease via Nrf2 Activation.
Topics: Animals; Cardiovascular Diseases; Diabetes Mellitus, Experimental; Humans; Isothiocyanates; NF-E2-Re | 2015 |
23 other studies available for sulforaphane and Alloxan Diabetes
| Article | Year |
|---|---|
Protective effects of sulforaphane on type 2 diabetes-induced cardiomyopathy via AMPK-mediated activation of lipid metabolic pathways and NRF2 function.
Topics: AMP-Activated Protein Kinases; Animals; Cardiotonic Agents; Diabetes Mellitus, Experimental; Diabete | 2020 |
Sulforaphane improves voiding function via the preserving mitochondrial function in diabetic rats.
Topics: Animals; Apoptosis; Diabetes Mellitus, Experimental; Endoplasmic Reticulum Stress; Isothiocyanates; | 2020 |
Sulforaphane attenuates apoptosis of hippocampal neurons induced by high glucose via regulating endoplasmic reticulum.
Topics: Animals; Apoptosis; Diabetes Mellitus, Experimental; Endoplasmic Reticulum; Endoplasmic Reticulum Ch | 2020 |
Sulforaphane protects against skeletal muscle dysfunction in spontaneous type 2 diabetic db/db mice.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Heme Oxygenase-1; | 2020 |
Sulforaphane delays diabetes-induced retinal photoreceptor cell degeneration.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Disease Models, Animal; Endoplasmic | 2020 |
Sulforaphane Ameliorates Diabetes-Induced Renal Fibrosis through Epigenetic Up-Regulation of BMP-7.
Topics: Animals; Bone Morphogenetic Protein 7; Diabetes Mellitus, Experimental; Epigenesis, Genetic; Fibrosi | 2021 |
The induction of the transcription factor Nrf2 enhances the antinociceptive effects of delta-opioid receptors in diabetic mice.
Topics: Animals; Benzamides; Blood Glucose; Blotting, Western; Body Weight; Diabetes Mellitus, Experimental; | 2017 |
Protective Effects of Sulforaphane on Cognitive Impairments and AD-like Lesions in Diabetic Mice are Associated with the Upregulation of Nrf2 Transcription Activity.
Topics: Alzheimer Disease; Animals; Antioxidants; Cognitive Dysfunction; Diabetes Mellitus, Experimental; Di | 2018 |
Extracellular Matrix Remodeling and Modulation of Inflammation and Oxidative Stress by Sulforaphane in Experimental Diabetic Peripheral Neuropathy.
Topics: Animals; Anticarcinogenic Agents; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabe | 2018 |
Contrast media (meglumine diatrizoate) aggravates renal inflammation, oxidative DNA damage and apoptosis in diabetic rats which is restored by sulforaphane through Nrf2/HO-1 reactivation.
Topics: Animals; Antioxidants; Apoptosis; Cell Line; Contrast Media; Diabetes Mellitus, Experimental; Diatri | 2019 |
Protection against diabetic cardiomyopathy is achieved using a combination of sulforaphane and zinc in type 1 diabetic OVE26 mice.
Topics: Animals; Cardiotonic Agents; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Ca | 2019 |
Sulforaphane attenuation of type 2 diabetes-induced aortic damage was associated with the upregulation of Nrf2 expression and function.
Topics: Animals; Aorta; Apoptosis; Cell Proliferation; Diabetes Mellitus, Experimental; Diabetes Mellitus, T | 2014 |
Sulforaphane reduction of testicular apoptotic cell death in diabetic mice is associated with the upregulation of Nrf2 expression and function.
Topics: Animals; Apoptosis; Diabetes Mellitus, Experimental; Isothiocyanates; Male; Mice; Mice, Inbred C57BL | 2014 |
Protection by sulforaphane from type 1 diabetes-induced testicular apoptosis is associated with the up-regulation of Nrf2 expression and function.
Topics: Animals; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Cell Proliferation; Cytoprotection; | 2014 |
Sulforaphane prevents the development of cardiomyopathy in type 2 diabetic mice probably by reversing oxidative stress-induced inhibition of LKB1/AMPK pathway.
Topics: Adenylate Kinase; AMP-Activated Protein Kinases; Animals; Autophagy; Cardiotonic Agents; Diabetes Me | 2014 |
Sulforaphane attenuation of experimental diabetic nephropathy involves GSK-3 beta/Fyn/Nrf2 signaling pathway.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antioxidants; Cells, Cultured; Collagen Type IV; Deoxyguanosin | 2015 |
Metallothionein plays a prominent role in the prevention of diabetic nephropathy by sulforaphane via up-regulation of Nrf2.
Topics: Animals; Anticarcinogenic Agents; Blotting, Western; Diabetes Mellitus, Experimental; Diabetes Melli | 2015 |
Sulforaphane Prevents Neuronal Apoptosis and Memory Impairment in Diabetic Rats.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Brain-Derived Neurotrophic Factor; Caspase 3; Cognitive | 2016 |
Metallothionein Is Downstream of Nrf2 and Partially Mediates Sulforaphane Prevention of Diabetic Cardiomyopathy.
Topics: Animals; Anticarcinogenic Agents; Blotting, Western; Diabetes Mellitus, Experimental; Diabetes Melli | 2017 |
Sulforaphane protects against cytokine- and streptozotocin-induced beta-cell damage by suppressing the NF-kappaB pathway.
Topics: Animals; Cell Death; Cell Line; Cytokines; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type | 2009 |
Prevention of diabetic nephropathy by sulforaphane: possible role of Nrf2 upregulation and activation.
Topics: Animals; Anticarcinogenic Agents; Catalase; Cell Line; Diabetes Mellitus, Experimental; Diabetic Nep | 2012 |
Prevention by sulforaphane of diabetic cardiomyopathy is associated with up-regulation of Nrf2 expression and transcription activation.
Topics: Animals; Catalase; Cell Line; Connective Tissue Growth Factor; Diabetes Mellitus, Experimental; Diab | 2013 |
Application of sulforaphane--does it lead to improvement of islet graft survival after warm and/or cold ischemia.
Topics: Animals; Cryopreservation; Cytoprotection; Diabetes Mellitus, Experimental; Free Radical Scavengers; | 2004 |