sulforaphane has been researched along with Neoplasms in 70 studies
sulforaphane: from Cardaria draba L.
sulforaphane : An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.
Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Breast cancer is second most leading cause of death in all over the world and not only limited to the females." | 5.51 | Tamoxifen and Sulphoraphane for the breast cancer management: A synergistic nanomedicine approach. ( Kohli, K; Mangla, B; Neupane, YR; Singh, A, 2019) |
| "Sulforaphane (SF) is a chemopreventive isothiocyanate (ITC) derived from glucoraphanin (GRP) hydrolysis by myrosinase, a thioglucoside present in broccoli." | 2.77 | Enhancing sulforaphane absorption and excretion in healthy men through the combined consumption of fresh broccoli sprouts and a glucoraphanin-rich powder. ( Cramer, JM; Jeffery, EH; Teran-Garcia, M, 2012) |
| "SFN may prevent different types of cancer and has the ability to improve hypertensive states, to prevent type 2 diabetes-induced cardiomyopathy, and to protect against gastric ulcer." | 2.72 | Potential of Sulforaphane as a Natural Immune System Enhancer: A Review. ( Castillo, A; Mahn, A, 2021) |
| "SF targets cancer stem cells through modulation of nuclear factor kappa B (NF-κB), Sonic hedgehog (SHH), epithelial-mesenchymal transition, and Wnt/β-catenin pathways." | 2.72 | Sulforaphane as a Promising Natural Molecule for Cancer Prevention and Treatment. ( Elkashty, OA; Tran, SD, 2021) |
| "Sulforaphane has demonstrated great antitumor activity and is able to significantly inhibit proliferation, viability, migration, malignancy, and epithelial-to-mesenchymal transition of cancer cells." | 2.66 | MicroRNAs as novel targets of sulforaphane in cancer therapy: The beginning of a new tale? ( Ahmadi, Z; Ashrafizadeh, M; Rafiei, H, 2020) |
| "Sulforaphane (SFE) is a traditional Chinese herbal medicine." | 2.66 | Sulforaphane: Expected to Become a Novel Antitumor Compound. ( Duan, Y; Lin, W; Ou, C; Wang, X; Wu, G; Xu, Z; Yan, Y; Zeng, S; Zhou, J; Zhou, Y, 2020) |
| "Sulforaphane is an isothiocyanate compound that has been derived from cruciferous vegetables." | 2.66 | Sulforaphane as an anticancer molecule: mechanisms of action, synergistic effects, enhancement of drug safety, and delivery systems. ( Akter, S; Kamal, MM; Lin, CN; Nazzal, S, 2020) |
| "Sulforaphane is an isothiocyanate occurring in stored form as glucoraphanin in cruciferous vegetables such as cabbage, cauliflower, and kale, and at high levels in broccoli especially in broccoli sprouts." | 2.61 | Isothiocyanate from Broccoli, Sulforaphane, and Its Properties. ( Anzenbacher, P; Anzenbacherova, E; Vanduchova, A, 2019) |
| "Sulforaphane (SFN) is a naturally occurring isothiocyanate derived from cruciferous vegetables such as broccoli." | 2.61 | Sulforaphane as anticancer agent: A double-edged sword? Tricky balance between effects on tumor cells and immune cells. ( Hänsch, GM; Hübner, K; Liang, J; Samstag, Y, 2019) |
| "Sulforaphane was found to be active against several forms of cancer." | 2.58 | Nrf2 targeting by sulforaphane: A potential therapy for cancer treatment. ( Daglia, M; Nabavi, SF; Nabavi, SM; Russo, GL; Russo, M; Skalicka-Woźniak, K; Sobarzo-Sánchez, E; Spagnuolo, C, 2018) |
| "SFN is able to promote apoptosis in cancer cells by many mechanisms, the production of reactive oxygen species being one of the most relevant ones." | 2.58 | New highlights on the health-improving effects of sulforaphane. ( Briones-Herrera, A; Eugenio-Pérez, D; Pedraza-Chaverri, J; Reyes-Ocampo, JG; Rivera-Mancía, S, 2018) |
| "Cancer is one of the major causes of morbidity and mortality in the world." | 2.58 | Chemopreventive activity of sulforaphane. ( Ji, R; Jiang, X; Liu, Y; Lv, G; Ma, L; Qu, Y; Xin, Y, 2018) |
| "This population is associated with cancer recurrence and is therefore clinically significant." | 2.53 | Targeting cancer stem-like cells using dietary-derived agents - Where are we now? ( Bayliss, R; Brown, K; Gescher, A; Howells, L; Karmokar, A; Khan, S; Thomas, AL, 2016) |
| "According to recent estimates, cancer continues to remain the second leading cause of death and is becoming the leading one in old age." | 2.52 | Cytotoxic and Antitumor Activity of Sulforaphane: The Role of Reactive Oxygen Species. ( Fimognari, C; Sestili, P, 2015) |
| "Sulforaphane (SFN) is a molecule within the isothiocyanate (ITC) group of organosulfur compounds." | 2.52 | The antioxidant properties of organosulfur compounds (sulforaphane). ( Binda, NS; Caligiorne, RB; de Figueiredo, SM; Nogueira-Machado, JA; Vieira-Filho, SA, 2015) |
| "Sulforaphane (SFN) is an isothiocyanate derived from glucoraphanin (GRA), which is found in great amounts especially in broccoli." | 2.50 | Clinical and molecular evidence of the consumption of broccoli, glucoraphanin and sulforaphane in humans. ( Conzatti, A; Fróes, FC; Schweigert Perry, ID; Souza, CG, 2014) |
| "Cancer is a complex disease characterized by multiple genetic and molecular alterations involving transformation, deregulation of apoptosis, proliferation, invasion, angiogenesis, and metastasis." | 2.50 | Sulforaphane as a promising molecule for fighting cancer. ( Fimognari, C; Hrelia, P; Lenzi, M, 2014) |
| "Sulforaphane is a natural product that is constantly under biological investigation for its unique biological properties." | 2.50 | Isothiocyanate synthetic analogs: biological activities, structure-activity relationships and synthetic strategies. ( Fimognari, C; Milelli, A; Minarini, A; Neviani, P; Ticchi, N; Tumiatti, V, 2014) |
| "There is growing evidence that cancer chemopreventive agents including isothiocyanates (ITCs) from cruciferous vegetables target epigenetic mechanisms." | 2.49 | Epigenetic impact of dietary isothiocyanates in cancer chemoprevention. ( Gerhauser, C, 2013) |
| "Sulforaphane is a promising agent under preclinical evaluation in many models of disease prevention." | 2.49 | Keap1-nrf2 signaling: a target for cancer prevention by sulforaphane. ( Agyeman, AS; Chen, JG; Chen, TY; Egner, PA; Fahey, JW; Groopman, JD; Kensler, TW; Talalay, P; Visvanathan, K, 2013) |
| "Even though conventional cancer therapies, comprising surgery and chemo- and radiotherapy, play an important role in the treatment of most solid tumours, successful therapeutic outcome is often limited due to high toxicity and related side-effects, as well as the development of multi-drug resistances." | 2.48 | Phytochemicals resveratrol and sulforaphane as potential agents for enhancing the anti-tumor activities of conventional cancer therapies. ( Kaminski, BM; Stein, JM; Steinhilber, D; Ulrich, S, 2012) |
| "The emergence of cancer stem cell theory has profound implications for cancer chemoprevention and therapy." | 2.47 | Implications of cancer stem cell theory for cancer chemoprevention by natural dietary compounds. ( Li, Y; Schwartz, SJ; Sun, D; Wicha, MS, 2011) |
| "Development of cancer is a long-term and multistep process which comprises initiation, progression, and promotion stages of carcinogenesis." | 2.46 | Molecular targets of dietary phenethyl isothiocyanate and sulforaphane for cancer chemoprevention. ( Cheung, KL; Kong, AN, 2010) |
| "In vitro studies using various types of cancer cells have revealed the ability of SFN to arrest the cell cycle, particularly in G2/M, while SFN at higher concentration is shown to activate apoptotic pathways." | 2.46 | [Sulforaphane--a possible agent in prevention and therapy of cancer]. ( Olejnik, A; Tomczyk, J, 2010) |
| "SF modulates many cancer-related events, including susceptibility to carcinogens, cell death, cell cycle, angiogenesis, invasion and metastasis." | 2.44 | Discovery and development of sulforaphane as a cancer chemopreventive phytochemical. ( Tang, L; Zhang, Y, 2007) |
| "Sulforaphane (SFN) is an isothiocyanate found in cruciferous vegetables, such as broccoli and broccoli sprouts." | 2.44 | Dietary histone deacetylase inhibitors: from cells to mice to man. ( Dashwood, RH; Ho, E, 2007) |
| "Sulforaphane (SFN) is an isothiocyanate found in cruciferous vegetables, with particularly high levels detected in broccoli and broccoli sprouts." | 2.43 | Chemoprotection by sulforaphane: keep one eye beyond Keap1. ( Dashwood, RH; Myzak, MC, 2006) |
| "Cancer is a multi-factorial process involving genetic and epigenetic events which result in neoplastic transformation." | 2.43 | Histone deacetylases as targets for dietary cancer preventive agents: lessons learned with butyrate, diallyl disulfide, and sulforaphane. ( Dashwood, RH; Myzak, MC, 2006) |
| "The association of decreased cancer risk with intake of cruciferous vegetables and selenium is stronger than that reported for fruits and vegetables in general." | 2.43 | Part of the series: from dietary antioxidants to regulators in cellular signaling and gene regulation. Sulforaphane and selenium, partners in adaptive response and prevention of cancer. ( Banning, A; Brigelius-Flohé, R, 2006) |
| "Cancer cachexia is common in many cancers and the loss of skeletal muscle mass compromises the response to therapies and quality of life." | 1.91 | Sulforaphane attenuates cancer cell-induced atrophy of C2C12 myotubes. ( Blazev, R; Li, W; Lynch, GS; Murphy, KT; Parker, BL; Swiderski, K; Trieu, J, 2023) |
| "Cancer is one of the most devastating diseases, and recently, a variety of natural compounds with preventive effects on cancer developments have been reported." | 1.72 | Metabolism, absorption, and anti-cancer effects of sulforaphane: an update. ( Du, M; Gu, HF; Mao, XY, 2022) |
| "Breast cancer is second most leading cause of death in all over the world and not only limited to the females." | 1.51 | Tamoxifen and Sulphoraphane for the breast cancer management: A synergistic nanomedicine approach. ( Kohli, K; Mangla, B; Neupane, YR; Singh, A, 2019) |
| "Chemoresistant A549 lung cancer cells that display constitutive dominant hyperactivation of Nrf2 signaling are particularly vulnerable to VSVΔ51 oncolysis." | 1.46 | Activation of Nrf2 Signaling Augments Vesicular Stomatitis Virus Oncolysis via Autophagy-Driven Suppression of Antiviral Immunity. ( Beljanski, V; Chiang, C; Dinkova-Kostova, AT; Ferrari, M; Goulet, ML; Hadj, SB; Hiscott, J; Jiang, Y; Knatko, EV; Lababidi, RR; Lin, R; Liu, Y; Naidu, SD; Olagnier, D; Sze, A, 2017) |
| "Interestingly, a cancer-promoting function of Nrf2 has recently been observed in many types of tumors due to deregulation of the Nrf2-Keap1 axis, which leads to constitutive activation of Nrf2." | 1.39 | Arsenic inhibits autophagic flux, activating the Nrf2-Keap1 pathway in a p62-dependent manner. ( Lau, A; Tao, S; Wang, H; White, E; Whitman, SA; Zhang, DD; Zheng, Y, 2013) |
| " The bioavailability and excretion of the mercapturic acid pathway metabolites isothiocyanates after human consumption of broccoli supplements has not been tested." | 1.37 | Bioavailability and inter-conversion of sulforaphane and erucin in human subjects consuming broccoli sprouts or broccoli supplement in a cross-over study design. ( Bella, D; Clarke, JD; Ho, E; Hsu, A; Riedl, K; Schwartz, SJ; Stevens, JF, 2011) |
| "Sulforaphane (SFN) is a biologically active compound extracted from cruciferous vegetables, and possessing potent anti-cancer and anti-inflammatory activities." | 1.35 | Sulforaphane suppresses TNF-alpha-mediated activation of NF-kappaB and induces apoptosis through activation of reactive oxygen species-dependent caspase-3. ( Choi, YH; Kang, SH; Kim, GY; Kim, MO; Moon, DO, 2009) |
| "Sulforaphane-treated cells accumulated in metaphase as determined by flow cytometry [4C DNA content, cyclin A(-), cyclin B1(+), and phospho-histone H3 (Ser(10))(+)]." | 1.32 | The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice. ( Cao, P; Gronda, M; Hedley, DW; Jacobberger, JW; Pham, NA; Schimmer, AD, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (1.43) | 18.2507 |
| 2000's | 15 (21.43) | 29.6817 |
| 2010's | 43 (61.43) | 24.3611 |
| 2020's | 11 (15.71) | 2.80 |
| Authors | Studies |
|---|---|
| Andreani, A | 1 |
| Burnelli, S | 1 |
| Granaiola, M | 1 |
| Leoni, A | 1 |
| Locatelli, A | 1 |
| Morigi, R | 1 |
| Rambaldi, M | 1 |
| Varoli, L | 1 |
| Landi, L | 1 |
| Prata, C | 1 |
| Dalla Sega, FV | 1 |
| Caliceti, C | 1 |
| Shoemaker, RH | 1 |
| Xi, MY | 1 |
| Jia, JM | 1 |
| Sun, HP | 1 |
| Sun, ZY | 1 |
| Jiang, JW | 1 |
| Wang, YJ | 1 |
| Zhang, MY | 1 |
| Zhu, JF | 1 |
| Xu, LL | 1 |
| Jiang, ZY | 1 |
| Xue, X | 1 |
| Ye, M | 1 |
| Yang, X | 1 |
| Gao, Y | 1 |
| Tao, L | 1 |
| Guo, XK | 1 |
| Xu, XL | 1 |
| Guo, QL | 1 |
| Zhang, XJ | 1 |
| Hu, R | 1 |
| You, QD | 1 |
| Lee, CY | 1 |
| Yun, JH | 1 |
| Kang, K | 1 |
| Nho, CW | 1 |
| Shin, D | 1 |
| Li, W | 1 |
| Trieu, J | 1 |
| Blazev, R | 1 |
| Parker, BL | 1 |
| Murphy, KT | 1 |
| Swiderski, K | 1 |
| Lynch, GS | 1 |
| Mangla, B | 1 |
| Neupane, YR | 1 |
| Singh, A | 1 |
| Kohli, K | 1 |
| Vaghefinezhad, N | 1 |
| Farsani, SF | 1 |
| Gharaghani, S | 1 |
| Rafiei, H | 1 |
| Ashrafizadeh, M | 1 |
| Ahmadi, Z | 1 |
| Wu, G | 1 |
| Yan, Y | 1 |
| Zhou, Y | 1 |
| Duan, Y | 1 |
| Zeng, S | 1 |
| Wang, X | 1 |
| Lin, W | 1 |
| Ou, C | 1 |
| Zhou, J | 1 |
| Xu, Z | 1 |
| Kamal, MM | 1 |
| Akter, S | 1 |
| Lin, CN | 1 |
| Nazzal, S | 1 |
| Gu, HF | 1 |
| Mao, XY | 1 |
| Du, M | 1 |
| Mahn, A | 1 |
| Castillo, A | 1 |
| Elkashty, OA | 1 |
| Tran, SD | 1 |
| Li, L | 1 |
| Chen, N | 1 |
| Xia, D | 1 |
| Xu, S | 1 |
| Dai, W | 1 |
| Tong, Y | 1 |
| Wang, L | 2 |
| Jiang, Z | 1 |
| You, Q | 1 |
| Xu, X | 1 |
| Khan, S | 2 |
| Awan, KA | 1 |
| Iqbal, MJ | 1 |
| Lee, J | 1 |
| Han, Y | 1 |
| Wang, W | 1 |
| Jo, H | 1 |
| Kim, H | 1 |
| Kim, S | 1 |
| Yang, KM | 1 |
| Kim, SJ | 1 |
| Dhanasekaran, DN | 1 |
| Song, YS | 1 |
| Olagnier, D | 1 |
| Lababidi, RR | 1 |
| Hadj, SB | 1 |
| Sze, A | 1 |
| Liu, Y | 2 |
| Naidu, SD | 1 |
| Ferrari, M | 1 |
| Jiang, Y | 1 |
| Chiang, C | 1 |
| Beljanski, V | 1 |
| Goulet, ML | 1 |
| Knatko, EV | 1 |
| Dinkova-Kostova, AT | 1 |
| Hiscott, J | 1 |
| Lin, R | 1 |
| Palliyaguru, DL | 2 |
| Yuan, JM | 1 |
| Kensler, TW | 3 |
| Fahey, JW | 2 |
| Briones-Herrera, A | 1 |
| Eugenio-Pérez, D | 1 |
| Reyes-Ocampo, JG | 1 |
| Rivera-Mancía, S | 1 |
| Pedraza-Chaverri, J | 2 |
| Wang, Y | 1 |
| Mandal, AK | 1 |
| Son, YO | 1 |
| Pratheeshkumar, P | 1 |
| Wise, JTF | 1 |
| Zhang, Z | 1 |
| Shi, X | 1 |
| Chen, Z | 1 |
| Jiang, X | 1 |
| Ma, L | 1 |
| Ji, R | 1 |
| Qu, Y | 1 |
| Xin, Y | 1 |
| Lv, G | 1 |
| Vanduchova, A | 1 |
| Anzenbacher, P | 1 |
| Anzenbacherova, E | 1 |
| Milczarek, M | 1 |
| Mielczarek, L | 1 |
| Lubelska, K | 1 |
| Dąbrowska, A | 1 |
| Chilmonczyk, Z | 1 |
| Matosiuk, D | 1 |
| Wiktorska, K | 1 |
| Liang, J | 1 |
| Hänsch, GM | 1 |
| Hübner, K | 1 |
| Samstag, Y | 1 |
| Lau, A | 1 |
| Zheng, Y | 1 |
| Tao, S | 1 |
| Wang, H | 1 |
| Whitman, SA | 1 |
| White, E | 1 |
| Zhang, DD | 1 |
| Gerhauser, C | 2 |
| Li, Y | 2 |
| Zhang, T | 1 |
| de Figueiredo, SM | 2 |
| Filho, SA | 1 |
| Nogueira-Machado, JA | 2 |
| Caligiorne, RB | 2 |
| Negrette-Guzmán, M | 1 |
| Huerta-Yepez, S | 1 |
| Tapia, E | 1 |
| Lenzi, M | 1 |
| Fimognari, C | 4 |
| Hrelia, P | 1 |
| Houghton, CA | 1 |
| Fassett, RG | 1 |
| Coombes, JS | 1 |
| Turrini, E | 1 |
| Ferruzzi, L | 1 |
| Tortorella, SM | 1 |
| Royce, SG | 1 |
| Licciardi, PV | 1 |
| Karagiannis, TC | 1 |
| Milelli, A | 1 |
| Ticchi, N | 1 |
| Neviani, P | 1 |
| Minarini, A | 1 |
| Tumiatti, V | 1 |
| Conzatti, A | 1 |
| Fróes, FC | 1 |
| Schweigert Perry, ID | 1 |
| Souza, CG | 1 |
| Amin, PJ | 1 |
| Shankar, BS | 1 |
| Binda, NS | 1 |
| Vieira-Filho, SA | 1 |
| Sestili, P | 1 |
| Pal, S | 1 |
| Konkimalla, VB | 1 |
| Tuorkey, MJ | 1 |
| Yang, L | 1 |
| Karmokar, A | 1 |
| Howells, L | 1 |
| Thomas, AL | 1 |
| Bayliss, R | 1 |
| Gescher, A | 1 |
| Brown, K | 1 |
| Russo, M | 1 |
| Spagnuolo, C | 1 |
| Russo, GL | 1 |
| Skalicka-Woźniak, K | 1 |
| Daglia, M | 1 |
| Sobarzo-Sánchez, E | 1 |
| Nabavi, SF | 1 |
| Nabavi, SM | 1 |
| Dashwood, RH | 5 |
| Ho, E | 4 |
| Moon, DO | 1 |
| Kim, MO | 1 |
| Kang, SH | 1 |
| Choi, YH | 1 |
| Kim, GY | 1 |
| Shabbeer, S | 1 |
| Sobolewski, M | 1 |
| Anchoori, RK | 1 |
| Kachhap, S | 1 |
| Hidalgo, M | 1 |
| Jimeno, A | 1 |
| Davidson, N | 1 |
| Carducci, MA | 1 |
| Khan, SR | 1 |
| Nian, H | 1 |
| Delage, B | 1 |
| Cheung, KL | 1 |
| Kong, AN | 1 |
| Beevi, SS | 1 |
| Mangamoori, LN | 1 |
| Subathra, M | 1 |
| Edula, JR | 1 |
| Tomczyk, J | 1 |
| Olejnik, A | 1 |
| Wicha, MS | 1 |
| Schwartz, SJ | 2 |
| Sun, D | 1 |
| DeWeerdt, S | 1 |
| Kaminski, BM | 1 |
| Steinhilber, D | 1 |
| Stein, JM | 1 |
| Ulrich, S | 1 |
| Clarke, JD | 1 |
| Hsu, A | 1 |
| Riedl, K | 1 |
| Bella, D | 1 |
| Stevens, JF | 1 |
| Latté, KP | 1 |
| Appel, KE | 1 |
| Lampen, A | 1 |
| Cramer, JM | 1 |
| Teran-Garcia, M | 1 |
| Jeffery, EH | 1 |
| Xu, T | 1 |
| Ren, D | 1 |
| Sun, X | 1 |
| Yang, G | 1 |
| Egner, PA | 1 |
| Agyeman, AS | 1 |
| Visvanathan, K | 1 |
| Groopman, JD | 1 |
| Chen, JG | 1 |
| Chen, TY | 1 |
| Talalay, P | 1 |
| Herr, I | 1 |
| Lozanovski, V | 1 |
| Houben, P | 1 |
| Schemmer, P | 1 |
| Büchler, MW | 1 |
| Swiderski, A | 1 |
| Sterkowicz, P | 1 |
| Kaszycki, P | 1 |
| Kołoczek, H | 1 |
| Pham, NA | 1 |
| Jacobberger, JW | 1 |
| Schimmer, AD | 1 |
| Cao, P | 1 |
| Gronda, M | 1 |
| Hedley, DW | 1 |
| Finley, JW | 1 |
| Sigrid-Keck, A | 1 |
| Robbins, RJ | 1 |
| Hintze, KJ | 1 |
| Gasper, AV | 1 |
| Al-Janobi, A | 1 |
| Smith, JA | 1 |
| Bacon, JR | 1 |
| Fortun, P | 1 |
| Atherton, C | 1 |
| Taylor, MA | 1 |
| Hawkey, CJ | 1 |
| Barrett, DA | 1 |
| Mithen, RF | 1 |
| Myzak, MC | 2 |
| Bertl, E | 1 |
| Bartsch, H | 1 |
| Brigelius-Flohé, R | 1 |
| Banning, A | 1 |
| Zhang, Y | 1 |
| Tang, L | 1 |
| Bradlow, HL | 1 |
| Telang, NT | 1 |
| Sepkovic, DW | 1 |
| Osborne, MP | 1 |
| Steinkellner, H | 1 |
| Rabot, S | 1 |
| Freywald, C | 1 |
| Nobis, E | 1 |
| Scharf, G | 1 |
| Chabicovsky, M | 1 |
| Knasmüller, S | 1 |
| Kassie, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A 12-weeks, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety and Related Mechanism of Sulforaphane in Treatment of Autism Spectrum Disorder[NCT02879110] | 110 participants (Actual) | Interventional | 2016-08-31 | Completed | |||
| Double-blind, Phase II Study to Assess the Effectiveness of Lycopene vs Placebo to Reduce Skin Toxicity in Patients With Colorectal Carcinoma Treated With Panitumumab[NCT03167268] | Phase 2 | 28 participants (Actual) | Interventional | 2016-08-03 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
43 reviews available for sulforaphane and Neoplasms
| Article | Year |
|---|---|
MicroRNAs as novel targets of sulforaphane in cancer therapy: The beginning of a new tale?
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Brassica; Epithelial-Mesenchymal Transition; | 2020 |
Sulforaphane: Expected to Become a Novel Antitumor Compound.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Cell Proliferation; Female; Humans; | 2020 |
Sulforaphane as an anticancer molecule: mechanisms of action, synergistic effects, enhancement of drug safety, and delivery systems.
Topics: Antineoplastic Agents; Cell Cycle Checkpoints; Cell Proliferation; Drug Delivery Systems; Humans; Is | 2020 |
Potential of Sulforaphane as a Natural Immune System Enhancer: A Review.
Topics: Animals; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Humans; Immune System; Isothiocyanates; | 2021 |
Sulforaphane as a Promising Natural Molecule for Cancer Prevention and Treatment.
Topics: Animals; Biological Products; Brassica; Chemoprevention; Clinical Trials as Topic; Humans; Isothiocy | 2021 |
Sulforaphane as a potential remedy against cancer: Comprehensive mechanistic review.
Topics: Antineoplastic Agents; Cell Cycle Checkpoints; Humans; Isothiocyanates; Neoplasms; Sulfoxides | 2022 |
Phytochemicals in Cancer Immune Checkpoint Inhibitor Therapy.
Topics: Animals; Antigens, CD; Antineoplastic Agents; B7 Antigens; B7-H1 Antigen; Camptothecin; CTLA-4 Antig | 2021 |
Isothiocyanates: Translating the Power of Plants to People.
Topics: Brassica; Cardiovascular Diseases; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Humans; Isot | 2018 |
New highlights on the health-improving effects of sulforaphane.
Topics: Animals; Humans; Isothiocyanates; Neoplasms; NF-E2-Related Factor 2; Oxidative Stress; Sulfoxides | 2018 |
Chemopreventive activity of sulforaphane.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Proliferation; Humans; Iso | 2018 |
Isothiocyanate from Broccoli, Sulforaphane, and Its Properties.
Topics: Animals; Antineoplastic Agents, Phytogenic; Autistic Disorder; Brassica; Glucosinolates; Humans; Imi | 2019 |
Sulforaphane as anticancer agent: A double-edged sword? Tricky balance between effects on tumor cells and immune cells.
Topics: Animals; Glutathione; Humans; Immunity, Cellular; Isothiocyanates; Neoplasm Proteins; Neoplasms; Rea | 2019 |
Epigenetic impact of dietary isothiocyanates in cancer chemoprevention.
Topics: Animals; Anticarcinogenic Agents; Brassica; Catechin; Chemoprevention; Diet; DNA Methylation; Epigen | 2013 |
The anti-oxidant properties of isothiocyanates: a review.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Brassica; Brassicaceae; Humans; Isothiocyanates; Neo | 2013 |
Modulation of mitochondrial functions by the indirect antioxidant sulforaphane: a seemingly contradictory dual role and an integrative hypothesis.
Topics: Animals; Antioxidants; Apoptosis; Humans; Isothiocyanates; Mitochondria; Mitochondrial Turnover; Neo | 2013 |
Sulforaphane as a promising molecule for fighting cancer.
Topics: Animals; Anticarcinogenic Agents; Humans; Isothiocyanates; Neoplasms; Sulfoxides | 2014 |
Sulforaphane: translational research from laboratory bench to clinic.
Topics: Anticarcinogenic Agents; Brassica; Dietary Supplements; Humans; Isothiocyanates; Neoplasms; Sulfoxid | 2013 |
Natural compounds to overcome cancer chemoresistance: toxicological and clinical issues.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Curcumin; Drug Resista | 2014 |
Dietary Sulforaphane in Cancer Chemoprevention: The Role of Epigenetic Regulation and HDAC Inhibition.
Topics: Animals; Anticarcinogenic Agents; Chemoprevention; Dietary Supplements; Epigenetic Repression; Histo | 2015 |
Isothiocyanate synthetic analogs: biological activities, structure-activity relationships and synthetic strategies.
Topics: Animals; Anticarcinogenic Agents; Biological Products; Humans; Isothiocyanates; Neoplasms; Structure | 2014 |
Clinical and molecular evidence of the consumption of broccoli, glucoraphanin and sulforaphane in humans.
Topics: Anticarcinogenic Agents; Brassica; Diet; Glucosinolates; Humans; Imidoesters; Isothiocyanates; Myoca | 2014 |
The antioxidant properties of organosulfur compounds (sulforaphane).
Topics: Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; Dietary Supplements; Drug Desig | 2015 |
Cytotoxic and Antitumor Activity of Sulforaphane: The Role of Reactive Oxygen Species.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Apoptosis; Cell Survival; Cytotoxins; Dose-Response | 2015 |
Hormetic Potential of Sulforaphane (SFN) in Switching Cells' Fate Towards Survival or Death.
Topics: Aging; Animals; Anti-Inflammatory Agents; Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic | 2016 |
Cancer Therapy with Phytochemicals: Present and Future Perspectives.
Topics: Acetophenones; Antineoplastic Agents, Phytogenic; Benzopyrans; Benzylisoquinolines; Catechols; Heter | 2015 |
Frugal chemoprevention: targeting Nrf2 with foods rich in sulforaphane.
Topics: Animals; Anticarcinogenic Agents; Brassica; Chemoprevention; Glucosinolates; Humans; Imidoesters; Is | 2016 |
Targeting cancer stem-like cells using dietary-derived agents - Where are we now?
Topics: Animals; Anticarcinogenic Agents; Catechin; Cell Line, Tumor; Curcumin; Diet; Disease Models, Animal | 2016 |
Nrf2 targeting by sulforaphane: A potential therapy for cancer treatment.
Topics: Antineoplastic Agents, Phytogenic; Brassica; Gene Expression Regulation; Humans; Isothiocyanates; Ne | 2018 |
Dietary agents as histone deacetylase inhibitors: sulforaphane and structurally related isothiocyanates.
Topics: Animals; Anticarcinogenic Agents; Brassicaceae; Cell Line, Tumor; Diet; Enzyme Inhibitors; Epigenesi | 2008 |
Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: studies with sulforaphane and garlic organosulfur compounds.
Topics: Allyl Compounds; Animals; Anticarcinogenic Agents; Cell Line, Tumor; Garlic; Histone Deacetylase Inh | 2009 |
Molecular targets of dietary phenethyl isothiocyanate and sulforaphane for cancer chemoprevention.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Cell Cycle; Cytochrome P-450 Enzyme Inhibitors; Diet; E | 2010 |
[Sulforaphane--a possible agent in prevention and therapy of cancer].
Topics: Anticarcinogenic Agents; Humans; Isothiocyanates; Neoplasms; Sulfoxides; Thiocyanates | 2010 |
Implications of cancer stem cell theory for cancer chemoprevention by natural dietary compounds.
Topics: Alkaloids; Animals; Anticarcinogenic Agents; Benzodioxoles; beta Catenin; Carotenoids; Catechin; Cel | 2011 |
Phytochemicals resveratrol and sulforaphane as potential agents for enhancing the anti-tumor activities of conventional cancer therapies.
Topics: Animals; Antineoplastic Agents, Phytogenic; Drug Interactions; Drug Resistance, Multiple; Drug Resis | 2012 |
Health benefits and possible risks of broccoli - an overview.
Topics: Animals; Antineoplastic Agents; Ascorbic Acid; Brassica; DNA Damage; Glucosinolates; Glycoside Hydro | 2011 |
Keap1-nrf2 signaling: a target for cancer prevention by sulforaphane.
Topics: Animals; Clinical Trials as Topic; Gene Expression Regulation; Humans; Intracellular Signaling Pepti | 2013 |
Chemoprotection by sulforaphane: keep one eye beyond Keap1.
Topics: Anticarcinogenic Agents; Cell Cycle; Humans; Intracellular Signaling Peptides and Proteins; Isothioc | 2006 |
Histone deacetylases as targets for dietary cancer preventive agents: lessons learned with butyrate, diallyl disulfide, and sulforaphane.
Topics: Acetylation; Allyl Compounds; Animals; Anticarcinogenic Agents; Butyrates; Diet; Disulfides; Histone | 2006 |
Part of the series: from dietary antioxidants to regulators in cellular signaling and gene regulation. Sulforaphane and selenium, partners in adaptive response and prevention of cancer.
Topics: Animals; Antioxidants; Colonic Neoplasms; Gene Expression Regulation; Humans; Isothiocyanates; Mice; | 2006 |
Dietary histone deacetylase inhibitors: from cells to mice to man.
Topics: Animals; Diet; Enzyme Inhibitors; Epigenesis, Genetic; Histone Deacetylase Inhibitors; Humans; Isoth | 2007 |
Discovery and development of sulforaphane as a cancer chemopreventive phytochemical.
Topics: Animals; Anticarcinogenic Agents; Humans; Isothiocyanates; Neoplasms; Sulfoxides; Thiocyanates | 2007 |
Phytochemicals as modulators of cancer risk.
Topics: Anticarcinogenic Agents; Catechin; Estrogens, Non-Steroidal; Female; Humans; Indoles; Isoflavones; I | 1999 |
Effects of cruciferous vegetables and their constituents on drug metabolizing enzymes involved in the bioactivation of DNA-reactive dietary carcinogens.
Topics: Animals; Anticarcinogenic Agents; Biotransformation; Brassicaceae; Carcinogens; Chemoprevention; Cyt | 2001 |
3 trials available for sulforaphane and Neoplasms
| Article | Year |
|---|---|
Sulforaphane induces ROS mediated induction of NKG2D ligands in human cancer cell lines and enhances susceptibility to NK cell mediated lysis.
Topics: Anticarcinogenic Agents; Female; Gene Expression Regulation, Neoplastic; Histocompatibility Antigens | 2015 |
Enhancing sulforaphane absorption and excretion in healthy men through the combined consumption of fresh broccoli sprouts and a glucoraphanin-rich powder.
Topics: Absorption; Acetylcysteine; Adolescent; Adult; Anticarcinogenic Agents; Biomarkers; Brassica; Cross- | 2012 |
Glutathione S-transferase M1 polymorphism and metabolism of sulforaphane from standard and high-glucosinolate broccoli.
Topics: Adolescent; Adult; Alleles; Area Under Curve; Brassica; Cross-Over Studies; Double-Blind Method; Fem | 2005 |
24 other studies available for sulforaphane and Neoplasms
| Article | Year |
|---|---|
Antitumor activity and COMPARE analysis of bis-indole derivatives.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Human | 2010 |
3-aroylmethylene-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-ones as potent Nrf2/ARE inducers in human cancer cells and AOM-DSS treated mice.
Topics: Active Transport, Cell Nucleus; Adenoma; Animals; Antineoplastic Agents; Antioxidant Response Elemen | 2013 |
Identification of dialkyl diacetylene diols with potent cancer chemopreventive activity.
Topics: Acetylene; Anticarcinogenic Agents; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Drug | 2015 |
Sulforaphane attenuates cancer cell-induced atrophy of C2C12 myotubes.
Topics: Antioxidants; Dimethyl Sulfoxide; Fluorouracil; Humans; Muscle Fibers, Skeletal; Muscular Atrophy; N | 2023 |
Tamoxifen and Sulphoraphane for the breast cancer management: A synergistic nanomedicine approach.
Topics: Animals; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neo | 2019 |
Topics: Anticarcinogenic Agents; Drug Design; Humans; Hydrophobic and Hydrophilic Interactions; Isothiocyana | 2021 |
Metabolism, absorption, and anti-cancer effects of sulforaphane: an update.
Topics: Brassica; Humans; Isothiocyanates; Neoplasms; Sulfoxides | 2022 |
Discovery of a covalent inhibitor of heat shock protein 90 with antitumor activity that blocks the co-chaperone binding via C-terminal modification.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle Proteins; Cell Line, Tumor; Cell Movement; Cha | 2021 |
Activation of Nrf2 Signaling Augments Vesicular Stomatitis Virus Oncolysis via Autophagy-Driven Suppression of Antiviral Immunity.
Topics: Animals; Antineoplastic Agents; Antioxidants; Autophagy; Cell Line; Combined Modality Therapy; Disea | 2017 |
Roles of ROS, Nrf2, and autophagy in cadmium-carcinogenesis and its prevention by sulforaphane.
Topics: Anticarcinogenic Agents; Apoptosis Regulatory Proteins; Autophagy; Cadmium; Carcinogenesis; Cell Lin | 2018 |
In Vitro Evaluation of Sulforaphane and a Natural Analog as Potent Inducers of 5-Fluorouracil Anticancer Activity.
Topics: Antineoplastic Agents; Caco-2 Cells; Caspases; Cell Line, Tumor; Cell Proliferation; Cell Survival; | 2018 |
Arsenic inhibits autophagic flux, activating the Nrf2-Keap1 pathway in a p62-dependent manner.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Animals; Arsenic; Autophagy; Cell Line; Cell Surviv | 2013 |
Targeting cancer stem cells with sulforaphane, a dietary component from broccoli and broccoli sprouts.
Topics: Anticarcinogenic Agents; Brassica; Epithelial-Mesenchymal Transition; Hedgehog Proteins; Humans; Iso | 2013 |
Sulforaphane suppresses TNF-alpha-mediated activation of NF-kappaB and induces apoptosis through activation of reactive oxygen species-dependent caspase-3.
Topics: Anticarcinogenic Agents; Apoptosis; Blotting, Western; Caspase 3; Cell Proliferation; Electrophoreti | 2009 |
Fenugreek: a naturally occurring edible spice as an anticancer agent.
Topics: Anticarcinogenic Agents; Breast Neoplasms; Cell Death; Cell Line, Tumor; Diosgenin; Dose-Response Re | 2009 |
Hexane extract of Raphanus sativus L. roots inhibits cell proliferation and induces apoptosis in human cancer cells by modulating genes related to apoptotic pathway.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Proliferation; DNA-B | 2010 |
Food: The omnivore's labyrinth.
Topics: Animals; Brassica; Breeding; Cooking; Curcumin; Diet; Fruit; Genetic Variation; Genistein; Genome, H | 2011 |
Bioavailability and inter-conversion of sulforaphane and erucin in human subjects consuming broccoli sprouts or broccoli supplement in a cross-over study design.
Topics: Adult; Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Biological Availability; Brassica | 2011 |
Dual roles of sulforaphane in cancer treatment.
Topics: Angiogenesis Inhibitors; Animals; Anticarcinogenic Agents; Apoptosis; Humans; Isothiocyanates; Neopl | 2012 |
Sulforaphane and related mustard oils in focus of cancer prevention and therapy.
Topics: Animals; Anticarcinogenic Agents; Brassica; Case-Control Studies; DNA Damage; Feeding Behavior; Gluc | 2013 |
[Herb honey containing sulforaphane-aglycone with potential use in cancer prophylaxis].
Topics: Chromatography, High Pressure Liquid; Complementary Therapies; Doxorubicin; Honey; Humans; Isothiocy | 2003 |
The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice.
Topics: Animals; Anticarcinogenic Agents; Antigens; Apoptosis; Blotting, Western; Caspase 3; Caspase 8; Casp | 2004 |
Selenium enrichment of broccoli: interactions between selenium and secondary plant compounds.
Topics: Anticarcinogenic Agents; Brassica; Dietary Supplements; Humans; Isothiocyanates; Neoplasms; Phenols; | 2005 |
Inhibition of angiogenesis and endothelial cell functions are novel sulforaphane-mediated mechanisms in chemoprevention.
Topics: Angiogenesis Inhibitors; Anticarcinogenic Agents; Basement Membrane; Cell Line; Cell Proliferation; | 2006 |