Target type: cellularcomponent
A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein. [PMID:15571813, PMID:15688063]
The Cul3-RING ubiquitin ligase complex is a multi-protein assembly that plays a crucial role in the ubiquitination of target proteins, a critical process for regulating protein stability, localization, and activity. The core of the complex consists of the E3 ligase Cul3, a scaffold protein that interacts with a variety of substrate-specific adaptor proteins, known as BTB-domain proteins. These adaptor proteins bind to specific target proteins, thereby recruiting them to the Cul3 complex. The Cul3-RING complex also includes RING-domain proteins, such as RBX1, which act as E2 ubiquitin ligase-binding proteins.
The cellular component of the Cul3-RING ubiquitin ligase complex is found primarily in the cytoplasm, where it functions to ubiquitinate a wide range of substrates. The complex can associate with different cellular structures, including the proteasome, the endoplasmic reticulum, and the Golgi apparatus, depending on the specific adaptor protein involved.
The Cul3-RING complex plays a critical role in a variety of cellular processes, including:
- Regulation of cell cycle progression
- Control of signal transduction pathways
- Maintenance of protein homeostasis
- Modulation of DNA repair mechanisms
- Immune response regulation
The complex has also been implicated in the development of various diseases, including cancer and neurodegenerative disorders.
In summary, the Cul3-RING ubiquitin ligase complex is a highly dynamic and versatile molecular machine that plays a central role in cellular ubiquitination processes. Its diverse functionality and involvement in various cellular processes highlight its importance in maintaining cellular homeostasis and its potential implications in human health.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Kelch-like ECH-associated protein 1 | A kelch-like ECH-associated protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14145] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| 3-phenylpropionic acid | 3-phenylpropionic acid : A monocarboxylic acid that is propionic acid substituted at position 3 by a phenyl group. 3-phenylpropionic acid: RN given refers to parent cpd | benzenes; monocarboxylic acid | antifungal agent; human metabolite; plant metabolite |
| sulforaphane | sulforaphane : An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen. sulforaphane: from Cardaria draba L. | isothiocyanate; sulfoxide | antineoplastic agent; antioxidant; EC 3.5.1.98 (histone deacetylase) inhibitor; plant metabolite |
| 1-naphthylamine | 1-naphthylamine : A naphthylamine that is naphthalene substituted by an amino group at position 1. 1-Naphthylamine: A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic. naphthylamine : A primary arylamine that is naphthalene substituted by an amino group at unspecified position. | naphthylamine | human xenobiotic metabolite |
| iberin | isothiocyanate; sulfoxide | apoptosis inducer; plant metabolite; quorum sensing inhibitor | |
| 3-morpholinopropylamine | 3-morpholinopropylamine : A member of the class of morpholines that is morpholine substituted by a 3-aminopropyl group a the N atom. | morpholines; primary amino compound | |
| 2,4'-bisphenol f | 2,4'-bisphenol F: contact allergen; structure given in first source | ||
| hei 712 | organofluorine compound; quinolone | ||
| 2-(5-Chlorobenzo[b]thiophen-3-yl)acetic acid | 1-benzothiophenes | ||
| alyssin | sulfoxide | ||
| dimethyl fumarate | diester; enoate ester; methyl ester | antipsoriatic; immunomodulator | |
| umi-77 | UMI-77: an Mcl-1 inhibitor; structure in first source | ||
| 6-methylsulfinylhexyl isothiocyanate | 6-(Methylsulfinyl)hexyl isothiocyanate: showed a dose-dependent inhibition of LPS-induced nitric oxide (NO), iNOS mRNA and protein. | sulfoxide | |
| (1S,2R)-2-[[(1S)-1-[(1,3-dioxo-2-isoindolyl)methyl]-3,4-dihydro-1H-isoquinolin-2-yl]-oxomethyl]-1-cyclohexanecarboxylic acid | LH601A: inhibits the interaction between KEAP1 and NRF2; structure in first source | phthalimides | |
| nk 252 | NK 252: potentiates the action of antitumor drugs against drug-sensitive tumors; structure given in first source |