Page last updated: 2024-11-04

sulforaphane and Adenocarcinoma

sulforaphane has been researched along with Adenocarcinoma in 17 studies

sulforaphane: from Cardaria draba L.
sulforaphane : An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.

Adenocarcinoma: A malignant epithelial tumor with a glandular organization.

Research Excerpts

ExcerptRelevanceReference
"Sulforaphane induces Xuanwei lung adenocarcinoma cell apoptosis."7.85Sulforaphane-induced apoptosis in Xuanwei lung adenocarcinoma cell line XWLC-05. ( Fan, L; Huang, YC; Jiang, H; Li, Y; Wang, CQ; Yao, Q; Zhou, L, 2017)
"We have shown previously that naturally occurring isothiocyanates derived from cruciferous vegetables and their N-acetylcysteine conjugates inhibit lung adenoma formation induced by tobacco carcinogens in A/J mice at the post-initiation stage."7.73Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice. ( Chung, FL; Conaway, CC; Hecht, SS; McIntee, EJ; Pittman, B; Schwartz, JE; Tian, D; Wang, CX; Yang, YM, 2005)
"Sulforaphane is a cruciferous vegetable-derived isothiocyanate with promising chemopreventive and therapeutic activities."5.42Sulforaphane down-regulates SKP2 to stabilize p27(KIP1) for inducing antiproliferation in human colon adenocarcinoma cells. ( Chang, CC; Chi-Hung Or, R; Chung, YK; Lu, CH; Ouyang, WT; Yang, SY, 2015)
" We have shown previously that prostate cancer prevention by sulforaphane (SFN) in Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) model is associated with inhibition of fatty acid metabolism."3.91Reversal of the Warburg phenomenon in chemoprevention of prostate cancer by sulforaphane. ( Alumkal, JJ; Foley, LM; Hahm, ER; Hitchens, TK; Jacobs, BL; Parikh, RA; Shiva, SS; Singh, KB; Singh, SV, 2019)
" We have shown previously that oral administration of sulforaphane (SFN) significantly inhibits the incidence and/or burden of prostatic intraepithelial neoplasia and well-differentiated adenocarcinoma in TRansgenic Adenocarcinoma of Mouse Prostate (TRAMP) mice."3.88Prostate cancer chemoprevention by sulforaphane in a preclinical mouse model is associated with inhibition of fatty acid metabolism. ( Hahm, ER; Jacobs, BL; Kim, SH; Pore, SK; Singh, KB; Singh, SV, 2018)
"Sulforaphane induces Xuanwei lung adenocarcinoma cell apoptosis."3.85Sulforaphane-induced apoptosis in Xuanwei lung adenocarcinoma cell line XWLC-05. ( Fan, L; Huang, YC; Jiang, H; Li, Y; Wang, CQ; Yao, Q; Zhou, L, 2017)
"We have shown previously that naturally occurring isothiocyanates derived from cruciferous vegetables and their N-acetylcysteine conjugates inhibit lung adenoma formation induced by tobacco carcinogens in A/J mice at the post-initiation stage."3.73Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice. ( Chung, FL; Conaway, CC; Hecht, SS; McIntee, EJ; Pittman, B; Schwartz, JE; Tian, D; Wang, CX; Yang, YM, 2005)
"Sulforaphane is a cruciferous vegetable-derived isothiocyanate with promising chemopreventive and therapeutic activities."1.42Sulforaphane down-regulates SKP2 to stabilize p27(KIP1) for inducing antiproliferation in human colon adenocarcinoma cells. ( Chang, CC; Chi-Hung Or, R; Chung, YK; Lu, CH; Ouyang, WT; Yang, SY, 2015)
"Exposure of prostate cancer cells (LNCaP, 22Rv1, C4-2, and PC-3) to pharmacologically applicable concentrations of PEITC, benzyl isothiocyanate (BITC), and SFN (2."1.42CXCR4 is a novel target of cancer chemopreventative isothiocyanates in prostate cancer cells. ( Amjad, AI; Chinni, SR; Parikh, R; Sakao, K; Singh, SV; Vyas, AR, 2015)
"D,L-Sulforaphane (SFN) is a promising chemopreventive agent with in vivo efficacy against prostate cancer in experimental rodents."1.40Functional relevance of D,L-sulforaphane-mediated induction of vimentin and plasminogen activator inhibitor-1 in human prostate cancer cells. ( Singh, SV; Vyas, AR, 2014)
"Pancreatic cancer is a deadly disease killing 37,000 Americans each year."1.39A novel combinatorial nanotechnology-based oral chemopreventive regimen demonstrates significant suppression of pancreatic cancer neoplastic lesions. ( Grandhi, BK; Prabhu, S; Thakkar, A; Wang, J, 2013)
"Erucin (ER) is a dietary ITC, which has been recently considered a promising cancer chemopreventive phytochemical."1.39Antiproliferative activity of the dietary isothiocyanate erucin, a bioactive compound from cruciferous vegetables, on human prostate cancer cells. ( Catania, S; Costa, C; Francisco, M; Maimone, P; Melchini, A; Miceli, N; Mithen, RF; Taviano, MF; Traka, MH, 2013)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (41.18)29.6817
2010's9 (52.94)24.3611
2020's1 (5.88)2.80

Authors

AuthorsStudies
Liang, H1
Lai, B1
Yuan, Q1
Singh, KB3
Hahm, ER3
Alumkal, JJ1
Foley, LM1
Hitchens, TK1
Shiva, SS1
Parikh, RA1
Jacobs, BL2
Singh, SV5
Kim, SH2
Powolny, AA1
Pore, SK1
Grandhi, BK1
Thakkar, A1
Wang, J1
Prabhu, S1
Vyas, AR2
Forster, T1
Rausch, V1
Zhang, Y1
Isayev, O1
Heilmann, K1
Schoensiegel, F1
Liu, L1
Nessling, M1
Richter, K1
Labsch, S1
Nwaeburu, CC1
Mattern, J1
Gladkich, J1
Giese, N1
Werner, J1
Schemmer, P1
Gross, W1
Gebhard, MM1
Gerhauser, C1
Schaefer, M1
Herr, I1
Chung, YK1
Chi-Hung Or, R1
Lu, CH1
Ouyang, WT1
Yang, SY1
Chang, CC1
Sakao, K1
Chinni, SR1
Amjad, AI1
Parikh, R1
Zhou, L1
Yao, Q1
Li, Y1
Huang, YC1
Jiang, H1
Wang, CQ1
Fan, L1
Mastrangelo, L1
Cassidy, A1
Mulholland, F1
Wang, W1
Bao, Y2
Melchini, A1
Traka, MH1
Catania, S1
Miceli, N1
Taviano, MF1
Maimone, P1
Francisco, M1
Mithen, RF1
Costa, C1
Svehlíková, V1
Wang, S1
Jakubíková, J1
Williamson, G1
Mithen, R1
Jackson, SJ1
Singletary, KW1
Conaway, CC1
Wang, CX1
Pittman, B1
Yang, YM1
Schwartz, JE1
Tian, D1
McIntee, EJ1
Hecht, SS1
Chung, FL1
Kuroiwa, Y1
Nishikawa, A1
Kitamura, Y1
Kanki, K1
Ishii, Y1
Umemura, T1
Hirose, M1
Jin, CY1
Moon, DO1
Lee, JD1
Heo, MS1
Choi, YH1
Lee, CM1
Park, YM1
Kim, GY1

Other Studies

17 other studies available for sulforaphane and Adenocarcinoma

ArticleYear
Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.
    Journal of natural products, 2008, Volume: 71, Issue:11

    Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Anticarcinogenic Agents; Apoptosis; Brassica; Cell

2008
Reversal of the Warburg phenomenon in chemoprevention of prostate cancer by sulforaphane.
    Carcinogenesis, 2019, 12-31, Volume: 40, Issue:12

    Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Chemoprevention; Glycolysis; Humans; Isothiocyanat

2019
The Role of Lysosome-associated Membrane Protein 2 in Prostate Cancer Chemopreventive Mechanisms of Sulforaphane.
    Cancer prevention research (Philadelphia, Pa.), 2020, Volume: 13, Issue:8

    Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Disease Mo

2020
Prostate cancer chemoprevention by sulforaphane in a preclinical mouse model is associated with inhibition of fatty acid metabolism.
    Carcinogenesis, 2018, 05-28, Volume: 39, Issue:6

    Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Chemoprevention; Fatty Acid Synthases; Fatty Acids

2018
A novel combinatorial nanotechnology-based oral chemopreventive regimen demonstrates significant suppression of pancreatic cancer neoplastic lesions.
    Cancer prevention research (Philadelphia, Pa.), 2013, Volume: 6, Issue:10

    Topics: Adenocarcinoma; Administration, Oral; Animals; Antineoplastic Agents; Antineoplastic Combined Chemot

2013
Functional relevance of D,L-sulforaphane-mediated induction of vimentin and plasminogen activator inhibitor-1 in human prostate cancer cells.
    European journal of nutrition, 2014, Volume: 53, Issue:3

    Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Apoptosis; Cadherins; Cell Line; Cell Line, Tumor;

2014
Sulforaphane counteracts aggressiveness of pancreatic cancer driven by dysregulated Cx43-mediated gap junctional intercellular communication.
    Oncotarget, 2014, Mar-30, Volume: 5, Issue:6

    Topics: Adenocarcinoma; Anticarcinogenic Agents; Apoptosis; Blotting, Western; Carcinoma, Pancreatic Ductal;

2014
Sulforaphane down-regulates SKP2 to stabilize p27(KIP1) for inducing antiproliferation in human colon adenocarcinoma cells.
    Journal of bioscience and bioengineering, 2015, Volume: 119, Issue:1

    Topics: Adenocarcinoma; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Cyclin-Dependent Kinase Inh

2015
CXCR4 is a novel target of cancer chemopreventative isothiocyanates in prostate cancer cells.
    Cancer prevention research (Philadelphia, Pa.), 2015, Volume: 8, Issue:5

    Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Cell Line, Tumor; Chemoprevention; Humans; Isothio

2015
Sulforaphane-induced apoptosis in Xuanwei lung adenocarcinoma cell line XWLC-05.
    Thoracic cancer, 2017, Volume: 8, Issue:1

    Topics: Adenocarcinoma; Adenocarcinoma of Lung; Anticarcinogenic Agents; Apoptosis; bcl-2-Associated X Prote

2017
Serotonin receptors, novel targets of sulforaphane identified by proteomic analysis in Caco-2 cells.
    Cancer research, 2008, Jul-01, Volume: 68, Issue:13

    Topics: Adenocarcinoma; Biomarkers, Pharmacological; Biomarkers, Tumor; Caco-2 Cells; Colonic Neoplasms; Dru

2008
Antiproliferative activity of the dietary isothiocyanate erucin, a bioactive compound from cruciferous vegetables, on human prostate cancer cells.
    Nutrition and cancer, 2013, Volume: 65, Issue:1

    Topics: Adenocarcinoma; Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell P

2013
Interactions between sulforaphane and apigenin in the induction of UGT1A1 and GSTA1 in CaCo-2 cells.
    Carcinogenesis, 2004, Volume: 25, Issue:9

    Topics: Adenocarcinoma; Anticarcinogenic Agents; Apigenin; Bacterial Proteins; Caco-2 Cells; Carrier Protein

2004
Sulforaphane inhibits human MCF-7 mammary cancer cell mitotic progression and tubulin polymerization.
    The Journal of nutrition, 2004, Volume: 134, Issue:9

    Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Breast Neoplasms; Cattle; Cell Cycle; Cell Divisio

2004
Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice.
    Cancer research, 2005, Sep-15, Volume: 65, Issue:18

    Topics: Acetylcysteine; Adenocarcinoma; Adenoma; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Body Weig

2005
Protective effects of benzyl isothiocyanate and sulforaphane but not resveratrol against initiation of pancreatic carcinogenesis in hamsters.
    Cancer letters, 2006, Sep-28, Volume: 241, Issue:2

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents, Phytogenic; Carcinogenicity Tests; Carcinogens; Cell

2006
Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis through downregulation of ERK and Akt in lung adenocarcinoma A549 cells.
    Carcinogenesis, 2007, Volume: 28, Issue:5

    Topics: Adenocarcinoma; Anticarcinogenic Agents; Apoptosis; Caspase 3; Cell Line, Tumor; Down-Regulation; Hu

2007