Compounds > salpichrolide g
Page last updated: 2024-11-13

salpichrolide g

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

salpichrolide G: withanolide from Salpichroa origanifolia; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
Salpichroagenus[no description available]SolanaceaeA plant family of the order SOLANALES, class MAGNOLIOPSIDA. Among the most noted are POTATOES; TOMATOES; CAPSICUM (green and red peppers); TOBACCO; and BELLADONNA.[MeSH]

Cross-References

ID SourceID
PubMed CID44558902
CHEMBL ID470236
MeSH IDM0422851

Synonyms (2)

Synonym
CHEMBL470236
salpichrolide g

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" The antiestrogenic activity was evaluated by performing dose-response experiments in ER(+) MCF-7 breast cancer cells."( Synthesis and biological evaluation of salpichrolide analogs as antiestrogenic agents.
Alvarez, LD; Burton, G; Gargiulo, L; Lüthy, I; Rivero, EM; Sonego, JM; Veleiro, AS, 2014)		0.4
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Other Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Quinone oxidoreductaseMus musculus (house mouse)CD11.60000.20002.74219.8000AID334281
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (18)

Assay IDTitleYearJournalArticle
AID334284Chemoprevention index, ratio of IC50 for mouse Hepa-1c1c7 cells to drug level required to double specific quinone reductase activity in mouse Hepa-1c1c7 cells2002Journal of natural products, May, Volume: 65, Issue:5
Induction of quinone reductase by withanolides.
AID334283Growth inhibition of mouse Hepa-1c1c7 cells by crystal violet staining2002Journal of natural products, May, Volume: 65, Issue:5
Induction of quinone reductase by withanolides.
AID376851Antifeedant activity against Musca domestica CIPEIN larvae assessed as inhibition of larvae development after 18 days2000Journal of natural products, Aug, Volume: 63, Issue:8
Antifeedant activity of withanolides from Salpichroa origanifolia on Musca domestica.
AID480906Antiproliferative activity against estrogen receptor deficient human SKBR3 cells after 48 hrs by SRB assay2010Journal of natural products, May-28, Volume: 73, Issue:5
Antiproliferative activity of withanolides against human breast cancer cell lines.
AID334281Induction of quinone reductase activity in mouse Hepa-1c1c7 cells assessed as drug level required to double enzyme activity after 48 hrs by NADPH-dependent MTT reduction assay2002Journal of natural products, May, Volume: 65, Issue:5
Induction of quinone reductase by withanolides.
AID1155379Inhibition of 17beta-estradiol-induced in ERalpha positive human MCF7 cells proliferation assessed as [3H]-thymidine incorporation after 72 hrs by liquid scintillation counting2014European journal of medicinal chemistry, Jul-23, Volume: 82Synthesis and biological evaluation of salpichrolide analogs as antiestrogenic agents.
AID376597Antifeedant activity in Musca domestica CIPEIN larvae assessed as time needed to pupate 50% at 100 ppm2000Journal of natural products, Aug, Volume: 63, Issue:8
Antifeedant activity of withanolides from Salpichroa origanifolia on Musca domestica.
AID376856Antifeedant activity against Musca domestica CIPEIN larvae assessed as time needed to pupate 50% at 2000 ppm2000Journal of natural products, Aug, Volume: 63, Issue:8
Antifeedant activity of withanolides from Salpichroa origanifolia on Musca domestica.
AID334282Induction of quinone reductase activity in mouse Hepa-1c1c7 cells assessed as drug level required to induce 4-fold increase in enzyme activity after 48 hrs by NADPH-dependent MTT reduction assay2002Journal of natural products, May, Volume: 65, Issue:5
Induction of quinone reductase by withanolides.
AID1155383Cytotoxicity against ERalpha negative human MDA-MB-231 cells at 10 nM and 1 uM2014European journal of medicinal chemistry, Jul-23, Volume: 82Synthesis and biological evaluation of salpichrolide analogs as antiestrogenic agents.
AID480905Antiproliferative activity against estrogen receptor deficient human MDA-MB-231 cells after 48 hrs by SRB assay2010Journal of natural products, May-28, Volume: 73, Issue:5
Antiproliferative activity of withanolides against human breast cancer cell lines.
AID376857Antifeedant activity against Musca domestica CIPEIN larvae assessed as larval mortality at 200 ppm after 18 days2000Journal of natural products, Aug, Volume: 63, Issue:8
Antifeedant activity of withanolides from Salpichroa origanifolia on Musca domestica.
AID1155382Cytotoxicity against ERalpha positive human MCF7 cells at 10 nM and 1 uM2014European journal of medicinal chemistry, Jul-23, Volume: 82Synthesis and biological evaluation of salpichrolide analogs as antiestrogenic agents.
AID480903Antiproliferative activity against human T47D cells expressing estrogen receptor after 48 hrs by SRB assay2010Journal of natural products, May-28, Volume: 73, Issue:5
Antiproliferative activity of withanolides against human breast cancer cell lines.
AID334285Chemoprevention index, ratio of IC50 for mouse Hepa-1c1c7 cells to drug level required to induce 4-fold increase in quinone reductase activity in mouse Hepa-1c1c7 cells2002Journal of natural products, May, Volume: 65, Issue:5
Induction of quinone reductase by withanolides.
AID480902Antiproliferative activity against human MCF7 cells expressing estrogen receptor after 48 hrs by SRB assay2010Journal of natural products, May-28, Volume: 73, Issue:5
Antiproliferative activity of withanolides against human breast cancer cell lines.
AID376855Antifeedant activity against Musca domestica CIPEIN larvae assessed as time needed to pupate 50% at 500 ppm2000Journal of natural products, Aug, Volume: 63, Issue:8
Antifeedant activity of withanolides from Salpichroa origanifolia on Musca domestica.
AID480904Antiproliferative activity against human MCF7/BUS cells expressing estrogen receptor after 48 hrs by SRB assay2010Journal of natural products, May-28, Volume: 73, Issue:5
Antiproliferative activity of withanolides against human breast cancer cell lines.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (66.67)29.6817
2010's2 (33.33)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.84

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.84 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.78 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.84)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
fluorouracil
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.		2.0510nucleobase analogue;
organofluorine compound		antimetabolite;
antineoplastic agent;
environmental contaminant;
immunosuppressive agent;
radiosensitizing agent;
xenobiotic
sulforaphane
sulforaphane: from Cardaria draba L.. sulforaphane : An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.		2.0110isothiocyanate;
sulfoxide		antineoplastic agent;
antioxidant;
EC 3.5.1.98 (histone deacetylase) inhibitor;
plant metabolite
camptothecin
NSC 100880: carboxylate (opened lactone) form of camptothecin; RN refers to (S)-isomer; structure given in first source		2.0510delta-lactone;
pyranoindolizinoquinoline;
quinoline alkaloid;
tertiary alcohol		antineoplastic agent;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
genotoxin;
plant metabolite
4beta-Hydroxywithanolide E
[no description available]		2.0510withanolide
fulvestrant
Fulvestrant: An estradiol derivative and estrogen receptor antagonist that is used for the treatment of estrogen receptor-positive, locally advanced or metastatic breast cancer.. fulvestrant : A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.		2.11017beta-hydroxy steroid;
3-hydroxy steroid;
organofluorine compound;
sulfoxide		antineoplastic agent;
estrogen antagonist;
estrogen receptor antagonist
withanolides
Withanolides: Ergostane derivatives of 28 carbons with oxygens at C1, C22, and C26 positions and the side chain cyclized. They are found in WITHANIA plant genus and have cytotoxic and other effects.		2.0210
ergosterol
[no description available]		2.72303beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
ergostanoid;
phytosterols		fungal metabolite;
Saccharomyces cerevisiae metabolite
salpichrolide a
salpichrolide A: isolated from Salpichroa origanifolia; structure in first source		2.7230
withanolide a
[no description available]		2.0110withanolide
salpichrolide c
salpichrolide C: isolated from Salpichroa origanifolia; structure in first source		2.9340
ConditionIndicatedRelationship StrengthStudiesTrials
Hepatocellular Carcinoma
[description not available]		02.0110
Carcinoma, Hepatocellular
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.		02.0110
Breast Cancer
[description not available]		02.0510
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.0510