sulforaphane has been researched along with Skin Neoplasms in 20 studies
sulforaphane: from Cardaria draba L.
sulforaphane : An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.
Skin Neoplasms: Tumors or cancer of the SKIN.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Atypical nevi were photographed on days 1 and 28, and plasma and nevus samples were taken on days 1, 2, and 28." | 6.87 | Evaluation of Biodistribution of Sulforaphane after Administration of Oral Broccoli Sprout Extract in Melanoma Patients with Multiple Atypical Nevi. ( Beumer, JH; Butterfield, LH; Cassidy, PB; Christner, SM; Dietz, CM; Fahey, JW; Ferris, LK; Hahm, ER; Hughes, E; Kirkwood, JM; Leachman, SA; Lin, Y; Rao, UN; Rose, A; Sander, C; Singh, SV; Tahata, S; Tarhini, AA; Tawbi, H; Wilson, M; Zarour, HM, 2018) |
| "Melanoma is a severe form of cancer, resistant to conventional therapies." | 5.48 | Anticarcinogenic activities of sulforaphane are influenced by Nerve Growth Factor in human melanoma A375 cells. ( Arcidiacono, P; Bottoni, U; Calvieri, S; Crisanti, A; Pistilli, A; Ragonese, F; Rende, M; Spaccapelo, R; Stabile, AM, 2018) |
| "Sulforaphane (SF) is a promising isothiocyanate compound occurring in cruciferous plants with reported antiproliferative and proapoptotic activity in several tumor cell lines including melanoma." | 5.40 | Sulforaphane-induced apoptosis involves p53 and p38 in melanoma cells. ( Cervinka, M; Rudolf, E; Rudolf, K, 2014) |
| "Atypical nevi were photographed on days 1 and 28, and plasma and nevus samples were taken on days 1, 2, and 28." | 2.87 | Evaluation of Biodistribution of Sulforaphane after Administration of Oral Broccoli Sprout Extract in Melanoma Patients with Multiple Atypical Nevi. ( Beumer, JH; Butterfield, LH; Cassidy, PB; Christner, SM; Dietz, CM; Fahey, JW; Ferris, LK; Hahm, ER; Hughes, E; Kirkwood, JM; Leachman, SA; Lin, Y; Rao, UN; Rose, A; Sander, C; Singh, SV; Tahata, S; Tarhini, AA; Tawbi, H; Wilson, M; Zarour, HM, 2018) |
| "Melanoma is less common among all other types of skin cancers but causes higher mortality." | 2.58 | Epigenetics of skin cancer: Interventions by selected bioactive phytochemicals. ( Meeran, SM; Penta, D; Somashekar, BS, 2018) |
| "Sulforaphane (SFN) is a promising cancer prevention and treatment agent that strongly suppresses the cutaneous squamous cell carcinoma (CSCC) cell cancer phenotype." | 1.91 | Sulforaphane inhibits CD44v6/YAP1/TEAD signaling to suppress the cancer phenotype. ( Adhikary, G; Chen, X; Eckert, RL; Ma, E; Naselsky, W; Newland, JJ; Xu, W, 2023) |
| "Sulforaphane (SFN) is an important diet-derived cancer prevention agent that is known to possess a reactive isothiocyanate group and has potent anticancer activity." | 1.72 | Sulforaphane covalently interacts with the transglutaminase 2 cancer maintenance protein to alter its structure and suppress its activity. ( Adhikary, G; Eckert, RL; Gates, EWJ; Godoy-Ruiz, R; Keillor, JW; Lakowicz, JR; Puranik, P; Rorke, EA; Szmacinski, H; Weber, DJ, 2022) |
| "Sulforaphane is an isothiocyanate, which is found in cruciferous vegetables." | 1.51 | Antitumor activity of sulforaphane in mice model of skin cancer via blocking sulfatase-2. ( Alyoussef, A; Taha, M, 2019) |
| "Sulforaphane is a diet-derived cancer prevention agent that is effective in suppressing tumor growth in animal models of skin cancer." | 1.48 | Combination cisplatin and sulforaphane treatment reduces proliferation, invasion, and tumor formation in epidermal squamous cell carcinoma. ( Adhikary, G; Eckert, RL; George, N; Grun, D; Kerr, C, 2018) |
| "Melanoma is a severe form of cancer, resistant to conventional therapies." | 1.48 | Anticarcinogenic activities of sulforaphane are influenced by Nerve Growth Factor in human melanoma A375 cells. ( Arcidiacono, P; Bottoni, U; Calvieri, S; Crisanti, A; Pistilli, A; Ragonese, F; Rende, M; Spaccapelo, R; Stabile, AM, 2018) |
| "Sulforaphane (SF) is a promising isothiocyanate compound occurring in cruciferous plants with reported antiproliferative and proapoptotic activity in several tumor cell lines including melanoma." | 1.40 | Sulforaphane-induced apoptosis involves p53 and p38 in melanoma cells. ( Cervinka, M; Rudolf, E; Rudolf, K, 2014) |
| "Sulforaphane treatment also increases cleavage of procaspase 3, 8, and 9 and enhances PARP cleavage and apoptosis." | 1.37 | Sulforaphane suppresses polycomb group protein level via a proteasome-dependent mechanism in skin cancer cells. ( Balasubramanian, S; Chew, YC; Eckert, RL, 2011) |
| "Sulforaphane is a compound widely present in consumed vegetables, particularly broccoli." | 1.36 | Sulforaphane inhibited melanin synthesis by regulating tyrosinase gene expression in B16 mouse melanoma cells. ( Kamada, M; Liu, MC; Matsui, T; Sakakibara, Y; Shirasugi, I; Suiko, M, 2010) |
| "(R)L-sulforaphane (SF) is a compound that protects against erythema, but it can also induce DNA fragmentation that leads to cell death by apoptosis." | 1.35 | Effect of (R)L-sulforaphane on 5-aminolevulinic acid-mediated photodynamic therapy. ( Juzeniene, A; Mikolajewska, P; Moan, J, 2008) |
| "Sulforaphane is an isothiocyanate derived from cruciferous vegetables that has been linked to decreased risk of certain cancers." | 1.35 | Inhibition of activator protein-1 by sulforaphane involves interaction with cysteine in the cFos DNA-binding domain: implications for chemoprevention of UVB-induced skin cancer. ( Bowden, GT; Dickinson, SE; Melton, TF; Olson, ER; Saboda, K; Zhang, J, 2009) |
| " Quantitative assessment of the activity of NQO1 24 h after dosing showed increases of 1." | 1.34 | Induction of the phase 2 response in mouse and human skin by sulforaphane-containing broccoli sprout extracts. ( Dinkova-Kostova, AT; Fahey, JW; Fuchs, EJ; Jenkins, SN; Kerns, ML; Shapiro, TA; Talalay, P; Wade, KL, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (30.00) | 29.6817 |
| 2010's | 11 (55.00) | 24.3611 |
| 2020's | 3 (15.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rorke, EA | 1 |
| Adhikary, G | 4 |
| Szmacinski, H | 1 |
| Lakowicz, JR | 1 |
| Weber, DJ | 1 |
| Godoy-Ruiz, R | 1 |
| Puranik, P | 1 |
| Keillor, JW | 1 |
| Gates, EWJ | 1 |
| Eckert, RL | 6 |
| Yepes-Molina, L | 1 |
| Carvajal, M | 1 |
| Chen, X | 1 |
| Ma, E | 1 |
| Newland, JJ | 1 |
| Naselsky, W | 1 |
| Xu, W | 1 |
| Kerr, C | 1 |
| Grun, D | 2 |
| George, N | 1 |
| Saha, K | 2 |
| Fisher, ML | 1 |
| Penta, D | 1 |
| Somashekar, BS | 1 |
| Meeran, SM | 1 |
| Arcidiacono, P | 1 |
| Stabile, AM | 1 |
| Ragonese, F | 1 |
| Pistilli, A | 1 |
| Calvieri, S | 1 |
| Bottoni, U | 1 |
| Crisanti, A | 1 |
| Spaccapelo, R | 1 |
| Rende, M | 1 |
| Tahata, S | 1 |
| Singh, SV | 1 |
| Lin, Y | 1 |
| Hahm, ER | 1 |
| Beumer, JH | 1 |
| Christner, SM | 1 |
| Rao, UN | 1 |
| Sander, C | 1 |
| Tarhini, AA | 1 |
| Tawbi, H | 1 |
| Ferris, LK | 1 |
| Wilson, M | 1 |
| Rose, A | 1 |
| Dietz, CM | 1 |
| Hughes, E | 1 |
| Fahey, JW | 3 |
| Leachman, SA | 1 |
| Cassidy, PB | 1 |
| Butterfield, LH | 1 |
| Zarour, HM | 1 |
| Kirkwood, JM | 1 |
| Alyoussef, A | 1 |
| Taha, M | 1 |
| Hornyak, TJ | 1 |
| Rudolf, K | 1 |
| Cervinka, M | 1 |
| Rudolf, E | 1 |
| Su, ZY | 1 |
| Zhang, C | 1 |
| Lee, JH | 1 |
| Shu, L | 1 |
| Wu, TY | 1 |
| Khor, TO | 2 |
| Conney, AH | 2 |
| Lu, YP | 1 |
| Kong, AN | 2 |
| Mikolajewska, P | 1 |
| Juzeniene, A | 1 |
| Moan, J | 1 |
| Dickinson, SE | 1 |
| Melton, TF | 1 |
| Olson, ER | 1 |
| Zhang, J | 1 |
| Saboda, K | 1 |
| Bowden, GT | 1 |
| Shirasugi, I | 1 |
| Kamada, M | 1 |
| Matsui, T | 1 |
| Sakakibara, Y | 1 |
| Liu, MC | 1 |
| Suiko, M | 1 |
| Balasubramanian, S | 1 |
| Chew, YC | 1 |
| Gills, JJ | 1 |
| Jeffery, EH | 1 |
| Matusheski, NV | 1 |
| Moon, RC | 1 |
| Lantvit, DD | 1 |
| Pezzuto, JM | 1 |
| Dinkova-Kostova, AT | 2 |
| Jenkins, SN | 2 |
| Ye, L | 1 |
| Wehage, SL | 1 |
| Liby, KT | 1 |
| Stephenson, KK | 1 |
| Wade, KL | 2 |
| Talalay, P | 2 |
| Xu, C | 1 |
| Huang, MT | 1 |
| Shen, G | 1 |
| Yuan, X | 1 |
| Lin, W | 1 |
| Shapiro, TA | 1 |
| Fuchs, EJ | 1 |
| Kerns, ML | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Role and Clinical Relevance of Nerve Growth Factor (NGF) and Its Receptors (TrKA and p75NTR) in Patients With Erectile Dysfunction and Diabetes With or Wothout Metabolic Syndrome[NCT03862547] | 40 participants (Anticipated) | Interventional | 2019-01-30 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for sulforaphane and Skin Neoplasms
| Article | Year |
|---|---|
Epigenetics of skin cancer: Interventions by selected bioactive phytochemicals.
Topics: Anticarcinogenic Agents; Catechin; DNA Methylation; Epigenesis, Genetic; Histones; Humans; Isothiocy | 2018 |
Epigenetic cancer prevention mechanisms in skin cancer.
Topics: Animals; Anticarcinogenic Agents; Epigenesis, Genetic; Humans; Isothiocyanates; Polyphenols; Skin Ne | 2013 |
Sulforaphane prevents mouse skin tumorigenesis during the stage of promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Anticarcinogenic Agents; Brassic | 2006 |
1 trial available for sulforaphane and Skin Neoplasms
| Article | Year |
|---|---|
Evaluation of Biodistribution of Sulforaphane after Administration of Oral Broccoli Sprout Extract in Melanoma Patients with Multiple Atypical Nevi.
Topics: Administration, Oral; Adult; Aged; Biomarkers, Tumor; Biopsy; Brassica; Capsules; Feasibility Studie | 2018 |
16 other studies available for sulforaphane and Skin Neoplasms
| Article | Year |
|---|---|
Sulforaphane covalently interacts with the transglutaminase 2 cancer maintenance protein to alter its structure and suppress its activity.
Topics: Animals; Antineoplastic Agents; Binding Sites; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Prol | 2022 |
Nanoencapsulation of sulforaphane in broccoli membrane vesicles and their
Topics: Anticarcinogenic Agents; Aquaporin 3; Brassica; Cell Line, Tumor; Cell Proliferation; Dose-Response | 2021 |
Sulforaphane inhibits CD44v6/YAP1/TEAD signaling to suppress the cancer phenotype.
Topics: Adaptor Proteins, Signal Transducing; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation | 2023 |
Combination cisplatin and sulforaphane treatment reduces proliferation, invasion, and tumor formation in epidermal squamous cell carcinoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Squamous Cell; Cell L | 2018 |
Sulforaphane suppresses PRMT5/MEP50 function in epidermal squamous cell carcinoma leading to reduced tumor formation.
Topics: Adaptor Proteins, Signal Transducing; Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Move | 2017 |
Anticarcinogenic activities of sulforaphane are influenced by Nerve Growth Factor in human melanoma A375 cells.
Topics: Anticarcinogenic Agents; Apoptosis; Caspase 3; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Sur | 2018 |
Antitumor activity of sulforaphane in mice model of skin cancer via blocking sulfatase-2.
Topics: Animals; Anthracenes; Anticarcinogenic Agents; Antioxidants; Apoptosis; Carcinogens; Caspase 3; Dise | 2019 |
Sulforaphane-induced apoptosis involves p53 and p38 in melanoma cells.
Topics: Anticarcinogenic Agents; Apoptosis; Caspases; Cell Line, Tumor; Humans; Isothiocyanates; Melanoma; M | 2014 |
Requirement and epigenetics reprogramming of Nrf2 in suppression of tumor promoter TPA-induced mouse skin cell transformation by sulforaphane.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Epi | 2014 |
Effect of (R)L-sulforaphane on 5-aminolevulinic acid-mediated photodynamic therapy.
Topics: Aminolevulinic Acid; Anticarcinogenic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; Drug Scree | 2008 |
Inhibition of activator protein-1 by sulforaphane involves interaction with cysteine in the cFos DNA-binding domain: implications for chemoprevention of UVB-induced skin cancer.
Topics: Animals; Anticarcinogenic Agents; Binding Sites; Carcinoma, Squamous Cell; Cysteine; Disease Models, | 2009 |
Sulforaphane inhibited melanin synthesis by regulating tyrosinase gene expression in B16 mouse melanoma cells.
Topics: Animals; Arbutin; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Isothiocya | 2010 |
Sulforaphane suppresses polycomb group protein level via a proteasome-dependent mechanism in skin cancer cells.
Topics: Base Sequence; Cell Cycle; Cell Line, Tumor; Cell Proliferation; DNA Primers; Humans; Isothiocyanate | 2011 |
Protection against UV-light-induced skin carcinogenesis in SKH-1 high-risk mice by sulforaphane-containing broccoli sprout extracts.
Topics: Animals; Anticarcinogenic Agents; Comet Assay; DNA; DNA Damage; Dose-Response Relationship, Drug; Do | 2006 |
Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Disease Susceptibility; DNA, Neo | 2006 |
Induction of the phase 2 response in mouse and human skin by sulforaphane-containing broccoli sprout extracts.
Topics: Animals; Brassica; Female; Humans; Immunohistochemistry; Isothiocyanates; Mice; NAD(P)H Dehydrogenas | 2007 |