Page last updated: 2024-12-11
sulphoraphene
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
sulphoraphene: from radish; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
ID Source | ID |
---|---|
PubMed CID | 6433206 |
CHEMBL ID | 49659 |
SCHEMBL ID | 2937706 |
MeSH ID | M0449015 |
Synonyms (27)
Synonym |
---|
unii-nco9mc39io |
nco9mc39io , |
sulphoraphene |
isothiocyanic acid, 4-(methylsulfinyl)-3-butenyl ester |
sulforaphene |
1-butene, 4-isothiocyanato-1-(methylsulfinyl)- |
raphanin |
sulforaphen |
4-isothiocyanato-1-(methylsulfinyl)-1-butene |
sulphoraphen |
CHEMBL49659 |
592-95-0 |
(e)-4-isothiocyanato-1-methylsulfinylbut-1-ene |
AKOS006274434 |
SCHEMBL2937706 |
AC-34422 |
(1e)-4-isothiocyanato-1-methanesulfinylbut-1-ene |
(r)-(e)-sulforaphene |
s-sulforaphene , |
HY-N2450 |
F21504 |
Q7294040 |
1-methylsulfinylbutenyl isothiocyante |
CS-0022676 |
MS-22937 |
(-)4-isothiocyanato-4r-(methylsulfinyl)-1-butene |
AKOS040760048 |
Research Excerpts
Pharmacokinetics
Excerpt | Reference | Relevance |
---|---|---|
" This novel LC-MS-MS method shows satisfactory accuracy and precision and is sufficiently sensitive for the performance of pharmacokinetic studies in rats." | ( Development and validation of an LC-MS-MS method for the simultaneous determination of sulforaphane and its metabolites in rat plasma and its application in pharmacokinetic studies. Khor, TO; Kong, AN; Lin, W; Nomeir, AA; Shen, G; Wang, H, ) | 0.13 |
Bioavailability
Excerpt | Reference | Relevance |
---|---|---|
"The evaluation of the bioavailability of bioactive compounds from cruciferous foods is one challenge in the design of clinical trials for studying their functionality." | ( Bioavailability and new biomarkers of cruciferous sprouts consumption. Baenas, N; García-Viguera, C; Moreno, DA; Suárez-Martínez, C, 2017) | 0.46 |
" However, chemopreventive metabolites are typically inactive and have low bioavailability and poor host absorption." | ( Engineered commensal microbes for diet-mediated colorectal-cancer chemoprevention. Chang, MW; Chua, KJ; Ho, CL; Kang, A; Lee, YS; Lim, KH; Ling, KL; Tan, HQ; Thiery, JP; Yew, WS, 2018) | 0.48 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Protein Targets (1)
Other Measurements
Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
Quinone oxidoreductase | Mus musculus (house mouse) | CD | 0.4000 | 0.2000 | 2.7421 | 9.8000 | AID163303 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Bioassays (26)
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID1418252 | Antiproliferative activity against human HeLa cells after 72 hrs by CCK8 assay | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells. |
AID1418268 | Cell cycle arrest in human SMMC7721 cells assessed as accumulation at G0/G1 phase at 8 uM after 72 hrs by RNase/propidium iodide staining-based flow cytometric analysis (Rvb = 67.26%) | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells. |
AID1418270 | Cell cycle arrest in human SMMC7721 cells assessed as accumulation at G2/M phase at 8 uM after 72 hrs by RNase/propidium iodide staining-based flow cytometric analysis (Rvb = 24.78%) | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells. |
AID1418253 | Drug degradation in methanol after 10 hrs at 50 degC by HPLC analysis | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells. |
AID1418250 | Antiproliferative activity against human A375 cells after 72 hrs by CCK8 assay | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells. |
AID1418266 | Cell cycle arrest in human SMMC7721 cells assessed as accumulation at S phase at 4 uM after 72 hrs by RNase/propidium iodide staining-based flow cytometric analysis (Rvb = 7.96%) | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells. |
AID1418247 | Antiproliferative activity against human SMMC7721 cells assessed as inhibition of cell proliferation at 32 uM after 72 hrs by CCK8 assay | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells. |
AID1418261 | Induction of apoptosis in human SMMC7721 cells assessed as necrotic cells at 8 uM after 72 hrs by Alexa Fluor 488 Annexin/propidium iodide staining-based flow cytometric analysis (Rvb = 6.76%) | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells. |
AID1418245 | Antiproliferative activity against human A375 cells assessed as inhibition of cell proliferation at 32 uM after 72 hrs by CCK8 assay | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells. |
AID1418244 | Antiproliferative activity against human A375 cells assessed as inhibition of cell proliferation at 16 uM after 72 hrs by CCK8 assay | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells. |
AID1418256 | Inhibition of colony formation in human SMMC7721 cells at 2 to 8 uM after 7 days by crystal violet staining-based assay | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells. |
AID1418265 | Cell cycle arrest in human SMMC7721 cells assessed as accumulation at G0/G1 phase at 4 uM after 72 hrs by RNase/propidium iodide staining-based flow cytometric analysis (Rvb = 67.26%) | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells. |
AID1418249 | Antiproliferative activity against human A549 cells after 72 hrs by CCK8 assay | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells. |
AID1418267 | Cell cycle arrest in human SMMC7721 cells assessed as accumulation at G2/M phase at 4 uM after 72 hrs by RNase/propidium iodide staining-based flow cytometric analysis (Rvb = 24.78%) | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells. |
AID1418248 | Antiproliferative activity against human SMMC7721 cells after 72 hrs by CCK8 assay | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells. |
AID163303 | In vitro potency to induce quinone reductase activity in murine hepatoma cells was determined | 1994 | Journal of medicinal chemistry, Jan-07, Volume: 37, Issue:1 | Design and synthesis of bifunctional isothiocyanate analogs of sulforaphane: correlation between structure and potency as inducers of anticarcinogenic detoxication enzymes. |
AID1418264 | Induction of apoptosis in human SMMC7721 cells assessed as viable cells at 8 uM after 72 hrs by Alexa Fluor 488 Annexin/propidium iodide staining-based flow cytometric analysis (Rvb = 91.92%) | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells. |
AID1418262 | Induction of apoptosis in human SMMC7721 cells assessed as late apoptotic cells at 8 uM after 72 hrs by Alexa Fluor 488 Annexin/propidium iodide staining-based flow cytometric analysis (Rvb = 0.62%) | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells. |
AID1418258 | Induction of apoptosis in human SMMC7721 cells assessed as late apoptotic cells at 4 uM after 72 hrs by Alexa Fluor 488 Annexin/propidium iodide staining-based flow cytometric analysis (Rvb = 0.62%) | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells. |
AID1418246 | Antiproliferative activity against human SMMC7721 cells assessed as inhibition of cell proliferation at 16 uM after 72 hrs by CCK8 assay | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells. |
AID1418263 | Induction of apoptosis in human SMMC7721 cells assessed as early apoptotic cells at 8 uM after 72 hrs by Alexa Fluor 488 Annexin/propidium iodide staining-based flow cytometric analysis (Rvb = 0.70%) | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells. |
AID1418259 | Induction of apoptosis in human SMMC7721 cells assessed as early apoptotic cells at 4 uM after 72 hrs by Alexa Fluor 488 Annexin/propidium iodide staining-based flow cytometric analysis (Rvb = 0.70%) | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells. |
AID1418260 | Induction of apoptosis in human SMMC7721 cells assessed as viable cells at 4 uM after 72 hrs by Alexa Fluor 488 Annexin/propidium iodide staining-based flow cytometric analysis (Rvb = 91.92%) | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells. |
AID1418257 | Induction of apoptosis in human SMMC7721 cells assessed as necrotic cells at 4 uM after 72 hrs by Alexa Fluor 488 Annexin/propidium iodide staining-based flow cytometric analysis (Rvb = 6.76%) | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells. |
AID1418251 | Antiproliferative activity against human HCT116 cells after 72 hrs by CCK8 assay | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells. |
AID1418269 | Cell cycle arrest in human SMMC7721 cells assessed as accumulation at S phase at 8 uM after 72 hrs by RNase/propidium iodide staining-based flow cytometric analysis (Rvb = 7.96%) | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (51)
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 1 (1.96) | 18.7374 |
1990's | 1 (1.96) | 18.2507 |
2000's | 3 (5.88) | 29.6817 |
2010's | 31 (60.78) | 24.3611 |
2020's | 15 (29.41) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 46.58
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.
| This Compound (46.58) All Compounds (24.57) |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 52 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |