Page last updated: 2024-11-04

sulforaphane and Colorectal Cancer

sulforaphane has been researched along with Colorectal Cancer in 14 studies

sulforaphane: from Cardaria draba L.
sulforaphane : An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.

Research Excerpts

ExcerptRelevanceReference
"The objective of this study was to investigate, whether the plant-derived isothiocyanate Sulforaphane (SFN) enhances the antitumor activities of the chemotherapeutic agent oxaliplatin (Ox) in a cell culture model of colorectal cancer."7.77Sulforaphane potentiates oxaliplatin-induced cell growth inhibition in colorectal cancer cells via induction of different modes of cell death. ( Brüne, B; Kaminski, BM; Schumacher, M; Stein, J; Steinhilber, D; Ulrich, S; Weigert, A; Wenzel, U, 2011)
"The objective of this study was to elucidate molecular mechanisms behind the antitumor activities of the isothiocyanate sulforaphane (SFN) in colorectal cancer cells."7.76Isothiocyanate sulforaphane inhibits protooncogenic ornithine decarboxylase activity in colorectal cancer cells via induction of the TGF-β/Smad signaling pathway. ( Kaminski, BM; Loitsch, SM; Ochs, MJ; Reuter, KC; Stein, J; Steinhilber, D; Ulrich, S, 2010)
"The long pre‑cancerous state of colorectal cancer (CRC) provides an opportunity to prevent the occurrence and development of CRC."5.56Sulforaphane suppresses carcinogenesis of colorectal cancer through the ERK/Nrf2‑UDP glucuronosyltransferase 1A metabolic axis activation. ( Hao, Q; Li, C; Lin, YM; Liu, F; Sun, NX; Wang, M; Zhu, C; Zhu, WW, 2020)
"The objective of this study was to investigate, whether the plant-derived isothiocyanate Sulforaphane (SFN) enhances the antitumor activities of the chemotherapeutic agent oxaliplatin (Ox) in a cell culture model of colorectal cancer."3.77Sulforaphane potentiates oxaliplatin-induced cell growth inhibition in colorectal cancer cells via induction of different modes of cell death. ( Brüne, B; Kaminski, BM; Schumacher, M; Stein, J; Steinhilber, D; Ulrich, S; Weigert, A; Wenzel, U, 2011)
"The objective of this study was to elucidate molecular mechanisms behind the antitumor activities of the isothiocyanate sulforaphane (SFN) in colorectal cancer cells."3.76Isothiocyanate sulforaphane inhibits protooncogenic ornithine decarboxylase activity in colorectal cancer cells via induction of the TGF-β/Smad signaling pathway. ( Kaminski, BM; Loitsch, SM; Ochs, MJ; Reuter, KC; Stein, J; Steinhilber, D; Ulrich, S, 2010)
"Colorectal cancer is an increasingly significant cause of mortality whose risk is linked to diet and inversely correlated with cruciferous vegetable consumption."2.55The Role of MicroRNAs in the Chemopreventive Activity of Sulforaphane from Cruciferous Vegetables. ( Bao, Y; Dacosta, C, 2017)
"The long pre‑cancerous state of colorectal cancer (CRC) provides an opportunity to prevent the occurrence and development of CRC."1.56Sulforaphane suppresses carcinogenesis of colorectal cancer through the ERK/Nrf2‑UDP glucuronosyltransferase 1A metabolic axis activation. ( Hao, Q; Li, C; Lin, YM; Liu, F; Sun, NX; Wang, M; Zhu, C; Zhu, WW, 2020)
"Sporadic colorectal cancer (CRC) is a typical multifactorial disease."1.39Identification of microRNAs regulated by isothiocyanates and association of polymorphisms inside their target sites with risk of sporadic colorectal cancer. ( Bienertova-Vasku, J; Bischofová, S; Brezkova, V; Hezova, R; Kovarikova, A; Sachlova, M; Sevcikova, S; Slaby, O; Svoboda, M; Vasku, A; Vyzula, R, 2013)
"Sulforaphane (SFN) is an isothiocyanate that is present abundantly in widely consumed cruciferous vegetables and has a particularly high content in broccoli and cauliflower."1.33Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable. ( Chada, K; Chen, C; Hebbar, V; Hu, R; Jeong, WS; Khor, TO; Kong, AN; Reddy, B; Shen, G; Xu, C, 2006)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (7.14)29.6817
2010's9 (64.29)24.3611
2020's4 (28.57)2.80

Authors

AuthorsStudies
Xi, MY1
Jia, JM1
Sun, HP1
Sun, ZY1
Jiang, JW1
Wang, YJ1
Zhang, MY1
Zhu, JF1
Xu, LL1
Jiang, ZY1
Xue, X1
Ye, M1
Yang, X1
Gao, Y1
Tao, L1
Guo, XK1
Xu, XL1
Guo, QL1
Zhang, XJ1
Hu, R2
You, QD1
Chen, Y3
Wang, MH1
Wu, JY1
Zhu, JY1
Xie, CF1
Li, XT1
Wu, JS1
Geng, SS1
Li, YD1
Han, HY1
Zhong, CY1
Tang, L1
Ye, X1
Shan, E1
Han, H1
Zhong, C1
Baralić, K1
Živančević, K1
Marić, Đ1
Bozic, D1
Buha Djordjevic, A1
Antonijević Miljaković, E1
Ćurčić, M1
Bulat, Z1
Antonijević, B1
Đukić-Ćosić, D1
Hao, Q1
Wang, M1
Sun, NX1
Zhu, C1
Lin, YM1
Li, C1
Liu, F1
Zhu, WW1
Dacosta, C1
Bao, Y2
Terasaki, M1
Maeda, H1
Miyashita, K1
Mutoh, M1
Rajendran, P1
Johnson, G1
Li, L1
Chen, YS1
Dashwood, M1
Nguyen, N1
Ulusan, A1
Ertem, F1
Zhang, M1
Li, J1
Sun, D1
Huang, Y1
Wang, S1
Leung, HC1
Lieberman, D1
Beaver, L1
Ho, E1
Bedford, M1
Chang, K1
Vilar, E1
Dashwood, R1
Slaby, O1
Sachlova, M1
Brezkova, V1
Hezova, R1
Kovarikova, A1
Bischofová, S1
Sevcikova, S1
Bienertova-Vasku, J1
Vasku, A1
Svoboda, M1
Vyzula, R1
Holzner, S1
Senfter, D1
Stadler, S1
Staribacher, A1
Nguyen, CH1
Gaggl, A1
Geleff, S1
Huttary, N1
Krieger, S1
Jäger, W1
Dolznig, H1
Mader, RM1
Krupitza, G1
Kaminski, BM2
Loitsch, SM1
Ochs, MJ1
Reuter, KC1
Steinhilber, D2
Stein, J2
Ulrich, S2
Weigert, A1
Brüne, B1
Schumacher, M1
Wenzel, U1
Barrera, LN1
Johnson, IT1
Cassidy, A1
Belshaw, NJ1
Khor, TO1
Shen, G1
Jeong, WS1
Hebbar, V1
Chen, C1
Xu, C1
Reddy, B1
Chada, K1
Kong, AN1

Reviews

1 review available for sulforaphane and Colorectal Cancer

ArticleYear
The Role of MicroRNAs in the Chemopreventive Activity of Sulforaphane from Cruciferous Vegetables.
    Nutrients, 2017, Aug-19, Volume: 9, Issue:8

    Topics: Anticarcinogenic Agents; Brassicaceae; Colorectal Neoplasms; Diet; Humans; Isothiocyanates; MicroRNA

2017

Other Studies

13 other studies available for sulforaphane and Colorectal Cancer

ArticleYear
3-aroylmethylene-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-ones as potent Nrf2/ARE inducers in human cancer cells and AOM-DSS treated mice.
    Journal of medicinal chemistry, 2013, Oct-24, Volume: 56, Issue:20

    Topics: Active Transport, Cell Nucleus; Adenoma; Animals; Antineoplastic Agents; Antioxidant Response Elemen

2013
ΔNp63α mediates sulforaphane suppressed colorectal cancer stem cell properties through transcriptional regulation of Nanog/Oct4/Sox2.
    The Journal of nutritional biochemistry, 2022, Volume: 107

    Topics: Cell Line, Tumor; Colorectal Neoplasms; Humans; Isothiocyanates; Nanog Homeobox Protein; Neoplastic

2022
Regulation of ZO-1 on β-catenin mediates sulforaphane suppressed colorectal cancer stem cell properties in colorectal cancer.
    Food & function, 2022, Nov-28, Volume: 13, Issue:23

    Topics: beta Catenin; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Gene Expression Regulation

2022
Testing sulforaphane as a strategy against toxic chemicals of public health concern by toxicogenomic data analysis: Friend or foe at the gene level - Colorectal carcinoma case study.
    Environmental research, 2023, 06-15, Volume: 227

    Topics: Aldehyde Dehydrogenase, Mitochondrial; Benzhydryl Compounds; Colorectal Neoplasms; Humans; Isothiocy

2023
Sulforaphane suppresses carcinogenesis of colorectal cancer through the ERK/Nrf2‑UDP glucuronosyltransferase 1A metabolic axis activation.
    Oncology reports, 2020, Volume: 43, Issue:4

    Topics: Anticarcinogenic Agents; Antioxidants; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Pro

2020
Induction of Anoikis in Human Colorectal Cancer Cells by Fucoxanthinol.
    Nutrition and cancer, 2017, Volume: 69, Issue:7

    Topics: Allyl Compounds; Anoikis; Antineoplastic Agents, Phytogenic; beta Carotene; Cell Line, Tumor; Cell P

2017
Acetylation of CCAR2 Establishes a BET/BRD9 Acetyl Switch in Response to Combined Deacetylase and Bromodomain Inhibition.
    Cancer research, 2019, 03-01, Volume: 79, Issue:5

    Topics: Acetylation; Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Combined Chemotherapy Pro

2019
Identification of microRNAs regulated by isothiocyanates and association of polymorphisms inside their target sites with risk of sporadic colorectal cancer.
    Nutrition and cancer, 2013, Volume: 65, Issue:2

    Topics: 3' Untranslated Regions; Aged; Binding Sites; Case-Control Studies; Cell Line; Colorectal Neoplasms;

2013
Colorectal cancer cell-derived microRNA200 modulates the resistance of adjacent blood endothelial barriers in vitro.
    Oncology reports, 2016, Volume: 36, Issue:5

    Topics: Benzamides; Cell Line, Tumor; Cell Movement; Coculture Techniques; Colorectal Neoplasms; Endothelial

2016
Isothiocyanate sulforaphane inhibits protooncogenic ornithine decarboxylase activity in colorectal cancer cells via induction of the TGF-β/Smad signaling pathway.
    Molecular nutrition & food research, 2010, Volume: 54, Issue:10

    Topics: Anticarcinogenic Agents; Caco-2 Cells; Cell Proliferation; Colorectal Neoplasms; DNA-Binding Protein

2010
Sulforaphane potentiates oxaliplatin-induced cell growth inhibition in colorectal cancer cells via induction of different modes of cell death.
    Cancer chemotherapy and pharmacology, 2011, Volume: 67, Issue:5

    Topics: Antineoplastic Agents; Apoptosis; Caco-2 Cells; Cell Proliferation; Colorectal Neoplasms; Dose-Respo

2011
Colorectal cancer cells Caco-2 and HCT116 resist epigenetic effects of isothiocyanates and selenium in vitro.
    European journal of nutrition, 2013, Volume: 52, Issue:4

    Topics: Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Antioxidants; Caco-2 Cells; Cell Prolife

2013
Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable.
    Carcinogenesis, 2006, Volume: 27, Issue:10

    Topics: Adenoma; Animals; Anticarcinogenic Agents; Cell Proliferation; Codon, Nonsense; Colorectal Neoplasms

2006