sulforaphane has been researched along with Melanoma in 10 studies
sulforaphane: from Cardaria draba L.
sulforaphane : An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have utilised an in vitro model of malignant melanoma [consisting of human (A375, Hs294T, VMM1) and murine (B16F-10) melanoma cell lines as well as a non-melanoma (A431) and a non-tumorigenic immortalised keratinocyte (HaCaT) cell line] exposed to sulforaphane or iberin." | 8.02 | Sulforaphane and iberin are potent epigenetic modulators of histone acetylation and methylation in malignant melanoma. ( Franco, R; Mitsiogianni, M; Panayiotidis, MI; Pappa, A; Trafalis, DT; Zoumpourlis, V, 2021) |
| "Atypical nevi were photographed on days 1 and 28, and plasma and nevus samples were taken on days 1, 2, and 28." | 6.87 | Evaluation of Biodistribution of Sulforaphane after Administration of Oral Broccoli Sprout Extract in Melanoma Patients with Multiple Atypical Nevi. ( Beumer, JH; Butterfield, LH; Cassidy, PB; Christner, SM; Dietz, CM; Fahey, JW; Ferris, LK; Hahm, ER; Hughes, E; Kirkwood, JM; Leachman, SA; Lin, Y; Rao, UN; Rose, A; Sander, C; Singh, SV; Tahata, S; Tarhini, AA; Tawbi, H; Wilson, M; Zarour, HM, 2018) |
| "Sulforaphane (SFN) is an organosulfur compound extracted from cruciferous vegetables and has biological effects." | 5.72 | Sulforaphane induces cell differentiation, melanogenesis and also inhibit the proliferation of melanoma cells. ( Eom, YS; Kim, SJ; Shah, FH, 2022) |
| "Human melanoma is a highly aggressive incurable cancer due to intrinsic cellular resistance to apoptosis, reprogramming, proliferation and survival during tumour progression." | 5.48 | Antitumor activity and expression profiles of genes induced by sulforaphane in human melanoma cells. ( Arcidiacono, P; Bottoni, U; Calvieri, S; Crisanti, A; Kuligina, E; Pistilli, A; Ragonese, F; Rende, M; Spaccapelo, R; Stabile, A, 2018) |
| "Melanoma is a severe form of cancer, resistant to conventional therapies." | 5.48 | Anticarcinogenic activities of sulforaphane are influenced by Nerve Growth Factor in human melanoma A375 cells. ( Arcidiacono, P; Bottoni, U; Calvieri, S; Crisanti, A; Pistilli, A; Ragonese, F; Rende, M; Spaccapelo, R; Stabile, AM, 2018) |
| "Melanoma is a metastatic cancer associated with poor survival." | 5.43 | The Ezh2 polycomb group protein drives an aggressive phenotype in melanoma cancer stem cells and is a target of diet derived sulforaphane. ( Adhikary, G; Eckert, RL; Fisher, ML; Grun, D; Kaetzel, DM, 2016) |
| "Sulforaphane (SF) is a promising isothiocyanate compound occurring in cruciferous plants with reported antiproliferative and proapoptotic activity in several tumor cell lines including melanoma." | 5.40 | Sulforaphane-induced apoptosis involves p53 and p38 in melanoma cells. ( Cervinka, M; Rudolf, E; Rudolf, K, 2014) |
| "We have utilised an in vitro model of malignant melanoma [consisting of human (A375, Hs294T, VMM1) and murine (B16F-10) melanoma cell lines as well as a non-melanoma (A431) and a non-tumorigenic immortalised keratinocyte (HaCaT) cell line] exposed to sulforaphane or iberin." | 4.02 | Sulforaphane and iberin are potent epigenetic modulators of histone acetylation and methylation in malignant melanoma. ( Franco, R; Mitsiogianni, M; Panayiotidis, MI; Pappa, A; Trafalis, DT; Zoumpourlis, V, 2021) |
| "Atypical nevi were photographed on days 1 and 28, and plasma and nevus samples were taken on days 1, 2, and 28." | 2.87 | Evaluation of Biodistribution of Sulforaphane after Administration of Oral Broccoli Sprout Extract in Melanoma Patients with Multiple Atypical Nevi. ( Beumer, JH; Butterfield, LH; Cassidy, PB; Christner, SM; Dietz, CM; Fahey, JW; Ferris, LK; Hahm, ER; Hughes, E; Kirkwood, JM; Leachman, SA; Lin, Y; Rao, UN; Rose, A; Sander, C; Singh, SV; Tahata, S; Tarhini, AA; Tawbi, H; Wilson, M; Zarour, HM, 2018) |
| "Melanoma is less common among all other types of skin cancers but causes higher mortality." | 2.58 | Epigenetics of skin cancer: Interventions by selected bioactive phytochemicals. ( Meeran, SM; Penta, D; Somashekar, BS, 2018) |
| "Sulforaphane (SFN) is an organosulfur compound extracted from cruciferous vegetables and has biological effects." | 1.72 | Sulforaphane induces cell differentiation, melanogenesis and also inhibit the proliferation of melanoma cells. ( Eom, YS; Kim, SJ; Shah, FH, 2022) |
| "Human melanoma is a highly aggressive incurable cancer due to intrinsic cellular resistance to apoptosis, reprogramming, proliferation and survival during tumour progression." | 1.48 | Antitumor activity and expression profiles of genes induced by sulforaphane in human melanoma cells. ( Arcidiacono, P; Bottoni, U; Calvieri, S; Crisanti, A; Kuligina, E; Pistilli, A; Ragonese, F; Rende, M; Spaccapelo, R; Stabile, A, 2018) |
| "Melanoma is a severe form of cancer, resistant to conventional therapies." | 1.48 | Anticarcinogenic activities of sulforaphane are influenced by Nerve Growth Factor in human melanoma A375 cells. ( Arcidiacono, P; Bottoni, U; Calvieri, S; Crisanti, A; Pistilli, A; Ragonese, F; Rende, M; Spaccapelo, R; Stabile, AM, 2018) |
| "Melanoma is a metastatic cancer associated with poor survival." | 1.43 | The Ezh2 polycomb group protein drives an aggressive phenotype in melanoma cancer stem cells and is a target of diet derived sulforaphane. ( Adhikary, G; Eckert, RL; Fisher, ML; Grun, D; Kaetzel, DM, 2016) |
| "Sulforaphane (SF) is a promising isothiocyanate compound occurring in cruciferous plants with reported antiproliferative and proapoptotic activity in several tumor cell lines including melanoma." | 1.40 | Sulforaphane-induced apoptosis involves p53 and p38 in melanoma cells. ( Cervinka, M; Rudolf, E; Rudolf, K, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (60.00) | 24.3611 |
| 2020's | 4 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yepes-Molina, L | 1 |
| Carvajal, M | 1 |
| Eom, YS | 1 |
| Shah, FH | 1 |
| Kim, SJ | 1 |
| Mitsiogianni, M | 1 |
| Trafalis, DT | 1 |
| Franco, R | 1 |
| Zoumpourlis, V | 1 |
| Pappa, A | 1 |
| Panayiotidis, MI | 1 |
| Serini, S | 1 |
| Guarino, R | 1 |
| Ottes Vasconcelos, R | 1 |
| Celleno, L | 1 |
| Calviello, G | 1 |
| Arcidiacono, P | 2 |
| Ragonese, F | 2 |
| Stabile, A | 1 |
| Pistilli, A | 2 |
| Kuligina, E | 1 |
| Rende, M | 2 |
| Bottoni, U | 2 |
| Calvieri, S | 2 |
| Crisanti, A | 2 |
| Spaccapelo, R | 2 |
| Penta, D | 1 |
| Somashekar, BS | 1 |
| Meeran, SM | 1 |
| Stabile, AM | 1 |
| Tahata, S | 1 |
| Singh, SV | 1 |
| Lin, Y | 1 |
| Hahm, ER | 1 |
| Beumer, JH | 1 |
| Christner, SM | 1 |
| Rao, UN | 1 |
| Sander, C | 1 |
| Tarhini, AA | 1 |
| Tawbi, H | 1 |
| Ferris, LK | 1 |
| Wilson, M | 1 |
| Rose, A | 1 |
| Dietz, CM | 1 |
| Hughes, E | 1 |
| Fahey, JW | 1 |
| Leachman, SA | 1 |
| Cassidy, PB | 1 |
| Butterfield, LH | 1 |
| Zarour, HM | 1 |
| Kirkwood, JM | 1 |
| Rudolf, K | 1 |
| Cervinka, M | 1 |
| Rudolf, E | 1 |
| Fisher, ML | 1 |
| Adhikary, G | 1 |
| Grun, D | 1 |
| Kaetzel, DM | 1 |
| Eckert, RL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Role and Clinical Relevance of Nerve Growth Factor (NGF) and Its Receptors (TrKA and p75NTR) in Patients With Erectile Dysfunction and Diabetes With or Wothout Metabolic Syndrome[NCT03862547] | 40 participants (Anticipated) | Interventional | 2019-01-30 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for sulforaphane and Melanoma
| Article | Year |
|---|---|
Epigenetics of skin cancer: Interventions by selected bioactive phytochemicals.
Topics: Anticarcinogenic Agents; Catechin; DNA Methylation; Epigenesis, Genetic; Histones; Humans; Isothiocy | 2018 |
1 trial available for sulforaphane and Melanoma
| Article | Year |
|---|---|
Evaluation of Biodistribution of Sulforaphane after Administration of Oral Broccoli Sprout Extract in Melanoma Patients with Multiple Atypical Nevi.
Topics: Administration, Oral; Adult; Aged; Biomarkers, Tumor; Biopsy; Brassica; Capsules; Feasibility Studie | 2018 |
8 other studies available for sulforaphane and Melanoma
| Article | Year |
|---|---|
Nanoencapsulation of sulforaphane in broccoli membrane vesicles and their
Topics: Anticarcinogenic Agents; Aquaporin 3; Brassica; Cell Line, Tumor; Cell Proliferation; Dose-Response | 2021 |
Sulforaphane induces cell differentiation, melanogenesis and also inhibit the proliferation of melanoma cells.
Topics: Animals; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Isothiocyanates; Melanins; Mela | 2022 |
Sulforaphane and iberin are potent epigenetic modulators of histone acetylation and methylation in malignant melanoma.
Topics: Acetylation; Animals; Cell Line, Tumor; Epigenesis, Genetic; Histone Acetyltransferases; Histones; H | 2021 |
The Combination of Sulforaphane and Fernblock
Topics: Antineoplastic Agents; Antioxidants; Brassica; Cell Line, Tumor; Cell Movement; Humans; Inflammasome | 2020 |
Antitumor activity and expression profiles of genes induced by sulforaphane in human melanoma cells.
Topics: Anticarcinogenic Agents; Apoptosis; Brassicaceae; Cell Line, Tumor; Cell Survival; Gene Expression R | 2018 |
Anticarcinogenic activities of sulforaphane are influenced by Nerve Growth Factor in human melanoma A375 cells.
Topics: Anticarcinogenic Agents; Apoptosis; Caspase 3; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Sur | 2018 |
Sulforaphane-induced apoptosis involves p53 and p38 in melanoma cells.
Topics: Anticarcinogenic Agents; Apoptosis; Caspases; Cell Line, Tumor; Humans; Isothiocyanates; Melanoma; M | 2014 |
The Ezh2 polycomb group protein drives an aggressive phenotype in melanoma cancer stem cells and is a target of diet derived sulforaphane.
Topics: Animals; Anticarcinogenic Agents; Cell Movement; Enhancer of Zeste Homolog 2 Protein; Gene Knockdown | 2016 |