sulforaphane has been researched along with Acute Confusional Senile Dementia in 16 studies
sulforaphane: from Cardaria draba L.
sulforaphane : An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sulforaphane (SFN) has neuroprotective effects for AD." | 1.91 | Sulforaphane attenuates microglia-mediated neuronal damage by down-regulating the ROS/autophagy/NLRP3 signal axis in fibrillar Aβ-activated microglia. ( Dong, B; Fu, Y; Gong, M; Liu, T; Lü, T; Qiu, P; Wang, Y; Xie, W; Yang, C; Yang, Y; Zhang, J, 2023) |
| "Sulforaphane (SFN) treatment has shown to induce the phagocytic activity of Aβo treated microglial cells." | 1.56 | Sulforaphane Attenuates Aβ Oligomers Mediated Decrease in Phagocytic Activity of Microglial Cells. ( Chilakala, RR; Kumar, A; Manchikalapudi, AL; Sunkaria, A, 2020) |
| "Depression is one of the most common behavioral and psychological symptoms in people with Alzheimer's disease (AD)." | 1.56 | Sulforaphane Reverses the Amyloid-β Oligomers Induced Depressive-Like Behavior. ( Jia, J; Li, T; Quan, M; Wang, W; Wei, C, 2020) |
| "Sulforaphane (SFN) is a pharmacological activator of Nrf2 that provokes Nrf2-mediated intracellular defenses, including antioxidant and anti-inflammatory responses, under oxidative stress (OS) conditions." | 1.48 | Protective Effects of Sulforaphane on Cognitive Impairments and AD-like Lesions in Diabetic Mice are Associated with the Upregulation of Nrf2 Transcription Activity. ( Chen, J; Luo, C; Lv, A; Pu, D; Sun, Y; Xiao, Q; Zhao, K; Zhao, Y; Zhu, S, 2018) |
| "Sulforaphane is an herbal isothiocyanate enriched in cruciferous vegetables." | 1.48 | Sulforaphane Upregulates the Heat Shock Protein Co-Chaperone CHIP and Clears Amyloid-β and Tau in a Mouse Model of Alzheimer's Disease. ( Choi, BR; Han, JS; Kim, J; LaFerla, FM; Lee, KW; Lee, S; Park, JHY, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (6.25) | 29.6817 |
| 2010's | 11 (68.75) | 24.3611 |
| 2020's | 4 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bolognesi, ML | 1 |
| Cavalli, A | 1 |
| Bergamini, C | 1 |
| Fato, R | 1 |
| Lenaz, G | 1 |
| Rosini, M | 1 |
| Bartolini, M | 1 |
| Andrisano, V | 1 |
| Melchiorre, C | 1 |
| Yang, Y | 1 |
| Zhang, J | 3 |
| Yang, C | 1 |
| Dong, B | 1 |
| Fu, Y | 1 |
| Wang, Y | 1 |
| Gong, M | 1 |
| Liu, T | 1 |
| Qiu, P | 1 |
| Xie, W | 1 |
| Lü, T | 1 |
| Sestito, S | 1 |
| Pruccoli, L | 1 |
| Runfola, M | 1 |
| Citi, V | 1 |
| Martelli, A | 1 |
| Saccomanni, G | 1 |
| Calderone, V | 1 |
| Tarozzi, A | 1 |
| Rapposelli, S | 1 |
| Chilakala, RR | 1 |
| Manchikalapudi, AL | 1 |
| Kumar, A | 1 |
| Sunkaria, A | 1 |
| Wang, W | 2 |
| Wei, C | 1 |
| Quan, M | 1 |
| Li, T | 1 |
| Jia, J | 1 |
| Kim, J | 5 |
| Zhao, F | 1 |
| Chang, N | 1 |
| Hou, TT | 1 |
| Yang, HY | 1 |
| Wu, QQ | 1 |
| Tian, YR | 1 |
| Jia, JP | 1 |
| Pu, D | 1 |
| Zhao, Y | 3 |
| Chen, J | 1 |
| Sun, Y | 1 |
| Lv, A | 1 |
| Zhu, S | 1 |
| Luo, C | 1 |
| Zhao, K | 1 |
| Xiao, Q | 1 |
| Lee, S | 2 |
| Choi, BR | 2 |
| LaFerla, FM | 2 |
| Park, JHY | 1 |
| Han, JS | 2 |
| Lee, KW | 2 |
| Zhang, R | 2 |
| Miao, QW | 1 |
| Zhu, CX | 1 |
| Liu, L | 1 |
| Yang, J | 1 |
| An, L | 2 |
| Fang, L | 1 |
| Li, X | 1 |
| Shi, W | 1 |
| Masci, A | 1 |
| Mattioli, R | 1 |
| Costantino, P | 1 |
| Baima, S | 1 |
| Morelli, G | 1 |
| Punzi, P | 1 |
| Giordano, C | 1 |
| Pinto, A | 1 |
| Donini, LM | 1 |
| d'Erme, M | 1 |
| Mosca, L | 1 |
| An, YW | 1 |
| Jhang, KA | 1 |
| Woo, SY | 1 |
| Kang, JL | 1 |
| Chong, YH | 1 |
| Yang, H | 1 |
| Hwang, Y | 1 |
| Park, JH | 1 |
| Kim, HV | 1 |
| Kim, HY | 1 |
| Ehrlich, HY | 1 |
| Choi, SY | 1 |
| Kim, DJ | 1 |
| Kim, Y | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized,Double-blind, Placebo-controlled, Efficacy and Safety Study of Sulforaphane in Patients With Prodromal to Mild Alzheimer's Disease[NCT04213391] | 160 participants (Anticipated) | Interventional | 2020-05-10 | Recruiting | |||
| A Multi-center Longitudinal Cohort Study of Familial Alzheimer's Disease in China[NCT03657732] | 40,000 participants (Anticipated) | Observational [Patient Registry] | 2005-01-10 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for sulforaphane and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Pre-Clinical Neuroprotective Evidences and Plausible Mechanisms of Sulforaphane in Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Biomarkers; Cell Line, Tumor; Disease Models, Ani | 2021 |
15 other studies available for sulforaphane and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks.
Topics: Alkanes; Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Cell Line, Tumor; Drug Design; Elec | 2009 |
Sulforaphane attenuates microglia-mediated neuronal damage by down-regulating the ROS/autophagy/NLRP3 signal axis in fibrillar Aβ-activated microglia.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Autophagy; Humans; Inflammasomes; Microglia; Neurons; NLR | 2023 |
Design and synthesis of H
Topics: Alzheimer Disease; Animals; Antioxidants; Cell Line; Dose-Response Relationship, Drug; Drug Design; | 2019 |
Sulforaphane Attenuates Aβ Oligomers Mediated Decrease in Phagocytic Activity of Microglial Cells.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Humans; Isothiocyanates; Microglia; Phagocytes; Phagocytos | 2020 |
Sulforaphane Reverses the Amyloid-β Oligomers Induced Depressive-Like Behavior.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Brain; Depression; Disease Models, | 2020 |
Epigenetic modification of Nrf2 by sulforaphane increases the antioxidative and anti-inflammatory capacity in a cellular model of Alzheimer's disease.
Topics: Active Transport, Cell Nucleus; Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory | 2018 |
Sulforaphane Inhibits the Generation of Amyloid-β Oligomer and Promotes Spatial Learning and Memory in Alzheimer's Disease (PS1V97L) Transgenic Mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Cell Survival; Cerebral Cortex; Fem | 2018 |
Sulforaphane Inhibits the Generation of Amyloid-β Oligomer and Promotes Spatial Learning and Memory in Alzheimer's Disease (PS1V97L) Transgenic Mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Cell Survival; Cerebral Cortex; Fem | 2018 |
Sulforaphane Inhibits the Generation of Amyloid-β Oligomer and Promotes Spatial Learning and Memory in Alzheimer's Disease (PS1V97L) Transgenic Mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Cell Survival; Cerebral Cortex; Fem | 2018 |
Sulforaphane Inhibits the Generation of Amyloid-β Oligomer and Promotes Spatial Learning and Memory in Alzheimer's Disease (PS1V97L) Transgenic Mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Cell Survival; Cerebral Cortex; Fem | 2018 |
Protective Effects of Sulforaphane on Cognitive Impairments and AD-like Lesions in Diabetic Mice are Associated with the Upregulation of Nrf2 Transcription Activity.
Topics: Alzheimer Disease; Animals; Antioxidants; Cognitive Dysfunction; Diabetes Mellitus, Experimental; Di | 2018 |
Sulforaphane Upregulates the Heat Shock Protein Co-Chaperone CHIP and Clears Amyloid-β and Tau in a Mouse Model of Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cerebral Cortex; Disease Models, Animal; Female; | 2018 |
Sulforaphane ameliorates neurobehavioral deficits and protects the brain from amyloid β deposits and peroxidation in mice with Alzheimer-like lesions.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Behavior, Animal; Cerebral Cortex; Disease Models | 2015 |
Neuroprotective effects of sulforaphane on cholinergic neurons in mice with Alzheimer's disease-like lesions.
Topics: Aluminum; Alzheimer Disease; Animals; Body Weight; CA1 Region, Hippocampal; Cholinergic Neurons; Fem | 2014 |
Neuroprotective Effect of Brassica oleracea Sprouts Crude Juice in a Cellular Model of Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Apoptosis; Brassica; Cell Line, Tumor; Glutathione; Heme O | 2015 |
Sulforaphane exerts its anti-inflammatory effect against amyloid-β peptide via STAT-1 dephosphorylation and activation of Nrf2/HO-1 cascade in human THP-1 macrophages.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Anti-Inflammatory Agents; Cathepsin B; Cell Line; Heme Oxy | 2016 |
Sulforaphane epigenetically enhances neuronal BDNF expression and TrkB signaling pathways.
Topics: Alzheimer Disease; Animals; Brain-Derived Neurotrophic Factor; Cells, Cultured; Cerebral Cortex; Dis | 2017 |
Amelioration of Alzheimer's disease by neuroprotective effect of sulforaphane in animal model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Avoidance Learning; Cell Line; Cogn | 2013 |