Compounds > yamogenin
Page last updated: 2024-12-08

yamogenin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID441900
CHEMBL ID400807
CHEBI ID10086
SCHEMBL ID6040875
MeSH IDM0503063

Synonyms (36)

Synonym
nsc-226132
yamogenin
C08918
512-06-1
CHEMBL400807
chebi:10086 ,
LMST01080045
(25s)-spirost-5-en-3beta-ol
nsc 226132
spirost-5-en-3-ol, (3beta,25s)-
neodiosgenin
jamogenin
unii-m487od4xw3
25-epi-diosgenin
m487od4xw3 ,
S5675
(2r,5's)-5'-tetramethylspiro[[?]-2,2'-tetrahydropyran]ol
SCHEMBL6040875
AKOS025402417
AC-8895
WQLVFSAGQJTQCK-CAKNJAFZSA-N
(22r,25s)-(20.alpha.)-spirost-5-en-3.beta.-ol
spirost-5-en-3-ol, (3.beta.,25s)-
(20alpha,22r,25s)-spirosta-5-ene-3beta-ol
(2'r,4s,5's,6ar,6bs,8as,8br,9s,11as,12as,12bs)-5',6a,8a,9-tetramethyl-1,3,3',4,4',5,5',6,6a,6b,6',7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-4-ol
HY-N2078
Q8048088
CS-0018583
DTXSID60903922 ,
(1s,2s,4s,5's,6r,7s,8r,9s,12s,13r,16s)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-oxane]-16-ol
yamogenin - 70%
XY165194
bdbm604165
us11660306, example yamogenin
(22r,25s)-(20alpha)-spirost-5-en-3beta-ol
dtxcid201331882

Research Excerpts

Overview

Yamogenin is a diastereomer of diosgenin, which we have identified as the compound responsible for the anti-hyperlipidemic effect of fenugreek.

ExcerptReferenceRelevance
"Yamogenin is a diastereomer of diosgenin, which we have identified as the compound responsible for the anti-hyperlipidemic effect of fenugreek. "( Yamogenin in fenugreek inhibits lipid accumulation through the suppression of gene expression in fatty acid synthesis in hepatocytes.
Goto, T; Hoshino, S; Kawada, T; Moriwaki, S; Murakami, H; Narukami, T; Takahashi, N; Taketani, K; Tsuge, N; Uemura, T, 2014)		3.29
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
triterpenoidAny terpenoid derived from a triterpene. The term includes compounds in which the C30 skeleton of the parent triterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups).
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (5)

Assay IDTitleYearJournalArticle
AID744419Cytotoxicity against human MDA-MB-231 cells2013Bioorganic & medicinal chemistry letters, May-01, Volume: 23, Issue:9
Spirostanoids with 1,4-dien-3-one or 3β,7α-diol-5,6-ene moieties from Solanum violaceum.
AID744418Cytotoxicity against human A549 cells2013Bioorganic & medicinal chemistry letters, May-01, Volume: 23, Issue:9
Spirostanoids with 1,4-dien-3-one or 3β,7α-diol-5,6-ene moieties from Solanum violaceum.
AID744421Cytotoxicity against human HepG2 cells2013Bioorganic & medicinal chemistry letters, May-01, Volume: 23, Issue:9
Spirostanoids with 1,4-dien-3-one or 3β,7α-diol-5,6-ene moieties from Solanum violaceum.
AID744420Cytotoxicity against human MCF7 cells2013Bioorganic & medicinal chemistry letters, May-01, Volume: 23, Issue:9
Spirostanoids with 1,4-dien-3-one or 3β,7α-diol-5,6-ene moieties from Solanum violaceum.
AID744422Cytotoxicity against human Hep3B cells2013Bioorganic & medicinal chemistry letters, May-01, Volume: 23, Issue:9
Spirostanoids with 1,4-dien-3-one or 3β,7α-diol-5,6-ene moieties from Solanum violaceum.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (18)

TimeframeStudies, This Drug (%)All Drugs %
pre-19907 (38.89)18.7374
1990's2 (11.11)18.2507
2000's3 (16.67)29.6817
2010's5 (27.78)24.3611
2020's1 (5.56)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 24.92

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index24.92 (24.57)
Research Supply Index3.04 (2.92)
Research Growth Index4.63 (4.65)
Search Engine Demand Index26.67 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (24.92)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other20 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
sulfuric acid
sulfuric acid : A sulfur oxoacid that consists of two oxo and two hydroxy groups joined covalently to a central sulfur atom.		2.0110sulfur oxoacidcatalyst
2-propanol
2-Propanol: An isomer of 1-PROPANOL. It is a colorless liquid having disinfectant properties. It is used in the manufacture of acetone and its derivatives and as a solvent. Topically, it is used as an antiseptic.. propan-2-ol : A secondary alcohol that is propane in which one of the hydrogens attached to the central carbon is substituted by a hydroxy group.		2.0110secondary alcohol;
secondary fatty alcohol		protic solvent
boranes
Boranes: The collective name for the boron hydrides, which are analogous to the alkanes and silanes. Numerous boranes are known. Some have high calorific values and are used in high-energy fuels. (From Grant & Hackh's Chemical Dictionary, 5th ed). borane : The simplest borane, consisting of a single boron atom carrying three hydrogens.. boranes : The molecular hydrides of boron.		2.1110boranes;
mononuclear parent hydride
boron trifluoride
[no description available]		2.1110boron fluorideNMR chemical shift reference compound
silver nitrate
Silver Nitrate: A silver salt with powerful germicidal activity. It has been used topically to prevent OPHTHALMIA NEONATORUM.		1.9410inorganic nitrate salt;
silver salt		astringent
sarsasapogenin
[no description available]		210sapogenin
diosgenin
[no description available]		4.231803beta-sterol;
hexacyclic triterpenoid;
sapogenin;
spiroketal		antineoplastic agent;
antiviral agent;
apoptosis inducer;
metabolite
3-hydroxystigmast-5-en-7-one
[no description available]		2.0810steroid
methyl protodioscin
methyl protodioscin: structure in first source		2.0510
syringaresinol
(+)-syringaresinol : The (7alpha,7'alpha,8alpha,8'alpha)-stereoisomer of syringaresinol.		2.0810syringaresinolantineoplastic agent
scopoletin
[no description available]		2.0810hydroxycoumarinplant growth regulator;
plant metabolite
ergosterol-5,8-peroxide
ergosterol-5,8-peroxide: also inhibits sulfatase; isolated from fungus Cercospora kikuchii; structure given in first source. ergosterol peroxide : An ergostanoid that is ergosta-6,22-dien-3-ol with a peroxy group between positions 5 and 8 (the 3beta,5alpha,8alpha,22E stereoisomer). Isolated from Ganoderma lucidum and Cordyceps sinensis, it exhibits antimycobacterial, trypanocidal and antineoplastic activities.		2.08103beta-sterol;
ergostanoid;
organic peroxide;
phytosterols		antimycobacterial drug;
antineoplastic agent;
metabolite;
trypanocidal drug
antimony
Antimony: A metallic element that has the atomic symbol Sb, atomic number 51, and atomic weight 121.75. It is used as a metal alloy and as medicinal and poisonous salts. It is toxic and an irritant to the skin and the mucous membranes.		6.9410metalloid atom;
pnictogen
beta-escin
[no description available]		3.4780
diosgenone
diosgenone: RN given for (25R)-isomer; isolated from Solanum nudum; structure in first source		2.0810
5,8-epidioxyergosta-6,9(11),22-trien-3-ol
5,8-epidioxyergosta-6,9(11),22-trien-3-ol: from Ganoderma lucidum; structure given in first source		2.0810
phytosterols
Phytosterols: A class of organic compounds known as sterols or STEROIDS derived from plants.. phytosterols : Sterols similar to cholesterol which occur in plants and vary only in carbon side chains and/or presence or absence of a double bond.		1.9510
sapogenins
Sapogenins: The aglucon moiety of a saponin molecule. It may be triterpenoid or steroid, usually spirostan, in nature.		2.6930
edetic acid
solasodine: RN given refers to (3beta,22alpha,25R)-isomer; structure. solasodine : An oxaspiro compound and steroid alkaloid sapogenin with formula C27H43NO2 found in the Solanum (nightshade) family. It is used as a precursor in the synthesis of complex steroidal compounds such as contraceptive pills.		210
ConditionIndicatedRelationship StrengthStudiesTrials
Depression
Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.		02.610
Injury, Myocardial Reperfusion
[description not available]		02.0510
Actinic Reticuloid Syndrome
[description not available]		01.9810
Plant Poisoning
Poisoning by the ingestion of plants or its leaves, berries, roots or stalks. The manifestations in both humans and animals vary in severity from mild to life threatening. In animals, especially domestic animals, it is usually the result of ingesting moldy or fermented forage.		01.9810
Ovine Diseases
[description not available]		01.9810
Biliary Tract Diseases
Diseases in any part of the BILIARY TRACT including the BILE DUCTS and the GALLBLADDER.		01.9810
Extravascular Hemolysis
[description not available]		01.9710
Hemolysis
The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.		01.9710