Compounds > 2-acetamidoethanethiol
Page last updated: 2024-12-05

2-acetamidoethanethiol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2-Acetamidoethanethiol, also known as N-acetylcysteine (NAC), is a naturally occurring amino acid derivative. It is synthesized commercially by reacting cysteine with acetic anhydride. NAC is a potent antioxidant, protecting cells from damage caused by free radicals. It is widely used as a mucolytic agent to thin mucus in respiratory diseases like cystic fibrosis and chronic obstructive pulmonary disease (COPD). Additionally, NAC is used to treat acetaminophen overdose, as it helps replenish glutathione levels, a critical antioxidant in the liver. Its ability to increase glutathione levels also makes it a promising agent in various other conditions, including cancer, HIV infection, and neurodegenerative diseases. Research on NAC focuses on understanding its antioxidant mechanisms, exploring its therapeutic potential in different diseases, and investigating its safety and efficacy in various clinical settings.'

2-acetamidoethanethiol: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

N-acetylcysteamine : A member of the class of acetamides that is the N-acetyl-deriavtive of cysteamine. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID14484
CHEBI ID74410
SCHEMBL ID474178
MeSH IDM0081247

Synonyms (46)

Synonym
n-acetyl cysteamin
cysteamine, n-acetyl-
n-acetylcysteamine
ethanethiol, 2-(acetylamino)-
n-(2-mercaptoethyl)acetamide
nsc38835
nsc-38835
2-acetamidoethanethiol
wln: sh2mv1
acetylcysteamine
acetamide, n-(2-mercaptoethyl)-
1190-73-4
acetamide, n-(.beta.-mercaptoethyl)-
n-acetylmercaptoethylamine
n-acetyl cysteamine
brn 1743117
nsc 38835
acetamide, n-(beta-mercaptoethyl)-
cysteamine,n-acetyl
n-acetyl cysteamin [german]
n-acetylcysteamine, 95%
n-(2-sulfanylethyl)acetamide
FT-0693701
thiol n-acetyl-beta-mercaptoethylamine
nsh3f3jx85 ,
4-04-00-01607 (beilstein handbook reference)
n-acetyl-beta-mercaptoethylamine
unii-nsh3f3jx85
AKOS006223010
CHEBI:74410
n-(2-mercaptoethyl)-acetamide
n-(2-mercapto-ethyl)-acetamide
2-acetylaminoethyl mercaptan
SCHEMBL474178
acetamide n-(2-mercaptoethyl)-
n-(2-sulfanylethyl)acetamide #
DTXSID90152289
J-004064
AS-60537
AT13754
Q27144656
n-acetyl-.beta.-mercaptoethylamine
mfcd00037831
A892671
EN300-211454
SY117216
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
acetamidesCompounds with the general formula RNHC(=O)CH3.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (60.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.53

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.53 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.53)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
cysteamine
Cysteamine: A mercaptoethylamine compound that is endogenously derived from the COENZYME A degradative pathway. The fact that cysteamine is readily transported into LYSOSOMES where it reacts with CYSTINE to form cysteine-cysteamine disulfide and CYSTEINE has led to its use in CYSTINE DEPLETING AGENTS for the treatment of CYSTINOSIS.. cysteamine : An amine that consists of an ethane skeleton substituted with a thiol group at C-1 and an amino group at C-2.		3.0850amine;
thiol		geroprotector;
human metabolite;
mouse metabolite;
radiation protective agent
hydrazine
diamine : Any polyamine that contains two amino groups.		2.1110azane;
hydrazines		EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor
silver nitrate
Silver Nitrate: A silver salt with powerful germicidal activity. It has been used topically to prevent OPHTHALMIA NEONATORUM.		2.1110inorganic nitrate salt;
silver salt		astringent
coenzyme a
[no description available]		1.9610adenosine 3',5'-bisphosphatecoenzyme;
Escherichia coli metabolite;
mouse metabolite
acetyl coenzyme a
Acetyl Coenzyme A: Acetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.		1.9610acyl-CoAacyl donor;
coenzyme;
effector;
fundamental metabolite
succinyl phosphate
succinyl phosphate: RN given refers to parent cpd		1.9610
maytansine
Maytansine: An ansa macrolide isolated from the MAYTENUS genus of East African shrubs.. maytansine : An organic heterotetracyclic compound and 19-membered macrocyclic lactam antibiotic originally isolated from the Ethiopian shrub Maytenus serrata but also found in other Maytenus species. It exhibits cytotoxicity against many tumour cell lines.		2.0310alpha-amino acid ester;
carbamate ester;
epoxide;
maytansinoid;
organic heterotetracyclic compound;
organochlorine compound		antimicrobial agent;
antimitotic;
antineoplastic agent;
plant metabolite;
tubulin modulator
indium
Indium: A metallic element, atomic number 49, atomic weight 114.818, symbol In. It is named from its blue line in the spectrum.. indium atom : A metallic element first identified and named from the brilliant indigo (Latin indicum) blue line in its flame spectrum.		2.1110boron group element atom
sulfur
Sulfur: An element that is a member of the chalcogen family. It has an atomic symbol S, atomic number 16, and atomic weight [32.059; 32.076]. It is found in the amino acids cysteine and methionine.		2.1110chalcogen;
nonmetal atom		macronutrient
nitrophenols
Nitrophenols: PHENOLS carrying nitro group substituents.		1.9610
ConditionIndicatedRelationship StrengthStudiesTrials