Page last updated: 2024-09-28

Nevus of Ota

A macular lesion on the side of the FACE, involving the CONJUNCTIVA and EYELIDS, as well as the adjacent facial skin, SCLERA; OCULOMOTOR MUSCLES; and PERIOSTEUM. Histological features vary from those of a MONGOLIAN SPOT to those of a BLUE NEVUS.

Synonyms(2)

Synonym
Nevus of Ota
Ota's Nevus

Research Excerpts

Overview

ExcerptReference
"The nevus of Ota is a benign dermal melanocytic lesion, which, due to its large size and periocular location, has been notoriously difficult to treat."( Alster, TS; Williams, CM, 1995)
"Nevus of Ota is a benign dermal melanocytosis that may pose significant psychosocial distress to patients."( Loh, TY; Wu, DC, 2021)

Research

Studies (43)

TimeframeStudies, This Condition (%)All Conditions %
pre-19904 (9.30)23.3326
1990's14 (32.56)12.5806
2000's11 (25.58)18.1394
2010's11 (25.58)28.8240
2020's3 (6.98)9.53
DrugIndicatedRelationship StrengthStudiesTrials
salicylic acid0low20
dihydroxyphenylalanine0low20
2-propanol0low40
tyrosine0low10
valine0low10
betamethasone0medium11
neodymium0medium72
titanium0low10
yttrium0low50
silver nitrate0low10
trolamine salicylate0low10
levamisole0low10
glutamic acid0low10
timolol0low20
propiconazole0low10
trazodone hydrochloride0low10
fusidic acid0medium11
phenylephrine hydrochloride0low10
aluminum0low30
beryllium0medium83
cysteine0low10
mart-1 antigen0low10
aluminum oxide0low40
epidermal growth factor0medium11
eye0low50

Protein Targets (302)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
hypoxia-inducible factor 1 alpha subunit1001
RAR-related orphan receptor gamma4004
GLI family zinc finger 35005
AR protein6006
aldehyde dehydrogenase 1 family, member A14004
retinoic acid nuclear receptor alpha variant 12002
retinoid X nuclear receptor alpha5005
estrogen nuclear receptor alpha8008
peroxisome proliferator-activated receptor delta2002
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a3003
activating transcription factor 61001
v-jun sarcoma virus 17 oncogene homolog (avian)1001
Histone H2A.x1001
thyroid hormone receptor beta isoform a3003
heat shock protein beta-11001
nuclear factor erythroid 2-related factor 2 isoform 15005
lamin isoform A-delta103003
Voltage-dependent calcium channel gamma-2 subunit3003
Glutamate receptor 24217
pregnane X receptor2002
progesterone receptor3003
cytochrome P450 family 3 subfamily A polypeptide 43003
glucocorticoid receptor [Homo sapiens]3003
estrogen-related nuclear receptor alpha4004
farnesoid X nuclear receptor2002
pregnane X nuclear receptor3003
vitamin D (1,25- dihydroxyvitamin D3) receptor2002
IDH12002
aryl hydrocarbon receptor2002
nuclear receptor subfamily 1, group I, member 21001
nuclear factor erythroid 2-related factor 2 isoform 21001
galanin receptor type 30101
ATP-binding cassette sub-family C member 30404
Multidrug resistance-associated protein 40404
Bile salt export pump0606
Glucocorticoid receptor0202
Glycine receptor subunit alpha-10202
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Canalicular multispecific organic anion transporter 10303
ORF730011
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE1001
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
Chain A, 2-oxoglutarate Oxygenase4004
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
endonuclease IV1001
15-lipoxygenase, partial1001
TDP1 protein6006
Microtubule-associated protein tau1001
Bloom syndrome protein isoform 12002
polyunsaturated fatty acid lipoxygenase ALOX121001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 13003
runt-related transcription factor 1 isoform AML1b1001
core-binding factor subunit beta isoform 21001
mitogen-activated protein kinase 11001
DNA polymerase kappa isoform 11001
Epidermal growth factor receptor0101
Glutamate receptor 11214
Glutamate receptor 31214
Glutamate receptor 41214
Caspase-71001
Chain A, Type Iii Chloramphenicol Acetyltransferase0101
thioredoxin glutathione reductase1001
vitamin D3 receptor isoform VDRA2002
chromobox protein homolog 15005
geminin4004
streptokinase A precursor0011
Bile salt export pump0303
Albumin0112
Estrogen receptor0011
Guanine nucleotide-binding protein G2002
Estrogen receptor beta0011
Canalicular multispecific organic anion transporter 10101
Broad substrate specificity ATP-binding cassette transporter ABCG20101
large T antigen0101
Chain A, GLUTAMATE RECEPTOR SUBUNIT 20101
Chain A, Glutamate Receptor Subunit 20101
Chain B, Glutamate Receptor Subunit 20101
Chain A, Slr1257 protein0011
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]0101
glp-1 receptor, partial3003
thioredoxin reductase6006
phosphopantetheinyl transferase2002
GLS protein1001
regulator of G-protein signaling 42002
euchromatic histone-lysine N-methyltransferase 24004
beta-2 adrenergic receptor2002
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
Metabotropic glutamate receptor 80202
Metabotropic glutamate receptor 60113
Glutamate receptor ionotropic, NMDA 2D0101
Excitatory amino acid transporter 40101
Glutamate receptor ionotropic, NMDA 3B0101
Glutathione reductase, mitochondrial0202
Bifunctional aspartokinase/homoserine dehydrogenase 10101
Prothrombin0011
Carbonic anhydrase 10204
Carbonic anhydrase 20204
Integrin beta-30011
Integrin alpha-IIb0011
ATP-citrate synthase 0101
Glutamate receptor ionotropic, kainate 10213
Metabotropic glutamate receptor 10112
Metabotropic glutamate receptor 20011
Metabotropic glutamate receptor 30011
Metabotropic glutamate receptor 40112
Metabotropic glutamate receptor 50011
Metabotropic glutamate receptor 60011
Metabotropic glutamate receptor 70011
Glutamate receptor ionotropic, NMDA 1 0214
Glutamate receptor ionotropic, kainate 10112
Metabotropic glutamate receptor 50113
Glutamate receptor ionotropic, kainate 20213
Glutamate receptor 10213
Glutamate receptor 20213
Glutamate receptor 30112
Glutamate receptor ionotropic, kainate 30202
Excitatory amino acid transporter 10203
Excitatory amino acid transporter 20203
Excitatory amino acid transporter 30203
Metabotropic glutamate receptor 80011
Glutamate receptor 40213
Excitatory amino acid transporter 3 0001
Glutamate racemase0001
Metabotropic glutamate receptor 80112
Fatty-acid amide hydrolase 10101
Glutamate receptor ionotropic, NMDA 2A 0214
Glutamate receptor ionotropic, NMDA 2B0214
Glutamate receptor ionotropic, NMDA 2C0214
Glutamate receptor ionotropic, kainate 40202
Glutamate carboxypeptidase 20101
Glutamate receptor ionotropic, NMDA 10101
Glutamate receptor ionotropic, NMDA 2A0101
Glutamate receptor ionotropic, kainate 20112
Glutamate receptor ionotropic, kainate 30101
Glutamate receptor ionotropic, NMDA 2B0101
Metabotropic glutamate receptor 10113
Metabotropic glutamate receptor 20113
Metabotropic glutamate receptor 70113
Metabotropic glutamate receptor 30113
Metabotropic glutamate receptor 40113
Glutamate receptor ionotropic, NMDA 2C0101
Glutamate receptor ionotropic, kainate 50101
Carbonic anhydrase-like protein, putative0002
Glutamate receptor ionotropic, NMDA 2D0214
Glutamate receptor ionotropic, kainate 50202
Glutamate racemase0001
Prolyl 4-hydroxylase0101
Glutamate receptor ionotropic, NMDA 3A0101
Glutamate receptor ionotropic, NMDA 3B0214
Alpha-ketoglutarate-dependent dioxygenase FTO0101
Glutamate receptor ionotropic, NMDA 3A0214
dopamine D1 receptor1001
cytochrome P450 2D63003
atrial natriuretic peptide receptor 1 precursor1001
flap endonuclease 11001
Alkaline phosphatase, tissue-nonspecific isozyme0202
Alkaline phosphatase, placental type0101
Alkaline phosphatase, tissue-nonspecific isozyme 0202
Intestinal-type alkaline phosphatase0101
Intestinal-type alkaline phosphatase0101
5'-nucleotidase0101
Phospholipase A-2-activating protein0101
ATP-dependent phosphofructokinase2002
HLA class I histocompatibility antigen, A alpha chain 0112
5-hydroxytryptamine receptor 2C0101
5-hydroxytryptamine receptor 2A0101
5-hydroxytryptamine receptor 2B0101
Gastrin/cholecystokinin type B receptor0101
GALC protein1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
peroxisome proliferator activated receptor gamma2002
thyroid stimulating hormone receptor1001
lysosomal alpha-glucosidase preproprotein1001
mu-type opioid receptor isoform MOR-10011
Vpr1001
peripheral myelin protein 221001
5-hydroxytryptamine receptor 2A0011
Cellular tumor antigen p532002
Neuronal acetylcholine receptor subunit alpha-41001
Neuronal acetylcholine receptor subunit beta-21001
Spike glycoprotein1001
Chain A, Beta-lactamase1001
Chain A, Ferritin light chain2002
SMAD family member 21001
SMAD family member 31001
estrogen receptor 2 (ER beta)1001
nuclear receptor subfamily 1, group I, member 32002
nonstructural protein 11001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
thyroid hormone receptor beta isoform 21001
heat shock protein HSP 90-alpha isoform 20001
DNA polymerase iota isoform a (long)1001
nuclear receptor ROR-gamma isoform 11001
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Cytochrome P450 3A40101
Histamine H2 receptor1001
TAR DNA-binding protein 431001
ATPase family AAA domain-containing protein 51001
Ataxin-21001
heat shock protein 90, putative0001
chaperonin-containing TCP-1 beta subunit homolog1001
survival motor neuron protein isoform d1001
histone acetyltransferase KAT2A isoform 11001
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
Solute carrier family 22 member 60101
Polyphenol oxidase 20103
Carbonic anhydrase 120102
5'-AMP-activated protein kinase subunit beta-20001
Polymerase acidic protein0011
Carbonic anhydrase 30102
Stromelysin-10011
Tyrosine-protein phosphatase YopH0101
High mobility group protein B10011
Aldo-keto reductase family 1 member B10101
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
Acetylcholinesterase0101
Carbonic anhydrase 40102
Prostaglandin G/H synthase 10101
Carbonic anhydrase 60102
Cystathionine gamma-lyase0101
Carbonic anhydrase 5A, mitochondrial0102
Prostaglandin G/H synthase 20101
Carbonic anhydrase 70102
5'-AMP-activated protein kinase subunit gamma-10001
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10001
Carbonic anhydrase 90102
Carbonic anhydrase0101
Solute carrier family 22 member 60101
Solute carrier family 22 member 70001
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200101
Solute carrier family 22 member 80101
Solute carrier family 22 member 60101
Ubiquitin-like domain-containing CTD phosphatase 10101
Carbonic anhydrase 150102
Carbonic anhydrase 130101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20001
Carbonic anhydrase 140102
Carbonic anhydrase 5B, mitochondrial0102
5'-AMP-activated protein kinase subunit beta-10001
NFKB1 protein, partial1001
Beta-1 adrenergic receptor 0011
arylsulfatase A1001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
cytochrome P450 2D6 isoform 11001
cytochrome P450 3A4 isoform 11001
muscarinic acetylcholine receptor M11001
Gamma-aminobutyric acid receptor subunit pi1012
Beta-2 adrenergic receptor0202
Beta-1 adrenergic receptor0202
Cytochrome P450 2D60101
Beta-3 adrenergic receptor0202
Gamma-aminobutyric acid receptor subunit beta-11012
Beta-1 adrenergic receptor0101
Gamma-aminobutyric acid receptor subunit delta1012
Gamma-aminobutyric acid receptor subunit gamma-21012
5-hydroxytryptamine receptor 1A0213
Gamma-aminobutyric acid receptor subunit alpha-51012
Gamma-aminobutyric acid receptor subunit alpha-31012
Gamma-aminobutyric acid receptor subunit gamma-11012
Gamma-aminobutyric acid receptor subunit alpha-21012
Gamma-aminobutyric acid receptor subunit alpha-41012
Gamma-aminobutyric acid receptor subunit gamma-31012
5-hydroxytryptamine receptor 1B0202
Gamma-aminobutyric acid receptor subunit alpha-61012
Gamma-aminobutyric acid receptor subunit alpha-11012
Gamma-aminobutyric acid receptor subunit beta-31012
Gamma-aminobutyric acid receptor subunit beta-21012
Beta-2 adrenergic receptor0011
GABA theta subunit1012
Gamma-aminobutyric acid receptor subunit epsilon1012
acid sphingomyelinase1001
67.9K protein1001
potassium voltage-gated channel subfamily H member 2 isoform d1001
Chain A, CHORISMATE MUTASE0101
Chain A, TYROSYL-tRNA SYNTHETASE0011
Plasma kallikrein0001
Adenosine receptor A10001
Adenosine receptor A2a0001
Carbonic anhydrase0001
Carbonic anhydrase0001
Large neutral amino acids transporter small subunit 10202
SLC16A10 protein0001
Carbonic anhydrase 0001
Carbonic anhydrase0001
Carbonic anhydrase0001
Carbonic anhydrase 0001
Tubulin--tyrosine ligase0101
Monocarboxylate transporter 100001
Taste receptor type 2 member 140001
Chain A, Arginase 10101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]
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