6''-o-malonyldaidzin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

6''-O-malonyldaidzin: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

malonyldaidzin : A glycosyloxyisoflavone that is daidzein substituted by a 6-O-(carboxyacetyl)-beta-D-glucopyranosyl residue at position 7 via a glycosidic linkage. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID Source	ID
PubMed CID	9913968
CHEMBL ID	3426719
CHEBI ID	80371
MeSH ID	M0431145

Synonyms (27)

Synonym
malonyldaidzin
6''-o-malonyldaidzin
124590-31-4
daidzin 6''-o-malonate
CHEBI:80371 ,
3-(4-hydroxyphenyl)-4-oxo-4h-1-benzopyran-7-yl 6-o-(carboxyacetyl)-beta-d-glucopyranoside
unii-54ce6owe7a
3-(4-hydroxyphenyl)-4-oxo-4h-chromen-8-yl 6-o-(carboxyacetyl)-beta-d-glucopyranoside
4h-1-benzopyran-4-one, 7-[[6-o-(2-carboxyacetyl)-.beta.-d-glucopyranosyl]oxy]-3-(4-hydroxyphenyl)-
3-(4-hydroxyphenyl)-4-oxo-4h-chromen-8-yl 6-o-(carboxyacetyl)-.beta.-d-glucopyranoside
malonyldaidzin, (-)-
malonyl daidzin (constituent of soy isoflavones) [dsc]
54CE6OWE7A ,
CHEMBL3426719
malonyl-daidzin
Q27149376
malonyl daidzin
6-o-malonyldaidzin
3-oxo-3-(((2r,3s,4s,5r,6s)-3,4,5-trihydroxy-6-((3-(4-hydroxyphenyl)-4-oxo-4h-chromen-7-yl)oxy)tetrahydro-2h-pyran-2-yl)methoxy)propanoic acid
MS-29327
HY-N4073
CS-0030648
3-oxo-3-[[(2r,3s,4s,5r,6s)-3,4,5-trihydroxy-6-[3-(4-hydroxyphenyl)-4-oxochromen-7-yl]oxyoxan-2-yl]methoxy]propanoic acid
E88875
DTXSID201319060
AKOS040760360
PD165367

Research Excerpts

Compound-Compound Interactions

Excerpt	Reference	Relevance
"The crude methanol extract of Pueraria lobata was investigated by dual high-resolution α-glucosidase inhibition and radical scavenging profiling combined with hyphenated HPLC-HRMS-SPE-NMR."	( Dual high-resolution α-glucosidase and radical scavenging profiling combined with HPLC-HRMS-SPE-NMR for identification of minor and major constituents directly from the crude extract of Pueraria lobata. Jäger, AK; Kongstad, KT; Liu, B; Nyberg, NT; Qinglei, S; Staerk, D, 2015)	0.42

Bioavailability

Excerpt	Reference	Relevance
"Despite considerable interest in the physiologic effects of isoflavones, the in vivo bioavailability of the most common isoflavone forms, malonylglucoside conjugates, has not been determined."	( Malonylglucoside conjugates of isoflavones are much less bioavailable compared with unconjugated β-glucosidic forms in rats. Gallaher, DD; Ismail, B; Yerramsetty, V, 2014)	0.4

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

Role	Description
plant metabolite	Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (4)

Class	Description
hydroxyisoflavone	Member of the class of isoflavones bearing at least one hydroxy group.
glycosyloxyisoflavone	A member of the class of isoflavones having one or more glycosyl residues attached at unspecified positions.
malonate ester	An ester of malonic acid; any compound containing a malonate ester skeleton.
monosaccharide derivative	A carbohydrate derivative that is formally obtained from a monosaccharide.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (2)

Assay ID	Title	Year	Journal	Article
AID1204996	Inhibition of Saccharomyces cerevisiae alpha-glucosidase type 1 assessed as 4-nitrophenol cleavage product by high-resolution biochromatogram	2015	Journal of natural products, Feb-27, Volume: 78, Issue:2	Dual high-resolution α-glucosidase and radical scavenging profiling combined with HPLC-HRMS-SPE-NMR for identification of minor and major constituents directly from the crude extract of Pueraria lobata.
AID1204997	Antioxidant activity of the compound assessed as inhibition of ABTS radicals after 20 mins by spectrophotometric analysis	2015	Journal of natural products, Feb-27, Volume: 78, Issue:2	Dual high-resolution α-glucosidase and radical scavenging profiling combined with HPLC-HRMS-SPE-NMR for identification of minor and major constituents directly from the crude extract of Pueraria lobata.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (11.11)	29.6817
2010's	7 (77.78)	24.3611
2020's	1 (11.11)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.06

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	13.06 (24.57)
Research Supply Index	2.40 (2.92)
Research Growth Index	5.45 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (13.06)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	10 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
salicylic acid Scalp: The outer covering of the calvaria. It is composed of several layers: SKIN; subcutaneous connective tissue; the occipitofrontal muscle which includes the tendinous galea aponeurotica; loose connective tissue; and the pericranium (the PERIOSTEUM of the SKULL).	2.15	1	monohydroxybenzoic acid	algal metabolite; antifungal agent; antiinfective agent; EC 1.11.1.11 (L-ascorbate peroxidase) inhibitor; keratolytic drug; plant hormone; plant metabolite
glycine [no description available]	2.15	1	alpha-amino acid; amino acid zwitterion; proteinogenic amino acid; serine family amino acid	EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor; fundamental metabolite; hepatoprotective agent; micronutrient; neurotransmitter; NMDA receptor agonist; nutraceutical
ethylene Plastipore: high density polyethylene sponge biocompatible material; used as posts in dental bridges	2.13	1	alkene; gas molecular entity	plant hormone; refrigerant
cyclopentane Cyclopentanes: A group of alicyclic hydrocarbons with the general formula R-C5H9.. cyclopentanes : Cyclopentane and its derivatives formed by substitution.	2.13	1	cycloalkane; cyclopentanes; volatile organic compound	non-polar solvent
silver nitrate Silver Nitrate: A silver salt with powerful germicidal activity. It has been used topically to prevent OPHTHALMIA NEONATORUM.	2.15	1	inorganic nitrate salt; silver salt	astringent
deuterium Deuterium: The stable isotope of hydrogen. It has one neutron and one proton in the nucleus.	2.1	1	dihydrogen
cuprous chloride cuprous chloride: RN given refers to unlabeled cpd. copper(I) chloride : An inorganic chloride of copper in which the metal is in the +1 oxidation state.	2.15	1	copper molecular entity; inorganic chloride	agrochemical; molluscicide
glucose, (beta-d)-isomer beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.	3.63	8	D-glucopyranose	epitope; mouse metabolite
benzo-1,2,3-thiadiazole [no description available]	2.15	1
daidzin daidzin: a potent, selective, and reversible inhibitor of human mitochondrial aldehyde dehydrogenase. daidzein 7-O-beta-D-glucoside : A glycosyloxyisoflavone that is daidzein attached to a beta-D-glucopyranosyl residue at position 7 via a glycosidic linkage. It is used in the treatment of alcohol dependency (antidipsotropic).	3.39	6	7-hydroxyisoflavones 7-O-beta-D-glucoside; hydroxyisoflavone; monosaccharide derivative	plant metabolite
glyceollin glyceollin: found in plants; structure	2.15	1	organic heteropentacyclic compound
glycitin glycitin: structure in first source. glycitin : A glycosyloxyisoflavone that is isoflavone substituted by a methoxy group at position 6, a hydroxy group at position 4' and a beta-D-glucopyranosyloxy group at position 7.	2.53	2	7-hydroxyisoflavones 7-O-beta-D-glucoside; hydroxyisoflavone; methoxyisoflavone; monosaccharide derivative	plant metabolite
ononin [no description available]	2.11	1	4'-methoxyisoflavones; 7-hydroxyisoflavones 7-O-beta-D-glucoside; monosaccharide derivative	plant metabolite
glycosides [no description available]	2.13	1
sesquiterpenes [no description available]	2.15	1
Jasmone jasmone: RN refers to (Z)-isomer; structure given in first source	2.13	1	cyclic ketone
formononetin [no description available]	2.11	1	4'-methoxyisoflavones; 7-hydroxyisoflavones	phytoestrogen; plant metabolite
genistein [no description available]	3.06	4	7-hydroxyisoflavones	antineoplastic agent; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; geroprotector; human urinary metabolite; phytoestrogen; plant metabolite; tyrosine kinase inhibitor
genistin genistin: glycoside of soy bean isoflavone, gentistein	3.39	6	7-hydroxyisoflavones 7-O-beta-D-glucoside
daidzein [no description available]	3.24	5	7-hydroxyisoflavones	antineoplastic agent; EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor; EC 3.2.1.20 (alpha-glucosidase) inhibitor; phytoestrogen; plant metabolite
genistein-8-c-glucoside genistein 8-C-glucoside : A C-glycosyl compound that is genistein substituted by a beta-D-glucopyranosyl residue at position 8 via a C-glucosidic linkage.	2.11	1	7-hydroxyisoflavones; C-glycosyl compound	plant metabolite
puerarin [no description available]	2.11	1	C-glycosyl compound; hydroxyisoflavone	plant metabolite
glycitein glycitein : A methoxyisoflavone that is isoflavone substituted by a methoxy group at position 6 and hydroxy groups at positions 7 and 4'. It has been isolated from the mycelia of the fungus Cordyceps sinensis.	2.13	1	7-hydroxyisoflavone; methoxyisoflavone	fungal metabolite; phytoestrogen; plant metabolite
aminoethoxyvinylglycine aminoethoxyvinylglycine: RN given for (S-(E))-isomer	2.15	1
malonylgenistin malonylgenistin: structure in first source. malonylgenistin : A glycosyloxyisoflavone that is genistin in which the hydroxy hydrogen at position 6'' has been replaced by a malonyl group.	3.62	8	beta-D-glucoside; glycosyloxyisoflavone; hydroxyisoflavone; malonate ester; monosaccharide derivative	plant metabolite

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