Endoleak

Postoperative hemorrhage from an endovascular AORTIC ANEURYSM repaired with endoluminal placement of stent grafts (BLOOD VESSEL PROSTHESIS IMPLANTATION). It is associated with pressurization, expansion, and eventual rupture of the aneurysm.

Synonym
Endoleak
Perigraft Leak

Excerpt	Reference
"An endoleak is defined by vascular flow outside of the graft."	( Koyfman, A; Long, B; Slama, R, 2016)
"Endoleak is a common complication of endovascular aneurysm repair (EVAR) for abdominal aortic aneurysm (AAA) but can be detected only through prolonged follow-up with repeated aortic imaging."	( Boult, M; Fitridge, RA; Golledge, J; Lazzaroni, SM; Moxon, JV; Ng, E; Velu, R, 2018)
"Persistent endoleaks are associated with increased sac strain, an observation that may help guide management."	( Alturkistani, H; Bertrand-Grenier, A; Bhatnagar, S; Cloutier, G; Lerouge, S; Roy-Cardinal, MH; Sivakumaran, L; Soulez, G; Thérasse, É; Zehtabi, F, 2022)
"Endoleaks are a common complication after endovascular aortic repair (EVAR) and thoracic endovascular aortic repair (TEVAR)."	( Becker, BV; Brockmann, MA; Overhoff, D; Waldeck, S, 2023)

Excerpt	Reference
"Complications unique to endovascular treatment include endoleak and endotension, which can eventually lead to rupture."	( Eefting, D; Hoencamp, R; Ottevanger, J; Sudiono, DR; van der Linden, E, 2017)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	0 (0.00)	18.1394
2010's	114 (78.62)	28.8240
2020's	31 (21.38)	9.53

Drug	Relationship Strength	Studies	Trials
lactic acid	low	1	0
dimethyl sulfoxide	low	25	0
iodine	low	2	0
aspirin	low	3	0
iodixanol	low	1	0
iohexol	low	5	0
iomeprol	low	7	0
iopromide	low	1	0
ketorolac	low	1	0
ticlopidine	low	1	0
tranexamic acid	medium	5	1
meglumine	low	2	0
cdta	low	1	0
vancomycin	low	1	0
sulfur hexafluoride	low	15	0
enbucrilate	medium	23	1
tantalum	low	11	0
gadolinium	low	3	0
azides	low	1	0
clopidogrel	low	2	0
iopamidol	low	11	0
fluorodeoxyglucose f18	low	2	0
fibrinogen	low	3	0
homocysteine	low	1	0
deoxyglucose	low	1	0
1,3,4,6-tetra-o-acetyl-2-azido-2-deoxyglucopyranose	low	1	0
technetium tc 99m pentetate	medium	2	1
meropenem	low	1	0
clindamycin	low	1	0
freedom	low	1	0
nitinol	low	10	0
osteoprotegerin	low	1	0
ono 1301	low	1	0
gadolinium dtpa	low	1	0
indocyanine green	low	2	0
chitosan	medium	3	1
sodium tetradecyl sulfate	medium	2	1
gadofosveset trisodium	low	2	0
warfarin	low	6	0
epidermal growth factor	low	1	0
rome	low	2	0
chondroitin sulfates	low	1	0

Protein Targets (237)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	2	0	0	2
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	1	0	0	1
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, HADH2 protein	2	0	0	2
Chain B, HADH2 protein	2	0	0	2
Chain A, 2-oxoglutarate Oxygenase	2	0	0	2
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	1	0	0	1
thioredoxin reductase	2	0	0	2
GLS protein	1	0	0	1
AR protein	5	0	0	5
aldehyde dehydrogenase 1 family, member A1	3	0	0	3
thyroid stimulating hormone receptor	1	0	0	1
hypothetical protein, conserved	1	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	4	0	0	4
EWS/FLI fusion protein	6	0	0	6
glucocorticoid receptor [Homo sapiens]	7	0	0	7
retinoic acid nuclear receptor alpha variant 1	6	0	0	6
estrogen-related nuclear receptor alpha	6	0	0	6
estrogen nuclear receptor alpha	8	0	0	8
cytochrome P450 2D6	3	0	0	3
glucocerebrosidase	1	0	0	1
peroxisome proliferator-activated receptor delta	3	0	0	3
Rac1 protein	0	0	1	1
IDH1	1	0	0	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
euchromatic histone-lysine N-methyltransferase 2	3	0	0	3
Bloom syndrome protein isoform 1	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
DNA polymerase iota isoform a (long)	2	0	0	2
DNA polymerase kappa isoform 1	2	0	0	2
muscarinic acetylcholine receptor M1	1	0	0	1
lethal factor (plasmid)	2	0	0	2
Prostaglandin-H2 D-isomerase	0	1	0	1
ATP-binding cassette sub-family C member 3	0	3	0	3
Multidrug resistance-associated protein 4	0	3	0	3
Solute carrier family 22 member 6	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Bile salt export pump	0	5	0	5
Epidermal growth factor receptor	0	1	0	1
Carbonic anhydrase 1	0	3	0	3
Carbonic anhydrase 2	0	3	0	3
Fatty acid-binding protein, liver	0	2	0	2
Integrin beta-3	1	1	0	2
Myeloperoxidase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	1	1	0	2
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	3	0	3
Adenosine receptor A1	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Substance-P receptor	0	1	0	1
Prostaglandin G/H synthase 2	0	3	0	3
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	1	0	0	1
Ras-related protein Rab-2A	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	1	1	0	2
Prostaglandin G/H synthase 2	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	2	1	3
Sigma non-opioid intracellular receptor 1	0	0	1	1
Carbonic anhydrase 4	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 15	0	1	0	1
Protein-arginine deiminase type-4	0	1	0	1
nonstructural protein 1	1	0	0	1
chromobox protein homolog 1	3	0	0	3
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
geminin	2	0	0	2
Cytochrome P450 2C8	0	2	0	2
Cytochrome P450 2B6	0	3	0	3
Liver carboxylesterase 1	0	0	0	1
Sodium-dependent serotonin transporter	0	2	0	2
Cytochrome P450 2C19	0	3	0	3
Rap guanine nucleotide exchange factor 4	1	0	0	1
P2Y purinoceptor 12	0	1	0	1
Cereblon isoform 4	0	2	0	2
GLI family zinc finger 3	2	0	0	2
retinoid X nuclear receptor alpha	3	0	0	3
vitamin D (1,25- dihydroxyvitamin D3) receptor	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	4	0	0	4
Insulin-like growth factor-binding protein 5	0	0	1	1
Choline O-acetyltransferase	0	1	0	1
Protein cereblon	0	2	0	2
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
Luciferase	4	0	0	4
acetylcholinesterase	4	0	0	4
hypoxia-inducible factor 1 alpha subunit	2	0	0	2
RAR-related orphan receptor gamma	5	0	0	5
progesterone receptor	3	0	0	3
pregnane X nuclear receptor	4	0	0	4
peroxisome proliferator activated receptor gamma	2	0	0	2
aryl hydrocarbon receptor	2	0	0	2
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	2	0	0	2
activating transcription factor 6	2	0	0	2
v-jun sarcoma virus 17 oncogene homolog (avian)	4	0	0	4
histone deacetylase 9 isoform 3	1	0	0	1
Voltage-dependent calcium channel gamma-2 subunit	1	0	0	1
Glutamate receptor 2	1	0	0	1
Cellular tumor antigen p53	3	0	0	3
ATAD5 protein, partial	2	0	0	2
nuclear receptor subfamily 1, group I, member 3	3	0	0	3
Spike glycoprotein	3	0	0	3
USP1 protein, partial	2	0	0	2
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
peripheral myelin protein 22	1	0	0	1
lamin isoform A-delta10	3	0	0	3
farnesoid X nuclear receptor	2	0	0	2
importin subunit beta-1 isoform 1	1	0	0	1
snurportin-1	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
ras-related protein Rab-9A	1	0	0	1
Albumin	0	1	2	3
Fatty acid-binding protein, intestinal	0	1	1	2
Caspase-1	0	1	0	1
Caspase-3	0	1	0	1
Caspase-4	0	1	0	1
Caspase-5	0	1	0	1
Caspase-9	0	1	0	1
Cell division control protein 42 homolog	0	1	0	1
Ras-related C3 botulinum toxin substrate 1	0	1	0	1
Serine/threonine-protein kinase PAK 1	0	1	0	1
Ataxin-2	1	0	0	1
estrogen receptor 2 (ER beta)	2	0	0	2
thyroid stimulating hormone receptor	3	0	0	3
cellular tumor antigen p53 isoform a	1	0	0	1
Beta-lactamase	0	0	0	1
G	2	0	0	2
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	1	2
Metallo-beta-lactamase VIM-11	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
streptokinase A precursor	0	0	1	1
Interferon beta	3	0	0	3
HLA class I histocompatibility antigen, B alpha chain	2	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase TEM	0	0	0	1
B2 metallo-beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-13	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	1	2
Metallo-b-lactamase	0	0	0	1
Beta-lactamase IMP-1	0	0	0	1
BlaVIM-1	0	0	0	1
Inositol hexakisphosphate kinase 1	2	0	0	2
Beta-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Histamine H3 receptor	0	0	0	1
Beta-lactamase class B VIM-2	0	0	1	2
Beta-lactamase	0	0	0	1
Beta-lactamase VIM-1	0	0	0	1
cytochrome P450 2C9, partial	2	0	0	2
Sphingosine kinase 2	0	2	0	2
Sphingosine kinase 1	0	1	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	2	0	0	2
thyroid hormone receptor beta isoform 2	3	0	0	3
heat shock protein beta-1	2	0	0	2
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
Chain A, Ferritin light chain	1	0	0	1
glp-1 receptor, partial	1	0	0	1
TDP1 protein	1	0	0	1
cytochrome P450 2D6 isoform 1	1	0	0	1
cytochrome P450 2C19 precursor	1	0	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
cytochrome P450 3A4 isoform 1	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	1	0	0	1
Bile salt export pump	0	1	0	1
Alpha-2A adrenergic receptor	0	3	0	3
Cytochrome P450 2D6	0	1	0	1
Cytochrome P450 2C9	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	1	0	0	1
Alpha-2B adrenergic receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	1	0	0	1
Alpha-2C adrenergic receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	1	0	0	1
Cytochrome P450 2J2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	1	0	0	1
Gamma-aminobutyric acid receptor subunit beta-2	1	0	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
GABA theta subunit	1	0	0	1
Gamma-aminobutyric acid receptor subunit epsilon	1	0	0	1
Chain A, PLASMINOGEN	0	0	1	1
Chain A, PLASMINOGEN	0	0	1	1
Plasminogen	0	2	1	3
Urokinase-type plasminogen activator	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
10 kDa heat shock protein, mitochondrial	0	1	0	1
D-alanyl-D-alanine dipeptidase	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Transporter	0	1	0	1
Chain A, Beta-lactamase	1	0	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
PPM1D protein	1	0	0	1
thyroid hormone receptor beta isoform a	1	0	0	1
Albumin	0	0	1	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Protease	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(2)

Research Excerpts

Overview

Treatment

Research

Studies (145)

Protein Targets (237)

Endoleak

Synonyms(2)

Research Excerpts

Overview

Treatment

Research

Studies (145)

Drugs Studied (49)

Protein Targets (237)