Page last updated: 2024-09-27

Embolic Infarction, Posterior Cerebral Artery

NECROSIS induced by ISCHEMIA in the POSTERIOR CEREBRAL ARTERY distribution system which supplies portions of the BRAIN STEM; the THALAMUS; TEMPORAL LOBE, and OCCIPITAL LOBE. Depending on the size and location of infarction, clinical features include OLFACTION DISORDERS and visual problems (AGNOSIA; ALEXIA; HEMIANOPSIA).

Synonyms(11)

Synonym
PCA Infarct
Posterior Cerebral Artery Thrombotic Infarction
Posterior Cerebral Artery Syndrome
Posterior Cerebral Artery Stroke
Posterior Cerebral Artery Infarction
Posterior Cerebral Artery Embolic Infarction
PCA Infarction
Infarction, Posterior Cerebral Artery
Stroke, Posterior Cerebral Artery
Thrombotic Infarction, Posterior Cerebral Artery
Embolic Infarction, Posterior Cerebral Artery

Research Excerpts

Research

Studies (24)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's10 (41.67)18.1394
2010's13 (54.17)28.8240
2020's1 (4.17)9.53
DrugIndicatedRelationship StrengthStudiesTrials
thiamine0low10
aspirin0low30
verapamil0low10
furosemide0low10
hydroxyurea0low10
iohexol0low20
iopromide0low10
nimodipine0low10
ticlopidine0low10
alanine0low10
adenosine monophosphate0low10
mannitol0low10
cyclohexanol0low10
pyrroles0low10
meglumine0medium21
gadolinium0medium11
clopidogrel0low10
atorvastatin0low10
venlafaxine hydrochloride0low10
fibrinogen0low20
perindopril0low10
bradykinin0low10
digitoxin0low10
vinpocetine0low10
D-fructopyranose0low10
dermatan sulfate0low10
cinepazide0low10
topiramate0low10
2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane0low10
icatibant0low10
endothelin-10low10
heparitin sulfate0low10
vitamin b 120low10
s 89320low10
chondroitin sulfates0low10
folic acid0low10

Protein Targets (455)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Sodium-dependent dopamine transporter 0202
Chain A, Glycogen Phosphorylase B0011
Chain B, Glycogen Phosphorylase B0011
Chain A, ADP-dependent glucokinase0101
Chain A, Ribonuclease pancreatic0101
Chain A, Ribonuclease pancreatic0101
Chain A, phosphodiesterase-nucleotide pyrophosphatase0101
Chain A, GLYCOGEN PHOSPHORYLASE B0011
Chain B, GLYCOGEN PHOSPHORYLASE B0011
Chain A, GLYCOGEN PHOSPHORYLASE B0011
RAR-related orphan receptor gamma5005
AR protein120012
regulator of G-protein signaling 43003
glucocorticoid receptor [Homo sapiens]100010
estrogen-related nuclear receptor alpha9009
euchromatic histone-lysine N-methyltransferase 27007
v-jun sarcoma virus 17 oncogene homolog (avian)4004
2'-deoxynucleoside 5'-phosphate N-hydrolase 10101
Mitogen-activated protein kinase kinase kinase 70011
2'-deoxynucleoside 5'-phosphate N-hydrolase 10101
5'-AMP-activated protein kinase subunit beta-20011
Transient receptor potential cation channel subfamily M member 20101
Alcohol dehydrogenase E chain0101
Alcohol dehydrogenase S chain0101
L-lactate dehydrogenase A chain0112
Adenylate kinase isoenzyme 10001
Fructose-1,6-bisphosphatase 10101
Alkaline phosphatase, tissue-nonspecific isozyme0001
Fructose-1,6-bisphosphatase 10101
2-dehydropantoate 2-reductase0112
Inosine-5'-monophosphate dehydrogenase0101
Cytochrome P450 2C9 0505
Proto-oncogene tyrosine-protein kinase Src0101
Amine oxidase [flavin-containing] B0101
5'-nucleotidase0001
Choline O-acetyltransferase0101
Adenylate kinase 2, mitochondrial0102
GTP:AMP phosphotransferase AK3, mitochondrial0001
Adenosine receptor A10011
Adenylate kinase isoenzyme 1 0102
P2Y purinoceptor 20011
P2Y purinoceptor 10011
P2Y purinoceptor 10011
5'-AMP-activated protein kinase subunit gamma-10022
5'-AMP-activated protein kinase catalytic subunit alpha-20011
Adenylate kinase 2, mitochondrial0001
Glycine--tRNA ligase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10022
Adenosine deaminase-like protein0001
Protease 0112
P2Y purinoceptor 110011
Histamine H3 receptor0101
5'-AMP-activated protein kinase subunit gamma-30011
5'-AMP-activated protein kinase subunit gamma-20011
5'-AMP-activated protein kinase subunit beta-10022
ATP-dependent phosphofructokinase1001
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE6006
Chain A, TYROSYL-DNA PHOSPHODIESTERASE3003
Carbonic anhydrase 10609
Carbonic anhydrase 207112
Alanine racemase, biosynthetic0001
5-hydroxytryptamine receptor 1D0001
Glutamate receptor ionotropic, NMDA 1 0101
Proton-coupled amino acid transporter 10101
Adenosine deaminase0001
Carbonic anhydrase 40203
Chain A, Phospholipase A2 isoform 30011
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
Chain A, 2-oxoglutarate Oxygenase3003
GTP-binding protein (rab7)0011
ras protein, partial0011
interleukin 81001
thioredoxin reductase5005
GLS protein3003
aldehyde dehydrogenase 1 family, member A15005
thyroid stimulating hormone receptor3003
hypothetical protein, conserved1001
cytochrome P450 family 3 subfamily A polypeptide 47007
EWS/FLI fusion protein7007
retinoic acid nuclear receptor alpha variant 17007
estrogen nuclear receptor alpha140014
cytochrome P450 2D64004
glucocerebrosidase3003
peroxisome proliferator-activated receptor delta4004
Rac1 protein0011
IDH13003
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
Bloom syndrome protein isoform 14004
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
DNA polymerase iota isoform a (long)3003
DNA polymerase kappa isoform 12002
muscarinic acetylcholine receptor M11001
lethal factor (plasmid)1001
Prostaglandin-H2 D-isomerase0101
ATP-binding cassette sub-family C member 30808
Multidrug resistance-associated protein 40809
Solute carrier family 22 member 60202
Prostaglandin G/H synthase 1 0101
Prostaglandin G/H synthase 2 0101
Bile salt export pump010010
Epidermal growth factor receptor0101
Fatty acid-binding protein, liver0101
Integrin beta-30101
Myeloperoxidase0101
Prostaglandin G/H synthase 10101
Seed linoleate 13S-lipoxygenase-10101
Integrin alpha-IIb0101
Glutathione hydrolase 1 proenzyme0101
Prostaglandin G/H synthase 10202
Adenosine receptor A10101
Adenosine receptor A2a0202
Substance-P receptor0101
Prostaglandin G/H synthase 20303
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0101
Nuclear receptor ROR-gamma1001
Ras-related protein Rab-2A0011
Gamma-aminobutyric acid receptor subunit alpha-12103
Prostaglandin G/H synthase 20101
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200101
Solute carrier family 22 member 60101
Canalicular multispecific organic anion transporter 10808
Sigma non-opioid intracellular receptor 10213
Sigma non-opioid intracellular receptor 10011
Chain A, Cruzipain3003
SMAD family member 22002
SMAD family member 32002
GLI family zinc finger 38008
caspase 7, apoptosis-related cysteine protease1001
estrogen receptor 2 (ER beta)5005
nuclear receptor subfamily 1, group I, member 37007
retinoid X nuclear receptor alpha7007
pregnane X nuclear receptor110011
peroxisome proliferator activated receptor gamma3003
vitamin D (1,25- dihydroxyvitamin D3) receptor6006
caspase-31001
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a1001
Caspase-71001
vitamin D3 receptor isoform VDRA3003
thyroid hormone receptor beta isoform a2002
caspase-31001
thyroid hormone receptor beta isoform 28008
nuclear factor erythroid 2-related factor 2 isoform 15005
geminin100010
Voltage-dependent calcium channel gamma-2 subunit2002
Solute carrier organic anion transporter family member 2B1 0001
3-hydroxy-3-methylglutaryl-coenzyme A reductase0202
Cellular tumor antigen p535005
ATP-dependent translocase ABCB103111
Insulin receptor 0101
Glutamate receptor 22002
Dipeptidyl peptidase 40101
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0101
Histone deacetylase 10101
Histone deacetylase 20101
Solute carrier organic anion transporter family member 1B30001
Histone deacetylase 60101
Broad substrate specificity ATP-binding cassette transporter ABCG20415
Solute carrier organic anion transporter family member 1B10304
histone acetyltransferase KAT2A isoform 11001
Angiotensin-converting enzyme 0102
B2 bradykinin receptor0101
B2 bradykinin receptor0215
B1 bradykinin receptor0101
Olfactory receptor 51E20011
nonstructural protein 12002
chromobox protein homolog 14004
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
Cytochrome P450 2C80404
Cytochrome P450 2B60303
Liver carboxylesterase 10001
Sodium-dependent serotonin transporter0505
Cytochrome P450 2C190505
Rap guanine nucleotide exchange factor 42002
P2Y purinoceptor 120101
aryl hydrocarbon receptor4004
Chain A, Beta-lactamase3003
acetylcholinesterase3003
ATAD5 protein, partial5005
TDP1 protein6006
Microtubule-associated protein tau2002
STAT3, partial0101
Smad31001
progesterone receptor5005
farnesoid X nuclear receptor5005
67.9K protein1001
thyroid stimulating hormone receptor4004
activating transcription factor 65005
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
nuclear receptor subfamily 1, group I, member 21001
NPC intracellular cholesterol transporter 1 precursor1001
nuclear factor erythroid 2-related factor 2 isoform 23003
potassium voltage-gated channel subfamily H member 2 isoform d6006
ras-related protein Rab-9A1001
signal transducer and activator of transcription 1-alpha/beta isoform alpha0101
nuclear receptor ROR-gamma isoform 13003
lamin isoform A-delta107007
Interferon beta5005
Sodium/potassium-transporting ATPase subunit alpha-1 0101
Sodium/potassium-transporting ATPase subunit beta-10101
Replicase polyprotein 1ab0213
Sodium/potassium-transporting ATPase subunit alpha-30101
Sodium/potassium-transporting ATPase subunit beta-20101
Sodium/potassium-transporting ATPase subunit alpha-20101
Sodium/potassium-transporting ATPase subunit alpha-10101
Sodium/potassium-transporting ATPase subunit beta-30101
Sodium/potassium-transporting ATPase subunit gamma0101
Sodium/potassium-transporting ATPase subunit alpha-40101
Solute carrier organic anion transporter family member 4C10101
ATPase family AAA domain-containing protein 51001
Ataxin-22002
Endothelin-1 receptor0101
Chain A, Dihydrofolate reductase0011
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, Ferritin light chain3003
acid sphingomyelinase1001
glp-1 receptor, partial4004
USP1 protein, partial5005
alpha-galactosidase1001
lysosomal alpha-glucosidase preproprotein2002
DNA polymerase beta1001
Thymidylate synthase0202
Thymidylate synthase0101
Dihydrofolate reductase0011
Aldo-keto reductase family 1 member B10101
Alpha-synuclein1001
Folylpolyglutamate synthase, mitochondrial0001
Solute carrier organic anion transporter family member 1A30101
Folylpolyglutamate synthase, mitochondrial0001
Multidrug resistance associated protein0001
thyrotropin-releasing hormone receptor1001
Carbonic anhydrase 120204
Bile salt export pump0303
Albumin0112
Carbonic anhydrase 30202
Glucose-6-phosphate 1-dehydrogenase0101
Carbonic anhydrase 40305
Carbonic anhydrase 60305
Serum paraoxonase/arylesterase 10101
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Carbonic anhydrase 5A, mitochondrial0316
Carbonic anhydrase 70204
Adenosine receptor A10101
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Cytochrome P450 2J20404
6-phosphogluconate dehydrogenase, decarboxylating0101
Spike glycoprotein4015
Holo-[acyl-carrier-protein] synthase0101
Solute carrier organic anion transporter family member 2A10101
Sodium/bile acid cotransporter0101
Carbonic anhydrase 90306
Multidrug and toxin extrusion protein 10101
Carbonic anhydrase 130204
G-protein coupled receptor 350112
CDGSH iron-sulfur domain-containing protein 10202
Carbonic anhydrase 140204
Carbonic anhydrase 5B, mitochondrial0204
Fumarate hydratase2002
NFKB1 protein, partial1001
polyprotein2002
Histone H2A.x1001
peripheral myelin protein 22 isoform 13003
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
cytochrome P450 3A4 isoform 12002
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit pi2002
Gamma-aminobutyric acid receptor subunit delta0101
Stromelysin-10011
Gamma-aminobutyric acid receptor subunit alpha-10101
Urease subunit alpha0101
Gamma-aminobutyric acid receptor subunit beta-12002
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit delta2002
Gamma-aminobutyric acid receptor subunit gamma-20101
Gamma-aminobutyric acid receptor subunit gamma-22002
Gamma-aminobutyric acid receptor subunit alpha-52002
Gamma-aminobutyric acid receptor subunit alpha-32002
Gamma-aminobutyric acid receptor subunit gamma-12002
Gamma-aminobutyric acid receptor subunit alpha-22002
Ribonucleoside-diphosphate reductase large subunit0101
Gamma-aminobutyric acid receptor subunit alpha-42002
Gamma-aminobutyric acid receptor subunit beta-30101
Gamma-aminobutyric acid receptor subunit gamma-32002
Gamma-aminobutyric acid receptor subunit alpha-62002
Gamma-aminobutyric acid receptor subunit alpha-50101
Gamma-aminobutyric acid receptor subunit alpha-30101
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit beta-20101
Gamma-aminobutyric acid receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit beta-32002
Gamma-aminobutyric acid receptor subunit beta-22002
Urease subunit beta0101
Gamma-aminobutyric acid receptor subunit epsilon0101
Inositol monophosphatase 11001
Gamma-aminobutyric acid receptor subunit alpha-60101
Gamma-aminobutyric acid receptor subunit gamma-10101
GABA theta subunit2002
Gamma-aminobutyric acid receptor subunit gamma-30101
Gamma-aminobutyric acid receptor subunit epsilon2002
Gamma-aminobutyric acid receptor subunit theta0101
importin subunit beta-1 isoform 11001
snurportin-11001
GTP-binding nuclear protein Ran isoform 11001
lethal(3)malignant brain tumor-like protein 1 isoform I1001
TAR DNA-binding protein 432002
endonuclease IV1001
G4004
Parkin1001
bromodomain adjacent to zinc finger domain 2B2002
arylsulfatase A2002
peripheral myelin protein 221001
M-phase phosphoprotein 82002
neuropeptide S receptor isoform A1001
Voltage-dependent L-type calcium channel subunit beta-40101
Voltage-dependent P/Q-type calcium channel subunit alpha-1A0101
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Voltage-dependent T-type calcium channel subunit alpha-1G0101
Voltage-dependent calcium channel gamma-3 subunit0101
Voltage-dependent L-type calcium channel subunit alpha-1F0202
Nuclear receptor subfamily 1 group I member 20011
Voltage-dependent T-type calcium channel subunit alpha-1H0101
HLA class I histocompatibility antigen, B alpha chain 4004
Adenosine receptor A30101
Cannabinoid receptor 10202
Voltage-dependent L-type calcium channel subunit beta-30101
Voltage-dependent calcium channel subunit alpha-2/delta-10101
Voltage-dependent calcium channel gamma-7 subunit0101
Voltage-dependent N-type calcium channel subunit alpha-1B0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0202
Voltage-dependent L-type calcium channel subunit beta-10101
Voltage-dependent calcium channel gamma-1 subunit0101
Voltage-dependent L-type calcium channel subunit beta-20101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Voltage-dependent L-type calcium channel subunit alpha-1S0202
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0303
Voltage-dependent R-type calcium channel subunit alpha-1E0101
Voltage-dependent calcium channel subunit alpha-2/delta-40101
Transient receptor potential cation channel subfamily A member 10011
Voltage-dependent calcium channel subunit alpha-2/delta-30101
Voltage-dependent calcium channel gamma-8 subunit0101
Inositol hexakisphosphate kinase 14004
Bile acid receptor0101
Voltage-dependent calcium channel gamma-6 subunit0101
Voltage-dependent calcium channel subunit alpha-2/delta-20101
Voltage-dependent T-type calcium channel subunit alpha-1I0101
Voltage-dependent calcium channel gamma-4 subunit0101
Voltage-dependent calcium channel gamma-5 subunit0101
Voltage-dependent calcium channel gamma-2 subunit0101
cytochrome P450 2C9, partial4004
NS5 0101
Spike glycoprotein0011
Replicase polyprotein 1ab0011
Transmembrane protease serine 20011
Procathepsin L0011
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Angiotensin-converting enzyme 2 0011
Chain A, ykoF0011
Chain B, ykoF0011
Chain A, ThiT0011
Thiamine transporter ThiT0011
Solute carrier family 22 member 1 0304
Transketolase0011
Thiamine-binding periplasmic protein0011
Solute carrier family 22 member 10101
Solute carrier family 22 member 20101
Chain A, JmjC domain-containing histone demethylation protein 3A1001
Luciferase1001
cytochrome P450 2D6 isoform 11001
cytochrome P450 2C19 precursor1001
heat shock protein beta-11001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
Alpha-2A adrenergic receptor0404
Cytochrome P450 2D60101
Alpha-2B adrenergic receptor0202
Alpha-2C adrenergic receptor0202
Disintegrin and metalloproteinase domain-containing protein 171001
Chain A, Carbonic anhydrase 10101
Carbonic anhydrase 0001
Carbonic anhydrase 0101
Carbonic anhydrase 0101
Carbonic anhydrase 0101
Carbonic anhydrase0101
Carbonic anhydrase0101
Prolyl endopeptidase0101
Carbonic anhydrase-related protein 110001
Sodium channel protein type 2 subunit alpha0101
Cytochrome P450 3A40202
Polyunsaturated fatty acid 5-lipoxygenase0101
Arachidonate 5-lipoxygenase-activating protein0101
Carbonic anhydrase 5A, mitochondrial0101
Carbonic anhydrase 20101
Delta-type opioid receptor0202
Delta-type opioid receptor0101
Mu-type opioid receptor0202
Carbonic anhydrase0101
Carbonic anhydrase0101
D(2) dopamine receptor0202
Carbonic anhydrase 0101
Mu-type opioid receptor0101
Beta-carbonic anhydrase 10101
Carbonic anhydrase 20101
Glutamate receptor ionotropic, NMDA 2B0101
Neuronal acetylcholine receptor subunit alpha-70101
Carbonic anhydrase, alpha family 0101
Carbonic anhydrase 0101
Carbonic anhydrase0101
Carbonic anhydrase0101
Carbonic anhydrase 0101
Delta carbonic anhydrase0101
Carbonic anhydrase 0101
Carbonic anhydrase 130101
Carbonic anhydrase 150101
hypoxia-inducible factor 1 alpha subunit1001
Sodium-dependent noradrenaline transporter 0101
huntingtin isoform 21001
5-hydroxytryptamine receptor 40202
Glycoprotein0101
Muscarinic acetylcholine receptor M20011
ATP-dependent translocase ABCB10101
5-hydroxytryptamine receptor 1A0202
ATP-dependent translocase ABCB10102
Catechol O-methyltransferase0101
Potassium voltage-gated channel subfamily A member 30101
Histamine H2 receptor0202
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0202
5-hydroxytryptamine receptor 1B0202
Multidrug resistance-associated protein 1 0214
D(3) dopamine receptor0202
Kappa-type opioid receptor0101
5-hydroxytryptamine receptor 2B0202
5-hydroxytryptamine receptor 70101
Potassium voltage-gated channel subfamily H member 20202
Sodium channel protein type 5 subunit alpha0101
Chloroquine resistance transporter0101
Hsf1 protein0011
thioredoxin glutathione reductase1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
Phosphodiesterase 0101
D(1A) dopamine receptor1001
survival motor neuron protein isoform d1001
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A0202
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0202
cGMP-inhibited 3',5'-cyclic phosphodiesterase B0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0101
cGMP-specific 3',5'-cyclic phosphodiesterase0101
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]