Theca Cell Tumor

A gonadal stromal neoplasm composed only of THECA CELLS, occurring mostly in the postmenopausal OVARY. It is filled with lipid-containing spindle cells and produces ESTROGENS that can lead to ENDOMETRIAL HYPERPLASIA; UTERINE HEMORRHAGE; or other malignancies in postmenopausal women and sexual precocity in girls. When tumors containing theca cells also contain FIBROBLASTS, they are identified as thecoma-fibroma tumors with less active hormone production.

Synonym
Thecoma
Theca Cell Tumor

Excerpt	Reference
"Ovarian thecoma is a relatively rare tumor which occurs before and after menopause."	( Mandai, H; Matsuoka, T; Nakagawa, S; Okada, I; Takemura, T; Takemura, Y; Takenobu, T, 2004)
"Fibrothecomas are the most common solid ovarian tumors and may undergo torsion."	( Chen, CY; Mak, CW; Tzeng, WS, 2009)
"Thecoma is a rare ovarian tumor, presenting usually in postmenopausal women as unilateral, benign, solid lesion."	( Czyzyk, A; Genazzani, AR; Katulski, K; Meczekalski, B; Moszynski, R; Podfigurna-Stopa, A; Sajdak, S, 2016)
"Ovarian thecoma is a benign and rare neoplasm that accounts for 0."	( He, Q; Zhang, L; Zhang, R; Zhou, T, 2019)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	116 (67.44)	23.3326
1990's	18 (10.47)	12.5806
2000's	21 (12.21)	18.1394
2010's	14 (8.14)	28.8240
2020's	3 (1.74)	9.53

Drug	Relationship Strength	Studies	Trials
3-methylcholanthrene	low	3	0
diatrizoic acid	low	1	0
carbamazepine	low	1	0
iohexol	low	1	0
iopromide	low	1	0
2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one	low	1	0
mitotane	low	1	0
procarbazine	medium	1	1
thiotepa	low	3	0
estriol	low	3	0
thyroxine	low	2	0
estrone	low	6	0
androsterone	low	2	0
etiocholanolone	low	1	0
dehydroepiandrosterone	low	4	0
ethinyl estradiol	low	1	0
9,10-dimethyl-1,2-benzanthracene	low	1	0
androstenedione	low	9	0
desoxycorticosterone	low	2	0
colchicine	low	1	0
norethindrone	low	2	0
mestranol	low	1	0
pregnenolone	low	3	0
chlormadinone acetate	low	1	0
reticulin	low	1	0
dihydrotestosterone	low	3	0
technetium	low	1	0
gadolinium	low	1	0
bromocriptine	low	1	0
phenyl acetate	low	2	0
algestone acetophenide	low	1	0
nitrosobis(2-oxopropyl)amine	low	1	0
colforsin	low	1	0
trenbolone acetate	low	2	0
fluorodeoxyglucose f18	low	2	0
17-alpha-hydroxypregnenolone	low	1	0
pregnanetriol	low	2	0
biotin	low	1	0
glycogen	low	1	0
oxytocin	low	1	0
diethylstilbestrol	low	1	0
dactinomycin	low	1	0
melphalan	low	1	0
bromochloroacetic acid	low	5	0
leuprolide	low	3	0
tamoxifen	low	1	0
toremifene	low	1	0
2-fluoro-2-deoxyglucose-6-phosphate	low	1	0
17-ketosteroids	low	17	0
lutein	low	5	0
radium	low	2	0
pregnanediol	low	2	0
gadolinium dtpa	low	1	0
altrenogest	low	2	0
11 beta-hydroxyandrosterone	low	1	0
non-ovlon	low	1	0
19-iodocholesterol	low	1	0
cetrorelix	low	1	0
transforming growth factor beta	low	1	0
rome	low	1	0
hyaluronoglucosaminidase	low	1	0
adrenomedullin	low	1	0
technetium tc 99m medronate	low	1	0
metallothionein	low	1	0

Protein Targets (548)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, Cruzipain	5	0	0	5
IDH1	8	0	0	8
DNA polymerase iota isoform a (long)	5	0	0	5
geminin	22	0	0	22
Sex hormone-binding globulin	0	1	12	13
Chain A, Proto-oncogene serine/threonine-protein kinase Pim-1	0	1	0	1
Chain A, Proto-oncogene serine/threonine-protein kinase Pim-1	0	1	0	1
Chain A, HADH2 protein	7	0	0	7
Chain B, HADH2 protein	7	0	0	7
Chain A, 2-oxoglutarate Oxygenase	2	0	0	2
Chain A, Methyltransferase Wbdd	0	1	0	1
thioredoxin reductase	7	0	0	7
15-lipoxygenase, partial	5	0	0	5
ATAD5 protein, partial	8	0	0	8
NFKB1 protein, partial	2	0	0	2
TDP1 protein	29	0	0	29
Thrombopoietin	2	0	0	2
aldehyde dehydrogenase 1 family, member A1	10	0	0	10
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	7	0	0	7
thyroid stimulating hormone receptor	7	0	0	7
regulator of G-protein signaling 4	6	0	0	6
EWS/FLI fusion protein	6	0	0	6
67.9K protein	5	0	0	5
Parkin	1	0	0	1
euchromatic histone-lysine N-methyltransferase 2	16	0	0	16
cytochrome P450 2D6 isoform 1	3	0	0	3
cellular tumor antigen p53 isoform a	4	0	0	4
cytochrome P450 2C19 precursor	3	0	0	3
cytochrome P450 2C9 precursor	2	0	0	2
chromobox protein homolog 1	12	0	0	12
flap endonuclease 1	2	0	0	2
serine/threonine-protein kinase mTOR isoform 1	3	0	0	3
survival motor neuron protein isoform d	8	0	0	8
cytochrome P450 3A4 isoform 1	12	0	0	12
M-phase phosphoprotein 8	3	0	0	3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	0	1	0	2
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	0	1	0	1
Serine/threonine-protein kinase PLK4	0	1	0	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	12	1	0	13
Polyunsaturated fatty acid lipoxygenase ALOX15B	3	0	0	3
Bromodomain-containing protein 4	0	1	0	1
5-hydroxytryptamine receptor 4	0	8	0	8
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Integrin beta-3	3	0	0	3
Cytochrome P450 1A2	0	2	0	2
Integrin alpha-IIb	3	0	0	3
Neuronal acetylcholine receptor subunit alpha-4	1	1	0	2
Serine/threonine-protein kinase pim-1	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	1	1	0	2
Gamma-aminobutyric acid receptor subunit beta-1	12	1	0	13
Gamma-aminobutyric acid receptor subunit delta	12	1	0	13
Gamma-aminobutyric acid receptor subunit gamma-2	12	1	0	13
Casein kinase II subunit alpha'	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	12	1	0	13
Gamma-aminobutyric acid receptor subunit alpha-3	12	1	0	13
Gamma-aminobutyric acid receptor subunit gamma-1	12	1	0	13
Gamma-aminobutyric acid receptor subunit alpha-2	12	1	0	13
Proteinase-activated receptor 1	0	0	0	1
Bromodomain-containing protein 2	0	1	0	1
Phosphatidylinositol 3-kinase regulatory subunit alpha	0	1	0	2
5-hydroxytryptamine receptor 2A	0	8	1	9
5-hydroxytryptamine receptor 2C	0	8	1	9
Gamma-aminobutyric acid receptor subunit alpha-4	12	1	0	13
Gamma-aminobutyric acid receptor subunit gamma-3	12	1	0	13
Gamma-aminobutyric acid receptor subunit alpha-6	12	1	0	13
Sodium-dependent serotonin transporter	0	2	0	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
5-hydroxytryptamine receptor 2B	0	12	0	12
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	2	0	3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0	1	0	3
Serine/threonine-protein kinase mTOR	0	1	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Histamine H2 receptor	4	0	0	4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	2
Glycogen synthase kinase-3 beta	0	1	0	1
D(1A) dopamine receptor	2	0	0	2
Serine/threonine-protein kinase PLK1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	12	1	0	13
Gamma-aminobutyric acid receptor subunit beta-3	12	1	0	13
Gamma-aminobutyric acid receptor subunit beta-2	12	1	0	13
Casein kinase II subunit beta	0	1	0	1
Casein kinase II subunit alpha	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	2	0	2
Mu-type opioid receptor	0	1	1	2
Serine-protein kinase ATM	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
Bromodomain-containing protein 3	0	1	0	1
Serine/threonine-protein kinase pim-3	0	1	0	1
Phosphoinositide 3-kinase regulatory subunit 5	0	1	0	1
GABA theta subunit	12	1	0	13
Gamma-aminobutyric acid receptor subunit epsilon	12	1	0	13
Serine/threonine-protein kinase PLK3	0	2	0	2
Serine/threonine-protein kinase PLK2	0	1	0	1
ATP-dependent phosphofructokinase	5	0	0	5
Luciferase	6	0	0	6
pregnane X receptor	6	0	0	6
phosphopantetheinyl transferase	5	0	0	5
RAR-related orphan receptor gamma	27	0	0	27
SMAD family member 2	9	0	0	9
SMAD family member 3	9	0	0	9
Microtubule-associated protein tau	7	0	0	7
AR protein	28	0	0	28
caspase 7, apoptosis-related cysteine protease	5	0	0	5
nuclear receptor subfamily 1, group I, member 3	21	0	0	21
retinoic acid nuclear receptor alpha variant 1	24	0	0	24
estrogen-related nuclear receptor alpha	25	0	0	25
farnesoid X nuclear receptor	17	0	0	17
pregnane X nuclear receptor	26	0	0	26
estrogen nuclear receptor alpha	28	0	0	28
peroxisome proliferator-activated receptor delta	18	0	0	18
peroxisome proliferator activated receptor gamma	21	0	0	21
caspase-3	5	0	0	5
aryl hydrocarbon receptor	9	0	0	9
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	20	0	0	20
activating transcription factor 6	11	0	0	11
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	12	0	0	12
thyroid hormone receptor beta isoform a	10	0	0	10
heat shock protein beta-1	8	0	0	8
nuclear factor erythroid 2-related factor 2 isoform 1	22	0	0	22
Voltage-dependent calcium channel gamma-2 subunit	16	0	0	16
Cellular tumor antigen p53	19	0	0	19
Tyrosine-protein kinase Lck	0	2	0	2
Tyrosine-protein kinase Fyn	0	3	0	3
Aldo-keto reductase family 1 member B1	0	12	0	12
Adenosine receptor A3	0	10	0	10
Alpha-1B adrenergic receptor	0	10	0	10
Glutamate receptor 2	16	0	0	16
Acetylcholinesterase	0	2	0	2
Sodium-dependent noradrenaline transporter	0	12	0	12
Aryl hydrocarbon receptor	0	0	1	1
Alpha-1A adrenergic receptor	0	10	0	10
Chain A, Beta-lactamase	6	0	0	6
Chain A, JmjC domain-containing histone demethylation protein 3A	5	0	0	5
acid sphingomyelinase	1	0	0	1
hypoxia-inducible factor 1 alpha subunit	11	0	0	11
GLI family zinc finger 3	21	0	0	21
apical membrane antigen 1, AMA1	4	0	0	4
estrogen receptor 2 (ER beta)	19	0	0	19
progesterone receptor	21	0	0	21
glucocorticoid receptor [Homo sapiens]	25	0	0	25
retinoid X nuclear receptor alpha	20	0	0	20
glucocerebrosidase	4	0	0	4
bromodomain adjacent to zinc finger domain 2B	4	0	0	4
P53	1	0	0	1
vitamin D (1,25- dihydroxyvitamin D3) receptor	18	0	0	18
thyroid stimulating hormone receptor	13	0	0	13
v-jun sarcoma virus 17 oncogene homolog (avian)	14	0	0	14
Caspase-7	6	0	0	6
serine-protein kinase ATM isoform a	2	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	2	0	0	2
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	4	0	0	4
caspase-3	6	0	0	6
thyroid hormone receptor beta isoform 2	23	0	0	23
mitogen-activated protein kinase 1	7	0	0	7
nuclear factor NF-kappa-B p105 subunit isoform 1	3	0	0	3
ras-related protein Rab-9A	3	0	0	3
urokinase-type plasminogen activator precursor	5	0	0	5
plasminogen precursor	5	0	0	5
urokinase plasminogen activator surface receptor precursor	5	0	0	5
nuclear receptor ROR-gamma isoform 1	7	0	0	7
lethal(3)malignant brain tumor-like protein 1 isoform I	2	0	0	2
caspase-1 isoform alpha precursor	3	0	0	3
Nuclear receptor ROR-gamma	10	0	0	10
Caspase-7	2	0	0	2
ATPase family AAA domain-containing protein 5	7	0	0	7
Ataxin-2	7	0	0	7
Chain A, Ferritin light chain	6	0	0	6
acetylcholinesterase	9	0	0	9
cytochrome P450 family 3 subfamily A polypeptide 4	18	0	0	18
G	13	0	0	13
cytochrome P450 2D6	7	0	0	7
Histone H2A.x	11	0	0	11
vitamin D3 receptor isoform VDRA	9	0	0	9
Interferon beta	18	0	0	18
HLA class I histocompatibility antigen, B alpha chain	13	0	0	13
Spike glycoprotein	8	0	2	10
Inositol hexakisphosphate kinase 1	13	0	0	13
cytochrome P450 2C9, partial	13	0	0	13
interleukin 8	6	0	0	6
Smad3	5	0	0	5
nonstructural protein 1	2	0	0	2
Bloom syndrome protein isoform 1	4	0	0	4
peripheral myelin protein 22 isoform 1	2	0	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	5	0	0	5
importin subunit beta-1 isoform 1	4	0	0	4
snurportin-1	4	0	0	4
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
peripheral myelin protein 22	12	0	0	12
muscleblind-like protein 1 isoform 1	2	0	0	2
lamin isoform A-delta10	12	0	0	12
neuropeptide S receptor isoform A	4	0	0	4
Beta-glucuronidase	0	2	0	2
Cholinesterase	0	1	0	1
Corticosteroid-binding globulin	0	9	0	9
Aromatase	0	4	0	7
Androgen receptor	0	20	1	21
Gastrin/cholecystokinin type B receptor	0	0	0	1
Testosterone 17-beta-dehydrogenase 3	0	3	0	3
Alpha-synuclein	3	4	0	7
TAR DNA-binding protein 43	8	0	0	8
Chain A, retinol dehydratase	0	1	0	1
histone acetyltransferase KAT2A isoform 1	2	0	0	2
Glucose-6-phosphate 1-dehydrogenase	0	4	0	4
Solute carrier organic anion transporter family member 1A1	0	3	0	3
G-protein coupled bile acid receptor 1	0	0	4	4
Chain A, Avidin	0	0	1	1
Chain A, Protein (streptavidin)	0	0	1	1
Chain B, Protein (streptavidin)	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin Complex With Biotin	0	0	1	1
Chain D, Circularly Permuted Core-streptavidin E51/a46	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Avidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
nonstructural protein 1	0	1	0	1
green fluorescent protein, partial	0	1	0	1
insulin-degrading enzyme isoform 1	0	0	1	1
Streptavidin	0	0	1	1
Receptor-type tyrosine-protein phosphatase beta	0	0	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	6	0	0	6
Genome polyprotein	0	1	1	2
dopamine D1 receptor	1	0	0	1
Fumarate hydratase	6	0	0	6
GLS protein	4	0	0	4
polyprotein	6	0	0	6
D(1A) dopamine receptor	2	0	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
ATP-dependent translocase ABCB1	0	2	0	2
ATP-dependent translocase ABCB1	0	5	1	8
Beta-1 adrenergic receptor	0	6	0	6
Cytochrome P450 3A4	0	4	0	4
5-hydroxytryptamine receptor 1A	0	2	0	2
Alpha-2A adrenergic receptor	0	8	0	8
D(2) dopamine receptor	0	6	1	7
Alpha-2B adrenergic receptor	0	6	0	6
Alpha-2C adrenergic receptor	0	4	0	4
D	0	1	0	1
D(3) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 1A	0	4	0	4
Alpha-2B adrenergic receptor	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	2
D(1A) dopamine receptor	0	6	0	6
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	6	0	6
D(1B) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 1B	0	4	0	4
D(4) dopamine receptor	0	1	0	1
D(3) dopamine receptor	0	6	0	6
5-hydroxytryptamine receptor 6	0	9	0	9
D(2) dopamine receptor	0	1	1	2
USP1 protein, partial	12	0	0	12
nuclear factor erythroid 2-related factor 2 isoform 2	5	0	0	5
Vpr	2	0	0	2
ATP-binding cassette sub-family C member 3	0	8	0	8
Multidrug resistance-associated protein 4	0	8	0	8
Bile salt export pump	0	1	0	1
Bile salt export pump	0	13	0	13
Albumin	0	0	1	1
Major prion protein	0	0	1	1
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	2	0	2
Cytochrome P450 2C9	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	0	0	2
Cytochrome P450 2B6	0	3	1	4
Sodium channel protein type 4 subunit alpha	0	1	0	2
Cytochrome P450 2J2	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	4	0	4
Sodium channel protein type 9 subunit alpha	0	2	0	2
Frizzled-8	0	0	1	1
Canalicular multispecific organic anion transporter 1	0	8	0	8
P2X purinoceptor 4	0	1	0	1
Gonadotropin-releasing hormone receptor	0	2	1	3
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
thioredoxin glutathione reductase	2	0	0	2
nuclear receptor subfamily 1, group I, member 2	4	0	0	4
transcriptional regulator ERG isoform 3	3	0	0	3
Glucocorticoid receptor	0	11	0	12
Glycine receptor subunit alpha-1	0	10	0	10
Glycine receptor subunit beta	0	10	0	10
Glycine receptor subunit alpha-2	0	10	0	10
Glycine receptor subunit alpha-3	0	10	0	10
Cytochrome P450 2C19	0	1	0	1
endonuclease IV	2	0	0	2
PAX8	0	0	0	1
PPM1D protein	5	0	0	5
nuclear receptor subfamily 0 group B member 1	0	2	0	2
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
steroidogenic factor 1	0	2	0	2
muscarinic acetylcholine receptor M1	2	0	0	2
lethal factor (plasmid)	4	0	0	4
Solute carrier family 22 member 3	0	1	0	1
Tubulin alpha-1A chain	0	2	1	3
Tubulin beta chain	0	2	1	3
Plasma kallikrein	0	1	0	2
Tubulin beta-4A chain	0	2	2	5
Tubulin beta chain	0	2	2	5
Tubulin alpha-3C chain	0	2	2	5
Tubulin alpha-1B chain	0	2	2	5
Tubulin alpha-4A chain	0	2	2	5
Tubulin beta-4B chain	0	2	2	5
Vesicular acetylcholine transporter	0	1	0	1
Tubulin beta-3 chain	0	2	2	5
Tubulin beta-2A chain	0	2	2	5
Tubulin polymerization-promoting protein	0	0	1	1
Tubulin beta-8 chain	0	2	2	5
Tubulin beta-2B chain	0	2	0	2
Tubulin alpha-3E chain	0	2	2	5
Tubulin alpha-1A chain	0	2	2	5
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
CREB-binding protein	1	0	0	1
Tubulin alpha-1C chain	0	2	2	5
Tubulin beta-6 chain	0	2	2	5
Tubulin beta-2B chain	0	2	2	5
Tubulin beta-1 chain	0	2	2	5
glp-1 receptor, partial	6	0	0	6
histone-lysine N-methyltransferase 2A isoform 2 precursor	3	0	0	3
relaxin receptor 1 isoform 1	1	0	0	1
relaxin receptor 2 isoform 1	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	1	2	3
Rap guanine nucleotide exchange factor 3	3	0	0	3
Solute carrier family 2, facilitated glucose transporter member 1	0	0	1	1
Adenylate cyclase type 2	0	0	1	1
Adenylate cyclase type 8	0	0	1	1
Adenylate cyclase type 1	0	1	1	2
Relaxin receptor 1	0	0	1	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
RAD51	0	1	0	1
huntingtin isoform 2	1	0	0	1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1	0	1	0	1
Growth factor receptor-bound protein 2	0	1	0	1
Pantothenate synthetase	0	1	0	1
Discoidin domain-containing receptor 2	0	1	0	1
Growth factor receptor-bound protein 2	0	1	0	1
Reverse transcriptase/RNaseH	0	1	0	1
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase	0	0	1	1
Beta-glucuronidase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
NPC1-like intracellular cholesterol transporter 1	0	0	1	1
GALC protein	3	0	0	3
Solute carrier family 22 member 3	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
serine/threonine-protein kinase PLK1	3	0	0	3
high affinity choline transporter 1 isoform a	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
Carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Estrogen receptor	0	14	4	20
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Muscarinic acetylcholine receptor M1	0	4	0	4
Polyunsaturated fatty acid lipoxygenase ALOX15	0	4	0	4
Muscarinic acetylcholine receptor M3	0	4	0	4
Substance-K receptor	0	4	0	4
Prostaglandin G/H synthase 1	0	2	0	2
Thromboxane-A synthase	0	2	0	2
Adenosine receptor A2a	0	6	0	6
Adenosine receptor A1	0	4	0	4
Sodium-dependent serotonin transporter	0	16	0	16
Mu-type opioid receptor	0	6	0	6
Vasopressin V1a receptor	0	4	1	5
Delta-type opioid receptor	0	4	0	4
Kappa-type opioid receptor	0	6	0	6
Estrogen-related receptor gamma	0	1	1	2
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Inositol monophosphatase 1	2	0	0	2
Sodium-dependent dopamine transporter	0	8	0	8
Aldehyde oxidase	0	2	0	2
UDP-glucose 4-epimerase	0	1	0	1
Mitogen-activated protein kinase 14	0	1	0	1
Estrogen receptor beta	0	6	4	11
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	2
Cysteinyl leukotriene receptor 1	0	2	0	2
Chain A, Sex Hormone-Binding Globulin	0	0	1	1
thyrotropin-releasing hormone receptor	2	0	0	2
Progesterone receptor	0	1	0	1
Progesterone receptor	0	4	3	7
Glucocorticoid receptor	0	1	0	1
Mineralocorticoid receptor	0	1	0	1
Sex hormone-binding globulin	0	1	0	1
Androgen receptor	0	2	2	6
Androgen receptor	0	1	1	2
Mineralocorticoid receptor	0	1	0	1
Angiotensin-converting enzyme	0	0	1	1
Cannabinoid receptor 2	0	1	0	1
Muscarinic acetylcholine receptor	0	1	0	1
Neuropeptide FF receptor 2	0	0	0	1
ALK tyrosine kinase receptor	0	1	0	1
Lanosterol 14-alpha demethylase	0	0	1	1
Olfactory receptor 51E2	0	0	1	1
UDP-glucuronosyltransferase 1A10	0	0	0	1
arylsulfatase A	2	0	0	2
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
Steryl-sulfatase	0	1	0	1
17-beta-hydroxysteroid dehydrogenase type 1	0	2	0	3
Mu-type opioid receptor	0	0	1	1
Cytochrome P450 1B1	0	1	0	1
Ghrelin O-acyltransferase	0	1	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
Solute carrier family 22 member 2	0	1	0	1
Cytochrome P450 2B1	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	2	0	3
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Sulfotransferase 1A1	0	2	1	4
Nuclear receptor subfamily 1 group I member 3	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Multidrug and toxin extrusion protein 1	0	1	0	1
Chain H, IGG1-KAPPA DB3 FAB (HEAVY CHAIN)	0	1	0	1
Chain L, IGG1-KAPPA DB3 FAB (LIGHT CHAIN)	0	1	0	1
Chain H, IGG1-KAPPA DB3 FAB (HEAVY CHAIN)	0	1	0	1
Chain L, IGG1-KAPPA DB3 FAB (LIGHT CHAIN)	0	1	0	1
Chain H, IGG1-KAPPA DB3 FAB (HEAVY CHAIN)	0	1	0	1
Chain L, IGG1-KAPPA DB3 FAB (LIGHT CHAIN)	0	1	0	1
ClpP	1	0	0	1
Guanine nucleotide-binding protein G	2	0	0	2
Gonadotropin-releasing hormone receptor	0	2	0	2
retinoic acid receptor alpha isoform 1	0	1	0	1
retinoic acid receptor RXR-alpha isoform a	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	3	0	0	3
Large neutral amino acids transporter small subunit 1	0	1	0	1
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 7	0	0	0	1
Cannabinoid receptor 1	0	2	0	2
Peroxisome proliferator-activated receptor alpha	1	0	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Estrogen receptor	0	0	2	3
Estrogen receptor beta	0	0	2	3
Vasopressin V2 receptor	0	1	1	2
Oxytocin receptor	0	2	2	4
Vasopressin V1a receptor	0	1	0	1
Vasopressin V1b receptor	0	1	1	2
Vasopressin V1b receptor	0	1	0	1
Oxytocin receptor	0	1	0	1
Oxytocin receptor	0	0	1	1
Vasopressin V2 receptor	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
Sphingosine kinase 2	0	2	0	2
Sphingosine kinase 1	0	1	0	1
Chain A, CES1 protein	0	1	0	1
DNA polymerase III, partial	1	0	0	1
Spike glycoprotein	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
interferon gamma precursor	0	0	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
streptokinase A precursor	0	0	1	1
Transmembrane protease serine 2	0	0	2	2
Serine/threonine-protein kinase D3	0	1	0	1
Epidermal growth factor receptor	0	1	0	1
Lysosomal acid glucosylceramidase	0	0	1	1
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C alpha type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Procathepsin L	0	0	2	2
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Replicase polyprotein 1a	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
Replicase polyprotein 1ab	0	1	2	3
Steroid hormone receptor ERR1	0	1	0	1
Transcriptional activator protein LuxR	0	1	0	1
Angiotensin-converting enzyme	0	2	0	2
Beta-3 adrenergic receptor	0	2	0	2
Protein kinase C alpha type	0	1	0	1
D(4) dopamine receptor	0	2	0	2
UDP-glucuronosyltransferase 1A4	0	0	0	1
Protein kinase C eta type	0	1	0	1
Histamine H2 receptor	0	2	0	2
Substance-P receptor	0	2	0	2
B2 bradykinin receptor	0	2	0	2
Melanocortin receptor 4	0	2	0	2
C-8 sterol isomerase	0	1	0	1
Melanocortin receptor 5	0	2	0	2
Protein kinase C iota type	0	1	0	1
Melanocortin receptor 3	0	2	0	2
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Phospholipase D1	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C theta type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Protein kinase C delta type	0	1	0	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Platelet-activating factor acetylhydrolase	0	1	0	1
Phospholipase D1	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	2	1	3
Serine/threonine-protein kinase D1	0	1	0	1
Protein kinase C eta type	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	2	0	2
Emopamil-binding protein-like	0	1	0	1
Angiotensin-converting enzyme 2	0	0	2	2
7-dehydrocholesterol reductase	0	1	1	2
Protein kinase C theta type	0	1	0	1
hemoglobin subunit beta	1	0	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
DNA polymerase eta isoform 1	1	0	0	1
DNA polymerase kappa isoform 1	1	0	0	1
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Transthyretin	0	1	0	2
Thyroid hormone receptor alpha	0	0	1	1
Thyroid hormone receptor beta	0	0	1	1
Proliferating cell nuclear antigen	0	1	0	1
Retinoic acid receptor RXR-alpha	0	0	2	2
Peroxisome proliferator-activated receptor gamma	0	0	2	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Solute carrier organic anion transporter family member 1B1	0	0	0	1
Envelope glycoprotein	0	0	2	2
Polymerase acidic protein	0	0	1	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(2)

Research Excerpts

Overview

Research

Studies (172)

Protein Targets (548)

Theca Cell Tumor

Synonyms(2)

Research Excerpts

Overview

Research

Studies (172)

Drugs Studied (82)

Protein Targets (548)