Compounds > acetyl triethyl citrate
Page last updated: 2024-11-05

acetyl triethyl citrate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Acetyl triethyl citrate (ATEC) is a synthetic compound derived from citric acid. It is commonly used as a plasticizer, solvent, and fragrance ingredient. ATEC is synthesized through a reaction between citric acid and ethanol, followed by acetylation. ATEC is a colorless, viscous liquid with a mild citrus odor. It is considered a safe and effective plasticizer, imparting flexibility and durability to polymers. It is also used as a solvent in various applications, including inks, paints, and coatings. ATEC has been studied for its potential applications in various fields, including medicine, agriculture, and cosmetics. It exhibits potential antimicrobial properties and has been investigated for its role in promoting wound healing. Moreover, ATEC's biocompatibility and non-toxicity make it a promising candidate for use in drug delivery systems and biodegradable materials.'

acetyl triethyl citrate: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID6504
CHEMBL ID2105928
SCHEMBL ID42702
MeSH IDM0449295

Synonyms (68)

Synonym
LS-14339
citroflex a 2
triethyl acetylcitrate
triethyl citrate acetate
nsc-3887
citric acid, acetyl triethyl ester
nsc3887
77-89-4
acetyl triethyl citrate
tricarballylic acid, .beta.-acetoxytributyl ester
citroflex a-2
1,3-propanetricarboxylic acid, 2-(acetyloxy)-, triethyl ester
triethyl 2-acetoxy-1,3-propanetricarboxylate
wln: 2ov1xvo2&ov1&1vo2
atec
o-acetylcitric acid triethyl ester
1,2,3-propanetricarboxylic acid, 2-(acetyloxy)-, triethyl ester
2-(acetyloxy)-1,2,3-propanetricarboxylic acid, triethyl ester
citric acid, triethyl ester, acetate
brn 1804947
triethyl o-acetylcitrate
triethyl 2-acetoxy-1,2,3-propanetricarboxylate
nsc 3887
triethylester kyseliny acetylcitronove [czech]
tricarballylic acid, beta-acetoxytributyl ester
triethyl citrate, acetate
ai3-03574
einecs 201-066-5
triethyl 2-acetylcitrate, 99%
A0086
triethyl 2-acetyloxypropane-1,2,3-tricarboxylate
triethyl 2-acetylcitrate
FT-0659670
triethyl acetyl citrate
acetyltriethyl citrate [nf]
acetyltriethyl citrate
triethylester kyseliny acetylcitronove
1,2,3-propanetricarboxylic acid, 2-(acetyloxy)-, 1,2,3-triethyl ester
unii-5wbr36t90e
3-03-00-01105 (beilstein handbook reference)
5wbr36t90e ,
cas-77-89-4
NCGC00256002-01
tox21_301483
dtxsid5044576 ,
dtxcid3024576
CHEMBL2105928
FT-0631334
acetyltriethyl citrate [usp-rs]
acetyl triethyl citrate [inci]
acetyltriethyl citrate [mart.]
triethyl 2-acetoxypropane-1,2,3-tricarboxylate
citric acid, o-acetyltriethyl ester
SCHEMBL42702
AKOS024464792
uniplex 82
WEAPVABOECTMGR-UHFFFAOYSA-N
1,2,3-propanetricarboxylic acid, 2-acetoxy-, triethyl ester
triethyl 2-(acetyloxy)-1,2,3-propanetricarboxylate #
mfcd00049378
SR-01000944782-1
sr-01000944782
acetyltriethyl citrate, united states pharmacopeia (usp) reference standard
triethyl 2-acetylcitrate, pharmaceutical secondary standard; certified reference material
E75747
ethchlorvynolciv(0.7ml)
Q27262956
CS-W009904

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" Dermal application was not toxic in rabbits."( Final report on the safety assessment of acetyl triethyl citrate, acetyl tributyl citrate, acetyl trihexyl citrate, and acetyl trioctyl citrate.
Johnson, W, 2002)		0.58
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (3)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency51.52020.001022.650876.6163AID1224838; AID1224839
pregnane X nuclear receptorHomo sapiens (human)Potency24.33650.005428.02631,258.9301AID1346982
estrogen nuclear receptor alphaHomo sapiens (human)Potency12.30280.000229.305416,493.5996AID743075
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (12.50)18.7374
1990's0 (0.00)18.2507
2000's2 (25.00)29.6817
2010's4 (50.00)24.3611
2020's1 (12.50)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 32.47

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index32.47 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.45 (4.65)
Search Engine Demand Index37.30 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (32.47)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (12.50%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (87.50%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
citric acid, anhydrous
Citric Acid: A key intermediate in metabolism. It is an acid compound found in citrus fruits. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium chelating ability.. citric acid : A tricarboxylic acid that is propane-1,2,3-tricarboxylic acid bearing a hydroxy substituent at position 2. It is an important metabolite in the pathway of all aerobic organisms.		1.9310tricarboxylic acidantimicrobial agent;
chelator;
food acidity regulator;
fundamental metabolite
lactic acid
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed). 2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.		7.02102-hydroxy monocarboxylic acidalgal metabolite;
Daphnia magna metabolite
benzyl benzoate
benzyl benzoate: structure; acarosan, a moist powder composed of wetted cellulose and benzyl benzoate, is used on carpets as an acaricide. benzyl benzoate : A benzoate ester obtained by the formal condensation of benzoic acid with benzyl alcohol. It has been isolated from the plant species of the genus Polyalthia.		7.3110benzoate ester;
benzyl ester		acaricide;
plant metabolite;
scabicide
iohexol
Iohexol: An effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality.. iohexol : A benzenedicarboxamide compound having N-(2,3-dihydroxypropyl)carbamoyl groups at the 1- and 3-positions, iodo substituents at the 2-, 4- and 6-positions and an N-(2,3-dihydroxypropyl)acetamido group at the 5-position.		2.9810benzenedicarboxamide;
organoiodine compound		environmental contaminant;
radioopaque medium;
xenobiotic
iopromide
iopromide: structure given in first source. iopromide : A dicarboxylic acid diamide that consists of N-methylisophthalamide bearing three iodo substituents at positions 2, 4 and 6, a methoxyacetyl substituent at position 5 and two 2,3-dihydroxypropyl groups attached to the amide nitrogens. A water soluble x-ray contrast agent for intravascular administration.		2.9810dicarboxylic acid diamide;
organoiodine compound		environmental contaminant;
nephrotoxic agent;
radioopaque medium;
xenobiotic
triacetin
Triacetin: A triglyceride that is used as an antifungal agent.. triacetin : A triglyceride obtained by acetylation of the three hydroxy groups of glycerol. It has fungistatic properties (based on release of acetic acid) and has been used in the topical treatment of minor dermatophyte infections.		2.2110triglycerideadjuvant;
antifungal drug;
food additive carrier;
food emulsifier;
food humectant;
fuel additive;
plant metabolite;
solvent
2-acetyltributylcitrate
[no description available]		3.7730organooxygen compound
ethyl citrate
ethyl citrate: structure		7.6830carbonyl compound
tributyl citrate
[no description available]		6.9310carbonyl compound
maleic anhydride
Maleic Anhydrides: Used in copolymerization reactions, in the Diels-Alder(diene)synthesis, in the preparation of resins, pharmaceuticals and agricultural chemicals. It is a powerful irritant and causes burns.. maleic anhydride : A cyclic dicarboxylic anhydride that is the cyclic anhydride of maleic acid.		7.0210cyclic dicarboxylic anhydride;
furans		allergen
diethylhexyl phthalate
Diethylhexyl Phthalate: An ester of phthalic acid. It appears as a light-colored, odorless liquid and is used as a plasticizer for many resins and elastomers.. bis(2-ethylhexyl) phthalate : A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.		2.2110diester;
phthalate ester		androstane receptor agonist;
apoptosis inhibitor;
plasticiser
paclitaxel
Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).		2.9810taxane diterpenoid;
tetracyclic diterpenoid		antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent
butyryl-n-trihexylcitrate
[no description available]		2.9810
cardiovascular agents
Cardiovascular Agents: Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume.		2.9810
ConditionIndicatedRelationship StrengthStudiesTrials