Page last updated: 2024-09-27

Nephrogenic Systemic Fibrosis

Synonyms(1)

Synonym
Nephrogenic Systemic Fibrosis

Research Excerpts

Overview

ExcerptReference
"Nephrogenic systemic fibrosis is a disabling progressive condition that is being reported with increased frequency in patients with kidney disease."( Chandran, S; Doeden, K; Fiorentino, D; Jacobs, C; Lafayette, RA; Petersen, J, 2009)
"Nephrogenic systemic fibrosis is a highly debilitating and emotionally depressing disorder."( Becker, S; Kribben, A; Witzke, O, 2009)
"Nephrogenic systemic fibrosis is characterized by skin induration preferentially affecting the extremities."( Barkhausen, J; Daul, AE; Erbel, R; Hillen, U; Kribben, A; Witzke, O, 2009)
"Nephrogenic systemic fibrosis is a progressive, potentially fatal multiorgan system fibrosing disease related to exposure of patients with renal failure to the gadolinium-based contrast agents used in magnetic resonance imaging."( Bernheisel, CR; Schlaudecker, JD, 2009)
"Nephrogenic systemic fibrosis is a sclerodermalike disease in patients with acute or chronic renal insuffiency related to administration of gadolinium-containing contrast agents."( Gambichler, T; Hahn, SA; Höxtermann, S; Kreuter, A; Schieren, G; Tigges, C, 2009)
"Nephrogenic systemic fibrosis is a fibrosing disorder associated with gadolinium (Gd)-based contrast agents dosed during renal insufficiency."( Brown, M; High, WA; Jackson, BP; Lanzirotti, A; Punshon, T; Ranville, JF, 2010)
"Nephrogenic systemic fibrosis is a serious and potentially devastating disorder characterized by progressive thickening and hardening of the skin and other body tissues, and complicated by flexion contractures of the joints."( Grossman, ME; Landman, J; Natalin, RA; Prince, MR; Silvers, D, 2010)
"Nephrogenic systemic fibrosis is a condition with significant and often debilitating cutaneous manifestations."( Abraham, JL; Boyd, AS; Sanyal, S, 2010)
"Nephrogenic systemic fibrosis is primarily a skin disorder associated with renal insufficiency and exposure to gadolinium-containing (GAD+) contrast."( Cupler, EJ; Edgar, E; Gultekin, SH; Watnick, S; Whitham, R; Woltjer, R, 2010)
"Nephrogenic systemic fibrosis is a clinical syndrome occurring in a small subset of patients with end-stage renal disease (ESRD)."( Dame, MK; DaSilva, M; Fligiel, SE; Johnson, KJ; O'Brien Deming, M; Swartz, RD; Varani, J, 2010)
"Nephrogenic systemic fibrosis is a recently recognized disease entity that is potentially debilitating."( Cheong, BY; Muthupillai, R, 2010)
"Nephrogenic systemic fibrosis is a rare fibrosing disorder associated with the use of gadolinium-based contrast agents in patients with renal dysfunction."( Djamali, A; Haemel, AK; Sadowski, EA; Shafer, MM, 2011)
"Nephrogenic systemic fibrosis is a new disease whose incidence has peaked and receded over the past decade."( Hellman, RN, 2011)
"Nephrogenic systemic fibrosis is a fibrosing disorder that affects patients with advanced renal dysfunction and is associated with gadolinium-based contrast media."( Igarashi, A; Kawaguchi, M; Matsumoto, Y; Mitsuhashi, Y; Miyabe, C; Monma, F; Suzuki, T; Tsuboi, R, 2012)
"Nephrogenic systemic fibrosis is a disease affecting the connective tissue of the skin and internal organs in patients with renal failure."( Buus, NH; Elmholdt, TR; Olesen, AB; Ramsing, M, 2013)
"Nephrogenic systemic fibrosis is a progressive, potentially fatal, multiorgan-system fibrosing disease related to exposure of patients with renal failure to gadolinium-based contrast agents used in magnetic resonance imaging."( Kitajima, K; Maeda, T; Sugimura, K; Ueno, Y; Watanabe, S, 2012)
"Nephrogenic Systemic Fibrosis is a rare condition appearing only in patients with severe renal impairment or failure and presents with dermal lesions and involvement of internal organs."( Bauer, WR; Nagel, E; Nordbeck, P; Prince, MR; Reiter, T; Ritter, O; Wanner, C, 2012)
"The pathology of nephrogenic systemic fibrosis is characterized by abnormal tissue repair: fibrosis and ectopic ossification."( Bose, C; Hall, KA; Hiatt, KM; Shah, SV; Swaminathan, S, 2013)
"Nephrogenic systemic fibrosis is a fibrosing disorder associated with exposure to gadolinium-based contrast agents in people with severely compromised renal function."( Abu-Alfa, AK; Belknap, SM; Bull, C; Cowper, SE; Dharnidharka, VR; Edwards, BJ; Godinez-Puig, V; Haryani, A; Laumann, AE; McKoy, JM; Miller, FH; Nardone, B; Raisch, DW; Saddleton, E; West, DP, 2014)
"Nephrogenic systemic fibrosis is a debilitating and painful disorder with an increased stimulation of the connective tissue in the skin and systemic tissues."( Elmholdt, TR; Jørgensen, B; Kvist, S; Marckmann, P; Olesen, AB; Pedersen, M; Skov, L; Thomsen, HS, 2013)
"Nephrogenic systemic fibrosis is a fibrosing disorder that affects patients with impaired renal function and is associated with the administration of gadolinium-based contrast media used in MRI."( Arias, M; Canga, A; de Francisco, AL; Fraga-Rivas, P; Kislikova, M; Martínez-Gálvez, M; Poyatos, C, 2014)
"Nephrogenic systemic fibrosis is associated with gadolinium contrast exposure in patients with reduced kidney function and carries high morbidity and mortality."( Bose, C; Hall, KA; Hiatt, KM; Karaduta, O; Megyesi, JK; Shah, SV; Swaminathan, S, 2015)
"Nephrogenic systemic fibrosis is a rare entity occurred in patients with renal failure."( Abderrahim, E; Ahlem, B; Faten, Z; Soumaya, R; Yoldez, H, 2018)

Context

ExcerptReference
"To date, nephrogenic systemic fibrosis has been observed only in patients with severe renal insufficiency."( Frenzel, T; Hütter, J; Lengsfeld, P; Löwe, A; Pietsch, H; Sieber, MA; Steger-Hartmann, T, 2009)
"Nephrogenic systemic fibrosis has been rarely reported in children."( Abu-Alfa, AK; Belknap, SM; Bull, C; Cowper, SE; Dharnidharka, VR; Edwards, BJ; Godinez-Puig, V; Haryani, A; Laumann, AE; McKoy, JM; Miller, FH; Nardone, B; Raisch, DW; Saddleton, E; West, DP, 2014)
"The prevalence of nephrogenic systemic fibrosis has so far never been determined at a national level."( Elmholdt, TR; Jørgensen, B; Kvist, S; Marckmann, P; Olesen, AB; Pedersen, M; Skov, L; Thomsen, HS, 2013)

Research

Studies (379)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's113 (29.82)18.1394
2010's228 (60.16)28.8240
2020's38 (10.03)9.53
DrugIndicatedRelationship StrengthStudiesTrials
gamma-aminobutyric acid0low10
adenine0low10
quinacrine0low10
iodine0low50
thiosulfates0low50
acetaminophen0low10
acetazolamide0low10
aspirin0low10
deferiprone0low10
hydroxychloroquine0low10
iohexol0low20
iopromide0low20
khellin0low20
pamidronate0low10
pentoxifylline0low10
thalidomide0low10
edetic acid0low40
meglumine0medium283
gadolinium0medium2813
barium sulfate0low10
sodium thiosulfate0low40
triamcinolone0low10
gadolinium chloride0low30
gadolinium edta0low30
bosentan anhydrous0low10
phosphites0low10
gadolinium 1,4,7,10-tetraazacyclododecane-n,n',n'',n'''-tetraacetate0medium31
imatinib mesylate0medium41
methotrexate0low10
ferric ferrocyanide0low10
sirolimus0low40
aluminum0low10
phosphorus0low20
pregabalin0low10
gadolinium dtpa0medium902
losartan potassium0low20
endothelin-10low10
optimark0low80
gadofosveset trisodium0low50
transforming growth factor beta0low30
gadoxetic acid disodium0medium71
epoetin alfa0low10
cyclosporine0low10
folic acid0low10

Protein Targets (901)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
RAR-related orphan receptor gamma8008
ATAD5 protein, partial7007
GLS protein2002
Microtubule-associated protein tau2002
Smad34004
aldehyde dehydrogenase 1 family, member A16006
thyroid stimulating hormone receptor5005
nuclear receptor subfamily 1, group I, member 38008
progesterone receptor8008
EWS/FLI fusion protein6006
retinoic acid nuclear receptor alpha variant 18008
retinoid X nuclear receptor alpha7007
estrogen-related nuclear receptor alpha120012
estrogen nuclear receptor alpha140014
peroxisome proliferator activated receptor gamma4004
aryl hydrocarbon receptor5005
chromobox protein homolog 16006
thyroid hormone receptor beta isoform 23003
peripheral myelin protein 225005
cytochrome P450 3A4 isoform 13003
Gamma-aminobutyric acid receptor subunit pi3306
ATP-binding cassette sub-family C member 3010010
Multidrug resistance-associated protein 4010012
Solute carrier family 22 member 60303
Carbonic anhydrase 120316
UDP-glucuronosyltransferase 1A90001
Bile salt export pump0404
Voltage-dependent calcium channel gamma-2 subunit7007
Bile salt export pump015015
Cytochrome P450 2B10001
Cytochrome P450 1A10001
Carbonic anhydrase 105110
Carbonic anhydrase 205210
Myoglobin0101
Cytochrome P450 1A10214
Cytochrome P450 1A20304
Prostaglandin G/H synthase 10303
Carbonic anhydrase 30316
Cytochrome P450 3A40405
Cytochrome P450 2D60303
Cytochrome P450 2C9 0606
Polyunsaturated fatty acid lipoxygenase ALOX150101
Gamma-aminobutyric acid receptor subunit beta-13306
Sulfotransferase 1A1 0001
Gamma-aminobutyric acid receptor subunit delta3306
Gamma-aminobutyric acid receptor subunit gamma-23317
UDP-glucuronosyltransferase 1-60001
Glutamate receptor 27007
Gamma-aminobutyric acid receptor subunit alpha-53306
Gamma-aminobutyric acid receptor subunit alpha-33306
Arachidonate 5-lipoxygenase-activating protein0202
UDP-glucuronosyltransferase 1A1 0001
Carbonic anhydrase 40315
Prostaglandin G/H synthase 10303
Carbonic anhydrase 60315
Gamma-aminobutyric acid receptor subunit gamma-13306
Gamma-aminobutyric acid receptor subunit alpha-23306
Gamma-aminobutyric acid receptor subunit alpha-43306
Gamma-aminobutyric acid receptor subunit gamma-33306
Gamma-aminobutyric acid receptor subunit alpha-63306
Carbonic anhydrase 5A, mitochondrial0316
Prostaglandin G/H synthase 20304
Carbonic anhydrase 70315
Nuclear receptor ROR-gamma2002
Cytochrome P450 2J20303
Gamma-aminobutyric acid receptor subunit alpha-13418
Gamma-aminobutyric acid receptor subunit beta-33306
Gamma-aminobutyric acid receptor subunit beta-23317
Carbonic anhydrase 90316
GABA theta subunit3306
Canalicular multispecific organic anion transporter 10808
Carbonic anhydrase 150203
Carbonic anhydrase 130304
Gamma-aminobutyric acid receptor subunit epsilon3306
Carbonic anhydrase 140316
Carbonic anhydrase 5B, mitochondrial0316
toxin B0001
Chain A, TYROSYL-DNA PHOSPHODIESTERASE5005
Chain A, CARBONIC ANHYDRASE II0011
Chain A, CARBONIC ANHYDRASE II0011
Chain A, CARBONIC ANHYDRASE II0011
Chain A, Carbonic Anhydrase Ii0011
Chain A, Carbonic Anhydrase Ii0011
Chain A, Beta-lactamase1001
Chain A, Endochitinase0101
Chain A, Endochitinase0101
Chain A, Endochitinase0101
Chain A, Class Iii Chitinase Chia10101
Chain A, Carbonic anhydrase 130101
Chain A, Carbonic anhydrase II0101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase0101
Chain B, Carbonic anhydrase0101
Chain A, Carbonic anhydrase 20101
Carbonic anhydrase 0001
Carbonic anhydrase 0101
thioredoxin reductase8008
GALC protein2002
GLI family zinc finger 38008
cytochrome P450 family 3 subfamily A polypeptide 48008
glucocorticoid receptor [Homo sapiens]8008
Carbonic anhydrase 0101
Carbonic anhydrase 0101
arylsulfatase A6006
Carbonic anhydrase0101
euchromatic histone-lysine N-methyltransferase 2100010
Bloom syndrome protein isoform 16006
thyroid hormone receptor beta isoform a3003
nuclear factor erythroid 2-related factor 2 isoform 17007
geminin100010
survival motor neuron protein isoform d4004
muscleblind-like protein 1 isoform 13003
Carbonic anhydrase0101
Prolyl endopeptidase0101
Carbonic anhydrase-related protein 110102
Glycogen phosphorylase, muscle form0101
Renin0202
Carbonic anhydrase 20202
Cathepsin B0101
Steryl-sulfatase0101
5-hydroxytryptamine receptor 2C0203
Polyunsaturated fatty acid 5-lipoxygenase0101
Cytochrome P450 2C80102
Cytochrome P450 2A60101
5-hydroxytryptamine receptor 2A0202
Androgen receptor0202
Translocator protein0101
Cannabinoid receptor 10101
Cytochrome P450 2B60101
Carbonic anhydrase 5A, mitochondrial0101
Adenosine receptor A10202
Serum paraoxonase/arylesterase 10101
Dipeptidyl peptidase 40001
Endochitinase0101
Adenosine receptor A2a0202
5-hydroxytryptamine receptor 2B0101
Sodium-dependent serotonin transporter0101
Delta-type opioid receptor0101
Cytochrome P450 2C190303
Delta-type opioid receptor0202
Mu-type opioid receptor0202
Carbonic anhydrase0101
Kappa-type opioid receptor0101
Carbonic anhydrase0101
D(1A) dopamine receptor1102
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Carbonic anhydrase0101
D(2) dopamine receptor0101
Cholinesterase0202
Carbonic anhydrase 0101
Mu-type opioid receptor0101
Fatty-acid amide hydrolase 10101
Beta-carbonic anhydrase 10101
Carbonic anhydrase 20101
Glutamate receptor ionotropic, NMDA 2B0101
Squalene synthase0101
Neuronal acetylcholine receptor subunit alpha-70101
Carbonic anhydrase0101
Carbonic anhydrase, alpha family 0101
Carbonic anhydrase 0101
Carbonic anhydrase 30101
Carbonic anhydrase0102
Carbonic anhydrase0102
Carbonic anhydrase 0101
Sigma intracellular receptor 20101
Delta carbonic anhydrase0101
Sigma non-opioid intracellular receptor 10101
Renin0101
Carbonic anhydrase 0101
Endochitinase A10101
Multidrug resistance-associated protein 10101
Carbonic anhydrase 130214
Carbonic anhydrase 40202
Acidic mammalian chitinase0101
Carbonic anhydrase 70101
Carbonic anhydrase 0101
Carbonic anhydrase 0101
Carbonic anhydrase 2, isoform A 0101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE8008
Chain A, MTA/SAH nucleosidase0101
Chain A, Ribosome-inactivating protein alpha-trichosanthin0011
Chain A, Ricin A chain0011
Chain A, Ribosome-inactivating protein 30011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
TDP1 protein8008
AR protein100010
pregnane X nuclear receptor7007
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a5005
nuclear factor erythroid 2-related factor 2 isoform 25005
heat shock protein beta-13003
importin subunit beta-1 isoform 14004
snurportin-14004
tumor susceptibility gene 101 protein2002
GTP-binding nuclear protein Ran isoform 13003
lamin isoform A-delta107007
Cyclin-dependent kinase 10112
Heat shock protein HSP 90-beta0101
Xanthine dehydrogenase/oxidase0101
TAR DNA-binding protein 433003
Protein mono-ADP-ribosyltransferase PARP150101
Leucine-rich repeat serine/threonine-protein kinase 20202
ATPase family AAA domain-containing protein 55005
Ataxin-26006
Chain A, Phospholipase A2 isoform 30011
Chain A, HADH2 protein4004
Chain B, HADH2 protein4004
Chain A, 2-oxoglutarate Oxygenase4004
GTP-binding protein (rab7)0011
ras protein, partial0011
interleukin 81001
hypothetical protein, conserved1001
cytochrome P450 2D63003
glucocerebrosidase2002
peroxisome proliferator-activated receptor delta3003
Rac1 protein0011
IDH14004
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 14004
DNA polymerase iota isoform a (long)5005
DNA polymerase kappa isoform 13003
muscarinic acetylcholine receptor M12002
lethal factor (plasmid)1001
Prostaglandin-H2 D-isomerase0101
Prostaglandin G/H synthase 1 0101
Prostaglandin G/H synthase 2 0101
Epidermal growth factor receptor0112
Fatty acid-binding protein, liver0202
Integrin beta-31102
Myeloperoxidase0101
Seed linoleate 13S-lipoxygenase-10101
Integrin alpha-IIb1102
Glutathione hydrolase 1 proenzyme0101
Substance-P receptor0101
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0101
Ras-related protein Rab-2A0011
Prostaglandin G/H synthase 20202
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200202
Solute carrier family 22 member 60202
Sigma non-opioid intracellular receptor 10112
Sigma non-opioid intracellular receptor 10011
phosphopantetheinyl transferase3003
estrogen receptor 2 (ER beta)3003
G2002
vitamin D (1,25- dihydroxyvitamin D3) receptor4004
activating transcription factor 64004
v-jun sarcoma virus 17 oncogene homolog (avian)4004
vitamin D3 receptor isoform VDRA2002
nuclear receptor ROR-gamma isoform 12002
Nuclear receptor subfamily 1 group I member 20022
Interferon beta4004
HLA class I histocompatibility antigen, B alpha chain 2002
Endothelin receptor type B0101
Endothelin receptor type B0213
Endothelin-1 receptor0303
Endothelin-1 receptor0213
Endothelin receptor type B0011
Deoxyhypusine synthase0101
Sodium/bile acid cotransporter0101
Endothelin-1 receptor0101
Inositol hexakisphosphate kinase 12002
cytochrome P450 2C9, partial2002
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
Chain A, JmjC domain-containing histone demethylation protein 3A1001
apical membrane antigen 1, AMA11001
nonstructural protein 11001
bromodomain adjacent to zinc finger domain 2B2002
cytochrome P450 2C19 precursor2002
cytochrome P450 2C9 precursor1001
Lysine-specific demethylase 6A0101
Lysine-specific demethylase 4A0101
Lysine-specific demethylase 5C0101
Histamine H2 receptor2002
Spike glycoprotein5016
Lysine-specific demethylase 2B0101
Deoxyhypusine hydroxylase0101
Lysine-specific demethylase 2A0101
hypoxia-inducible factor 1 alpha subunit3003
Histone H2A.x2002
Eyes absent homolog 20101
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Cellular tumor antigen p535005
Amyloid-beta precursor protein0101
Angiotensin-converting enzyme 0101
Metallo-beta-lactamase VIM-130101
Beta-lactamase 0101
Beta-lactamase 0101
Beta-lactamase VIM-1 0101
Chain A, Dihydrofolate reductase0011
Chain A, Ferritin light chain3003
acid sphingomyelinase2002
glp-1 receptor, partial4004
USP1 protein, partial6006
alpha-galactosidase2002
lysosomal alpha-glucosidase preproprotein1001
DNA polymerase beta2002
Thymidylate synthase0404
Thymidylate synthase0303
Dihydrofolate reductase0235
Aldo-keto reductase family 1 member B10101
Alpha-synuclein2002
Folylpolyglutamate synthase, mitochondrial0104
Solute carrier organic anion transporter family member 1A30102
Folylpolyglutamate synthase, mitochondrial0104
Multidrug resistance associated protein0103
Gamma-aminobutyric acid 0011
Gamma-aminobutyric acid receptor subunit rho-30011
Hsf1 protein0011
regulator of G-protein signaling 43003
D(1A) dopamine receptor2002
transcriptional regulator ERG isoform 32002
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
histone acetyltransferase KAT2A isoform 16006
neuropeptide S receptor isoform A1001
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit delta0101
Histone deacetylase 30101
Gamma-aminobutyric acid type B receptor subunit 20011
Gamma-aminobutyric acid type B receptor subunit 20101
Gamma-aminobutyric acid receptor subunit alpha-10112
Gamma-aminobutyric acid receptor subunit alpha-60011
Gamma-aminobutyric acid receptor subunit beta-10112
Gamma-aminobutyric acid receptor subunit gamma-20112
Gamma-aminobutyric acid receptor subunit gamma-20011
Gamma-aminobutyric acid receptor subunit delta0011
Sodium- and chloride-dependent GABA transporter 10101
Gamma-aminobutyric acid receptor subunit rho-10022
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit alpha-30011
Gamma-aminobutyric acid receptor subunit gamma-30011
Gamma-aminobutyric acid receptor subunit beta-30112
Gamma-aminobutyric acid receptor subunit rho-20011
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent taurine transporter0101
Gamma-aminobutyric acid receptor subunit alpha-50112
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-30112
Gamma-aminobutyric acid receptor subunit alpha-20112
Gamma-aminobutyric acid receptor subunit beta-20112
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-40112
Gamma-aminobutyric acid receptor subunit beta-10011
Histone deacetylase 40101
Gamma-aminobutyric acid receptor subunit alpha-10011
Gamma-aminobutyric acid receptor subunit beta-30011
Gamma-aminobutyric acid receptor subunit epsilon0101
4-aminobutyrate aminotransferase, mitochondrial0001
4-aminobutyrate aminotransferase, mitochondrial0001
Histone deacetylase 10101
Gamma-aminobutyric acid receptor subunit alpha-60112
Sterol O-acyltransferase 10011
Proton-coupled amino acid transporter 10101
Gamma-aminobutyric acid receptor subunit alpha-50011
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit pi0011
Histone deacetylase 70101
Histone deacetylase 20101
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
Gamma-aminobutyric acid receptor subunit gamma-30101
Histone deacetylase 80101
Gamma-aminobutyric acid receptor subunit alpha-40011
Platelet glycoprotein VI0011
Gamma-aminobutyric acid receptor subunit theta0011
Sodium- and chloride-dependent GABA transporter 20101
Gamma-aminobutyric acid receptor subunit gamma-10011
Histone deacetylase 60101
Gamma-aminobutyric acid type B receptor subunit 10011
Histone deacetylase 90101
Gamma-aminobutyric acid receptor subunit theta0101
Histone deacetylase 50101
Gamma-aminobutyric acid type B receptor subunit 10101
Genome polyprotein 0101
Spike glycoprotein0011
Replicase polyprotein 1ab0011
Transmembrane protease serine 20011
Procathepsin L0011
Muscarinic acetylcholine receptor M20404
Muscarinic acetylcholine receptor M40303
Muscarinic acetylcholine receptor M50303
Alpha-2A adrenergic receptor0303
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0112
Replicase polyprotein 1ab0213
Muscarinic acetylcholine receptor M10303
Alpha-2B adrenergic receptor0303
Alpha-2C adrenergic receptor0303
Muscarinic acetylcholine receptor M30303
Alpha-1D adrenergic receptor0404
Potassium voltage-gated channel subfamily H member 20101
Sigma intracellular receptor 20101
Cyclic GMP-AMP synthase0202
Angiotensin-converting enzyme 2 0011
Toll-like receptor 90101
Toll-like receptor 70101
Luciferase3003
acetylcholinesterase2002
SMAD family member 22002
SMAD family member 32002
farnesoid X nuclear receptor4004
thyroid stimulating hormone receptor1001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
serine/threonine-protein kinase mTOR isoform 12002
DNA repair protein RAD52 homolog isoform a0001
Tyrosine-protein kinase ABL10134
Mast/stem cell growth factor receptor Kit0112
Breakpoint cluster region protein0022
Platelet-derived growth factor receptor alpha0112
Cytochrome P450 3A50001
histone deacetylase 9 isoform 31001
cytochrome P450 2D6 isoform 11001
mitogen-activated protein kinase 11001
Cytochrome P450 1B10101
Type-1A angiotensin II receptor 0101
Type-1B angiotensin II receptor0202
Type-2 angiotensin II receptor0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase B0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0202
5-hydroxytryptamine receptor 1A0101
Type-1 angiotensin II receptor0101
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
dopamine D1 receptor3003
ClpP1001
15-lipoxygenase, partial1001
67.9K protein3003
Thymidylate synthase 0101
Thymidylate synthase 0101
cellular tumor antigen p53 isoform a1001
polyunsaturated fatty acid lipoxygenase ALOX121001
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
flap endonuclease 12002
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
DNA polymerase eta isoform 11001
transactivating tegument protein VP16 [Human herpesvirus 1]0101
M-phase phosphoprotein 82002
caspase-1 isoform alpha precursor1001
nuclear receptor coactivator 3 isoform a0101
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0203
Dihydrofolate reductase0203
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
High mobility group protein B10011
Dihydrofolate reductase0101
Thymidylate synthase0101
Glucose-6-phosphate 1-dehydrogenase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Dihydrofolate reductase0202
Histidine decarboxylase0101
Trifunctional purine biosynthetic protein adenosine-30101
Cyclin-dependent kinase 20022
Bifunctional purine biosynthesis protein ATIC0202
Multidrug resistance-associated protein 1 0001
Kappa-type opioid receptor0101
Reduced folate transporter0202
6-phosphogluconate dehydrogenase, decarboxylating0101
Caspase-71001
Dihydrofolate reductase0101
Pteridine reductase 10101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Solute carrier family 22 member 60001
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Dihydrofolate reductase 0101
Solute carrier family 22 member 80001
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Solute carrier organic anion transporter family member 1B30001
Solute carrier family 22 member 110001
Protein-arginine deiminase type-40101
Broad substrate specificity ATP-binding cassette transporter ABCG20102
ATP-dependent phosphofructokinase1001
Geranylgeranyl pyrophosphate synthase0101
Farnesyl pyrophosphate synthase0202
Hypoxanthine-guanine phosphoribosyltransferase0101
Farnesyl pyrophosphate synthase 0101
endonuclease IV1001
NFKB1 protein, partial2002
peripheral myelin protein 22 isoform 12002
vasopressin V1b receptor1001
ubiquitin carboxyl-terminal hydrolase 2 isoform a2002
relaxin receptor 1 isoform 11001
cGMP-dependent 3',5'-cyclic phosphodiesterase0101
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A0101
cGMP-specific 3',5'-cyclic phosphodiesterase0101
Tumor necrosis factor0101
Cholinesterase0101
Acetylcholinesterase0202
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0202
Adenosine receptor A2b0101
Disintegrin and metalloproteinase domain-containing protein 171001
Inositol monophosphatase 11001
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0202
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0202
Chitotriosidase-10213
Endochitinase B10213
luciferase0001
nuclear receptor subfamily 1, group I, member 21001
Estrogen receptor0202
Glucocorticoid receptor04110
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Glycine receptor subunit alpha-10404
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Androgen receptor0202
Glutamine synthetase0011
Glycine receptor subunit beta0404
Glycine receptor subunit alpha-20404
Glycine receptor subunit alpha-30404
Histamine H1 receptor0011
Nociceptin receptor0011
Estrogen receptor beta0202
Sodium-dependent noradrenaline transporter 0404
Voltage-dependent calcium channel subunit alpha-2/delta-10102
Voltage-dependent calcium channel subunit alpha-2/delta-20101
N0101
Fumarate hydratase1001
NPYLR7B0011
polyprotein1001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
NPC intracellular cholesterol transporter 1 precursor1001
cystic fibrosis transmembrane conductance regulator0101
ras-related protein Rab-9A1001
Glutathione reductase, mitochondrial0101
Riboflavin-binding protein0112
Major prion protein0011
Major prion protein0101
Histidine-rich protein PFHRP-II0101
Aldo-keto reductase family 1 member B10202
ATP-dependent translocase ABCB10112
Muscarinic acetylcholine receptor M10101
Muscarinic acetylcholine receptor M30101
Muscarinic acetylcholine receptor M40101
Muscarinic acetylcholine receptor M50101
DNA-directed RNA polymerase subunit alpha0101
DNA-directed RNA polymerase subunit omega0101
DNA-directed RNA polymerase subunit beta'0101
DNA-directed RNA polymerase subunit beta0101
Muscarinic acetylcholine receptor M20101
Phospholipase A2, membrane associated0101
Phospholipase A2, membrane associated0101
Acidic phospholipase A2 20101
Histamine H2 receptor0202
5-hydroxytryptamine receptor 2A0202
Trypanothione reductase0202
D(3) dopamine receptor0202
Aldehyde oxidase 10101
Aldehyde oxidase0101
2,3-bisphosphoglycerate-independent phosphoglycerate mutase1001
Bone morphogenetic protein receptor type-1B0011
Cell division cycle 7-related protein kinase0011
Serine/threonine-protein kinase PLK40011
ATP-dependent RNA helicase DDX3X0011
Pyridoxal kinase0011
Citron Rho-interacting kinase0011
Serine/threonine-protein kinase Chk10011
Aurora kinase A0011
Cyclin-G-associated kinase0011
Ephrin type-B receptor 60011
Peroxisomal acyl-coenzyme A oxidase 30011
Receptor-interacting serine/threonine-protein kinase 20011
Mitotic checkpoint serine/threonine-protein kinase BUB10011
Dynamin-like 120 kDa protein, mitochondrial0011
Tyrosine-protein kinase JAK20011
Eukaryotic translation initiation factor 5B0011
Rho-associated protein kinase 20011
Serine/threonine-protein kinase ULK10011
Serine/threonine-protein kinase/endoribonuclease IRE10011
Ribosomal protein S6 kinase alpha-50011
U5 small nuclear ribonucleoprotein 200 kDa helicase0011
Ribosomal protein S6 kinase alpha-40011
Serine/threonine-protein kinase 160011
Cyclin-dependent kinase-like 50011
Serine/threonine-protein kinase 100011
Serine/threonine-protein kinase D30011
Structural maintenance of chromosomes protein 20011
Mitogen-activated protein kinase kinase kinase 60011
Mitogen-activated protein kinase kinase kinase kinase 40011
Serine/threonine-protein kinase LATS10011
Serine/threonine-protein kinase PAK 40011
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
High affinity nerve growth factor receptor0011
ADP/ATP translocase 20011
Protein kinase C beta type0011
Insulin receptor0011
Tyrosine-protein kinase Lck0011
Tyrosine-protein kinase Fyn0011
Eukaryotic translation initiation factor 4E0011
Glycogen phosphorylase, liver form0011
Tyrosine-protein kinase Fes/Fps0011
Adenine phosphoribosyltransferase0011
Tyrosine-protein kinase Yes0011
Tyrosine-protein kinase Lyn0011
Proto-oncogene tyrosine-protein kinase receptor Ret0011
Insulin-like growth factor 1 receptor0011
Signal recognition particle receptor subunit alpha0011
Cytochrome c1, heme protein, mitochondrial0011
Hepatocyte growth factor receptor0011
Tyrosine-protein kinase HCK0011
Platelet-derived growth factor receptor beta0011
Tyrosine-protein kinase Fgr0011
Serine/threonine-protein kinase A-Raf0011
Glycogen phosphorylase, brain form0011
Serine/threonine-protein kinase pim-10011
Fibroblast growth factor receptor 10011
DNA topoisomerase 2-alpha0011
Cyclin-dependent kinase 40011
ADP/ATP translocase 30011
Inosine-5'-monophosphate dehydrogenase 20011
Proto-oncogene tyrosine-protein kinase Src0011
cAMP-dependent protein kinase type II-alpha regulatory subunit0011
Serine/threonine-protein kinase B-raf0011
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform0011
Ribosyldihydronicotinamide dehydrogenase [quinone]0011
Tyrosine-protein kinase Fer0011
Protein kinase C alpha type0011
cAMP-dependent protein kinase catalytic subunit alpha0011
General transcription and DNA repair factor IIH helicase subunit XPD0011
Casein kinase II subunit alpha'0011
Ras-related protein Rab-6A0011
Ephrin type-A receptor 10011
Multifunctional protein ADE20011
cAMP-dependent protein kinase catalytic subunit beta0011
Ferrochelatase, mitochondrial0011
Ribosomal protein S6 kinase beta-10011
Tyrosine-protein kinase JAK10011
Beta-adrenergic receptor kinase 10011
Probable ATP-dependent RNA helicase DDX60011
Peptidyl-prolyl cis-trans isomerase FKBP1A0101
Mitogen-activated protein kinase 3 0011
MAP/microtubule affinity-regulating kinase 30011
Deoxycytidine kinase0011
Mitogen-activated protein kinase 10011
Ephrin type-A receptor 20011
Ephrin type-B receptor 20011
Non-receptor tyrosine-protein kinase TYK20011
UMP-CMP kinase 0011
Phosphatidylethanolamine-binding protein 10011
Wee1-like protein kinase0011
Heme oxygenase 20011
S-adenosylmethionine synthase isoform type-20011
DnaJ homolog subfamily A member 10011
RAC-alpha serine/threonine-protein kinase0011
RAC-beta serine/threonine-protein kinase0011
Dual specificity protein kinase TTK0011
DNA replication licensing factor MCM40011
Myosin-100011
Dual specificity mitogen-activated protein kinase kinase 20011
Receptor-type tyrosine-protein kinase FLT30011
Bone morphogenetic protein receptor type-1A0011
Activin receptor type-1B0011
TGF-beta receptor type-10011
Serine/threonine-protein kinase receptor R30011
TGF-beta receptor type-20011
Electron transfer flavoprotein subunit beta0011
Tyrosine-protein kinase CSK0011
Glycine--tRNA ligase0011
Protein kinase C iota type0011
Exosome RNA helicase MTR40011
Serine/threonine-protein kinase mTOR0112
Tyrosine-protein kinase Tec0011
Tyrosine-protein kinase ABL20011
Tyrosine-protein kinase FRK0011
G protein-coupled receptor kinase 60011
Tyrosine-protein kinase SYK0011
26S proteasome regulatory subunit 6B0011
Mitogen-activated protein kinase 80011
Mitogen-activated protein kinase 90011
Dual specificity mitogen-activated protein kinase kinase 30011
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha0011
Casein kinase I isoform alpha0011
Casein kinase I isoform delta0011
MAP kinase-activated protein kinase 20011
Elongation factor Tu, mitochondrial0011
Choline-phosphate cytidylyltransferase A0011
Cysteine--tRNA ligase, cytoplasmic0011
Casein kinase I isoform epsilon0011
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial0011
Dual specificity protein kinase CLK10011
Dual specificity protein kinase CLK20011
Dual specificity protein kinase CLK30011
Glycogen synthase kinase-3 alpha0011
Glycogen synthase kinase-3 beta0011
Cyclin-dependent kinase 70011
Cyclin-dependent kinase 90011
Ras-related protein Rab-27A0011
Interleukin-1 receptor-associated kinase 10011
Ribosomal protein S6 kinase alpha-30011
Serine/threonine-protein kinase Nek20011
Serine/threonine-protein kinase Nek30011
Dual specificity mitogen-activated protein kinase kinase 60011
Serine/threonine-protein kinase PLK10011
LIM domain kinase 10011
LIM domain kinase 20011
Mitogen-activated protein kinase 100011
Tyrosine--tRNA ligase, cytoplasmic0011
5'-AMP-activated protein kinase subunit gamma-10011
Ephrin type-B receptor 30011
Ephrin type-A receptor 50011
Ephrin type-B receptor 40011
Ephrin type-A receptor 40011
Adenylate kinase 2, mitochondrial0011
Adenosine kinase0011
Ras-related protein Rab-100011
Actin-related protein 30011
Actin-related protein 20011
GTP-binding nuclear protein Ran0011
Peptidyl-prolyl cis-trans isomerase FKBP1A0213
Peptidyl-prolyl cis-trans isomerase FKBP1B0011
Casein kinase I isoform gamma-20011
Cyclin-dependent kinase 60011
Cyclin-dependent-like kinase 5 0011
Cyclin-dependent kinase 160011
Cyclin-dependent kinase 170011
ATP-dependent 6-phosphofructokinase, platelet type0011
Dual specificity mitogen-activated protein kinase kinase 10011
DNA topoisomerase 2-beta0011
Protein kinase C theta type0011
Activin receptor type-10011
Macrophage-stimulating protein receptor0011
Focal adhesion kinase 10011
Protein kinase C zeta type0011
Protein kinase C delta type0011
Tyrosine-protein kinase BTK0011
Cyclin-dependent kinase 180011
Activated CDC42 kinase 10011
Epithelial discoidin domain-containing receptor 10011
Mitogen-activated protein kinase kinase kinase kinase 20011
Tyrosine-protein kinase Mer0011
Serine/threonine-protein kinase 40011
5'-AMP-activated protein kinase catalytic subunit alpha-10011
Dual specificity mitogen-activated protein kinase kinase 50011
Mitogen-activated protein kinase 70011
Serine/threonine-protein kinase PAK 20011
Serine/threonine-protein kinase 30011
Mitogen-activated protein kinase kinase kinase 10011
Integrin-linked protein kinase0011
Peptidyl-prolyl cis-trans isomerase FKBP50101
Rho-associated protein kinase 10011
Non-receptor tyrosine-protein kinase TNK10011
Calcium/calmodulin-dependent protein kinase type II subunit gamma0011
Calcium/calmodulin-dependent protein kinase type II subunit delta0011
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0011
Activin receptor type-2B0011
Bone morphogenetic protein receptor type-20011
Protein-tyrosine kinase 60011
cGMP-dependent protein kinase 1 0011
Cyclin-dependent kinase 130011
Inhibitor of nuclear factor kappa-B kinase subunit epsilon0011
Protein-tyrosine kinase 2-beta0011
Maternal embryonic leucine zipper kinase0011
Structural maintenance of chromosomes protein 1A0011
Chromodomain-helicase-DNA-binding protein 40011
Peroxisomal acyl-coenzyme A oxidase 10011
Delta(24)-sterol reductase0011
Ribosomal protein S6 kinase alpha-10011
Dual specificity testis-specific protein kinase 10011
Myosin light chain kinase, smooth muscle0011
Mitogen-activated protein kinase 110011
Serine/threonine-protein kinase STK110011
Serine/threonine-protein kinase N10011
Serine/threonine-protein kinase N20011
Mitogen-activated protein kinase 140011
Calcium/calmodulin-dependent protein kinase type IV0011
Mitogen-activated protein kinase kinase kinase 110011
Discoidin domain-containing receptor 20011
AP2-associated protein kinase 10011
Myosin light chain kinase 30011
Uncharacterized aarF domain-containing protein kinase 50011
Programmed cell death protein 40011
Putative heat shock protein HSP 90-beta 20011
Serine/threonine-protein kinase MRCK alpha0011
Serine/threonine-protein kinase MRCK gamma0011
Acyl-CoA dehydrogenase family member 100011
Serine/threonine-protein kinase N30011
Serine/threonine-protein kinase ULK30011
Uncharacterized protein FLJ452520011
Acyl-CoA dehydrogenase family member 110011
Serine/threonine-protein kinase/endoribonuclease IRE20011
Serine/threonine-protein kinase MARK20011
ATP-dependent RNA helicase DHX300011
Serine/threonine-protein kinase TAO10011
STE20-related kinase adapter protein alpha0011
Myosin-140011
AarF domain-containing protein kinase 10011
Mitogen-activated protein kinase kinase kinase kinase 30011
MAP kinase-activated protein kinase 50011
Regulatory-associated protein of mTOR0101
Misshapen-like kinase 10011
Atypical kinase COQ8A, mitochondrial0011
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma0011
Mitogen-activated protein kinase 150011
Serine/threonine-protein kinase Nek90011
ATP-dependent RNA helicase DDX10011
Mitogen-activated protein kinase kinase kinase kinase 10011
Aurora kinase B0011
MAP/microtubule affinity-regulating kinase 40011
Calcium/calmodulin-dependent protein kinase type 1G0011
Serine/threonine-protein kinase Nek10011
PAS domain-containing serine/threonine-protein kinase0011
Calcium/calmodulin-dependent protein kinase kinase 20011
EKC/KEOPS complex subunit TP53RK0011
Dual specificity testis-specific protein kinase 20011
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase0011
Mitogen-activated protein kinase kinase kinase 50011
Mitogen-activated protein kinase kinase kinase 30011
Eukaryotic translation initiation factor 2-alpha kinase 10011
Target of rapamycin complex subunit LST80101
Nucleolar GTP-binding protein 10011
Serine/threonine-protein kinase D20011
RNA cytidine acetyltransferase0011
Serine/threonine-protein kinase SIK20011
STE20-like serine/threonine-protein kinase 0011
Serine/threonine-protein kinase TAO30011
dCTP pyrophosphatase 10011
Dual specificity protein kinase CLK40011
Casein kinase I isoform gamma-10011
Serine/threonine-protein kinase mTOR 0101
Phenylalanine--tRNA ligase beta subunit0011
Isoleucine--tRNA ligase, mitochondrial0011
BMP-2-inducible protein kinase0011
Obg-like ATPase 10011
Midasin0011
Interleukin-1 receptor-associated kinase 40011
Mitogen-activated protein kinase kinase kinase 200011
Cyclin-dependent kinase 120011
Serine/threonine-protein kinase 260011
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial0011
Serine/threonine-protein kinase NLK0011
5'-AMP-activated protein kinase subunit gamma-20011
Serine/threonine-protein kinase TBK10011
Septin-90011
Ribosomal protein S6 kinase alpha-60011
TRAF2 and NCK-interacting protein kinase0011
Serine/threonine-protein kinase TAO20011
Serine/threonine-protein kinase ICK0011
RAC-gamma serine/threonine-protein kinase0011
Serine/threonine-protein kinase SIK30011
Mitogen-activated protein kinase kinase kinase 20011
Thyroid hormone receptor-associated protein 30011
Dual specificity tyrosine-phosphorylation-regulated kinase 1B0011
Mitogen-activated protein kinase kinase kinase kinase 50011
Receptor-interacting serine/threonine-protein kinase 30011
Serine/threonine-protein kinase MRCK beta0011
Interleukin-1 receptor-associated kinase 30011
Serine/threonine-protein kinase 240011
Solute carrier organic anion transporter family member 1B10101
Casein kinase I isoform gamma-30011
Mitogen-activated protein kinase kinase kinase 40011
Cereblon isoform 40202
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0101
DNA-binding protein Ikaros0001
DNA damage-binding protein 10112
Protein cereblon0214
thioredoxin glutathione reductase1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
procathepsin L isoform 1 preproprotein0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]