Conditions > Liposclerotic Mesenteritis

Page last updated: 2024-09-28

Liposclerotic Mesenteritis

This entity represents the fibrotic stage of MESENTERY inflammation.

Synonyms(8)

Synonym
Retractile Mesenteritis
Liposclerotic Mesenteritis
Omental Panniculitis
Mesenteric Lipodystrophy
Mesenteric Panniculitis
Panniculitis, Peritoneal
Mesenteric Weber-Christian Disease
Sclerosing Mesenteritis

Research Excerpts

Overview

Excerpt	Reference
"Two patients with mesenteric panniculitis are presented."	( Edis, AJ; Kikiros, CS, 1989)
"Sclerosing mesenteritis is an uncommon condition of unknown etiology."	( Bellanger, J; Bellin, MF; Généreau, T; Godeau, P; Grellet, J; Le, TH; Wechsler, B, 1996)
"Sclerosing mesenteritis is a rare, idiopathic, and benign mesenteric lesion that is characterized by fat necrosis, fibrosis, and chronic inflammation."	( Behling, CA; Lyche, KD; Venkataramani, A, 1997)
"Retractile mesenteritis is a rare inflammatory mesenteric disorder that involves the intestine secondarily."	( Bai, JC; Boerr, L; Fernandez Marty, P; Kogan, Z; Mauriño, E; Mazure, R; Niveloni, S; Pedreira, S; Smecuol, E; Vazquez, H, 1998)
"Retractile mesenteritis is an extremely rare disease characterised by a non-specific inflammatory and fibrotic process of the mesenteric adipose tissue, which is usually accompanied by pain and a variety of other abdominal symptoms."	( Daskalogiannaki, ME; Eliopoulos, GD; Kouroumalis, EA; Papadaki, HA; Reppa, D; Roussomoustakaki, M; Stefanaki, K, 2000)
"Mesenteric panniculitis is a rare idiopathic inflammatory disorder that can lead to sclerosis."	( Agnarsson, BA; Matthíasson, P; Onundarson, PT; Vidarsson, B, 2002)
"Mesenteric panniculitis is a rare condition with no standard therapy."	( Ehrenpreis, ED; Ginsburg, PM, 2002)
"Mesenteric panniculitis is an inflammatory process of the adipose tissue of the mesentery."	( Blanes Gallego, A; Carbonell Biot, C; Colomer Rubio, E; Llamusí Lorente, A; Tomás Ivorra, H; Villar Grimalt, A, 2003)
"Sclerosing mesenteritis is a rare, combined inflammatory and fibrotic process of unknown etiology."	( Nguyen, BD, 2003)
"Sclerosing mesenteritis is a rare, usually benign disorder of the mesentery."	( Bley, T; Ghanem, N; Kotter, E; Langer, M; Pache, G, 2005)
"Two patients with mesenteric panniculitis are presented."	( Asada, Y; Kanda, K; Kohno, S; Mizuta, Y; Ozeki, K; Tanaka, T, 2006)
"Retractile mesenteritis is a rare benign inflammatory disease of the mesentery."	( Delikoukos, S; Kapsoritakis, AN; Koukoulis, GK; Kyriakou, D; Potamianos, SP; Rizos, CD, 2008)
"Sclerosing mesenteritis is a rare inflammatory disease of the bowel mesentery of unknown etiology, which can be mistaken for malignancy."	( Denecke, T; Grieser, C; Hamm, B; Hänninen, EL; Langrehr, J, 2008)
"Sclerosing mesenteritis is a chronic and extremely rare inflammatory process that predominantly affects the small bowel mesentery."	( Bernhardt, GA; Kornprat, P; Liegl-Atzwanger, B; Mischinger, HJ; Portugaller, H, 2010)
"Sclerosing mesenteritis is a rare inflammatory disease of the bowel mesentery."	( Ahn, SB; Bae, JH; Chang, YS; Jo, YJ; Jung, YM; Kim, SH; Park, YS; Son, BK, 2011)
"Mesenteric panniculitis is an underdiagnosed inflammatory condition of unknown etiology that involves the mesenteric adipose tissue."	( Albano, D; Bertagna, F; Bosio, G, 2016)
"Sclerosing mesenteritis is a non-neoplastic inflammatory disease that occurs in the bowel mesentery."	( Amaya, K; Kaji, M; Maeda, K; Matsui, K; Mochizuki, K; Saito, J; Shimizu, K; Takeshita, M; Terai, S; Tsukada, T; Uchiyama, A; Watanabe, T, 2017)
"Sclerosing mesenteritis is a rare condition characterized by chronic inflammation and fibrotic changes of the mesentery."	( Alhaj Moustafa, M; Bi, Y; Brahmbhatt, B; Cortés, P; Daoud, N; Ghoz, HM; Mzaik, O; Pang, M, 2022)

Context

Excerpt	Reference
"The diagnosis of sclerosing mesenteritis has increased with the more frequent use of MDCT and the popularization of the DICOM viewer."	( Akgoz, A; Akhan, O; Canyigit, M; Kara, T; Koksal, A; Sarisahin, M, 2011)

Research

Studies (77)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	2 (2.60)	23.3326
1990's	7 (9.09)	12.5806
2000's	21 (27.27)	18.1394
2010's	41 (53.25)	28.8240
2020's	6 (7.79)	9.53

Drug	Indicated	Relationship Strength	Studies	Trials
azathioprine	0	low	6	0
ibuprofen	0	low	1	0
iohexol	0	low	1	0
iomeprol	0	low	1	0
iopromide	0	low	1	0
mesalamine	0	low	1	0
pentoxifylline	0	low	1	0
sulfasalazine	0	low	1	0
thalidomide	0	medium	1	1
prednisolone	0	low	20	0
spironolactone	0	low	1	0
penicillamine	0	low	1	0
prednisone	0	low	14	0
colchicine	0	low	5	0
methylprednisolone	0	low	5	0
azacitidine	0	low	1	0
methylprednisolone hemisuccinate	0	low	1	0
sulfur hexafluoride	0	low	1	0
barium sulfate	0	low	3	0
trolamine salicylate	0	low	1	0
pergolide	0	low	1	0
iopamidol	0	low	1	0
fluorodeoxyglucose f18	0	low	9	0
methotrexate	0	low	1	0
meropenem	0	low	1	0
tacrolimus	0	low	1	0
mycophenolic acid	0	low	1	0
tamoxifen	0	low	6	0
6-methylprednisone	0	low	1	0
pulmicort	0	low	1	0
oxycodone	0	low	1	0
morphine	0	low	1	0
naltrexone	0	medium	1	1
guanylin	0	low	1	0
gadolinium dtpa	0	low	5	0
gallium ga 68 dotatate	0	low	1	0
cyclic gmp	0	low	1	0

Protein Targets (604)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	9	0	0	9
Chain A, Beta-lactamase	4	0	0	4
interleukin 8	4	0	0	4
glp-1 receptor, partial	5	0	0	5
pregnane X receptor	5	0	0	5
RAR-related orphan receptor gamma	15	0	0	15
ATAD5 protein, partial	8	0	0	8
Fumarate hydratase	4	0	0	4
NFKB1 protein, partial	4	0	0	4
PPM1D protein	4	0	0	4
TDP1 protein	13	0	0	13
GLI family zinc finger 3	11	0	0	11
Thrombopoietin	4	0	0	4
AR protein	17	0	0	17
Smad3	3	0	0	3
aldehyde dehydrogenase 1 family, member A1	9	0	0	9
estrogen receptor 2 (ER beta)	9	0	0	9
nuclear receptor subfamily 1, group I, member 3	12	0	0	12
progesterone receptor	10	0	0	10
cytochrome P450 family 3 subfamily A polypeptide 4	5	0	0	5
glucocorticoid receptor [Homo sapiens]	16	0	0	16
retinoic acid nuclear receptor alpha variant 1	11	0	0	11
retinoid X nuclear receptor alpha	15	0	0	15
estrogen-related nuclear receptor alpha	15	0	0	15
farnesoid X nuclear receptor	11	0	0	11
pregnane X nuclear receptor	12	0	0	12
estrogen nuclear receptor alpha	19	0	0	19
polyprotein	4	0	0	4
67.9K protein	8	0	0	8
Parkin	1	0	0	1
peroxisome proliferator-activated receptor delta	10	0	0	10
peroxisome proliferator activated receptor gamma	12	0	0	12
vitamin D (1,25- dihydroxyvitamin D3) receptor	10	0	0	10
arylsulfatase A	7	0	0	7
IDH1	9	0	0	9
euchromatic histone-lysine N-methyltransferase 2	14	0	0	14
aryl hydrocarbon receptor	9	0	0	9
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	13	0	0	13
thyroid stimulating hormone receptor	5	0	0	5
activating transcription factor 6	7	0	0	7
Bloom syndrome protein isoform 1	4	0	0	4
peripheral myelin protein 22 isoform 1	4	0	0	4
hemoglobin subunit beta	3	0	0	3
cellular tumor antigen p53 isoform a	5	0	0	5
chromobox protein homolog 1	7	0	0	7
thyroid hormone receptor beta isoform 2	12	0	0	12
huntingtin isoform 2	2	0	0	2
ras-related protein Rab-9A	3	0	0	3
serine/threonine-protein kinase mTOR isoform 1	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 1	15	0	0	15
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
urokinase plasminogen activator surface receptor precursor	3	0	0	3
geminin	14	0	0	14
peripheral myelin protein 22	9	0	0	9
histone acetyltransferase KAT2A isoform 1	4	0	0	4
muscarinic acetylcholine receptor M1	4	0	0	4
lamin isoform A-delta10	10	0	0	10
Interferon beta	9	0	0	9
Cellular tumor antigen p53	13	0	0	13
Integrin beta-3	3	0	0	3
Integrin alpha-IIb	3	0	0	3
Adenosine receptor A3	0	3	0	3
DNA (cytosine-5)-methyltransferase 1	0	1	0	1
Adenosine receptor A2a	0	3	0	3
Adenosine receptor A1	0	3	0	3
D(1A) dopamine receptor	2	0	0	2
Nuclear receptor ROR-gamma	4	0	0	4
Spike glycoprotein	8	0	1	9
Multidrug and toxin extrusion protein 1	0	2	0	2
Histone-lysine N-methyltransferase EHMT2	0	1	0	1
ATPase family AAA domain-containing protein 5	12	0	0	12
Ataxin-2	12	0	0	12
ATP-dependent phosphofructokinase	6	0	0	6
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	4	0	0	4
Chain A, Ferritin light chain	5	0	0	5
acetylcholinesterase	6	0	0	6
thioredoxin reductase	5	0	0	5
phosphopantetheinyl transferase	6	0	0	6
SMAD family member 2	5	0	0	5
SMAD family member 3	5	0	0	5
Microtubule-associated protein tau	6	0	0	6
thioredoxin glutathione reductase	2	0	0	2
EWS/FLI fusion protein	4	0	0	4
G	5	0	0	5
P53	1	0	0	1
v-jun sarcoma virus 17 oncogene homolog (avian)	8	0	0	8
Histone H2A.x	8	0	0	8
heat shock protein beta-1	2	0	0	2
DNA polymerase iota isoform a (long)	3	0	0	3
survival motor neuron protein isoform d	6	0	0	6
cytochrome P450 3A4 isoform 1	7	0	0	7
M-phase phosphoprotein 8	3	0	0	3
muscleblind-like protein 1 isoform 1	6	0	0	6
Gamma-aminobutyric acid receptor subunit pi	7	0	0	7
ATP-binding cassette sub-family C member 3	0	13	0	13
Multidrug resistance-associated protein 4	0	13	0	15
Bile salt export pump	0	4	0	4
Voltage-dependent calcium channel gamma-2 subunit	9	0	0	9
Bile salt export pump	0	19	0	19
HLA class I histocompatibility antigen, B alpha chain	5	0	0	5
Gamma-aminobutyric acid receptor subunit beta-1	7	0	0	7
Gamma-aminobutyric acid receptor subunit delta	7	0	0	7
Gamma-aminobutyric acid receptor subunit gamma-2	7	0	0	7
Glutamate receptor 2	9	1	0	10
Gamma-aminobutyric acid receptor subunit alpha-5	7	0	0	7
Gamma-aminobutyric acid receptor subunit alpha-3	7	0	0	7
Gamma-aminobutyric acid receptor subunit gamma-1	7	0	0	7
Gamma-aminobutyric acid receptor subunit alpha-2	7	0	0	7
Gamma-aminobutyric acid receptor subunit alpha-4	7	0	0	7
Gamma-aminobutyric acid receptor subunit gamma-3	7	0	0	7
Gamma-aminobutyric acid receptor subunit alpha-6	7	0	0	7
Gamma-aminobutyric acid receptor subunit alpha-1	7	0	0	7
Gamma-aminobutyric acid receptor subunit beta-3	7	0	0	7
Gamma-aminobutyric acid receptor subunit beta-2	7	0	0	7
GABA theta subunit	7	0	0	7
Inositol hexakisphosphate kinase 1	5	0	0	5
Canalicular multispecific organic anion transporter 1	0	12	0	12
Gamma-aminobutyric acid receptor subunit epsilon	7	0	0	7
Protein-arginine deiminase type-4	0	3	0	3
cytochrome P450 2C9, partial	5	0	0	5
Luciferase	7	0	0	7
endonuclease IV	3	0	0	3
PAX8	0	0	0	1
hypoxia-inducible factor 1 alpha subunit	5	0	0	5
USP1 protein, partial	9	0	0	9
thyroid stimulating hormone receptor	4	0	0	4
glucocerebrosidase	3	0	0	3
nuclear receptor subfamily 1, group I, member 2	5	0	0	5
cytochrome P450 2D6 isoform 1	2	0	0	2
nuclear receptor subfamily 0 group B member 1	0	1	0	1
cytochrome P450 2C19 precursor	2	0	0	2
cytochrome P450 2C9 precursor	3	0	0	3
thyroid hormone receptor beta isoform a	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 2	7	0	0	7
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
flap endonuclease 1	3	0	0	3
steroidogenic factor 1	0	1	0	1
caspase-1 isoform alpha precursor	3	0	0	3
lethal factor (plasmid)	4	0	0	4
neuropeptide S receptor isoform A	1	0	0	1
Solute carrier family 22 member 3	0	1	0	1
Tubulin alpha-1A chain	0	2	1	3
Tubulin beta chain	0	2	1	3
Plasma kallikrein	0	0	0	1
Tubulin beta-4A chain	0	2	2	5
ATP-dependent translocase ABCB1	0	2	0	2
Tubulin beta chain	0	2	2	5
ATP-dependent translocase ABCB1	0	5	2	8
Cytochrome P450 3A4	0	4	1	5
Tubulin alpha-3C chain	0	2	2	5
Serine/threonine-protein kinase pim-1	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	2
Histamine H2 receptor	4	0	0	4
Tubulin alpha-1B chain	0	2	2	5
Tubulin alpha-4A chain	0	2	2	5
Tubulin beta-4B chain	0	2	2	5
Vesicular acetylcholine transporter	0	1	0	1
Tubulin beta-3 chain	0	2	2	5
Tubulin beta-2A chain	0	2	2	5
Tubulin polymerization-promoting protein	0	0	1	1
Tubulin beta-8 chain	0	2	2	5
Tubulin beta-2B chain	0	2	0	2
Tubulin alpha-3E chain	0	2	2	5
Tubulin alpha-1A chain	0	2	2	5
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
CREB-binding protein	1	0	0	1
Tubulin alpha-1C chain	0	2	2	5
Tubulin beta-6 chain	0	2	2	5
Tubulin beta-2B chain	0	2	2	5
Tubulin beta-1 chain	0	2	2	5
Phosphodiesterase	0	1	0	1
Multidrug resistance-associated protein 5	0	0	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	2	0	2
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Skn7p	0	0	0	1
nonstructural protein 1	3	0	0	3
Vpr	2	0	0	2
Solute carrier family 22 member 8	0	0	0	1
Epidermal growth factor receptor	0	3	0	3
Amyloid-beta precursor protein	1	0	0	1
Thymidylate synthase	0	3	0	3
Aromatase	0	1	0	1
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
GLS protein	4	0	0	4
transcriptional regulator ERG isoform 3	3	0	0	3
importin subunit beta-1 isoform 1	3	0	0	3
snurportin-1	3	0	0	3
DNA polymerase kappa isoform 1	4	0	0	4
Acid-sensing ion channel 3	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Dihydrofolate reductase	0	3	0	4
Fatty acid-binding protein, liver	0	2	0	2
Albumin	0	1	1	2
Albumin	0	1	0	1
Albumin	0	0	1	1
Prostaglandin G/H synthase 1	0	4	0	4
Cholinesterase	0	2	0	2
Cytochrome P450 2C9	0	4	0	4
Fatty acid-binding protein, intestinal	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	2
UDP-glucuronosyltransferase 2B7	0	0	0	2
Acetylcholinesterase	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Adenosine receptor A1	0	1	0	1
Caspase-1	0	2	0	2
Adenosine receptor A2a	0	1	0	1
Substance-P receptor	0	1	0	1
Prostaglandin G/H synthase 2	0	3	0	3
Prostaglandin G/H synthase 2	0	1	0	2
UDP-glucuronosyltransferase 1A3	0	0	0	2
Aldo-keto reductase family 1 member C3	0	1	0	1
Caspase-3	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Caspase-4	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Cytochrome P450 2J2	0	3	0	3
Caspase-5	0	1	0	1
Caspase-9	0	1	0	1
Acid-sensing ion channel 1	0	1	0	1
Prostaglandin G/H synthase 2	0	3	0	3
Mu-type opioid receptor	0	5	1	7
Fatty-acid amide hydrolase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
TAR DNA-binding protein 43	3	0	0	3
Solute carrier family 22 member 6	0	1	0	2
Prostaglandin G/H synthase 1	0	1	0	2
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 8	0	1	0	2
Solute carrier family 22 member 6	0	2	0	2
Dehydrogenase/reductase SDR family member 9	0	1	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	1	2
Metallo-beta-lactamase VIM-11	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
streptokinase A precursor	0	0	2	2
Beta-lactamase	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase TEM	0	0	0	1
B2 metallo-beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-13	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	1	2
Metallo-b-lactamase	0	0	0	1
Beta-lactamase IMP-1	0	0	0	1
BlaVIM-1	0	0	0	1
Beta-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Histamine H3 receptor	0	0	0	1
Beta-lactamase class B VIM-2	0	0	1	2
Beta-lactamase	0	0	0	1
Beta-lactamase VIM-1	0	0	0	1
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
Chain A, HADH2 protein	5	0	0	5
Chain B, HADH2 protein	5	0	0	5
Chain A, 2-oxoglutarate Oxygenase	3	0	0	3
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
15-lipoxygenase, partial	2	0	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	5	0	0	5
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	4	0	0	4
vitamin D3 receptor isoform VDRA	5	0	0	5
microphthalmia-associated transcription factor isoform 9	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	3
Tumor necrosis factor	0	2	1	3
Neuraminidase	0	1	0	1
60 kDa chaperonin	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Platelet-activating factor receptor	1	0	0	1
Cystathionine gamma-lyase	0	2	0	2
Caspase-7	2	0	0	2
10 kDa heat shock protein, mitochondrial	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	4
Cystine/glutamate transporter	0	2	0	2
Hydroxyacid oxidase 1	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	3	0	4
large T antigen	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
acid sphingomyelinase	1	0	0	1
dopamine D1 receptor	3	0	0	3
ClpP	1	0	0	1
Thymidylate synthase	0	1	0	1
alpha-galactosidase	1	0	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
DNA polymerase beta	1	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Carbonic anhydrase 2	0	2	1	3
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	2	0	3
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
5-hydroxytryptamine receptor 2A	0	2	0	2
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	2	3
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	3	0	3
Multidrug resistance-associated protein 1	0	0	0	1
Delta-type opioid receptor	0	6	2	9
Mu-type opioid receptor	0	6	2	11
Kappa-type opioid receptor	0	6	2	9
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier family 22 member 11	0	0	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	3
bromodomain adjacent to zinc finger domain 2B	2	0	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Glucocorticoid receptor	0	10	4	19
Glycine receptor subunit alpha-1	0	10	0	10
Androgen receptor	0	11	0	12
Glycine receptor subunit beta	0	10	0	10
Glycine receptor subunit alpha-2	0	10	0	10
Glycine receptor subunit alpha-3	0	10	0	10
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Opioid receptor, delta 1b	0	1	0	1
Solute carrier family 22 member 1	0	3	0	3
Acetylcholinesterase	0	2	0	2
Opioid receptor homologue	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Alpha-2A adrenergic receptor	0	4	1	5
Muscarinic acetylcholine receptor M2	0	1	0	1
Translocator protein	0	0	1	1
Proteinase-activated receptor 1	0	1	1	2
Sodium-dependent serotonin transporter	0	4	0	4
Delta-type opioid receptor	0	3	1	6
Kappa-type opioid receptor	0	4	3	8
Mu-type opioid receptor	0	7	4	14
Delta-type opioid receptor	0	6	4	13
Kappa-type opioid receptor	0	5	0	6
Kappa-type opioid receptor	0	6	3	13
Mu-type opioid receptor	0	4	3	10
Nociceptin receptor	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	5	0	5
Beta-2 adrenergic receptor	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
Mu-type opioid receptor	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	5	0	5
Chain A, Inosine-5'-Monophosphate Dehydrogenase 2	0	1	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	4	0	0	4
UDP-glucuronosyltransferase 1A9	0	0	0	1
Inosine-5'-monophosphate dehydrogenase 2	0	2	0	2
Glutamate receptor 1	0	1	0	1
Glutamate receptor 3	0	1	0	1
Glutamate receptor 4	0	1	0	1
Inosine-5'-monophosphate dehydrogenase 1	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	0	0	2
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Alpha-synuclein	2	1	0	3
Inosine-5'-monophosphate dehydrogenase	0	1	0	2
UDP-glucuronosyltransferase 1A7	0	0	0	1
UDP-glucuronosyltransferase 1A10	0	0	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	2
5-hydroxytryptamine receptor 3E	0	1	0	1
cytochrome P450 2D6	3	0	0	3
5-hydroxytryptamine receptor 3B	0	1	0	1
Cytochrome P450 2D6	0	2	0	3
Nociceptin receptor	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	0	1
5-hydroxytryptamine receptor 3D	0	1	0	1
5-hydroxytryptamine receptor 3C	0	1	0	1
Succinyl-diaminopimelate desuccinylase	0	1	0	1
regulator of G-protein signaling 4	3	0	0	3
vasopressin V1b receptor	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
relaxin receptor 1 isoform 1	1	0	0	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	2	0	2
Adenosine receptor A2b	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Inositol monophosphatase 1	1	0	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	2	0	2
Chitotriosidase-1	0	2	1	3
Endochitinase B1	0	2	1	3
D(1A) dopamine receptor	2	0	0	2
mu-type opioid receptor isoform MOR-1	0	0	1	1
potassium voltage-gated channel subfamily H member 2 isoform d	1	0	0	1
5-hydroxytryptamine receptor 2A	0	0	1	1
5-hydroxytryptamine receptor 4	0	4	0	4
5-hydroxytryptamine receptor 1A	0	1	0	1
D(2) dopamine receptor	0	4	1	5
Alpha-2B adrenergic receptor	0	4	0	4
Alpha-2C adrenergic receptor	0	2	0	2
D	0	1	0	1
D(3) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 1A	0	4	0	4
Alpha-2B adrenergic receptor	0	1	0	1
D(2) dopamine receptor	0	1	0	1
D(1A) dopamine receptor	0	4	0	4
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	4	0	4
D(1B) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 2A	0	4	1	5
5-hydroxytryptamine receptor 2C	0	4	1	5
5-hydroxytryptamine receptor 1B	0	4	0	4
5-hydroxytryptamine receptor 1D	0	1	0	1
D(4) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 1F	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
5-hydroxytryptamine receptor 6	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
D(3) dopamine receptor	0	4	0	4
5-hydroxytryptamine receptor 3A	0	1	0	1
5-hydroxytryptamine receptor 2B	0	4	0	4
5-hydroxytryptamine receptor 6	0	4	0	4
D(2) dopamine receptor	0	2	1	3
5-hydroxytryptamine receptor 4	0	1	0	1
D	0	1	0	1
5-hydroxytryptamine receptor 3B	0	1	0	1
luciferase	0	0	0	1
Estrogen receptor	0	7	2	10
Progesterone receptor	0	6	1	8
Glucocorticoid receptor	0	2	1	3
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	5	2	8
Androgen receptor	0	4	1	5
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	6	2	8
nuclear receptor ROR-gamma isoform 1	4	0	0	4
Interleukin-5	0	1	0	1
Interleukin-5	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Interleukin-5 receptor subunit alpha	0	1	0	1
Chain A, Mineralocorticoid receptor	0	1	0	1
Chain A, Mineralocorticoid receptor	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
Cytochrome P450 2C19	0	1	0	1
Chain A, Glutathione S-transferase	0	1	0	1
Replicase polyprotein 1ab	0	0	2	2
histone deacetylase 9 isoform 3	1	0	0	1
Carbonic anhydrase 1	0	2	0	2
Interstitial collagenase	0	1	0	1
Fibroblast growth factor 1	0	0	1	1
Thromboxane-A synthase	0	2	0	2
Mitogen-activated protein kinase 1	0	1	0	1
Flavin reductase (NADPH)	0	0	1	1
Sodium/bile acid cotransporter	0	1	0	1
Cytochrome P450 3A5	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	0	0	2
Serine/threonine-protein kinase mTOR	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	2	0	2
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
Chain A, CES1 protein	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
apical membrane antigen 1, AMA1	1	0	0	1
DNA polymerase III, partial	1	0	0	1
caspase 7, apoptosis-related cysteine protease	1	0	0	1
caspase-3	1	0	0	1
thyrotropin-releasing hormone receptor	1	0	0	1
Caspase-7	1	0	0	1
Spike glycoprotein	0	0	1	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
interferon gamma precursor	0	0	0	1
caspase-3	1	0	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Transmembrane protease serine 2	0	0	1	1
Serine/threonine-protein kinase D3	0	1	0	1
Lysosomal acid glucosylceramidase	0	0	1	1
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C alpha type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Estrogen receptor	0	0	1	2
Tyrosine-protein kinase Lck	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
Procathepsin L	0	0	1	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
Beta-1 adrenergic receptor	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Muscarinic acetylcholine receptor M1	0	2	0	2
Steroid hormone receptor ERR1	0	1	0	1
Transcriptional activator protein LuxR	0	1	0	1
Angiotensin-converting enzyme	0	2	0	2
Beta-3 adrenergic receptor	0	2	0	2
Alpha-1B adrenergic receptor	0	2	0	2
Protein kinase C alpha type	0	1	0	1
Muscarinic acetylcholine receptor M3	0	2	0	2
Cytochrome P450 2B6	0	1	0	1
Substance-K receptor	0	2	0	2
D(4) dopamine receptor	0	2	0	2
Sodium-dependent noradrenaline transporter	0	2	0	2
Protein kinase C eta type	0	1	0	1
Histamine H2 receptor	0	2	0	2
Substance-P receptor	0	2	0	2
B2 bradykinin receptor	0	2	0	2
Sodium-dependent serotonin transporter	0	2	0	2
Melanocortin receptor 4	0	2	0	2
C-8 sterol isomerase	0	1	0	1
Melanocortin receptor 5	0	2	0	2
Protein kinase C iota type	0	1	0	1
Melanocortin receptor 3	0	2	0	2
Alpha-1A adrenergic receptor	0	2	0	2
Estrogen-related receptor gamma	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Phospholipase D1	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Protein kinase C epsilon type	0	1	0	1
Protein kinase C theta type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Protein kinase C delta type	0	1	0	1
Platelet-activating factor acetylhydrolase	0	1	0	1
Phospholipase D1	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	2	1	3
Serine/threonine-protein kinase D1	0	1	0	1
Estrogen receptor beta	0	0	1	2
Protein kinase C eta type	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Emopamil-binding protein-like	0	1	0	1
Angiotensin-converting enzyme 2	0	0	1	1
7-dehydrocholesterol reductase	0	1	1	2
Protein kinase C theta type	0	1	0	1
Cereblon isoform 4	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Protein cereblon	0	2	1	4
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]