Page last updated: 2024-09-27

Klatskin Tumor

Cholangiocarcinoma arising near or at the confluence of the right and left hepatic ducts (COMMON HEPATIC DUCT). These tumors are generally small, sharply localized, and seldom metastasizing.

Synonyms(1)

Synonym
Klatskin Tumor

Research

Studies (105)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's2 (1.90)12.5806
2000's11 (10.48)18.1394
2010's38 (36.19)28.8240
2020's54 (51.43)9.53
DrugIndicatedRelationship StrengthStudiesTrials
ammonium hydroxide0low10
glycine0low20
pentetic acid0low10
fluorouracil0low30
iohexol0low10
iomeprol0low10
iopromide0low10
oxonic acid0medium21
propofol0low10
tegafur0medium21
prednisone0low10
meglumine0low10
thiazoles0low10
fusarium0low10
hematoxylin0low10
eosine yellowish-(ys)0low10
deoxycytidine0medium264
sulfur hexafluoride0low20
gemcitabine0medium254
iopamidol0low10
fluorodeoxyglucose f180medium81
fibrinogen0low10
6-propylchromone-2-carboxylic acid0low10
technetium tc 99m pentetate0low10
acriflavine0low10
zn(ii)-phthalocyanine0low10
nitinol0low10
bilirubin0low160
phenylephrine hydrochloride0low10
biliverdine0low10
bismuth0low270
gadolinium dtpa0low10
gw 40640low10
edoxaban0low10
technetium tc 99m mebrofenin0low20
indocyanine green0medium21
hes1 protein, human0low10
olaparib0low10
interleukin-80low10
s 1 (combination)0medium21
transforming growth factor beta0low10
metallothionein0low10

Protein Targets (323)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE3003
acetylcholinesterase2002
hypoxia-inducible factor 1 alpha subunit3003
RAR-related orphan receptor gamma6006
SMAD family member 21001
Fumarate hydratase1001
SMAD family member 31001
TDP1 protein7007
GLI family zinc finger 37007
AR protein8008
caspase 7, apoptosis-related cysteine protease2002
estrogen receptor 2 (ER beta)4004
nuclear receptor subfamily 1, group I, member 34004
progesterone receptor5005
cytochrome P450 family 3 subfamily A polypeptide 45005
glucocorticoid receptor [Homo sapiens]8008
retinoic acid nuclear receptor alpha variant 15005
retinoid X nuclear receptor alpha2002
estrogen-related nuclear receptor alpha6006
farnesoid X nuclear receptor4004
pregnane X nuclear receptor6006
estrogen nuclear receptor alpha9009
cytochrome P450 2D61001
polyprotein1001
67.9K protein3003
peroxisome proliferator-activated receptor delta3003
peroxisome proliferator activated receptor gamma3003
vitamin D (1,25- dihydroxyvitamin D3) receptor3003
caspase-32002
aryl hydrocarbon receptor2002
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a6006
thyroid stimulating hormone receptor2002
activating transcription factor 63003
thyrotropin-releasing hormone receptor1001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
v-jun sarcoma virus 17 oncogene homolog (avian)5005
Histone H2A.x3003
potassium voltage-gated channel subfamily H member 2 isoform d3003
thyroid hormone receptor beta isoform 25005
nuclear factor erythroid 2-related factor 2 isoform 15005
Voltage-dependent calcium channel gamma-2 subunit3003
Interferon beta5005
Cellular tumor antigen p537007
Glutamate receptor 23003
Spike glycoprotein6017
ATPase family AAA domain-containing protein 54004
Ataxin-24004
Chain A, TYROSYL-DNA PHOSPHODIESTERASE4004
Chain A, Putative fructose-1,6-bisphosphate aldolase3003
Chain A, HADH2 protein3003
Chain B, HADH2 protein3003
Chain A, 2-oxoglutarate Oxygenase4004
Chain A, Cruzipain1001
phosphopantetheinyl transferase2002
USP1 protein, partial6006
Microtubule-associated protein tau4004
aldehyde dehydrogenase 1 family, member A14004
vitamin D3 receptor isoform VDRA4004
DNA polymerase kappa isoform 13003
caspase-1 isoform alpha precursor1001
lamin isoform A-delta107007
Caspase-71001
Inositol monophosphatase 12002
Solute carrier organic anion transporter family member 1B30203
Solute carrier organic anion transporter family member 1B10203
Thymidine kinase 2 0101
Deoxycytidine kinase0002
Probable deoxycytidylate deaminase0001
Cytidine deaminase0002
AAA family ATPase 0002
Reverse transcriptase/RNaseH 0011
Coagulation factor X0202
Chain A, Uracil Phosphoribosyltransferase0101
Luciferase2002
interleukin 81001
endonuclease IV2002
glp-1 receptor, partial2002
Skn7p0001
thioredoxin reductase4004
pregnane X receptor2002
ATAD5 protein, partial2002
Thrombopoietin1001
thyroid stimulating hormone receptor3003
EWS/FLI fusion protein2002
nonstructural protein 12002
arylsulfatase A2002
IDH12002
euchromatic histone-lysine N-methyltransferase 25005
peripheral myelin protein 22 isoform 12002
hemoglobin subunit beta1001
chromobox protein homolog 14004
nuclear factor erythroid 2-related factor 2 isoform 24004
huntingtin isoform 21001
flap endonuclease 13003
serine/threonine-protein kinase mTOR isoform 11001
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
geminin5005
Vpr2002
peripheral myelin protein 224004
survival motor neuron protein isoform d2002
muscleblind-like protein 1 isoform 11001
ATP-binding cassette sub-family C member 30303
Multidrug resistance-associated protein 40303
Solute carrier family 22 member 80001
Bile salt export pump0303
Epidermal growth factor receptor0101
Amyloid-beta precursor protein1001
Thymidylate synthase0101
Aromatase0101
Canalicular multispecific organic anion transporter 10303
HSP40, subfamily A [Plasmodium falciparum 3D7]0001
ATP-dependent phosphofructokinase3003
Chain A, DEOXYNUCLEOSIDE KINASE0101
Spike glycoprotein0011
Replicase polyprotein 1ab0011
Transmembrane protease serine 20011
Procathepsin L0011
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Equilibrative nucleoside transporter 10101
Angiotensin-converting enzyme 2 0011
Glycine receptor subunit alpha-10011
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Glutamate receptor ionotropic, NMDA 1 0213
Sodium- and chloride-dependent glycine transporter 10101
Glutamate receptor ionotropic, NMDA 2A 0213
Glutamate receptor ionotropic, NMDA 2B0213
Glutamate receptor ionotropic, NMDA 2C0213
Large neutral amino acids transporter small subunit 10101
Glutamate receptor ionotropic, NMDA 2D0213
Proton-coupled amino acid transporter 10101
Glutamate receptor ionotropic, NMDA 3B0213
Serine racemase0101
Olfactory receptor 51E20011
Glutamate receptor ionotropic, NMDA 3A0213
Sodium- and chloride-dependent glycine transporter 20101
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
Chain A, Ferritin light chain2002
Bloom syndrome protein isoform 14004
thyroid hormone receptor beta isoform a1001
tyrosine-protein kinase Yes1001
nuclear receptor ROR-gamma isoform 14004
histone acetyltransferase KAT2A isoform 12002
Cytochrome P450 3A40011
Vitamin D3 receptor0101
Bile acid receptor0011
Bile acid receptor0113
Chain E, Fibrin beta chain0101
Chain A, JmjC domain-containing histone demethylation protein 3A1001
Chain A, RNA-directed RNA polymerase NS50101
15-lipoxygenase, partial2002
WRN1001
Mcl-10101
MPI protein0101
Cyclin-dependent kinase 5, regulatory subunit 1 (p35)0001
PPM1D protein2002
alkaline phosphatase, intestinal0011
thioredoxin glutathione reductase2002
apical membrane antigen 1, AMA11001
hypothetical protein, conserved1001
regulator of G-protein signaling 41001
G2002
glucocerebrosidase1001
luciferase1001
bromodomain adjacent to zinc finger domain 2B1001
pyruvate kinase1001
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase0101
CDK50001
serine-protein kinase ATM isoform a1001
lysosomal alpha-glucosidase preproprotein2002
major prion protein preproprotein Prp precursor0101
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein0011
cellular tumor antigen p53 isoform a1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
glucose-6-phosphate 1-dehydrogenase isoform b0101
intestinal alkaline phosphatase precursor0011
DNA polymerase beta1001
mitogen-activated protein kinase 11001
serine/threonine-protein kinase PLK11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
DNA polymerase iota isoform a (long)2002
lethal(3)malignant brain tumor-like protein 1 isoform I1001
Vif0101
Tat0101
cytochrome P450 3A4 isoform 12002
DNA dC->dU-editing enzyme APOBEC-3G isoform 10101
alkaline phosphatase, germ cell type preproprotein0011
endoribonuclease toxin MazF0011
DNA dC->dU-editing enzyme APOBEC-3F isoform a1001
Gamma-aminobutyric acid receptor subunit pi2114
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
Rap guanine nucleotide exchange factor 31001
HLA class I histocompatibility antigen, B alpha chain 2002
Integrin beta-31001
Integrin alpha-IIb1001
Pyruvate kinase PKM0101
Gamma-aminobutyric acid receptor subunit beta-12114
Gamma-aminobutyric acid receptor subunit delta2114
Gamma-aminobutyric acid receptor subunit gamma-22114
Gamma-aminobutyric acid receptor subunit alpha-52114
Gamma-aminobutyric acid receptor subunit alpha-32114
Endothelin receptor type B1001
Gamma-aminobutyric acid receptor subunit gamma-12114
Gamma-aminobutyric acid receptor subunit alpha-22114
Endothelin-1 receptor1001
Gamma-aminobutyric acid receptor subunit alpha-42114
Gamma-aminobutyric acid receptor subunit gamma-32114
Gamma-aminobutyric acid receptor subunit alpha-62114
Histamine H2 receptor2002
Gamma-aminobutyric acid receptor subunit alpha-12114
Gamma-aminobutyric acid receptor subunit beta-32114
Gamma-aminobutyric acid receptor subunit beta-22114
GABA theta subunit2114
Inositol hexakisphosphate kinase 12002
Gamma-aminobutyric acid receptor subunit epsilon2114
cytochrome P450 2C9, partial2002
phosphoglycerate kinase1001
hypothetical protein CAALFM_CR05890CA0001
H3 histone acetyltransferase0001
large T antigen0101
nuclear receptor subfamily 1, group I, member 22002
importin subunit beta-1 isoform 11001
snurportin-11001
GTP-binding nuclear protein Ran isoform 11001
Poly [ADP-ribose] polymerase tankyrase-10101
Cytochrome P450 1A20101
Cholinesterase0101
Poly [ADP-ribose] polymerase 10224
Cytochrome P450 2D60101
Protein mono-ADP-ribosyltransferase PARP60101
Protein mono-ADP-ribosyltransferase PARP150101
Protein mono-ADP-ribosyltransferase PARP100112
Protein mono-ADP-ribosyltransferase PARP80011
Protein mono-ADP-ribosyltransferase PARP160112
Protein mono-ADP-ribosyltransferase PARP120101
Poly [ADP-ribose] polymerase tankyrase-20101
Histamine H3 receptor0101
Poly [ADP-ribose] polymerase 20123
Protein mono-ADP-ribosyltransferase PARP40112
Protein mono-ADP-ribosyltransferase PARP30123
GALC protein2002
cytochrome P450 2C19 precursor1001
M-phase phosphoprotein 81001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)3003
beta-2 adrenergic receptor1001
mu-type opioid receptor isoform MOR-10011
5-hydroxytryptamine receptor 2A0011
Neuronal acetylcholine receptor subunit alpha-41001
Neuronal acetylcholine receptor subunit beta-21001
luciferase0001
Fatty acid-binding protein, liver0101
Estrogen receptor0202
Glucocorticoid receptor04211
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Glycine receptor subunit alpha-10404
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Androgen receptor0202
Cytochrome P450 2C9 0101
Glutamine synthetase0011
Androgen receptor0101
Glycine receptor subunit beta0404
Glycine receptor subunit alpha-20404
Glycine receptor subunit alpha-30404
Histamine H1 receptor0011
Prostaglandin G/H synthase 20101
Nociceptin receptor0011
Cytochrome P450 2J20101
Estrogen receptor beta0202
Nuclear receptor ROR-gamma1001
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
GLS protein1001
D(1A) dopamine receptor1001
heat shock protein beta-11001
muscarinic acetylcholine receptor M11001
Fatty-acid amide hydrolase 10101
UDP-glucuronosyltransferase 1A90001
5-hydroxytryptamine receptor 40202
Carbonic anhydrase 10101
Carbonic anhydrase 20101
Aldo-keto reductase family 1 member B10202
Gamma-aminobutyric acid receptor subunit alpha-10001
Gamma-aminobutyric acid receptor subunit beta-10001
Gamma-aminobutyric acid receptor subunit alpha-20001
Gamma-aminobutyric acid receptor subunit alpha-30001
Polyunsaturated fatty acid lipoxygenase ALOX150101
Gamma-aminobutyric acid receptor subunit alpha-10112
Gamma-aminobutyric acid receptor subunit beta-10011
Gamma-aminobutyric acid receptor subunit gamma-20112
Gamma-aminobutyric acid receptor subunit alpha-40001
Gamma-aminobutyric acid receptor subunit gamma-20001
Prostaglandin G/H synthase 10101
Sodium-dependent noradrenaline transporter 0202
Sodium- and chloride-dependent GABA transporter 10101
5-hydroxytryptamine receptor 2C0202
Gamma-aminobutyric acid receptor subunit beta-30112
Gamma-aminobutyric acid receptor subunit alpha-50011
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-30011
5-hydroxytryptamine receptor 2B0202
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit beta-20011
Sodium- and chloride-dependent betaine transporter0101
Gamma-aminobutyric acid receptor subunit alpha-40011
Fatty-acid amide hydrolase 10101
Gamma-aminobutyric acid receptor subunit alpha-60011
UDP-glucuronosyltransferase 1A80001
Chain A, Beta-lactamase1001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]