spironolactone has been researched along with Debility in 1 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The impact of frailty on outcomes in randomized heart failure with preserved ejection fraction (HFpEF) trials has not been previously reported." | 2.87 | The frailty syndrome and outcomes in the TOPCAT trial. ( Claggett, B; Desai, AS; Fang, JC; Lewis, EF; Liu, J; Pfeffer, MA; Sanders, NA; Solomon, SD; Supiano, MA; Sweitzer, NK, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sanders, NA | 1 |
| Supiano, MA | 1 |
| Lewis, EF | 1 |
| Liu, J | 1 |
| Claggett, B | 1 |
| Pfeffer, MA | 1 |
| Desai, AS | 1 |
| Sweitzer, NK | 1 |
| Solomon, SD | 1 |
| Fang, JC | 1 |
1 trial available for spironolactone and Debility
| Article | Year |
|---|---|
The frailty syndrome and outcomes in the TOPCAT trial.
Topics: Aged; Americas; Double-Blind Method; Female; Frail Elderly; Frailty; Georgia (Republic); Heart Failu | 2018 |