propofol has been researched along with Debility in 2 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Guiding propofol induction dose according to baseline frailty score should also be considered to estimate individualized dosage profiles." | 1.51 | Bioelectrical impedance analysis of body composition for the anesthetic induction dose of propofol in older patients. ( Araújo, AM; Falcão, AC; Machado, HS; Soares-da-Silva, P, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cheung, EH | 1 |
| Cheung, JC | 1 |
| Yip, YY | 1 |
| Araújo, AM | 1 |
| Machado, HS | 1 |
| Falcão, AC | 1 |
| Soares-da-Silva, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Modelling Propofol Pharmacokinetics and Pharmacodynamics During an Intravenous Anaesthesia Guided by the Bispectral Index (BIS)[NCT02713698] | 60 participants (Actual) | Observational | 2016-04-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Arterial blood samples were obtained after LOC and every 20-30 minutes during propofol infusion. After stopping propofol infusion, arterial blood samples were obtained immediately after recovery of consciousness.~At the end of the surgery arterial blood samples were centrifuged at 2862xg for 5 minutes and they were preserved at -80ºC until analysis.~The quantification of propofol in serum was performed using gas chromatography/ion trap-mass spectrometry (GC/IT-MS)" (NCT02713698)
Timeframe: up to 2 hours
| Intervention | mcg/mL (Mean) |
|---|---|
| Group 1 (≥18 Years, BMI<35kg/m2) | 2.36 |
| Group 2 (≥18 Years, BMI≥35kg/m2) | 3.12 |
| Group 3 (≥65 Years) | 2.91 |
2 other studies available for propofol and Debility
| Article | Year |
|---|---|
Clinical Frailty Scale and the FRAIL checklist: Can they complement each other?
Topics: Aged; Checklist; Frail Elderly; Frailty; Humans; Propofol; Randomized Controlled Trials as Topic | 2023 |
Bioelectrical impedance analysis of body composition for the anesthetic induction dose of propofol in older patients.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anesthetics, Intravenous; Body Composition; | 2019 |