fluorouracil has been researched along with Debility in 3 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patient age, frailty and comorbidities will be considered to guide trial entry." | 3.30 | Personalizing neoadjuvant chemotherapy for locally advanced colon cancer: protocols for the international phase III FOxTROT2 and FOxTROT3 randomized controlled trials. ( Cairns, DA; Craig, Z; Glasbey, JC; Morton, D; Platt, JR; Seligmann, J; Williams, CJM, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 2 (66.67) | 2.80 |
| Authors | Studies |
|---|---|
| Aparicio, T | 1 |
| Bouché, O | 1 |
| Etienne, PL | 1 |
| Barbier, E | 1 |
| Mineur, L | 1 |
| Desgrippes, R | 1 |
| Guérin-Meyer, V | 1 |
| Hocine, F | 1 |
| Martin, J | 1 |
| Le Brun-Ly, V | 1 |
| Cretin, J | 1 |
| Desramé, J | 1 |
| Rinaldi, Y | 1 |
| Cany, L | 1 |
| Falandry, C | 1 |
| Lefevre, LB | 1 |
| Marous, M | 1 |
| Terrebonne, E | 1 |
| Mosser, L | 1 |
| Turpin, J | 1 |
| Turpin, A | 1 |
| Bauguion, L | 1 |
| Reichling, C | 1 |
| Van den Eynde, M | 1 |
| Carola, E | 1 |
| Hiret, S | 1 |
| Platt, JR | 1 |
| Williams, CJM | 1 |
| Craig, Z | 1 |
| Cairns, DA | 1 |
| Glasbey, JC | 1 |
| Morton, D | 1 |
| Seligmann, J | 1 |
| Macarulla, T | 1 |
| Carrato, A | 1 |
| Díaz, R | 1 |
| García, A | 1 |
| Laquente, B | 1 |
| Sastre, J | 1 |
| Álvarez, R | 1 |
| Muñoz, A | 1 |
| Hidalgo, M | 1 |
1 review available for fluorouracil and Debility
| Article | Year |
|---|---|
Management and supportive treatment of frail patients with metastatic pancreatic cancer.
Topics: Aged; Aged, 80 and over; Albumins; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogeni | 2019 |
2 trials available for fluorouracil and Debility
| Article | Year |
|---|---|
Preliminary tolerance analysis of adjuvant chemotherapy in older patients after resection of stage III colon cancer from the PRODIGE 34-FFCD randomized trial.
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Chemotherapy, Ad | 2023 |
Personalizing neoadjuvant chemotherapy for locally advanced colon cancer: protocols for the international phase III FOxTROT2 and FOxTROT3 randomized controlled trials.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Clinical Trials, Phase | 2023 |