phytic acid has been researched along with Disease Models, Animal in 31 studies
Phytic Acid: Complexing agent for removal of traces of heavy metal ions. It acts also as a hypocalcemic agent.
myo-inositol hexakisphosphate : A myo-inositol hexakisphosphate in which each hydroxy group of myo-inositol is monophosphorylated.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Phytic acid (PA) has been demonstrated to have a potent anticarcinogenic activity against colorectal cancer (CRC)." | 7.88 | Phytic acid improves intestinal mucosal barrier damage and reduces serum levels of proinflammatory cytokines in a 1,2-dimethylhydrazine-induced rat colorectal cancer model. ( Chen, C; Cheng, L; Li, X; Liu, C; Song, Y; Yang, F, 2018) |
| "The aim of this study was to investigate the effect of phytic acid (PA) on fatty liver and gut microflora in rats fed a high-sucrose (HSC) diet." | 7.83 | Dietary phytic acid prevents fatty liver by reducing expression of hepatic lipogenic enzymes and modulates gut microflora in rats fed a high-sucrose diet. ( Katayama, T; Okazaki, Y; Sekita, A, 2016) |
| "This study was aimed to evaluate the preventive role of phytic acid on lysosomal enzymes in isoproterenol (ISO)-induced myocardial infarction (MI) in male Wistar rats." | 7.81 | Preventive effect of phytic acid on lysosomal hydrolases in normal and isoproterenol-induced myocardial infarction in Wistar rats. ( Brindha, E; Rajasekapandiyan, M, 2015) |
| "Phytic acid (PA) has been demonstrated to have a potent anticarcinogenic activity against colorectal cancer (CRC)." | 3.88 | Phytic acid improves intestinal mucosal barrier damage and reduces serum levels of proinflammatory cytokines in a 1,2-dimethylhydrazine-induced rat colorectal cancer model. ( Chen, C; Cheng, L; Li, X; Liu, C; Song, Y; Yang, F, 2018) |
| "The aim of this study was to investigate the effect of phytic acid (PA) on fatty liver and gut microflora in rats fed a high-sucrose (HSC) diet." | 3.83 | Dietary phytic acid prevents fatty liver by reducing expression of hepatic lipogenic enzymes and modulates gut microflora in rats fed a high-sucrose diet. ( Katayama, T; Okazaki, Y; Sekita, A, 2016) |
| "This study was aimed to evaluate the preventive role of phytic acid on lysosomal enzymes in isoproterenol (ISO)-induced myocardial infarction (MI) in male Wistar rats." | 3.81 | Preventive effect of phytic acid on lysosomal hydrolases in normal and isoproterenol-induced myocardial infarction in Wistar rats. ( Brindha, E; Rajasekapandiyan, M, 2015) |
| " The aim of this study was to determine whether neutrophil accumulation would participate in the development of intimal hyperplasia after endothelial injury in mice, and whether d-myo-inositol hexakisphosphate (phytic acid) which inhibits the binding of L- and P-selectin to sialyl Lewis(X) could inhibit the development of intimal hyperplasia." | 3.73 | Neutrophil accumulation promotes intimal hyperplasia after photochemically induced arterial injury in mice. ( Hara, H; Kondo, K; Nakashima, M; Shimazawa, M; Umemura, K; Watanabe, S, 2005) |
| "Phytic acid (IP6) is a natural antioxidant that is found mainly in cereals and vegetables and, for a long period of time, was considered an antinutritional factor." | 2.53 | Phytic Acid: From Antinutritional to Multiple Protection Factor of Organic Systems. ( Bracarense, AP; Silva, EO, 2016) |
| "A striking anticancer action of IP(6) was demonstrated in different experimental models." | 2.43 | Protection against cancer by dietary IP6 and inositol. ( Shamsuddin, AM; Vucenik, I, 2006) |
| "A striking anticancer effect of IP6 was demonstrated in different experimental models." | 2.42 | Cancer inhibition by inositol hexaphosphate (IP6) and inositol: from laboratory to clinic. ( Shamsuddin, AM; Vucenik, I, 2003) |
| "Phytic acid was also found to protect intestinal barrier integrity in mice with UC by maintaining the expression of tight junction proteins (occludin, claudin-3 and ZO-1) and mucin-2." | 1.72 | The improved effect and its mechanism of phytic acid on DSS-induced UC mice. ( Dong, L; Hou, X; Sang, Y, 2022) |
| "Phytic acid was well tolerated." | 1.37 | Phytic acid as a potential treatment for alzheimer's pathology: evidence from animal and in vitro models. ( Anekonda, TS; Frahler, K; Harris, C; Petriko, B; Quinn, JF; Ralle, M; Sabin, R; Wadsworth, TL; Woltjer, R, 2011) |
| "Phytic acid (PA) also acts as a natural antioxidant and may have numerous health benefits." | 1.37 | Green tea, phytic acid, and inositol in combination reduced the incidence of azoxymethane-induced colon tumors in Fisher 344 male rats. ( Davis, S; Khatiwada, J; Verghese, M; Williams, LL, 2011) |
| "Deoxypyridinoline was significantly increased in rats in the non-phytate treatment group." | 1.36 | Effect of tetracalcium dimagnesium phytate on bone characteristics in ovariectomized rats. ( Grases, F; López-González, ÁA; Perelló, J; Prieto, RM; Sanchis, P, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.23) | 18.7374 |
| 1990's | 2 (6.45) | 18.2507 |
| 2000's | 9 (29.03) | 29.6817 |
| 2010's | 17 (54.84) | 24.3611 |
| 2020's | 2 (6.45) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, HJ | 1 |
| Jung, YS | 1 |
| Jung, YJ | 1 |
| Kim, OH | 1 |
| Oh, BC | 1 |
| Hou, X | 1 |
| Sang, Y | 1 |
| Dong, L | 1 |
| Yu, W | 1 |
| Liu, C | 3 |
| Li, X | 2 |
| Yang, F | 2 |
| Cheng, L | 2 |
| Song, Y | 2 |
| Chen, C | 1 |
| Ivarsson, ME | 1 |
| Durantie, E | 1 |
| Huberli, C | 1 |
| Huwiler, S | 1 |
| Hegde, C | 1 |
| Friedman, J | 1 |
| Altamura, F | 1 |
| Lu, J | 1 |
| Verdu, EF | 1 |
| Bercik, P | 1 |
| Logan, SM | 1 |
| Chen, W | 1 |
| Leroux, JC | 1 |
| Castagner, B | 1 |
| Kim, W | 1 |
| Kim, E | 1 |
| Min, H | 1 |
| Kim, MG | 1 |
| Eisenbeis, VB | 1 |
| Dutta, AK | 1 |
| Pavlovic, I | 1 |
| Jessen, HJ | 1 |
| Kim, S | 1 |
| Seong, RH | 1 |
| Araki, K | 1 |
| Mizokami, D | 1 |
| Tomifuji, M | 1 |
| Yamashita, T | 1 |
| Ohnuki, K | 1 |
| Umeda, IO | 1 |
| Fujii, H | 1 |
| Kosuda, S | 1 |
| Shiotani, A | 1 |
| Brindha, E | 1 |
| Rajasekapandiyan, M | 1 |
| Radtke, J | 1 |
| Schutkowski, A | 1 |
| Brandsch, C | 1 |
| Hirche, F | 1 |
| Hasenkopf, K | 1 |
| Stangl, GI | 1 |
| Funao, H | 1 |
| Nagai, S | 1 |
| Sasaki, A | 1 |
| Hoshikawa, T | 1 |
| Tsuji, T | 1 |
| Okada, Y | 1 |
| Koyasu, S | 1 |
| Toyama, Y | 1 |
| Nakamura, M | 1 |
| Aizawa, M | 1 |
| Matsumoto, M | 1 |
| Ishii, K | 1 |
| Sekita, A | 1 |
| Okazaki, Y | 1 |
| Katayama, T | 1 |
| Silva, EO | 1 |
| Bracarense, AP | 1 |
| Gavin, HE | 1 |
| Beubier, NT | 1 |
| Satchell, KJ | 1 |
| Arya, M | 1 |
| Tiwari, P | 1 |
| Tripathi, CB | 1 |
| Parashar, P | 1 |
| Singh, M | 1 |
| Sinha, P | 1 |
| Yadav, NP | 1 |
| Kaithwas, G | 1 |
| Gupta, KP | 2 |
| Saraf, SA | 1 |
| Singh, J | 1 |
| Anekonda, TS | 1 |
| Wadsworth, TL | 1 |
| Sabin, R | 1 |
| Frahler, K | 1 |
| Harris, C | 1 |
| Petriko, B | 1 |
| Ralle, M | 1 |
| Woltjer, R | 1 |
| Quinn, JF | 1 |
| Grases, F | 2 |
| Sanchis, P | 1 |
| Prieto, RM | 2 |
| Perelló, J | 2 |
| López-González, ÁA | 1 |
| Khatiwada, J | 1 |
| Verghese, M | 1 |
| Davis, S | 1 |
| Williams, LL | 1 |
| Bourgeaux, V | 1 |
| Aufradet, E | 1 |
| Campion, Y | 1 |
| De Souza, G | 1 |
| Horand, F | 1 |
| Bessaad, A | 1 |
| Chevrier, AM | 1 |
| Canet-Soulas, E | 1 |
| Godfrin, Y | 1 |
| Martin, C | 1 |
| Raina, K | 1 |
| Ravichandran, K | 1 |
| Rajamanickam, S | 1 |
| Huber, KM | 1 |
| Serkova, NJ | 1 |
| Agarwal, R | 1 |
| Schlemmer, U | 1 |
| Jany, KD | 1 |
| Berk, A | 1 |
| Schulz, E | 1 |
| Rechkemmer, G | 1 |
| Vucenik, I | 2 |
| Shamsuddin, AM | 2 |
| Simonet, BM | 1 |
| Torres, JJ | 1 |
| Shimazawa, M | 1 |
| Watanabe, S | 1 |
| Kondo, K | 1 |
| Hara, H | 1 |
| Nakashima, M | 1 |
| Umemura, K | 1 |
| Marks, G | 1 |
| Aydos, RD | 1 |
| Fagundes, DJ | 1 |
| Pontes, ER | 1 |
| Takita, LC | 1 |
| Amaral, EG | 1 |
| Rossini, A | 1 |
| Ynouye, CM | 1 |
| Flanagan, PR | 1 |
| Ferguson, LR | 1 |
| Harris, PJ | 1 |
| Sun, AS | 1 |
| Yeh, HC | 1 |
| Wang, LH | 1 |
| Huang, YP | 1 |
| Maeda, H | 1 |
| Pivazyan, A | 1 |
| Hsu, C | 1 |
| Lewis, ER | 1 |
| Bruckner, HW | 1 |
| Fasy, TM | 1 |
| Bode, AM | 1 |
| Dong, Z | 1 |
| Nadkarni, GD | 1 |
| Shimpi, HH | 1 |
| Noronha, OP | 1 |
5 reviews available for phytic acid and Disease Models, Animal
| Article | Year |
|---|---|
Phytic Acid: From Antinutritional to Multiple Protection Factor of Organic Systems.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Cell Line, Tumor; Disease Models, Animal; Edible Gra | 2016 |
Cancer inhibition by inositol hexaphosphate (IP6) and inositol: from laboratory to clinic.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Carcinogens; Colonic Neoplasms; Disease Mod | 2003 |
Protection against cancer by dietary IP6 and inositol.
Topics: Animals; Antineoplastic Agents; Cell Differentiation; Cell Division; Cell Transformation, Neoplastic | 2006 |
Protection against cancer by wheat bran: role of dietary fibre and phytochemicals.
Topics: Animals; Anticarcinogenic Agents; Breast Neoplasms; Colonic Neoplasms; Dietary Fiber; Disease Models | 1999 |
Signal transduction pathways: targets for chemoprevention of skin cancer.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Aspirin; Cell Transformat | 2000 |
26 other studies available for phytic acid and Disease Models, Animal
| Article | Year |
|---|---|
High-Phytate Diets Increase Amyloid β Deposition and Apoptotic Neuronal Cell Death in a Rat Model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein | 2021 |
The improved effect and its mechanism of phytic acid on DSS-induced UC mice.
Topics: Animals; Caco-2 Cells; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Animal; | 2022 |
Inositol hexaphosphate suppresses colorectal cancer cell proliferation via the Akt/GSK-3β/β-catenin signaling cascade in a 1,2-dimethylhydrazine-induced rat model.
Topics: 1,2-Dimethylhydrazine; Animals; Apoptosis; beta Catenin; Cell Proliferation; Colorectal Neoplasms; D | 2017 |
Phytic acid improves intestinal mucosal barrier damage and reduces serum levels of proinflammatory cytokines in a 1,2-dimethylhydrazine-induced rat colorectal cancer model.
Topics: 1,2-Dimethylhydrazine; Animals; Body Weight; Cadherins; Claudin-1; Colon; Colorectal Neoplasms; Cyto | 2018 |
Small-Molecule Allosteric Triggers of Clostridium difficile Toxin B Auto-proteolysis as a Therapeutic Strategy.
Topics: Allosteric Regulation; Animals; Bacterial Proteins; Bacterial Toxins; Clostridioides difficile; Clos | 2019 |
Inositol polyphosphates promote T cell-independent humoral immunity via the regulation of Bruton's tyrosine kinase.
Topics: Agammaglobulinaemia Tyrosine Kinase; Agammaglobulinemia; Animals; B-Lymphocytes; Disease Models, Ani | 2019 |
Novel Indocyanine Green-Phytate Colloid Technique for Sentinel Node Detection in Head and Neck: Mouse Study.
Topics: Animals; Colloids; Disease Models, Animal; Feasibility Studies; Fluorescence; Head and Neck Neoplasm | 2014 |
Preventive effect of phytic acid on lysosomal hydrolases in normal and isoproterenol-induced myocardial infarction in Wistar rats.
Topics: Acetylglucosaminidase; Animals; Antioxidants; Cathepsin B; Cathepsin D; Cytoprotection; Disease Mode | 2015 |
Isolated Conglutin γ from Lupin, but not Phytate, Lowers Serum Cholesterol Without Influencing Vascular Lesion Development in the ApoE-deficient Mouse Model.
Topics: Animals; Apolipoproteins E; Biomarkers; Cholesterol; Dehydrocholesterols; Disease Models, Animal; Lu | 2015 |
A novel hydroxyapatite film coated with ionic silver via inositol hexaphosphate chelation prevents implant-associated infection.
Topics: Animals; C-Reactive Protein; Cell Line; Cell Survival; Chelating Agents; Coated Materials, Biocompat | 2016 |
Dietary phytic acid prevents fatty liver by reducing expression of hepatic lipogenic enzymes and modulates gut microflora in rats fed a high-sucrose diet.
Topics: Animals; Diet; Dietary Sucrose; Disease Models, Animal; Fatty Liver; Gastrointestinal Microbiome; Li | 2016 |
The Effector Domain Region of the Vibrio vulnificus MARTX Toxin Confers Biphasic Epithelial Barrier Disruption and Is Essential for Systemic Spread from the Intestine.
Topics: Animals; Apoptosis; Bacterial Proteins; Bacterial Toxins; Cell Membrane; Disease Models, Animal; Epi | 2017 |
Colloidal Vesicular System of Inositol Hexaphosphate to Counteract DMBA Induced Dysregulation of Markers Pertaining to Cellular Proliferation/Differentiation and Inflammation of Epidermal Layer in Mouse Model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Differentiation; Cell Proliferation; Chemistry, Phar | 2017 |
Inositol hexaphosphate induces apoptosis by coordinative modulation of P53, Bcl-2 and sequential activation of caspases in 7,12 dimethylbenz[a]anthracene exposed mouse epidermis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Antineoplastic Agents; Apoptosis | 2008 |
Phytic acid as a potential treatment for alzheimer's pathology: evidence from animal and in vitro models.
Topics: Adenosine Triphosphate; Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Animals; Ant | 2011 |
Effect of tetracalcium dimagnesium phytate on bone characteristics in ovariectomized rats.
Topics: Amino Acids; Animals; Biomarkers; Bone and Bones; Bone Density; Bone Resorption; Calcium; Calcium, D | 2010 |
Green tea, phytic acid, and inositol in combination reduced the incidence of azoxymethane-induced colon tumors in Fisher 344 male rats.
Topics: Administration, Oral; Animals; Anticarcinogenic Agents; Antineoplastic Combined Chemotherapy Protoco | 2011 |
Efficacy of homologous inositol hexaphosphate-loaded red blood cells in sickle transgenic mice.
Topics: Anemia, Sickle Cell; Animals; Arterial Occlusive Diseases; Brain; Disease Models, Animal; Erythrocyt | 2012 |
Inositol hexaphosphate inhibits tumor growth, vascularity, and metabolism in TRAMP mice: a multiparametric magnetic resonance study.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Biomarkers, Tumor; Body Weight; Cell Proliferatio | 2013 |
Degradation of phytate in the gut of pigs--pathway of gastro-intestinal inositol phosphate hydrolysis and enzymes involved.
Topics: 6-Phytase; Alkaline Phosphatase; Animal Feed; Animals; Chromatography, High Pressure Liquid; Digesti | 2001 |
Dietary myo-inositol hexaphosphate prevents dystrophic calcifications in soft tissues: a pilot study in Wistar rats.
Topics: Administration, Oral; Animals; Calcinosis; Diet; Disease Models, Animal; Etidronic Acid; Injections, | 2004 |
Neutrophil accumulation promotes intimal hyperplasia after photochemically induced arterial injury in mice.
Topics: Animals; Antibodies; Cell Adhesion; Cells, Cultured; Disease Models, Animal; Dose-Response Relations | 2005 |
Modulation of transforming growth factor beta2 (TGF-beta2) by inositol hexaphosphate in colon carcinogenesis in rats.
Topics: Animals; Azoxymethane; Carcinogenicity Tests; Carcinogens; Colon; Colonic Neoplasms; Disease Models, | 2006 |
A model to produce pure zinc deficiency in rats and its use to demonstrate that dietary phytate increases the excretion of endogenous zinc.
Topics: Animals; Anorexia; Dietary Carbohydrates; Disease Models, Animal; Enteral Nutrition; Intestinal Abso | 1984 |
Pilot study of a specific dietary supplement in tumor-bearing mice and in stage IIIB and IV non-small cell lung cancer patients.
Topics: Adult; Aged; Aged, 80 and over; Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Coum | 2001 |
Biokinetics of 99mTc-labelled liver-imaging agents in an animal model of liver cirrhosis.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Liver; Liver Cirrhosis, Experimental; Male; O | 1991 |