Page last updated: 2024-12-07

1-diphosphoinositol pentakisphosphate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

## 1-Diphosphoinositol pentakisphosphate (InsP5)

1-Diphosphoinositol pentakisphosphate (InsP5) is a highly phosphorylated inositol phosphate, a molecule that plays a crucial role in various cellular processes. It is a highly charged, water-soluble molecule with a complex structure, characterized by:

* **Inositol ring:** A six-carbon ring that forms the core of the molecule.
* **Phosphate groups:** Five phosphate groups are attached to the inositol ring, with one of them being a diphosphate group.
* **Specific configuration:** The diphosphate group is located at the 1-position of the inositol ring, with the remaining phosphate groups at other positions.

**Importance for Research:**

InsP5 is gaining significant interest in research due to its potential involvement in diverse cellular pathways and functions. Here are some key areas where it is proving crucial:

* **Signaling pathways:** InsP5 is believed to act as a second messenger, relaying signals from extracellular stimuli to intracellular targets. This makes it a crucial player in various cellular processes, including:
* **Calcium signaling:** Regulating intracellular calcium levels, which are essential for cell function.
* **Cell growth and proliferation:** InsP5 can influence cell cycle progression and regulate the growth and division of cells.
* **Apoptosis (programmed cell death):** InsP5 can play a role in triggering or inhibiting apoptosis, contributing to cell survival or death.
* **Regulation of enzyme activity:** InsP5 has been shown to directly bind and regulate the activity of various enzymes, including kinases, phosphatases, and other proteins. This highlights its potential role in controlling important cellular processes.
* **Protein-protein interactions:** InsP5 can act as a scaffold, bringing together different proteins to form complex networks, ultimately affecting cellular function.
* **Transcriptional regulation:** There is evidence suggesting that InsP5 might influence gene expression by interacting with transcription factors or other regulatory proteins.
* **Potential therapeutic targets:** Due to its involvement in a variety of cellular processes, InsP5 is becoming a potential target for developing drugs for conditions like cancer, neurodegenerative diseases, and immune disorders.

**Challenges and Future Research:**

Despite its promising potential, research on InsP5 still faces several challenges:

* **Limited tools and methods:** Developing specific and sensitive tools to study InsP5 levels and its interactions within cells is crucial for understanding its role in detail.
* **Complex intracellular signaling:** Unraveling the intricate network of interactions and signaling pathways involving InsP5 is essential for understanding its exact roles in different cell types and conditions.
* **Therapeutic development:** Identifying specific and safe ways to target InsP5 for therapeutic interventions requires further research and testing.

**Conclusion:**

1-Diphosphoinositol pentakisphosphate is a fascinating molecule with significant potential in biological research. Its role in cellular signaling, enzyme regulation, and protein interactions makes it a promising target for future research and potentially for the development of new therapeutic strategies. Continued investigation of InsP5 will undoubtedly uncover even more insights into its crucial functions within cells.

1-diphosphoinositol pentakisphosphate: present as soluble ionic species in the cytosol of amoeba (Dictyostelium discoideum); rapidly metabolized in intact cells & can by synthesized in cell lysates from myo-inositol hexakisphosphate in the presence of ATP [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate : A myo-inositol pentakisphosphate that consists of myo-inositol having the five phospho groups located at positions 2, 3, 4, 5 and 6 as well as a diphospho group at position 1. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID127296
CHEMBL ID4293256
CHEBI ID62919
MeSH IDM0213605

Synonyms (22)

Synonym
diphosphoinositol pentakisphosphate
diphospho-myo-inositol pentakisphosphate
1-diphosinositol pentakisphosphate
148077-18-3
d-myo-inositol, 2,3,4,5,6-pentakis(dihydrogen phosphate) 1-(trihydrogen diphosphate)
1-diphosphoinositol pentakisphosphate
1-diphospho-1d-myo-inositol 2,3,4,5,6-pentakisphosphate
[(2r,3s,5r,6r)-2,3,4,5,6-pentaphosphonooxycyclohexyl] phosphono hydrogen phosphate
2,3,4,5,6-pentakis-o-phosphono-1d-myo-inositol 1-(trihydrogen diphosphate)
CHEBI:62919
1-pp-ip5
(1r,2r,3r,4r,5s,6r)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl trihydrogen diphosphate
pp-ip(5)
1-dpipk
1-(trihydrogen diphosphate)
d-myo-inositol, 2,3,4,5,6-pentakis(dihydrogen phosphate)
DTXSID20933301
1-o-diphospho-d-myo-inositol pentakisphosphate
Q27104903
o81 ,
(1s,2r,3r,4s,5s,6r)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl trihydrogen diphosphate
CHEMBL4293256
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (15)

Assay IDTitleYearJournalArticle
AID1413289Stabilization of N-terminal His-tagged DIPP3-beta (unknown origin) expressed in Escherichia coli assessed as increase in melting temperature up to 100 uM by SYPRO orange dye based DSF method2018MedChemComm, Jul-01, Volume: 9, Issue:7
A synthetic diphosphoinositol phosphate analogue of inositol trisphosphate.
AID1413281Stability in pH 7.5 Tris acetate/NaCl/DTT buffer after 20 mins in presence of Mn2+ by malachite green dye based assay2018MedChemComm, Jul-01, Volume: 9, Issue:7
A synthetic diphosphoinositol phosphate analogue of inositol trisphosphate.
AID1413275Substrate activity at N-terminal His-tagged DIPP3-alpha (unknown origin) expressed in Escherichia coli assessed as enzyme-mediated test compound metabolism after 20 mins in presence of Mg2+ by malachite green dye based assay2018MedChemComm, Jul-01, Volume: 9, Issue:7
A synthetic diphosphoinositol phosphate analogue of inositol trisphosphate.
AID1413280Substrate activity at N-terminal His-tagged DIPP3-beta (unknown origin) expressed in Escherichia coli assessed as enzyme-mediated test compound metabolism after 20 mins in presence of Mn2+ by malachite green dye based assay2018MedChemComm, Jul-01, Volume: 9, Issue:7
A synthetic diphosphoinositol phosphate analogue of inositol trisphosphate.
AID1413279Substrate activity at N-terminal His-tagged DIPP3-alpha (unknown origin) expressed in Escherichia coli assessed as enzyme-mediated test compound metabolism after 20 mins in presence of Mn2+ by malachite green dye based assay2018MedChemComm, Jul-01, Volume: 9, Issue:7
A synthetic diphosphoinositol phosphate analogue of inositol trisphosphate.
AID1413276Substrate activity at N-terminal His-tagged DIPP3-beta (unknown origin) expressed in Escherichia coli assessed as enzyme-mediated test compound metabolism after 20 mins in presence of Mg2+ by malachite green dye based assay2018MedChemComm, Jul-01, Volume: 9, Issue:7
A synthetic diphosphoinositol phosphate analogue of inositol trisphosphate.
AID1413277Substrate activity at N-terminal His-tagged DIPP1 (unknown origin) expressed in Escherichia coli assessed as enzyme-mediated test compound metabolism after 20 mins in presence of Mn2+ by malachite green dye based assay2018MedChemComm, Jul-01, Volume: 9, Issue:7
A synthetic diphosphoinositol phosphate analogue of inositol trisphosphate.
AID1413282Stability in pH 7.5 Tris acetate/NaCl/DTT buffer after 20 mins in presence of Mg2+ by malachite green dye based assay2018MedChemComm, Jul-01, Volume: 9, Issue:7
A synthetic diphosphoinositol phosphate analogue of inositol trisphosphate.
AID1413274Substrate activity at N-terminal His-tagged DIPP2 (unknown origin) expressed in Escherichia coli assessed as enzyme-mediated test compound metabolism after 20 mins in presence of Mg2+ by malachite green dye based assay2018MedChemComm, Jul-01, Volume: 9, Issue:7
A synthetic diphosphoinositol phosphate analogue of inositol trisphosphate.
AID1413288Stabilization of N-terminal His-tagged DIPP3-alpha (unknown origin) expressed in Escherichia coli assessed as increase in melting temperature up to 100 uM by SYPRO orange dye based DSF method2018MedChemComm, Jul-01, Volume: 9, Issue:7
A synthetic diphosphoinositol phosphate analogue of inositol trisphosphate.
AID1413273Substrate activity at N-terminal His-tagged DIPP1 (unknown origin) expressed in Escherichia coli assessed as enzyme-mediated test compound metabolism after 20 mins in presence of Mg2+ by malachite green dye based assay2018MedChemComm, Jul-01, Volume: 9, Issue:7
A synthetic diphosphoinositol phosphate analogue of inositol trisphosphate.
AID1413268Stabilization of N-terminal His-tagged DIPP1 (unknown origin) expressed in Escherichia coli assessed as increase in melting temperature at 0.1 mM by SYPRO orange dye based DSF method2018MedChemComm, Jul-01, Volume: 9, Issue:7
A synthetic diphosphoinositol phosphate analogue of inositol trisphosphate.
AID1413287Stabilization of N-terminal His-tagged DIPP2 (unknown origin) expressed in Escherichia coli assessed as increase in melting temperature up to 100 uM by SYPRO orange dye based DSF method2018MedChemComm, Jul-01, Volume: 9, Issue:7
A synthetic diphosphoinositol phosphate analogue of inositol trisphosphate.
AID1413286Stabilization of N-terminal His-tagged DIPP1 (unknown origin) expressed in Escherichia coli assessed as increase in melting temperature up to 100 uM by SYPRO orange dye based DSF method2018MedChemComm, Jul-01, Volume: 9, Issue:7
A synthetic diphosphoinositol phosphate analogue of inositol trisphosphate.
AID1413278Substrate activity at N-terminal His-tagged DIPP2 (unknown origin) expressed in Escherichia coli assessed as enzyme-mediated test compound metabolism after 20 mins in presence of Mn2+ by malachite green dye based assay2018MedChemComm, Jul-01, Volume: 9, Issue:7
A synthetic diphosphoinositol phosphate analogue of inositol trisphosphate.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (35)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's5 (14.29)18.2507
2000's15 (42.86)29.6817
2010's10 (28.57)24.3611
2020's5 (14.29)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.25

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.25 (24.57)
Research Supply Index3.58 (2.92)
Research Growth Index4.83 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.25)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (5.71%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other33 (94.29%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]