Compounds > pyromorphite
Page last updated: 2024-11-13

pyromorphite

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID25074062
MeSH IDM0446037

Synonyms (8)

Synonym
12190-77-1
pyromorphite (pb5cl(po4)3)
vv8h2g5wzx ,
unii-vv8h2g5wzx
pyromorphite
lead(2+);chloride;triphosphate
chloropyromorphite
DTXSID901047711

Research Excerpts

Effects

ExcerptReferenceRelevance
"Pyromorphite has been shown to be a potential source of nutrient phosphorus for common soil bacteria."( Pb remobilization by bacterially mediated dissolution of pyromorphite Pb5(PO4)3Cl in presence of phosphate-solubilizing Pseudomonas putida.
Kaschabek, S; Latowski, D; Manecki, M; Merkel, BJ; Rakovan, J; Topolska, J, 2014)		1.37

Bioavailability

The research examined the in vitro formation of pyromorphite (K(sp) = 10(-25) to significantly reduce Pb bioavailability via the reaction of PbCl(2) and Pb paint with cola soft drinks that contain phosphoric acid. It was observed that XRD was incapable of detecting pyrommorphite, the hopeful endpoint of the immobilization strategy.

ExcerptReferenceRelevance
"Soil amendments can be used to cost-effectively reduce the bioavailability and mobility of toxic metals in contaminated soils."( Impacts of phosphate amendments on lead biogeochemistry at a contaminated site.
Cao, X; Chen, M; Harris, WG; Ma, LQ; Singh, SP, 2002)		0.31
" Our research examined the in vitro formation of pyromorphite (K(sp) = 10(-25)) to significantly reduce Pb bioavailability via the reaction of PbCl(2) and Pb paint with cola soft drinks (regular, caffeine-free, and diet) that contain phosphoric acid."( In vitro formation of pyromorphite via reaction of Pb sources with soft-drink phosphoric acid.
Ryan, JA; Scheckel, KG, 2003)		0.89
"The determination of chemical speciation and spatial distribution is a prerequisite for a mechanistic understanding of contaminant bioavailability and toxicity to an organism."( Evidence for biogenic pyromorphite formation by the nematode Caenorhabditis elegans.
Bertsch, PM; Jackson, BP; Lanzirotti, A; Williams, PL, 2005)		0.64
" It was observed that XRD was incapable of detecting pyromorphite, the hopeful endpoint of the immobilization strategy for reduced Pb bioavailability in our studies."( Determining speciation of Pb in phosphate-amended soils: method limitations.
Allen, D; Lescano, NV; Ryan, JA; Scheckel, KG, 2005)		0.58
" It is concluded that standard sequential extraction procedures are probably not very useful in predicting lability and bioavailability of Pb in contaminated soils."( Evaluating specificity of sequential extraction for chemical forms of lead in artificially-contaminated and field-contaminated soils.
Li, Z; McBride, MB; Tai, Y, 2013)		0.39
"The effect of phosphate treatment on lead relative bioavailability (Pb RBA) was assessed in three distinct Pb-contaminated soils."( In situ formation of pyromorphite is not required for the reduction of in vivo pb relative bioavailability in contaminated soils.
Gancarz, D; Herde, C; Juhasz, AL; McClure, S; Scheckel, KG; Smith, E, 2014)		0.72
" The results of this study demonstrated that KP, SPP, and KPM can effectively decrease bioavailability of Pb."( Screening and assessment of solidification/stabilization amendments suitable for soils of lead-acid battery contaminated site.
Guo, G; Li, F; Rhee, JS; Teng, Y; Wang, J; Wang, S; Zhang, Z, 2015)		0.42
" The highest immobilization efficacy was observed with biochar produced at 300 °C, showing the maximum decreases of bioavailability by 94 and 70% for Pb and Cu, respectively, which were attributed to the abundance of functional groups in the biochar."( The role of biochar, natural iron oxides, and nanomaterials as soil amendments for immobilizing metals in shooting range soil.
Ahmad, M; Chang, JY; Kim, KR; Lee, SS; Ok, YS; Rajapaksha, AU; Vithanage, M, 2015)		0.42

Dosage Studied

ExcerptRelevanceReference
" Effects of dosage of adsorbent, pH, ionic strength, contact time, initial concentration of lead and temperature were investigated."( [Adsorption Behaviors of Lead on Multi-Walled Carbon Nanotube-Hydroxyapatite Composites].
Li, Y; Zhang, JL, 2015)		0.42
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (59)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's14 (23.73)29.6817
2010's37 (62.71)24.3611
2020's8 (13.56)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 33.37

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index33.37 (24.57)
Research Supply Index4.13 (2.92)
Research Growth Index4.88 (4.65)
Search Engine Demand Index85.58 (26.88)
Search Engine Supply Index3.91 (0.95)

This Compound (33.37)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other61 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
acetic acid
Acetic Acid: Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed). acetic acid : A simple monocarboxylic acid containing two carbons.		2.0510monocarboxylic acidantimicrobial food preservative;
Daphnia magna metabolite;
food acidity regulator;
protic solvent
methane
Methane: The simplest saturated hydrocarbon. It is a colorless, flammable gas, slightly soluble in water. It is one of the chief constituents of natural gas and is formed in the decomposition of organic matter. (Grant & Hackh's Chemical Dictionary, 5th ed). methane : A one-carbon compound in which the carbon is attached by single bonds to four hydrogen atoms. It is a colourless, odourless, non-toxic but flammable gas (b.p. -161degreeC).		2.1110alkane;
gas molecular entity;
mononuclear parent hydride;
one-carbon compound		bacterial metabolite;
fossil fuel;
greenhouse gas
citric acid, anhydrous
Citric Acid: A key intermediate in metabolism. It is an acid compound found in citrus fruits. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium chelating ability.. citric acid : A tricarboxylic acid that is propane-1,2,3-tricarboxylic acid bearing a hydroxy substituent at position 2. It is an important metabolite in the pathway of all aerobic organisms.		2.7730tricarboxylic acidantimicrobial agent;
chelator;
food acidity regulator;
fundamental metabolite
malic acid
malic acid : A 2-hydroxydicarboxylic acid that is succinic acid in which one of the hydrogens attached to a carbon is replaced by a hydroxy group.. 2-hydroxydicarboxylic acid : Any dicarboxylic acid carrying a hydroxy group on the carbon atom at position alpha to the carboxy group.		2.48202-hydroxydicarboxylic acid;
C4-dicarboxylic acid		food acidity regulator;
fundamental metabolite
formamide
formimidic acid : A carboximidic acid that is formic acid in which the carbonyl oxygen is replaced by an imino group.. primary carboxamide : A carboxamide resulting from the formal condensation of a carboxylic acid with ammonia; formula RC(=O)NH2.		2.0310carboximidic acid;
formamides;
monocarboxylic acid amide;
one-carbon compound		solvent
phytic acid
Phytic Acid: Complexing agent for removal of traces of heavy metal ions. It acts also as a hypocalcemic agent.. myo-inositol hexakisphosphate : A myo-inositol hexakisphosphate in which each hydroxy group of myo-inositol is monophosphorylated.		2.1310inositol phosphate
nickel
Nickel: A trace element with the atomic symbol Ni, atomic number 28, and atomic weight 58.69. It is a cofactor of the enzyme UREASE.. nickel ion : A nickel atom having a net electric charge.. nickel atom : Chemical element (nickel group element atom) with atomic number 28.		2.1710metal allergen;
nickel group element atom		epitope;
micronutrient
nitrates
Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.		2.8130monovalent inorganic anion;
nitrogen oxoanion;
reactive nitrogen species
oxalic acid
Oxalic Acid: A strong dicarboxylic acid occurring in many plants and vegetables. It is produced in the body by metabolism of glyoxylic acid or ascorbic acid. It is not metabolized but excreted in the urine. It is used as an analytical reagent and general reducing agent.. oxalic acid : An alpha,omega-dicarboxylic acid that is ethane substituted by carboxyl groups at positions 1 and 2.		3.2150alpha,omega-dicarboxylic acidalgal metabolite;
human metabolite;
plant metabolite
phosphoric acid
phosphoric acid: concise etchant is 37% H3PO4. phosphoric acid : A phosphorus oxoacid that consists of one oxo and three hydroxy groups joined covalently to a central phosphorus atom.		7.0110phosphoric acidsalgal metabolite;
fertilizer;
human metabolite;
NMR chemical shift reference compound;
solvent
potassium chloride
Potassium Chloride: A white crystal or crystalline powder used in BUFFERS; FERTILIZERS; and EXPLOSIVES. It can be used to replenish ELECTROLYTES and restore WATER-ELECTROLYTE BALANCE in treating HYPOKALEMIA.. potassium chloride : A metal chloride salt with a K(+) counterion.		2.1110inorganic chloride;
inorganic potassium salt;
potassium salt		fertilizer
sodium fluoride
[no description available]		2.0810fluoride saltmutagen
phencyclidine
Phencyclidine: A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to KETAMINE in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE). As a drug of abuse, it is known as PCP and Angel Dust.. phencyclidine : A member of the class of piperidines that is piperidine in which the nitrogen is substituted with a 1-phenylcyclohexyl group. Formerly used as an anaesthetic agent, it exhibits both hallucinogenic and neurotoxic effects.		2.1110benzenes;
piperidines		anaesthetic;
neurotoxin;
NMDA receptor antagonist;
psychotropic drug
durapatite
Durapatite: The mineral component of bones and teeth; it has been used therapeutically as a prosthetic aid and in the prevention and treatment of osteoporosis.. hydroxylapatite : A phosphate mineral with the formula Ca5(PO4)3(OH).		3.5270
lead sulfide
lead sulfide: surma refers to fine powder-like mascara, applied to conjunctival surfaces of eyes; originally contained antimony sulfide (derived from Urdu word for antimony); recently lead sulfide has been used due to scarcity of antimony; RN given refers to cpd with MF of Pb-S; galena is the principal ore of lead sulfide. Black kohl stone and red-brown kohl stone are widely used in eye cosmetics in the Middle East, Asia and Africa		2.7330
hydrocerussite
hydrocerussite: a minor lead ore		2.0810
carbonates
Carbonates: Salts or ions of the theoretical carbonic acid, containing the radical CO2(3-). Carbonates are readily decomposed by acids. The carbonates of the alkali metals are water-soluble; all others are insoluble. (From Grant & Hackh's Chemical Dictionary, 5th ed). carbonates : Organooxygen compounds that are salts or esters of carbonic acid, H2CO3.		3.0140carbon oxoanion
cadmium
Cadmium: An element with atomic symbol Cd, atomic number 48, and atomic weight 112.41. It is a metal and ingestion will lead to CADMIUM POISONING.. elemental cadmium : An element in the zinc group of the periodic table with atomic number 48, atomic mass 112, M.P. 321degreeC, and B.P. 765degreeC). An odourless, tasteless, and highly poisonous soft, ductile, lustrous metal with electropositive properties. It has eight stable isotopes: (106)Cd, (108)Cd,(110)Cd, (111)Cd, (112)Cd, (113)Cd, (114)Cd and (116)Cd, with (112)Cd and (114)Cd being the most common.		2.6620cadmium molecular entity;
zinc group element atom
chromium
Chromium: A trace element that plays a role in glucose metabolism. It has the atomic symbol Cr, atomic number 24, and atomic weight 52. According to the Fourth Annual Report on Carcinogens (NTP85-002,1985), chromium and some of its compounds have been listed as known carcinogens.. chromium ion : An chromium atom having a net electric charge.. chromium atom : A chromium group element atom that has atomic number 24.		2.1710chromium group element atom;
metal allergen		micronutrient
vanadium
Vanadium: A metallic element with the atomic symbol V, atomic number 23, and atomic weight 50.94. It is used in the manufacture of vanadium steel. Prolonged exposure can lead to chronic intoxication caused by absorption usually via the lungs.		2.1110elemental vanadium;
vanadium group element atom		micronutrient
lead sulfate
lead sulfate: RN given refers to cpd with MF of Pb-SO4		2.4920
lead phosphate
lead phosphate: RN given refers to unspecified MF		7.7930
phosphoric acid, trisodium salt
[no description available]		2.0610sodium phosphate
magnesium phosphate (2:3)
[no description available]		2.1710inorganic magnesium salt
tricalcium phosphate
tricalcium phosphate: a form of tricalcium phosphate used as bioceramic bone replacement material; see also records for alpha-tricalcium phosphate, beta-tricalcium phosphate, calcium phosphate; apatitic tricalcium phosphate Ca9(HPO4)(PO4)5(OH) is the calcium orthophosphate leading to beta tricalcium phosphate Ca3(PO4)2 (b-TCP). calcium phosphate : A calcium salt composed of calcium and phosphate/diphosphate ions; present in milk and used for the mineralisation of calcified tissues.		2.0510calcium phosphate
calcium sulfate
Calcium Sulfate: A calcium salt that is used for a variety of purposes including: building materials, as a desiccant, in dentistry as an impression material, cast, or die, and in medicine for immobilizing casts and as a tablet excipient. It exists in various forms and states of hydration. Plaster of Paris is a mixture of powdered and heat-treated gypsum.		2.4110calcium salt;
inorganic calcium salt
zinc phosphate
zinc phosphate: RN given refers to unspecified Zn salt; see also record for ZINC PHOSPHATE CEMENT RN 7779-90-0; hopeite was non-print entry term to ZINC PHOSPHATE CEMENT 1982-91		2.0810
lead nitrate
lead nitrate: RN given refers to unspecified lead nitrate		2.8130inorganic nitrate salt;
lead coordination entity
calcium sulfate dihydrate
phosphogypsum: used as fertilizer and in construction materials such as bricks, plaster etc; contains 11 components; found as industrial waste		2.4110calcium salt;
hydrate
calcium oxalate
Calcium Oxalate: The calcium salt of oxalic acid, occurring in the urine as crystals and in certain calculi.. calcium oxalate : The calcium salt of oxalic acid, which in excess in the urine may lead to formation of oxalate calculi (kidney stones).		2.1110organic calcium salt
potassium phosphate
potassium phosphate: used in dental materials and to treat hypophosphatemia; RN given refers to cpd with unspecified MF. tripotassium phosphate : An inorganic potassium salt that is the tripotassium salt of phosphoric acid.		2.5420inorganic phosphate salt;
inorganic potassium salt
aluminum phosphate
aluminum phosphate: gel used as immunologic adjuvent; RN given refers to Al salt		2.1710
cobalt
Cobalt: A trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.. cobalt(1+) : A monovalent inorganic cation obtained from cobalt.. cobalt atom : A cobalt group element atom that has atomic number 27.		2.1710cobalt group element atom;
metal allergen		micronutrient
tartaric acid
tartaric acid: RN given refers to cpd with unspecified isomeric designation. D-tartaric acid : The D-enantiomer of tartaric acid.		2.2110tartaric acidEscherichia coli metabolite
pyrophosphate
Diphosphates: Inorganic salts of phosphoric acid that contain two phosphate groups.		2.0610diphosphate ion
lead
Lead: A soft, grayish metal with poisonous salts; atomic number 82, atomic weight 207.2, symbol Pb.		5.35510carbon group element atom;
elemental lead;
metal atom		neurotoxin
antimony
Antimony: A metallic element that has the atomic symbol Sb, atomic number 51, and atomic weight 121.75. It is used as a metal alloy and as medicinal and poisonous salts. It is toxic and an irritant to the skin and the mucous membranes.		2.1110metalloid atom;
pnictogen
sulfur
Sulfur: An element that is a member of the chalcogen family. It has an atomic symbol S, atomic number 16, and atomic weight [32.059; 32.076]. It is found in the amino acids cysteine and methionine.		7.1310chalcogen;
nonmetal atom		macronutrient
phosphorus
Phosphorus: A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions.		8.7190monoatomic phosphorus;
nonmetal atom;
pnictogen		macronutrient
oxalates
Oxalates: Derivatives of OXALIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that are derived from the ethanedioic acid structure.		2.5520
whewellite
whewellite: calcium oxalate mineral		2.1110
fluorapatite
fluorapatite: RN refers to fluorapatite [Ca5F(PO4)3]). apatite : A phosphate mineral with the general formula Ca5(PO4)3X where X = OH, F or Cl.. fluorapatite : A phosphate mineral with the formula Ca5(PO4)3F.		2.1710
superphosphate
superphosphate: RN given refers to normal or enriched superphosphate, MF unknown		2.0610
ConditionIndicatedRelationship StrengthStudiesTrials
Poisoning, Lead
[description not available]		02.0110
Lead Poisoning
Poisoning that results from chronic or acute ingestion, injection, inhalation, or skin absorption of LEAD or lead compounds.		02.0110