Zellweger Syndrome

An autosomal recessive disorder due to defects in PEROXISOME biogenesis which involves more than 13 genes encoding peroxin proteins of the peroxisomal membrane and matrix. Zellweger syndrome is typically seen in the neonatal period with features such as dysmorphic skull; MUSCLE HYPOTONIA; SENSORINEURAL HEARING LOSS; visual compromise; SEIZURES; progressive degeneration of the KIDNEYS and the LIVER. Zellweger-like syndrome refers to phenotypes resembling the neonatal Zellweger syndrome but seen in children or adults with apparently intact peroxisome biogenesis.

Synonym
Zellweger Syndrome

Excerpt	Reference
"The Zellweger syndrome is characterized by a defect which results in the abnormal biogenesis of peroxisomes."	( Ashcraft, J; Kremser, K; Singh, AK; Singh, I; Stanczak, H; Stanley, W, 1992)
"Zellweger syndrome is a prototype of peroxisomal biogenesis disorders and a fatal autosomal recessive disease with no effective therapy."	( Fujiki, Y; Hashimoto, T; Kamijo, K; Kondo, N; Orii, T; Osumi, T; Shimozawa, N; Suzuki, Y; Tomatsu, S; Tsukamoto, T, 1996)
"Zellweger syndrome is the prototype of this group of disorders, with neonatal adrenoleukodystrophy and infantile Refsum disease as milder variants."	( Barth, PG; Dekker, C; Gootjes, J; Mooijer, PA; Poll-The, BT; Wanders, RJ; Waterham, HR, 2002)
"Zellweger syndrome is a lethal inherited disorder characterized by severe defects in peroxisome biogenesis and peroxisomal protein import."	( Faust, PL; Fliesler, SJ; Kovacs, WJ; Krisans, SK; Richards, MJ; Shackelford, JE; Tape, KN, 2004)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	14 (7.00)	23.3326
1990's	118 (59.00)	12.5806
2000's	41 (20.50)	18.1394
2010's	21 (10.50)	28.8240
2020's	6 (3.00)	9.53

Drug	Relationship Strength	Studies	Trials
adenine	low	1	0
adipic acid	low	1	0
betaine	low	2	0
carnitine	low	6	0
choline	low	2	0
chlorine	low	1	0
2-aminoadipic acid	low	1	0
methylmalonic acid	low	1	0
n(1)-acetylspermidine	low	1	0
creatine	low	1	0
lactic acid	low	1	0
dihydroxyacetone phosphate	low	1	0
glycine	low	2	0
glycerol	low	2	0
glycolic acid	low	1	0
pipecolic acid	low	8	0
malonic acid	low	1	0
methanol	low	1	0
phytic acid	low	1	0
n'-acetylspermine	low	1	0
nitrates	medium	1	1
nitrites	medium	1	1
palmitic acid	low	5	0
spermidine	low	1	0
spermine	low	1	0
taurine	low	1	0
trimethyloxamine	low	1	0
amitrole	low	1	0
adrenic acid	low	1	0
ethidium	low	1	0
iohexol	low	1	0
nocodazole	low	1	0
4-phenylbutyric acid	low	1	0
sebacic acid	low	3	0
stearic acid	low	3	0
estriol	low	2	0
thymidine	low	1	0
serine	low	1	0
aspartic acid	low	3	0
lysine	low	2	0
1,2-dipalmitoylphosphatidylcholine	low	1	0
arginine	low	1	0
methyl palmitate	low	1	0
4-hydroxyphenyllactic acid	low	2	0
fluorobenzenes	low	1	0
chenodeoxycholic acid	low	4	0
suberic acid	low	1	0
hexacosanoic acid	low	2	0
lignoceric acid	low	11	0
acetylcysteine	low	1	0
durapatite	low	1	0
d-alpha tocopherol	low	2	0
gadolinium	low	1	0
ferric chloride	low	1	0
deuterium	low	2	0
ammonium chloride	low	1	0
phytanic acid	low	27	0
tetradecanoylphorbol acetate	low	3	0
phosphotyrosine	low	1	0
phenyl acetate	low	1	0
pyrene	low	1	0
4-methoxyamphetamine	low	1	0
s-adenosylmethionine	low	1	0
fomesafen	low	1	0
ethyl 2-(5-(4-chlorophenyl)pentyl)oxiran-2-carboxylate	low	3	0
n-acetylaspartic acid	low	2	0
leupeptin	low	1	0
chimyl alcohol	low	1	0
pentafluorobenzyl bromide	low	1	0
coenzyme a	low	2	0
7-ketocholesterol	low	1	0
2-hydroxyisovaleric acid	low	1	0
1-hexadecyl-2-acetyl-glycero-3-phosphocholine	low	1	0
valerates	low	1	0
12-(1-pyrene)dodecanoic acid	low	4	0
caprylates	low	1	0
emeriamine	low	1	0
3,7,12-trihydroxycoprostanic acid	low	3	0
3,7,12-trihydroxycholestan-26-oic acid	low	2	0
pristanic acid	low	11	0
dihydroethidium	low	1	0
n',n''-diacetylspermine	low	1	0
biotin	low	1	0
isoputreanine	low	1	0
3-methylheptadecanoic acid	low	1	0
isospaglumic acid	low	1	0
2-hydroxyphytanic acid	low	3	0
cholic acid	medium	9	2
leupeptins	low	1	0
bradykinin	low	1	0
mevalonic acid	low	1	0
phytanoyl-coenzyme a	low	1	0
3,7-dihydroxycholestan-26-oic acid	low	3	0
5,6,7-trimethoxyflavone	low	1	0
arachidonic acid	low	5	0
retinol	low	1	0
oleic acid	low	3	0
eicosapentaenoic acid	low	1	0
isomethyleugenol	low	1	0
palmitoyl coenzyme a	low	1	0
dihydrosphingosine 1-phosphate	low	1	0
safingol	low	1	0
myelin basic protein	low	1	0
sphingosine	low	1	0
bilirubin	low	1	0
dinoprostone	medium	4	1
dinoprost	low	2	0
vitamin k semiquinone radical	low	1	0
leukotriene b4	low	1	0
leukotriene e4	medium	1	1
6-ketoprostaglandin f1 alpha	low	1	0
alpha-linolenic acid	low	1	0
erucic acid	low	1	0
nervonic acid	low	1	0
diosmetin	low	1	0
8-epi-prostaglandin f2alpha	low	1	0
tocotrienol, alpha	low	1	0
13-hydroxy-9,11-octadecadienoic acid	low	1	0
thromboxane b2	medium	3	1
2,3-dinor-thromboxane b2	low	1	0
lysophosphatidylcholines	low	2	0
12-hydroxy-5,8,10,14-eicosatetraenoic acid	low	1	0
15-hydroxy-5,8,11,13-eicosatetraenoic acid	low	1	0
diphenylhexatriene	low	1	0
cysteine	low	1	0
triolein	low	4	0
docosapentaenoic acid	low	3	0
oxalates	low	2	0
dizocilpine maleate	low	1	0
dolichols	low	1	0
tetracosahexaenoic acid	low	1	0
phosphocreatine	low	1	0
chlorhexidine	low	1	0
tocotrienols	low	1	0
nad	low	1	0
oligonucleotides	low	1	0
phosphatidylcholines	low	7	0
ubiquinone	low	1	0
tetracosapentaenoic acid	low	1	0
ganglioside, gd1a	low	1	0
glycolipids	low	4	0
warfarin	low	1	0
phenprocoumon	low	1	0
epidermal growth factor	low	1	0
g(m3) ganglioside	low	1	0
digitonin	low	3	0
3-methyladenine	low	1	0

Protein Targets (767)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	21	0	0	21
Chain A, Cruzipain	9	0	0	9
regulator of G-protein signaling 4	8	0	0	8
Platelet-activating factor receptor	0	2	0	2
Inositol monophosphatase 1	3	0	0	3
Solute carrier family 22 member 20	0	6	0	6
Solute carrier family 22 member 6	0	6	0	6
Chain A, DNA-3-methyladenine glycosylase I	0	0	1	1
Chain A, DNA-3-METHYLADENINE GLYCOSYLASE I	0	0	1	1
Chain A, Dna-3-methyladenine Glycosylase I	0	0	1	1
EWS/FLI fusion protein	6	0	0	6
5-hydroxytryptamine receptor 2C	0	1	1	2
5-hydroxytryptamine receptor 2A	0	1	1	2
5-hydroxytryptamine receptor 1A	0	1	1	2
5-hydroxytryptamine receptor 1B	0	1	1	2
5-hydroxytryptamine receptor 1D	0	1	1	2
5-hydroxytryptamine receptor 1F	0	1	1	2
5-hydroxytryptamine receptor 2B	0	1	1	2
5-hydroxytryptamine receptor 6	0	0	1	1
Sodium-dependent serotonin transporter	0	2	1	3
Sodium-dependent serotonin transporter	0	1	0	1
5-hydroxytryptamine receptor 7	0	0	1	1
5-hydroxytryptamine receptor 5A	0	0	1	1
5-hydroxytryptamine receptor 5B	0	0	1	1
5-hydroxytryptamine receptor 3A	0	0	1	1
5-hydroxytryptamine receptor 4	0	0	1	1
5-hydroxytryptamine receptor 3B	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
mitogen-activated protein kinase 1	6	0	0	6
survival motor neuron protein isoform d	2	0	0	2
Histone deacetylase 3	0	3	0	3
Histone deacetylase 4	0	3	0	3
Histone deacetylase 1	0	3	0	3
Histone deacetylase 7	0	3	0	3
Histone deacetylase 2	0	3	0	3
Polyamine deacetylase HDAC10	0	2	0	2
Histone deacetylase 11	0	2	0	2
Histone deacetylase 8	0	3	0	3
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
Histone deacetylase 6	0	3	0	3
Histone deacetylase 9	0	3	0	3
Histone deacetylase 5	0	3	0	3
Solute carrier organic anion transporter family member 2A1	0	1	0	6
TDP1 protein	17	0	0	17
serine/threonine-protein kinase PLK1	3	0	0	3
DNA polymerase iota isoform a (long)	9	0	0	9
geminin	17	0	0	17
Rap guanine nucleotide exchange factor 3	4	0	0	4
NPC1-like intracellular cholesterol transporter 1	0	0	1	1
aldehyde dehydrogenase 1 family, member A1	15	0	0	15
Chain A, JmjC domain-containing histone demethylation protein 3A	5	0	0	5
Chain A, 2-oxoglutarate Oxygenase	7	0	0	7
Chain A, ATP-DEPENDENT DNA HELICASE Q1	6	0	0	6
acetylcholinesterase	6	0	0	6
dopamine D1 receptor	2	0	0	2
15-lipoxygenase, partial	9	0	0	9
pregnane X receptor	4	0	0	4
phosphopantetheinyl transferase	16	0	0	16
RAR-related orphan receptor gamma	18	0	0	18
USP1 protein, partial	13	0	0	13
NFKB1 protein, partial	3	0	0	3
Microtubule-associated protein tau	11	0	0	11
Thrombopoietin	4	0	0	4
AR protein	23	0	0	23
glucocorticoid receptor [Homo sapiens]	21	0	0	21
retinoic acid nuclear receptor alpha variant 1	21	0	0	21
retinoid X nuclear receptor alpha	10	0	0	10
farnesoid X nuclear receptor	10	0	0	10
estrogen nuclear receptor alpha	26	0	0	26
vitamin D (1,25- dihydroxyvitamin D3) receptor	11	0	0	11
arylsulfatase A	5	0	0	5
euchromatic histone-lysine N-methyltransferase 2	20	0	0	20
Bloom syndrome protein isoform 1	11	0	0	11
D(1A) dopamine receptor	1	0	0	1
thyroid hormone receptor beta isoform a	10	0	0	10
thyroid hormone receptor beta isoform 2	15	0	0	15
heat shock protein beta-1	8	0	0	8
flap endonuclease 1	5	0	0	5
peripheral myelin protein 22	9	0	0	9
muscarinic acetylcholine receptor M1	6	0	0	6
Solute carrier family 22 member 6	0	1	0	1
Guanine nucleotide-binding protein G	3	0	0	3
Ataxin-2	4	0	0	4
ATP-dependent phosphofructokinase	7	0	0	7
Chain A, MTA/SAH nucleosidase	0	1	0	1
Chain A, Ribosome-inactivating protein alpha-trichosanthin	0	0	1	1
Chain A, Ricin A chain	0	0	1	1
Chain A, Ribosome-inactivating protein 3	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
nuclear receptor subfamily 1, group I, member 3	10	0	0	10
cytochrome P450 family 3 subfamily A polypeptide 4	8	0	0	8
estrogen-related nuclear receptor alpha	18	0	0	18
pregnane X nuclear receptor	9	0	0	9
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	7	0	0	7
nuclear factor erythroid 2-related factor 2 isoform 2	4	0	0	4
importin subunit beta-1 isoform 1	5	0	0	5
snurportin-1	5	0	0	5
tumor susceptibility gene 101 protein	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	3	0	0	3
lamin isoform A-delta10	15	0	0	15
Voltage-dependent calcium channel gamma-2 subunit	4	0	0	4
Bile salt export pump	0	9	0	9
Cyclin-dependent kinase 1	0	1	0	1
Heat shock protein HSP 90-beta	0	1	0	1
Glutamate receptor 2	4	0	0	4
Xanthine dehydrogenase/oxidase	0	1	0	1
TAR DNA-binding protein 43	4	0	0	4
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Leucine-rich repeat serine/threonine-protein kinase 2	0	2	0	2
ATPase family AAA domain-containing protein 5	3	0	0	3
GLI family zinc finger 3	16	0	0	16
cytochrome P450 2D6	4	0	0	4
peroxisome proliferator-activated receptor delta	11	0	0	11
histone acetyltransferase KAT2A isoform 1	10	0	0	10
lethal factor (plasmid)	7	0	0	7
Cellular tumor antigen p53	16	0	0	16
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	7	0	0	7
Chain A, Beta-lactamase	5	0	0	5
Chain A, HADH2 protein	8	0	0	8
Chain B, HADH2 protein	8	0	0	8
Luciferase	8	0	0	8
thioredoxin reductase	8	0	0	8
WRN	1	0	0	1
hypoxia-inducible factor 1 alpha subunit	4	0	0	4
SMAD family member 2	5	0	0	5
GLS protein	5	0	0	5
SMAD family member 3	5	0	0	5
thioredoxin glutathione reductase	3	0	0	3
estrogen receptor 2 (ER beta)	8	0	0	8
progesterone receptor	7	0	0	7
peroxisome proliferator activated receptor gamma	10	0	0	10
activating transcription factor 6	7	0	0	7
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	4	0	0	4
v-jun sarcoma virus 17 oncogene homolog (avian)	6	0	0	6
Caspase-7	2	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	4	0	0	4
phospholipase A2 precursor	0	1	0	1
vitamin D3 receptor isoform VDRA	14	0	0	14
caspase-3	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	15	0	0	15
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
DNA polymerase eta isoform 1	2	0	0	2
cysteine protease ATG4B isoform a	0	1	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	2	0	0	2
DNA polymerase kappa isoform 1	15	0	0	15
cytochrome P450 3A4 isoform 1	6	0	0	6
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	2	0	0	2
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	6	0	0	6
Free fatty acid receptor 1	0	0	1	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	5	0	0	5
Prostaglandin G/H synthase 1	0	6	0	7
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Trypsin	0	5	0	5
Coagulation factor VII	0	4	0	4
Aromatase	0	5	0	5
Tissue factor	0	4	0	4
Gamma-aminobutyric acid receptor subunit beta-1	6	0	0	6
Gamma-aminobutyric acid receptor subunit delta	6	0	0	6
Gamma-aminobutyric acid receptor subunit gamma-2	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-5	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-3	6	0	0	6
Prostaglandin G/H synthase 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-2	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-4	6	0	0	6
Gamma-aminobutyric acid receptor subunit gamma-3	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-6	6	0	0	6
Peroxisome proliferator-activated receptor gamma	0	0	2	2
Histamine H2 receptor	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-1	6	0	0	6
Gamma-aminobutyric acid receptor subunit beta-3	6	0	0	6
Gamma-aminobutyric acid receptor subunit beta-2	6	0	0	6
Prostaglandin G/H synthase 2	0	5	0	6
Free fatty acid receptor 4	0	0	1	1
GABA theta subunit	6	0	0	6
Gamma-aminobutyric acid receptor subunit epsilon	6	0	0	6
Integrase	0	1	0	1
Chain A, ADIPOCYTE LIPID-BINDING PROTEIN	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	2	2
Chain A, SERUM ALBUMIN	0	0	2	2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	2	0	0	2
cellular tumor antigen p53 isoform a	4	0	0	4
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
nuclear receptor ROR-gamma isoform 1	6	0	0	6
caspase-1 isoform alpha precursor	2	0	0	2
Fatty-acid amide hydrolase 1	0	2	0	2
60 kDa chaperonin	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Fatty acid-binding protein, adipocyte	0	5	3	8
Prostaglandin G/H synthase 2	0	1	1	3
Nuclear receptor subfamily 4 group A member 2	0	0	2	2
10 kDa heat shock protein, mitochondrial	0	1	0	1
Calmodulin	0	0	0	1
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Fatty acid-binding protein 5	0	4	1	5
Fatty acid-binding protein 5	0	0	1	1
Thiosulfate sulfurtransferase	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	4	0	5
Cytosolic phospholipase A2 gamma	0	1	0	1
Transient receptor potential cation channel subfamily V member 2	0	4	0	4
Solute carrier organic anion transporter family member 1B1	0	4	0	5
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
thyroid stimulating hormone receptor	9	0	0	9
alpha-galactosidase	2	0	0	2
cytochrome P450 2C19 precursor	5	0	0	5
chromobox protein homolog 1	5	0	0	5
Cytochrome P450 3A4	0	0	1	2
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	2	0	2
Chain A, Ferritin light chain	3	0	0	3
Metabotropic glutamate receptor 6	0	0	1	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate transporter homolog	0	0	1	1
Carbonic anhydrase 1	0	5	0	7
Carbonic anhydrase 2	0	5	0	7
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
5-hydroxytryptamine receptor 1D	0	0	0	1
Glutamate receptor ionotropic, NMDA 1	0	5	3	8
Excitatory amino acid transporter 1	0	1	0	1
Excitatory amino acid transporter 2	0	1	0	1
Excitatory amino acid transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	5	2	7
Glutamate receptor ionotropic, NMDA 2B	0	5	3	8
Glutamate receptor ionotropic, NMDA 2C	0	5	2	7
Metabotropic glutamate receptor 1	0	0	1	1
Metabotropic glutamate receptor 2	0	0	1	1
Carbonic anhydrase-like protein, putative	0	0	0	2
Glutamate receptor ionotropic, NMDA 2D	0	5	2	7
Glutamate receptor ionotropic, NMDA 3B	0	5	2	7
Carbonic anhydrase 4	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	5	2	7
Chain A, Betaine ABC transporter permease and substrate binding protein	0	0	1	1
Chain A, Osmoprotection protein (ProX)	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	2	2
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	2	2
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	2	2
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	2	2
Bile salt export pump	0	1	0	1
Proton-coupled amino acid transporter 1	0	5	0	5
Chain A, Putative fructose-1,6-bisphosphate aldolase	3	0	0	3
Caspase-7	1	0	0	1
Chain A, Avidin	0	0	1	1
Chain A, Protein (streptavidin)	0	0	1	1
Chain B, Protein (streptavidin)	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin Complex With Biotin	0	0	1	1
Chain D, Circularly Permuted Core-streptavidin E51/a46	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Avidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
apical membrane antigen 1, AMA1	2	0	0	2
nonstructural protein 1	0	1	0	1
green fluorescent protein, partial	0	1	0	1
insulin-degrading enzyme isoform 1	0	0	1	1
Streptavidin	0	0	1	1
Receptor-type tyrosine-protein phosphatase beta	0	0	0	1
Angiotensin-converting enzyme	0	0	0	1
B2 bradykinin receptor	0	1	0	1
B2 bradykinin receptor	0	2	1	5
B1 bradykinin receptor	0	1	0	1
Olfactory receptor 51E2	0	0	4	4
Chain A, Beta-lactoglobulin	0	0	1	1
Chain A, Beta-lactoglobulin	0	0	1	1
UDP-3-O-acyl-N-acetylglucosamine deacetylase	0	0	1	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 16	0	0	0	1
Solute carrier family 22 member 21	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
caspase 7, apoptosis-related cysteine protease	4	0	0	4
caspase-3	4	0	0	4
Alpha-2A adrenergic receptor	0	0	2	2
Vitamin D3 receptor	0	2	2	4
Alpha-2B adrenergic receptor	0	0	2	2
Alpha-2C adrenergic receptor	0	0	2	2
Retinoic acid receptor RXR-alpha	0	0	1	1
Ileal sodium/bile acid cotransporter	0	1	0	1
Bile acid receptor	0	0	1	1
G-protein coupled bile acid receptor 1	0	1	2	3
Bile acid receptor	0	0	2	2
Chain A, BCL-2-RELATED PROTEIN A1	0	0	2	2
acid sphingomyelinase	2	0	0	2
interleukin 8	2	0	0	2
PAX8	0	0	0	1
glp-1 receptor, partial	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	2	0	0	2
PINK1	1	0	0	1
G	2	0	0	2
67.9K protein	4	0	0	4
glucocerebrosidase	3	0	0	3
Parkin	1	0	0	1
heat shock protein 90	0	0	1	1
IDH1	4	0	0	4
calcineurin A1, putative	0	0	1	1
aryl hydrocarbon receptor	4	0	0	4
thyroid stimulating hormone receptor	7	0	0	7
Histone H2A.x	6	0	0	6
cytochrome P450 2D6 isoform 1	1	0	0	1
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
cytochrome P450 2C9 precursor	3	0	0	3
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	8	0	0	8
transcriptional regulator ERG isoform 3	2	0	0	2
huntingtin isoform 2	2	0	0	2
ubiquitin-conjugating enzyme E2 N	0	2	0	2
nuclear factor NF-kappa-B p105 subunit isoform 1	2	0	0	2
protein AF-9 isoform a	0	0	0	1
melanocortin receptor 4	0	1	0	1
CAAX prenyl protease	0	0	0	1
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
bcl-2-related protein A1	0	2	0	2
urokinase plasminogen activator surface receptor precursor	1	0	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
glycogen synthase kinase-3 alpha	0	0	0	1
hexokinase HKDC1	0	1	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
bcl-2-like protein 11 isoform 1	0	0	2	2
Synaptojanin-2	0	1	0	1
Solute carrier family 22 member 2	0	1	0	4
Solute carrier family 22 member 1	0	1	0	4
Synaptojanin-1	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Glutathione reductase, mitochondrial	0	3	0	4
Interferon beta	5	0	0	5
HLA class I histocompatibility antigen, B alpha chain	2	0	0	2
Integrin beta-3	2	0	0	2
72 kDa type IV collagenase	0	1	0	1
Integrin alpha-IIb	2	0	0	2
Matrix metalloproteinase-9	0	1	0	1
Trypanothione reductase	0	1	0	1
Alpha-synuclein	1	2	0	3
Nuclear receptor ROR-gamma	3	0	0	3
Spike glycoprotein	4	0	0	4
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase	0	2	0	2
Multidrug and toxin extrusion protein 2	0	1	0	1
Rap guanine nucleotide exchange factor 4	3	0	0	3
Inositol hexakisphosphate kinase 1	2	0	0	2
Multidrug and toxin extrusion protein 1	0	1	0	1
Spermine oxidase	0	1	0	1
cytochrome P450 2C9, partial	2	0	0	2
Carbonic anhydrase 4	0	5	0	5
Carbonic anhydrase	0	3	0	3
Carbonic anhydrase 15	0	5	0	5
Ubiquitin carboxyl-terminal hydrolase 2	0	1	0	1
Phospholipase A2	0	0	1	1
G-protein coupled bile acid receptor 1	0	1	0	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
Solute carrier family 22 member 1	0	1	0	2
Solute carrier family 22 member 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-5	0	1	0	1
Acetylcholinesterase	0	1	0	1
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Choline O-acetyltransferase	0	0	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-9	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Solute carrier family 22 member 1	0	1	0	2
High affinity choline transporter 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-10	0	1	0	1
Solute carrier family 22 member 2	0	1	0	2
Choline O-acetyltransferase	0	1	0	1
Histone acetyltransferase p300	0	1	0	1
Histone acetyltransferase KAT2B	0	1	0	1
Histone acetyltransferase KAT5	0	1	0	1
N-alpha-acetyltransferase 50	0	0	1	1
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
Chain A, HTH-type transcriptional regulator qacR	0	0	1	1
Chain B, HTH-type transcriptional regulator qacR	0	0	1	1
Chain A, PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY DEOR-FAMILY)	0	0	1	1
Chain B, PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY DEOR-FAMILY)	0	0	1	1
Chain A, ALDOLASE	0	0	1	1
Prostaglandin G/H synthase 2	0	1	0	1
Thromboxane A2 receptor	0	1	1	2
Prostaglandin E2 receptor EP1 subtype	0	3	2	5
Prostaglandin E2 receptor EP4 subtype	0	3	1	4
Prostaglandin F2-alpha receptor	0	2	0	2
Prostaglandin F2-alpha receptor	0	2	2	4
Prostaglandin E2 receptor EP3 subtype	0	3	2	5
Prostaglandin E2 receptor EP2 subtype	0	3	1	4
Prostaglandin F2-alpha receptor	0	0	1	1
Prostacyclin receptor	0	3	1	4
Prostaglandin D2 receptor	0	1	0	1
Solute carrier family 22 member 6	0	0	0	2
Solute carrier family 22 member 7	0	0	0	2
Solute carrier family 22 member 8	0	0	0	2
Solute carrier organic anion transporter family member 2A1	0	1	0	4
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	1	0	1
Solute carrier family 22 member 11	0	0	0	2
Solute carrier family 22 member 7	0	0	0	2
prostaglandin E2 receptor EP2 subtype	1	0	0	1
Multidrug resistance-associated protein 4	0	1	0	2
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 7	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
PPM1D protein	4	0	0	4
Lysine-specific histone demethylase 1A	0	1	0	1
Cytochrome P450 1A1	0	3	0	3
Cytochrome P450 1A2	0	3	0	3
Catechol O-methyltransferase	0	0	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Mitogen-activated protein kinase 10	0	1	0	1
Mitogen-activated protein kinase 14	0	1	0	1
Cytochrome P450 1B1	0	3	0	3
Inositol polyphosphate multikinase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	2	0	2
Aurora kinase B	0	1	0	1
Inositol hexakisphosphate kinase 2	0	1	0	1
Chain A, Protein (peroxisome Proliferator Activated Receptor (ppar-delta))	0	1	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	3	0	0	3
Retinoic acid receptor RXR-alpha	0	1	0	1
Oxoeicosanoid receptor 1	0	1	0	1
Carnitine O-palmitoyltransferase 2, mitochondrial	0	1	0	1
Carnitine O-palmitoyltransferase 2, mitochondrial	0	1	0	1
Carnitine O-palmitoyltransferase 1, liver isoform	0	1	0	1
Carnitine O-palmitoyltransferase 1, muscle isoform	0	1	0	1
Carnitine O-palmitoyltransferase 1, muscle isoform	0	1	0	1
Estrogen receptor	0	2	0	2
Glucocorticoid receptor	0	2	0	2
Sex hormone-binding globulin	0	0	1	1
Glycine receptor subunit alpha-1	0	2	0	2
Corticosteroid-binding globulin	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Androgen receptor	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	0	0	1
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Lanosterol 14-alpha demethylase	0	0	1	1
UDP-glucuronosyltransferase 1A10	0	0	0	1
Smad3	2	0	0	2
Reverse transcriptase/RNaseH	0	1	0	1
Chain A, Glutamine Binding Protein	0	0	1	1
peripheral myelin protein 22 isoform 1	2	0	0	2
Neutral amino acid transporter A	0	2	0	2
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	2	0	2
Amino acid transporter	0	2	0	2
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Serine racemase	0	3	0	3
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Chain B, Pulmonary surfactant-associated protein D	0	1	0	1
Chain A, Pulmonary surfactant-associated protein D	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	4	0	0	4
Amyloid-beta precursor protein	0	2	0	2
Sodium/myo-inositol cotransporter 2	0	1	0	1
ATAD5 protein, partial	5	0	0	5
ATP-binding cassette sub-family C member 3	0	1	0	1
Glutamate carboxypeptidase 2	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Leukotriene B4 receptor 1	0	2	0	2
Leukotriene B4 receptor 2	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	1
P2Y purinoceptor 12	0	0	1	1
Cysteinyl leukotriene receptor 2	0	0	1	1
Cysteinyl leukotriene receptor 1	0	0	1	1
Cathepsin B	0	1	0	1
Prothrombin	0	1	0	1
Plasminogen	0	1	0	1
Cationic trypsin	0	1	0	1
Papain	0	1	0	1
Plasma kallikrein	0	1	0	1
Serine protease hepsin	0	1	0	1
Plasminogen	0	1	0	1
Trypsin-1	0	1	0	1
Trypsin-2	0	1	0	1
Cathepsin B	0	1	0	1
Procathepsin L	0	1	0	1
Cathepsin B	0	2	0	2
Pro-cathepsin H	0	1	0	1
Trypsin-3	0	1	0	1
Calpain-1 catalytic subunit	0	1	0	1
Cathepsin K	0	1	0	1
Hepatocyte growth factor activator	0	1	0	1
Transmembrane protease serine 6	0	1	0	1
Cysteine protease	0	1	0	1
Cysteine proteinase falcipain 2a	0	1	0	1
Cysteine protease falcipain-3	0	1	0	1
Suppressor of tumorigenicity 14 protein	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Phosphoenolpyruvate carboxykinase	0	1	0	1
D-aspartate oxidase	0	1	0	1
L-lactate dehydrogenase A chain	0	0	1	1
Proto-oncogene tyrosine-protein kinase Src	0	1	0	2
D-amino-acid oxidase	0	1	0	1
D-aspartate oxidase	0	1	0	1
D-aspartate oxidase	0	2	0	2
Serine racemase	0	3	0	3
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Sodium/iodide cotransporter	0	1	0	1
Chain A, Glutathione-requiring prostaglandin D synthase	0	1	0	1
Fumarate hydratase	1	0	0	1
polyprotein	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
nuclear receptor subfamily 0 group B member 1	0	1	0	1
histone deacetylase 9 isoform 3	1	0	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	3	0	0	3
steroidogenic factor 1	0	1	0	1
neuropeptide S receptor isoform A	1	0	0	1
Tyrosine-protein kinase ABL1	0	1	0	1
Tubulin alpha-1A chain	0	1	0	1
Tubulin beta chain	0	1	0	1
Tubulin beta-4A chain	0	1	1	2
Tubulin beta chain	0	1	1	2
Tubulin alpha-3C chain	0	1	1	2
Amine oxidase [flavin-containing] A	0	1	0	1
Adenosine receptor A2a	0	2	0	2
Adenosine receptor A1	0	2	0	2
5-hydroxytryptamine receptor 2B	0	2	0	2
Tubulin alpha-1B chain	0	1	1	2
Tubulin alpha-4A chain	0	1	1	2
Tubulin beta-4B chain	0	1	1	2
Sodium-dependent dopamine transporter	0	2	0	2
Tubulin beta-3 chain	0	1	1	2
Tubulin beta-2A chain	0	1	1	2
Tubulin beta-8 chain	0	1	1	2
Tubulin beta-2B chain	0	1	0	2
Tubulin alpha-3E chain	0	1	1	2
Tubulin alpha-1A chain	0	1	1	2
Similar to alpha-tubulin isoform 1	0	1	0	2
Similar to alpha-tubulin isoform 1	0	1	0	2
CREB-binding protein	1	0	0	1
Tubulin alpha-1C chain	0	1	1	2
Tubulin beta-6 chain	0	1	1	2
Tubulin beta-2B chain	0	1	1	2
Tubulin beta-1 chain	0	1	1	2
Chain A, Adipocyte Lipid-binding Protein	0	0	1	1
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	2	2
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	2	2
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	2	2
putative potassium channel subunit	0	0	1	1
serine-protein kinase ATM isoform a	1	0	0	1
Sterol O-acyltransferase 1	0	1	0	1
Fatty acid-binding protein, liver	0	2	0	2
Fatty acid-binding protein, liver	0	1	1	2
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
DNA topoisomerase 1	0	1	0	1
Protein kinase C alpha type	0	1	1	3
Tyrosine-protein phosphatase non-receptor type 1	0	3	0	3
Sterol O-acyltransferase 1	0	1	0	1
Peroxisome proliferator-activated receptor delta	0	0	0	1
Peroxisome proliferator-activated receptor alpha	2	0	3	5
Chain A, Fatty acid-binding protein, adipocyte	0	1	0	1
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
Acetylcholinesterase	0	4	0	4
Toll-like receptor 2	0	1	0	1
Fatty acid-binding protein, intestinal	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Cytochrome P450 2D6	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Protease	0	3	0	3
Tyrosine-protein kinase Lck	0	0	0	1
Growth factor receptor-bound protein 2	0	0	0	1
Tyrosine-protein phosphatase non-receptor type 11	0	0	0	1
Chain D, PROTEIN (PHOSPHOGLYCERATE MUTASE 1)	0	1	0	1
Chain A, PROTEIN (PHOSPHOGLYCERATE MUTASE 1)	0	1	0	1
Chain A, Beta-arrestin 1	0	0	1	1
Peroxisomal sarcosine oxidase	0	0	0	1
GALC protein	2	0	0	2
Polypeptide N-acetylgalactosaminyltransferase 2	0	1	0	1
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Met repressor	0	0	2	2
Protein arginine N-methyltransferase 5	0	0	1	1
Histone H3K27 methylase	0	0	0	1
Phenylethanolamine N-methyltransferase	0	0	1	2
S-adenosylmethionine decarboxylase proenzyme	0	1	0	2
Protein-L-isoaspartate(D-aspartate) O-methyltransferase	0	1	0	1
Catechol O-methyltransferase	0	0	0	1
Protein arginine N-methyltransferase 1	0	1	0	1
Methylosome protein 50	0	0	1	1
Sphingosine kinase 1	0	2	0	2
Chain A, Porphobilinogen Synthase	0	1	0	1
Chain A, Porphobilinogen Synthase	0	1	0	1
Chain A, Porphobilinogen Synthase	0	1	0	1
Pyruvate kinase PKM	0	1	1	2
Cholinesterase	0	1	0	1
Carbonic anhydrase 12	0	2	0	2
Carbonic anhydrase 3	0	2	0	2
DNA topoisomerase 2-alpha	0	2	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	2	0	2
Cannabinoid receptor 1	0	2	0	2
Carbonic anhydrase 6	0	2	0	2
Carbonic anhydrase 5A, mitochondrial	0	2	0	2
Carbonic anhydrase 7	0	2	0	2
Sulfate anion transporter 1	0	0	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	2	0	2
Carbonic anhydrase 9	0	2	0	2
Carbonic anhydrase 13	0	2	0	2
Carbonic anhydrase 14	0	2	0	2
Carbonic anhydrase 5B, mitochondrial	0	2	0	2
Caspase-2	0	0	1	1
Glutamate receptor ionotropic, NMDA 2B	0	0	1	1
endonuclease IV	1	0	0	1
C-X-C chemokine receptor type 5 isoform 1	0	1	0	1
DNA polymerase beta	1	0	0	1
C-C chemokine receptor type 6	0	1	0	1
apelin receptor	0	1	0	1
streptokinase A precursor	0	0	1	1
Endoglycoceramidase II	0	0	0	1
Protein kinase C alpha type	0	1	0	1
Estrogen receptor	0	0	1	1
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
cAMP-dependent protein kinase catalytic subunit alpha	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Estrogen receptor beta	0	0	1	1
Protein kinase C eta type	0	1	0	1
Sphingosine kinase 2	0	1	0	1
Protein kinase C theta type	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Serine/threonine-protein kinase D3	0	0	1	1
Protein kinase C gamma type	0	1	1	2
Protein kinase C beta type	0	1	1	2
Luciferin 4-monooxygenase	0	0	1	1
Beta-1 adrenergic receptor	0	1	0	1
Protein kinase C eta type	0	0	1	1
Protein kinase C iota type	0	0	1	1
Protein kinase C epsilon type	0	1	1	2
Protein kinase C theta type	0	0	1	1
Protein kinase C zeta type	0	0	1	1
Protein kinase C delta type	0	1	1	2
Serine/threonine-protein kinase D1	0	0	1	1
Ras guanyl-releasing protein 3	0	0	1	1
Thymidine kinase	0	1	0	2
Thymidine kinase, cytosolic	0	2	0	4
Thymidine kinase	0	1	0	2
Thymidylate synthase	0	0	0	1
Thymidine phosphorylase	0	0	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Thymidine phosphorylase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	2
Thymidine kinase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase	0	1	0	2
Sterol O-acyltransferase 1	0	1	0	1
Thymidine kinase	0	0	0	1
Thymidine kinase	0	0	0	1
Carbonic anhydrase	0	1	0	1
Albumin	0	0	1	1
Albumin	0	0	1	1
Cytochrome P450 2C9	0	1	0	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Research

Studies (200)

Protein Targets (767)

Zellweger Syndrome

Synonyms(1)

Research Excerpts

Overview

Research

Studies (200)

Drugs Studied (174)

Protein Targets (767)